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Research | 21 October 2020 | Open
The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models
- Alina Klems
- , Jos van Rijssel
- , Anne S. Ramms
- , Raphael Wild
- , Julia Hammer
- , Melanie Merkel
- , Laura Derenbach
- , Laetitia Préau
- , Rabea Hinkel
- , Irina Suarez-Martinez
- , Stefan Schulte-Merker
- , Ramon Vidal
- , Sascha Sauer
- , Riikka Kivelä
- , Kari Alitalo
- , Christian Kupatt
- , Jaap D. van Buul
- & Ferdinand le Noble
Nature Communications 11 , 1–20

Rights & permissionsfor article The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models . Opens in a new window.
Research | 9 June 2020
Pro-lymphangiogenic VEGFR-3 signaling modulates memory T cell responses in allergic airway inflammation
- Katharina Maisel
- , Cara L. Hrusch
- , Jorge E. G. Medellin
- , Lambert Potin
- , David B. Chapel
- , Harri Nurmi
- , Daniel F. Camacho
- , Rachel Gleyzer
- , Kari Alitalo
- , Anne I. Sperling
- & Melody A. Swartz
Mucosal Immunology 14 , 144–151

Rights & permissionsfor article Pro-lymphangiogenic VEGFR-3 signaling modulates memory T cell responses in allergic airway inflammation . Opens in a new window.
Research | 14 August 2020 | Open
Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi
- Seon Pyo Hong
- , Myung Jin Yang
- , Hyunsoo Cho
- , Intae Park
- , Hosung Bae
- , Kibaek Choe
- , Sang Heon Suh
- , Ralf H. Adams
- , Kari Alitalo
- , Daesik Lim
- & Gou Young Koh
Nature Communications 11 , 1–16

Rights & permissionsfor article Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi . Opens in a new window.
Research | 8 June 2020 | Open
Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation
- Ines Martinez-Corral
- , Yan Zhang
- , Milena Petkova
- , Henrik Ortsäter
- , Sofie Sjöberg
- , Sandra D. Castillo
- , Pascal Brouillard
- , Louis Libbrecht
- , Dieter Saur
- , Mariona Graupera
- , Kari Alitalo
- , Laurence Boon
- , Miikka Vikkula
- & Taija Mäkinen
Nature Communications 11 , 1–14

Rights & permissionsfor article Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic <i>PIK3CA</i> mutation . Opens in a new window.
Research Highlights | 24 October 2017
White adipose tissue coloring by intermittent fasting
- Riikka Kivelä
- & Kari Alitalo
Cell Research 27 , 1300–1301

Rights & permissionsfor article White adipose tissue coloring by intermittent fasting . Opens in a new window.
Research | 28 March 2017 | Open
Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis
Scientific Reports 7 , 1–10

Rights & permissionsfor article Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis . Opens in a new window.
24 August 2000
The Bmx tyrosine kinase is activated by IL-3 and G-CSF in a PI-3K dependent manner
- Niklas Ekman
- , Elena Arighi
- , Iiro Rajantie
- , Pipsa Saharinen
- , Ari Ristimäki
- , Olli Silvennoinen
- & Kari Alitalo
Oncogene 19 , 4151–4158

Rights & permissionsfor article The Bmx tyrosine kinase is activated by IL-3 and G-CSF in a PI-3K dependent manner . Opens in a new window.
Reviews | 1 December 1999
Clinical applications of angiogenic growth factors and their inhibitors
- Napoleone Ferrara
- & Kari Alitalo
Nature Medicine 5 , 1359–1364

Rights & permissionsfor article Clinical applications of angiogenic growth factors and their inhibitors . Opens in a new window.
Research | 27 June 2004
Kaposi sarcoma herpesvirus–induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma
Nature Genetics 36 , 687–693

Rights & permissionsfor article Kaposi sarcoma herpesvirus–induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma . Opens in a new window.
22 May 1997
Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia
- Berndt Enholm
- , Karri Paavonen
- , Ari Ristimäki
- , Vijay Kumar
- , Yuji Gunji
- , Juha Klefstrom
- , Laura Kivinen
- , Marikki Laiho
- , Birgitta Olofsson
- , Vladimir Joukov
- , Ulf Eriksson
- & Kari Alitalo
Oncogene 14 , 2475–2483

