nature.com search

Loading Filters

Showing 1–50 of 68 results

Loading Filters

Reviews | 16 December 2020
Controlling and enhancing CRISPR systems
Nature Chemical Biology 17 , 10–19

Rights & permissionsfor article Controlling and enhancing CRISPR systems . Opens in a new window.
Amendments and Corrections | 4 October 2013
Erratum: Activating silent Argonautes
- Mary Anne Kidwell
- & Jennifer A Doudna
Nature Structural & Molecular Biology 20 , 1236–1236

Rights & permissionsfor article Erratum: Activating silent Argonautes . Opens in a new window.
Amendments and Corrections | 20 May 2020
Author Correction: Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity
- Michelle F. Richter
- , Kevin T. Zhao
- , Elliot Eton
- , Audrone Lapinaite
- , Gregory A. Newby
- , Benjamin W. Thuronyi
- , Christopher Wilson
- , Luke W. Koblan
- , Jing Zeng
- , Daniel E. Bauer
- , Jennifer A. Doudna
- & David R. Liu
Nature Biotechnology 38 , 901–901

Rights & permissionsfor article Author Correction: Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity . Opens in a new window.
Correspondence | 18 June 2020
Blueprint for a pop-up SARS-CoV-2 testing lab
- Alexandra M. Amen
- , Kerrie W. Barry
- , John M. Boyle
- , Cara E. Brook
- , Seunga Choo
- , L. T. Cornmesser
- , David J. Dilworth
- , Jennifer A. Doudna
- , Alexander J. Ehrenberg
- , Indro Fedrigo
- , Skyler E. Friedline
- , Thomas G. W. Graham
- , Ralph Green
- , