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Amendments and Corrections | 1 April 2006
Erratum: Mutations in different components of FGF signaling in LADD syndrome
- Edyta Rohmann
- , Han G Brunner
- , Hülya Kayserili
- , Oya Uyguner
- , Gudrun Nürnberg
- , Erin D Lew
- , Angus Dobbie
- , Veraragavan P Eswarakumar
- , Abdullah Uzumcu
- , Melike Ulubil-Emeroglu
- , Jules G Leroy
- , Yun Li
- , Christian Becker
- , Kai Lehnerdt
- , Cor W R J Cremers
- , Memnune Yüksel-Apak
- , Peter Nürnberg
- , Christian Kubisch
- , Joseph Schlessinger
- , Hans van Bokhoven
- & Bernd Wollnik
Nature Genetics 38 , 495–495

Rights & permissionsfor article Erratum: Mutations in different components of FGF signaling in LADD syndrome . Opens in a new window.
News and Views | 8 November 2019
Small molecule combats cancer-causing KRAS protein at last
- Roy S. Herbst
- & Joseph Schlessinger
Nature 575 , 294–295

Rights & permissionsfor article Small molecule combats cancer-causing KRAS protein at last . Opens in a new window.
Research | 28 April 2015 | Open
FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic–pituitary–adrenal axis
- Rachel J. Perry
- , Sangwon Lee
- , Lie Ma
- , Dongyan Zhang
- , Joseph Schlessinger
- & Gerald I. Shulman
Nature Communications 6 , 1–10

Rights & permissionsfor article FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic–pituitary–adrenal axis . Opens in a new window.
18 August 1999
Evidence for SH3 domain directed binding and phosphorylation of Sam68 by Src
Oncogene 18 , 4647–4653

Rights & permissionsfor article Evidence for SH3 domain directed binding and phosphorylation of Sam68 by Src . Opens in a new window.
Research | 14 August 1980
Insulin and antibodies against insulin receptor cap on the membrane of cultured human lymphocytes
Nature 286 , 729–731

Rights & permissionsfor article Insulin and antibodies against insulin receptor cap on the membrane of cultured human lymphocytes . Opens in a new window.
Research | 26 April 1979
Local aggregation of hormone–receptor complexes is required for activation by epidermal growth factor
Nature 278 , 835–838

Rights & permissionsfor article Local aggregation of hormone–receptor complexes is required for activation by epidermal growth factor . Opens in a new window.
News and Views | 1 March 2002
A solid base for assaying protein kinase activity
- Joseph Schlessinger
Nature Biotechnology 20 , 232–233

Rights & permissionsfor article A solid base for assaying protein kinase activity . Opens in a new window.
Research | 1 July 2000
Absence of marginal zone B cells in Pyk-2–deficient mice defines their role in the humoral response
Nature Immunology 1 , 31–36

Rights & permissionsfor article Absence of marginal zone B cells in Pyk-2–deficient mice defines their role in the humoral response . Opens in a new window.
Research | 6 May 1993
Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras
Nature 363 , 88–92

Rights & permissionsfor article Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras . Opens in a new window.
Research | 30 September 2002
A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions
Nature Genetics 32 , 411–414

Rights & permissionsfor article A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions . Opens in a new window.
Research | 10 January 1985
Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin
- Towia A. Libermann
- , Harris R. Nusbaum
- , Nissim Razon
- , Richard Kris
- , Irit Lax
- , Hermona Soreq
- , Nigel Whittle
- , Michael D. Waterfield
- , Axel Ullrich
- & Joseph Schlessinger
Nature 313 , 144–147

Rights & permissionsfor article Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin . Opens in a new window.
Research | 6 November 1986
A chimaeric receptor allows insulin to stimulate tyrosine kinase activity of epidermal growth factor receptor
Nature 324 , 68–70

Rights & permissionsfor article A chimaeric receptor allows insulin to stimulate tyrosine kinase activity of epidermal growth factor receptor . Opens in a new window.
News and Views | 1 September 1995
Scratching the surface with the PH domain
Nature Structural & Molecular Biology 2 , 715–718

Rights & permissionsfor article Scratching the surface with the PH domain . Opens in a new window.
News and Views | 1 March 2000
Novel fluorescent approaches for studying cell signaling in single cells
- Joseph Schlessinger
Nature Biotechnology 18 , 262–263