Rights & permissionsfor article Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia . Opens in a new window.
19 January 1999
Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response
Oncogene 18 , 1–8

Rights & permissionsfor article Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response . Opens in a new window.
4 September 1998
Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines
- Ju-Ock Kim
- , Marion M Nau
- , Kathrine A Allikian
- , Tomi P Mäkelä
- , Kari Alitalo
- , Bruce E Johnson
- & Michael J Kelley
Oncogene 17 , 1019–1026

Rights & permissionsfor article Co-amplification of a novel cyclophilin-like gene (<i>PPIE</i>) with L-<i>myc</i> in small cell lung cancer cell lines . Opens in a new window.
Research | 1 June 1983
A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells
Nature 303 , 497–501

Rights & permissionsfor article A cellular oncogene (c-Ki-<i>ras</i>) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells . Opens in a new window.
Research | 1 February 2001
Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis
- Mihaela Skobe
- , Thomas Hawighorst
- , David G. Jackson
- , Remko Prevo
- , Lauren Janes
- , Paula Velasco
- , Lucia Riccardi
- , Kari Alitalo
- , Kevin Claffey
- & Michael Detmar
Nature Medicine 7 , 192–198

Rights & permissionsfor article Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis . Opens in a new window.
8 April 1999
c-Myc and E1A induced cellular sensitivity to activated NK cells involves cytotoxic granules as death effectors
- Juha Klefstrom
- , Panu E Kovanen
- , Kristina Somersalo
- , Anne-Odile Hueber
- , Trevor Littlewood
- , Gerard I Evan
- , Arnold H Greenberg
- , Eero Saksela
- , Tuomo Timonen
- & Kari Alitalo
Oncogene 18 , 2181–2188

Rights & permissionsfor article c-Myc and E1A induced cellular sensitivity to activated NK cells involves cytotoxic granules as death effectors . Opens in a new window.
7 March 2000
Developmental expression of Pim kinases suggests functions also outside of the hematopoietic system
- Anne Eichmann
- , Li Yuan
- , Christiane Bréant
- , Kari Alitalo
- & Päivi J Koskinen
Oncogene 19 , 1215–1224

Rights & permissionsfor article Developmental expression of Pim kinases suggests functions also outside of the hematopoietic system . Opens in a new window.
Research | 23 May 1985
Amplification and enhanced expression of the c-myc oncogene in mouse SEWA tumour cells
- Manfred Schwab
- , Gary Ramsay
- , Kari Alitalo
- , Harold E. Varmus
- , J. Michael Bishop
- , Tommy Martinsson
- , Goran Levan
- & Albert Levan
Nature 315 , 345–347

Rights & permissionsfor article Amplification and enhanced expression of the c-<i>myc</i> oncogene in mouse SEWA tumour cells . Opens in a new window.
1 January 2002
Lymphatic endothelium: a new frontier of metastasis research
Nature Cell Biology 4 , E2–E5

Rights & permissionsfor article Lymphatic endothelium: a new frontier of metastasis research . Opens in a new window.
News and Views | 1 July 2001
The fatal detachment
- Kari Alitalo
Nature Cell Biology 3 , E157–E158

Rights & permissionsfor article The fatal detachment . Opens in a new window.
Research | 20 April 2008
Modeling lymphangiogenesis in a three-dimensional culture system
- Françoise Bruyère
- , Laurence Melen-Lamalle
- , Silvia Blacher
- , Guy Roland
- , Marc Thiry
- , Lieve Moons
- , Francis Frankenne
- , Peter Carmeliet
- , Kari Alitalo
- , Claude Libert
- , Jonathan P Sleeman
- , Jean-Michel Foidart
- & Agnès Noël
Nature Methods 5 , 431–437

Rights & permissionsfor article Modeling lymphangiogenesis in a three-dimensional culture system . Opens in a new window.
Research | 17 November 1983
Identification of nuclear proteins encoded by viral and cellular myc oncogenes
Nature 306 , 274–277

Rights & permissionsfor article Identification of nuclear proteins encoded by viral and cellular <i>myc</i> oncogenes . Opens in a new window.
Research | 15 September 1983
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour
- Manfred Schwab
- , Kari Alitalo
- , Karl-Heinz Klempnauer
- , Harold E. Varmus
- , J. Michael Bishop
- , Fred Gilbert
- , Garrett Brodeur
- , Milton Goldstein
- & Jeffrey Trent
Nature 305 , 245–248