Rights & permissionsfor article Novel fluorescent approaches for studying cell signaling in single cells . Opens in a new window.
Research | 25 June 1998
Structure of a heparin-linked biologically active dimer of fibroblast growth factor
Nature 393 , 812–817

Rights & permissionsfor article Structure of a heparin-linked biologically active dimer of fibroblast growth factor . Opens in a new window.
Research | 10 October 1996
A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation
Nature 383 , 547–550

Rights & permissionsfor article A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation . Opens in a new window.
Research | 9 February 1995
Catalytic specificity of protein-tyrosine kinases is critical for selective signalling
Nature 373 , 536–539

Rights & permissionsfor article Catalytic specificity of protein-tyrosine kinases is critical for selective signalling . Opens in a new window.
20 May 1999
The proto-oncogene c-Cbl is a negative regulator of DNA synthesis initiated by both receptor and cytoplasmic tyrosine kinases
Oncogene 18 , 2908–2912

Rights & permissionsfor article The proto-oncogene c-Cbl is a negative regulator of DNA synthesis initiated by both receptor and cytoplasmic tyrosine kinases . Opens in a new window.
Research | 26 February 2006
Mutations in different components of FGF signaling in LADD syndrome
- Edyta Rohmann
- , Han G Brunner
- , Hülya Kayserili
- , Oya Uyguner
- , Gudrun Nürnberg
- , Erin D Lew
- , Angus Dobbie
- , Veraragavan P Eswarakumar
- , Abdullah Uzumcu
- , Melike Ulubil-Emeroglu
- , Jules G Leroy
- , Yun Li
- , Christian Becker
- , Kai Lehnerdt
- , Cor W R J Cremers
- , Memnune Yüksel-Apak
- , Peter Nürnberg
- , Christian Kubisch
- , Joseph Schlessinger
- , Hans van Bokhoven
- & Bernd Wollnik
Nature Genetics 38 , 414–417

Rights & permissionsfor article Mutations in different components of FGF signaling in LADD syndrome . Opens in a new window.
Research | 9 December 1993
Interferon-induced nuclear signalling by Jak protein tyrosine kinases
Nature 366 , 583–585

Rights & permissionsfor article Interferon-induced nuclear signalling by Jak protein tyrosine kinases . Opens in a new window.
Research | 1 December 1976
Lateral motion and valence of Fc receptors on rat peritoneal mast cells
Nature 264 , 550–552

Rights & permissionsfor article Lateral motion and valence of Fc receptors on rat peritoneal mast cells . Opens in a new window.
Research | 7 September 2010
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
- Gideon Bollag
- , Peter Hirth
- , James Tsai
- , Jiazhong Zhang
- , Prabha N. Ibrahim
- , Hanna Cho
- , Wayne Spevak
- , Chao Zhang
- , Ying Zhang
- , Gaston Habets
- , Elizabeth A. Burton
- , Bernice Wong
- , Garson Tsang
- , Brian L. West
- , Ben Powell
- , Rafe Shellooe
- , Adhirai Marimuthu
- , Hoa Nguyen
- , Kam Y. J. Zhang
- , Dean R. Artis
- , Joseph Schlessinger
- , Fei Su
- , Brian Higgins
- , Raman Iyer
- , Kurt D’Andrea
- , Astrid Koehler
- , Michael Stumm
- , Paul S. Lin
- , Richard J. Lee
- , Joseph Grippo
- , Igor Puzanov
- , Kevin B. Kim
- , Antoni Ribas
- , Grant A. McArthur
- , Jeffrey A. Sosman
- , Paul B. Chapman
- , Keith T. Flaherty
- , Xiaowei Xu
- , Katherine L. Nathanson
- & Keith Nolop
Nature 467 , 596–599

Rights & permissionsfor article Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma . Opens in a new window.
Research | 1 January 2001
Variations of Proline-Rich Kinase Pyk2 Expression Correlate with Prostate Cancer Progression
Laboratory Investigation 81 , 51–59

Rights & permissionsfor article Variations of Proline-Rich Kinase Pyk2 Expression Correlate with Prostate Cancer Progression . Opens in a new window.
Research | 17 January 2018
Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling
- ...signalling. In this issue, Joseph Schlessinger and colleagues report crystal structures...
- Sangwon Lee
- , Jungyuen Choi
- , Jyotidarsini Mohanty
- , Leiliane P. Sousa
- , Francisco Tome
- , Els Pardon
- , Jan Steyaert
- , Mark A. Lemmon
- , Irit Lax
- & Joseph Schlessinger
Nature 553 , 501–505

Rights & permissionsfor article Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling . Opens in a new window.
Research | 7 March 2016 | Open
Data publication with the structural biology data grid supports live analysis
- Peter A. Meyer
- , Stephanie Socias
- , Jason Key
- , Elizabeth Ransey
- , Emily C. Tjon
- , Alejandro Buschiazzo
- , Ming Lei
- , Chris Botka
- , James Withrow
- , David Neau
- , Kanagalaghatta Rajashankar
- , Karen S. Anderson
- , Richard H. Baxter
- , Stephen C. Blacklow
- , Titus J. Boggon
- , Alexandre M. J. J. Bonvin
- , Dominika Borek
- , Tom J. Brett
- , Amedeo Caflisch
- , Chung-I Chang
- , Walter J. Chazin
- , Kevin D. Corbett
- , Michael S. Cosgrove
- , Sean Crosson
- , Sirano Dhe-Paganon
- , Enrico Di Cera
- , Catherine L. Drennan
- , Michael J. Eck
- , Brandt F. Eichman
- , Qing R. Fan
- , Adrian R. Ferré-D'Amaré
- , J. Christopher Fromme
- , K. Christopher Garcia
- , Rachelle Gaudet
- , Peng Gong
- , Stephen C. Harrison
- , Ekaterina E. Heldwein
- , Zongchao Jia
- , Robert J. Keenan
- , Andrew C. Kruse
- , Marc Kvansakul
- , Jason S. McLellan
- , Yorgo Modis
- , Yunsun Nam
- , Zbyszek Otwinowski
- , Emil F. Pai
- , Pedro José Barbosa Pereira
- , Carlo Petosa
- , C. S. Raman
- , Tom A. Rapoport
- , Antonina Roll-Mecak
- , Michael K. Rosen
- , Gabby Rudenko
- , Joseph Schlessinger
- , Thomas U. Schwartz
- , Yousif Shamoo
- , Holger Sondermann
- , Yizhi J. Tao
- , Niraj H. Tolia
- , Oleg V. Tsodikov
- , Kenneth D. Westover
- , Hao Wu
- , Ian Foster
- , James S. Fraser
- , Filipe R. N C. Maia
- , Tamir Gonen
- , Tom Kirchhausen
- , Kay Diederichs
- , Mercè Crosas
- & Piotr Sliz
Nature Communications 7 , 1–12

Rights & permissionsfor article Data publication with the structural biology data grid supports live analysis . Opens in a new window.
Research | 27 July 2015
Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas
- Michael Krauthammer
- , Yong Kong
- , Antonella Bacchiocchi
- , Perry Evans
- , Natapol Pornputtapong
- , Cen Wu
- , James P McCusker
- , Shuangge Ma
- , Elaine Cheng
- , Robert Straub
- , Merdan Serin
- , Marcus Bosenberg
- , Stephan Ariyan
- , Deepak Narayan
- , Mario Sznol
- , Harriet M Kluger
- , Shrikant Mane
- , Joseph Schlessinger
- , Richard P Lifton
- & Ruth Halaban
Nature Genetics 47 , 996–1002

Rights & permissionsfor article Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas . Opens in a new window.
Research | 1 December 1994
Structure of the N-terminal SH3 domain of GRB2 complexed with a peptide from the guanine nucleotide releasing factor Sos
- Hiroaki Terasawa
- , Daisuke Kohda
- , Hideki Hatanaka
- , Shigeo Tsuchiya
- , Kenji Ogura
- , Koji Nagata
- , Shunsuke Ishii
- , Valsan Mandiyan
- , Axel Ullrich
- , Joseph Schlessinger
- & Fuyuhiko Inagaki
Nature Structural & Molecular Biology 1 , 891–897

Rights & permissionsfor article Structure of the N-terminal SH3 domain of GRB2 complexed with a peptide from the guanine nucleotide releasing factor Sos . Opens in a new window.
Research | 30 January 2005
A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design
- Graeme L Card
- , Landy Blasdel
- , Bruce P England
- , Chao Zhang
- , Yoshihisa Suzuki
- , Sam Gillette
- , Daniel Fong
- , Prabha N Ibrahim
- , Dean R Artis
- , Gideon Bollag
- , Michael V Milburn
- , Sung-Hou Kim
- , Joseph Schlessinger
- & Kam Y J Zhang
Nature Biotechnology 23 , 201–207