Rights & permissionsfor article Amplified DNA with limited homology to <i>myc</i> cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour . Opens in a new window.
Research | 23 November 2003
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
- Marika J Karkkainen
- , Paula Haiko
- , Kirsi Sainio
- , Juha Partanen
- , Jussi Taipale
- , Tatiana V Petrova
- , Michael Jeltsch
- , David G Jackson
- , Marja Talikka
- , Heikki Rauvala
- , Christer Betsholtz
- & Kari Alitalo
Nature Immunology 5 , 74–80

Rights & permissionsfor article Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins . Opens in a new window.
Research | 11 April 2001
PDGF-D is a specific, protease-activated ligand for the PDGF β-receptor
- Erika Bergsten
- , Marko Uutela
- , Xuri Li
- , Kristian Pietras
- , Arne Östman
- , Carl-Henrik Heldin
- , Kari Alitalo
- & Ulf Eriksson
Nature Cell Biology 3 , 512–516

Rights & permissionsfor article PDGF-D is a specific, protease-activated ligand for the PDGF β-receptor . Opens in a new window.
Research | 1 February 2001
Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3
- Taija Mäkinen
- , Lotta Jussila
- , Tanja Veikkola
- , Terhi Karpanen
- , Mikko I. Kettunen
- , Kalevi J. Pulkkanen
- , Risto Kauppinen
- , David G. Jackson
- , Hajime Kubo
- , Shin-Ichi Nishikawa
- , Seppo Ylä-Herttuala
- & Kari Alitalo
Nature Medicine 7 , 199–205

Rights & permissionsfor article Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3 . Opens in a new window.
9 December 2000
Mechanisms of angiogenesis and their use in the inhibition of tumor growth and metastasis
Oncogene 19 , 6122–6129

Rights & permissionsfor article Mechanisms of angiogenesis and their use in the inhibition of tumor growth and metastasis . Opens in a new window.
News and Views | 1 August 2002
VEGF receptor 1 stimulates stem-cell recruitment and new hope for angiogenesis therapies
- Ulf Eriksson
- & Kari Alitalo
Nature Medicine 8 , 775–777

Rights & permissionsfor article VEGF receptor 1 stimulates stem-cell recruitment and new hope for angiogenesis therapies . Opens in a new window.
Research | 15 January 2020
VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours
- Eric Song
- , Tianyang Mao
- , Huiping Dong
- , Ligia Simoes Braga Boisserand
- , Salli Antila
- , Marcus Bosenberg
- , Kari Alitalo
- , Jean-Leon Thomas
- & Akiko Iwasaki
Nature 577 , 689–694

Rights & permissionsfor article VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours . Opens in a new window.
Research | 9 October 2019 | Open
Anatomy and function of the vertebral column lymphatic network in mice
- Laurent Jacob
- , Ligia Simoes Braga Boisserand
- , Luiz Henrique Medeiros Geraldo
- , Jose de Brito Neto
- , Thomas Mathivet
- , Salli Antila
- , Besma Barka
- , Yunling Xu
- , Jean-Mickael Thomas
- , Juliette Pestel
- , Marie-Stéphane Aigrot
- , Eric Song
- , Harri Nurmi
- , Seyoung Lee
- , Kari Alitalo
- , Nicolas Renier
- , Anne Eichmann
- & Jean-Leon Thomas
Nature Communications 10 , 1–16

Rights & permissionsfor article Anatomy and function of the vertebral column lymphatic network in mice . Opens in a new window.
Reviews | 17 October 2018
Cardiac lymphatics in health and disease
- Ebba Brakenhielm
- & Kari Alitalo
Nature Reviews Cardiology 16 , 56–68