Rights & permissionsfor article A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design . Opens in a new window.
Research | 16 December 2007
'Tuning' of type I interferon–induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages
- Lu Wang
- , Ioannis Tassiulas
- , Kyung-Hyun Park-Min
- , Alicia C Reid
- , Hava Gil-Henn
- , Joseph Schlessinger
- , Roland Baron
- , J Jillian Zhang
- & Lionel B Ivashkiv
Nature Immunology 9 , 186–193

Rights & permissionsfor article 'Tuning' of type I interferon–induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages . Opens in a new window.
Research | 7 March 2010
Spatial control of EGF receptor activation by reversible dimerization on living cells
- Inhee Chung
- , Robert Akita
- , Richard Vandlen
- , Derek Toomre
- , Joseph Schlessinger
- & Ira Mellman
Nature 464 , 783–787

Rights & permissionsfor article Spatial control of EGF receptor activation by reversible dimerization on living cells . Opens in a new window.
2 June 1998
Crk protein binds to PDGF receptor and insulin receptor substrate-1 with different modulating effects on PDGF- and insulin-dependent signaling pathways
Oncogene 16 , 2425–2434

Rights & permissionsfor article Crk protein binds to PDGF receptor and insulin receptor substrate-1 with different modulating effects on PDGF- and insulin-dependent signaling pathways . Opens in a new window.
Research | 29 July 2012
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
- Michael Krauthammer
- , Yong Kong
- , Byung Hak Ha
- , Perry Evans
- , Antonella Bacchiocchi
- , James P McCusker
- , Elaine Cheng
- , Matthew J Davis
- , Gerald Goh
- , Murim Choi
- , Stephan Ariyan
- , Deepak Narayan
- , Ken Dutton-Regester
- , Ana Capatana
- , Edna C Holman
- , Marcus Bosenberg
- , Mario Sznol
- , Harriet M Kluger
- , Douglas E Brash
- , David F Stern
- , Miguel A Materin
- , Roger S Lo
- , Shrikant Mane
- , Shuangge Ma
- , Kenneth K Kidd
- , Nicholas K Hayward
- , Richard P Lifton
- , Joseph Schlessinger
- , Titus J Boggon
- & Ruth Halaban
Nature Genetics 44 , 1006–1014

Rights & permissionsfor article Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma . Opens in a new window.

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Erratum: Mutations in different components of FGF signaling in LADD syndrome

Small molecule combats cancer-causing KRAS protein at last

FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic–pituitary–adrenal axis

Evidence for SH3 domain directed binding and phosphorylation of Sam68 by Src

Insulin and antibodies against insulin receptor cap on the membrane of cultured human lymphocytes

Local aggregation of hormone–receptor complexes is required for activation by epidermal growth factor

A solid base for assaying protein kinase activity

Absence of marginal zone B cells in Pyk-2–deficient mice defines their role in the humoral response

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

A chimaeric receptor allows insulin to stimulate tyrosine kinase activity of epidermal growth factor receptor

Scratching the surface with the PH domain

Novel fluorescent approaches for studying cell signaling in single cells

Structure of a heparin-linked biologically active dimer of fibroblast growth factor

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

The proto-oncogene c-Cbl is a negative regulator of DNA synthesis initiated by both receptor and cytoplasmic tyrosine kinases

Mutations in different components of FGF signaling in LADD syndrome

Interferon-induced nuclear signalling by Jak protein tyrosine kinases

Lateral motion and valence of Fc receptors on rat peritoneal mast cells

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

Variations of Proline-Rich Kinase Pyk2 Expression Correlate with Prostate Cancer Progression

Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling

Data publication with the structural biology data grid supports live analysis

Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas

Structure of the N-terminal SH3 domain of GRB2 complexed with a peptide from the guanine nucleotide releasing factor Sos

A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design

'Tuning' of type I interferon–induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages

Spatial control of EGF receptor activation by reversible dimerization on living cells

Crk protein binds to PDGF receptor and insulin receptor substrate-1 with different modulating effects on PDGF- and insulin-dependent signaling pathways

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

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