Rights & permissionsfor article Cardiac lymphatics in health and disease . Opens in a new window.
Research | 26 September 2018
Mechanosensing by β1 integrin induces angiocrine signals for liver growth and survival
- Linda Lorenz
- , Jennifer Axnick
- , Tobias Buschmann
- , Carina Henning
- , Sofia Urner
- , Shentong Fang
- , Harri Nurmi
- , Nicole Eichhorst
- , Richard Holtmeier
- , Kálmán Bódis
- , Jong-Hee Hwang
- , Karsten Müssig
- , Daniel Eberhard
- , Jörg Stypmann
- , Oliver Kuss
- , Michael Roden
- , Kari Alitalo
- , Dieter Häussinger
- & Eckhard Lammert
Nature 562 , 128–132

Rights & permissionsfor article Mechanosensing by β1 integrin induces angiocrine signals for liver growth and survival . Opens in a new window.
Research | 5 December 2018 | Open
uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis
- Tania Durré
- , Florent Morfoisse
- , Charlotte Erpicum
- , Marie Ebroin
- , Silvia Blacher
- , Melissa García-Caballero
- , Christophe Deroanne
- , Thomas Louis
- , Cédric Balsat
- , Maureen Van de Velde
- , Seppo Kaijalainen
- , Frédéric Kridelka
- , Lars Engelholm
- , Ingrid Struman
- , Kari Alitalo
- , Niels Behrendt
- , Jenny Paupert
- & Agnès Noel
Nature Communications 9 , 1–16

Rights & permissionsfor article uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis . Opens in a new window.
Research | 22 June 2018 | Open
PROX1 is a transcriptional regulator of MMP14
- Silvia Gramolelli
- , Jianpin Cheng
- , Ines Martinez-Corral
- , Markus Vähä-Koskela
- , Endrit Elbasani
- , Elisa Kaivanto
- , Ville Rantanen
- , Krista Tuohinto
- , Sampsa Hautaniemi
- , Mark Bower
- , Caj Haglund
- , Kari Alitalo
- , Taija Mäkinen
- , Tatiana V. Petrova
- , Kaisa Lehti
- & Päivi M. Ojala
Scientific Reports 8 , 1–13

Rights & permissionsfor article PROX1 is a transcriptional regulator of MMP14 . Opens in a new window.
Research | 3 April 2018 | Open
Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms
- Yan Zhang
- , Maria H. Ulvmar
- , Lukas Stanczuk
- , Ines Martinez-Corral
- , Maike Frye
- , Kari Alitalo
- & Taija Mäkinen
Nature Communications 9 , 1–15

Rights & permissionsfor article Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms . Opens in a new window.
Research | 18 September 2017 | Open
Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1
- Yidong Wang
- , Bingruo Wu
- , Pengfei Lu
- , Donghong Zhang
- , Brian Wu
- , Shweta Varshney
- , Gonzalo del Monte-Nieto
- , Zhenwu Zhuang
- , Rabab Charafeddine
- , Adam H. Kramer
- , Nicolas E. Sibinga
- , Nikolaos G. Frangogiannis
- , Richard N. Kitsis
- , Ralf H. Adams
- , Kari Alitalo
- , David J. Sharp
- , Richard P. Harvey
- , Pamela Stanley
- & Bin Zhou
Nature Communications 8 , 1–15

Rights & permissionsfor article Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking <i>Pofut1</i> . Opens in a new window.
Reviews | 19 May 2017
Therapeutic targeting of the angiopoietin–TIE pathway
Nature Reviews Drug Discovery 16 , 635–661

Rights & permissionsfor article Therapeutic targeting of the angiopoietin–TIE pathway . Opens in a new window.
Research | 7 July 2017 | Open
Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1
Scientific Reports 7 , 1–13

Rights & permissionsfor article Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1 . Opens in a new window.
Research | 12 October 2016 | Open
The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation
Nature Communications 7 , 1–11

Rights & permissionsfor article The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation . Opens in a new window.
Research | 11 August 2016 | Open
Transgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice
- Sinem Karaman
- , Maija Hollmén
- , Sun-Young Yoon
- , H. Furkan Alkan
- , Kari Alitalo
- , Christian Wolfrum
- & Michael Detmar
Scientific Reports 6 , 1–12

Rights & permissionsfor article Transgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice . Opens in a new window.
Research | 30 January 2015 | Open
Endothelial destabilization by angiopoietin-2 via integrin β1 activation
- Laura Hakanpaa
- , Tuomas Sipila
- , Veli-Matti Leppanen
- , Prson Gautam
- , Harri Nurmi
- , Guillaume Jacquemet
- , Lauri Eklund
- , Johanna Ivaska
- , Kari Alitalo
- & Pipsa Saharinen
Nature Communications 6 , 1–12

Rights & permissionsfor article Endothelial destabilization by angiopoietin-2 via integrin β1 activation . Opens in a new window.
Research | 7 April 2000
PDGF-C is a new protease-activated ligand for the PDGF α-receptor
- Xuri Li
- , Annica Pontén
- , Karin Aase
- , Linda Karlsson
- , Alexandra Abramsson
- , Marko Uutela
- , Gudrun Bäckström
- , Mats Hellström
- , Hans Boström
- , Hong Li
- , Philippe Soriano
- , Christer Betsholtz
- , Carl-Henrik Heldin
- , Kari Alitalo
- , Arne Östman
- & Ulf Eriksson
Nature Cell Biology 2 , 302–309

Rights & permissionsfor article PDGF-C is a new protease-activated ligand for the PDGF α-receptor . Opens in a new window.
Research | 2 December 2007
Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation
- Tuomas Tammela
- , Anne Saaristo
- , Tanja Holopainen
- , Johannes Lyytikkä
- , Anna Kotronen
- , Miia Pitkonen
- , Usama Abo-Ramadan
- , Seppo Ylä-Herttuala
- , Tatiana V Petrova
- & Kari Alitalo
Nature Medicine 13 , 1458–1466

Rights & permissionsfor article Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation . Opens in a new window.
Reviews | 14 December 2005
Lymphangiogenesis in development and human disease
Nature 438 , 946–953

Rights & permissionsfor article Lymphangiogenesis in development and human disease . Opens in a new window.
Reviews | 1 June 2007
Molecular regulation of angiogenesis and lymphangiogenesis
- Ralf H. Adams
- & Kari Alitalo
Nature Reviews Molecular Cell Biology 8 , 464–478

Rights & permissionsfor article Molecular regulation of angiogenesis and lymphangiogenesis . Opens in a new window.
Reviews | 1 June 2003
Gene transfer as a tool to induce therapeutic vascular growth
- Seppo Ylä-Herttuala
- & Kari Alitalo
Nature Medicine 9 , 694–701

Rights & permissionsfor article Gene transfer as a tool to induce therapeutic vascular growth . Opens in a new window.
Reviews | 1 August 2002
Lymphangiogenesis and cancer metastasis
Nature Reviews Cancer 2 , 573–583

Rights & permissionsfor article Lymphangiogenesis and cancer metastasis . Opens in a new window.
Reviews | 1 April 2001
Tie receptors: new modulators of angiogenic and lymphangiogenic responses
Nature Reviews Molecular Cell Biology 2 , 257–267

Rights & permissionsfor article Tie receptors: new modulators of angiogenic and lymphangiogenic responses . Opens in a new window.
Research | 1 June 2000
Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema
Nature Genetics 25 , 153–159

Rights & permissionsfor article Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema . Opens in a new window.
Research | 22 August 2004
Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis
- Tatiana V Petrova
- , Terhi Karpanen
- , Camilla Norrmén
- , Russell Mellor
- , Tomoki Tamakoshi
- , David Finegold
- , Robert Ferrell
- , Dontscho Kerjaschki
- , Peter Mortimer
- , Seppo Ylä-Herttuala
- , Naoyuki Miura
- & Kari Alitalo
Nature Medicine 10 , 974–981

Rights & permissionsfor article Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis . Opens in a new window.
Research | 2 March 2011
Copy number variation and selection during reprogramming to pluripotency
- Samer M. Hussein
- , Nizar N. Batada
- , Sanna Vuoristo
- , Reagan W. Ching
- , Reija Autio
- , Elisa Närvä
- , Siemon Ng
- , Michel Sourour
- , Riikka Hämäläinen
- , Cia Olsson
- , Karolina Lundin
- , Milla Mikkola
- , Ras Trokovic
- , Michael Peitz
- , Oliver Brüstle
- , David P. Bazett-Jones
- , Kari Alitalo
- , Riitta Lahesmaa
- , Andras Nagy
- & Timo Otonkoski
Nature 471 , 58–62

Rights & permissionsfor article Copy number variation and selection during reprogramming to pluripotency . Opens in a new window.

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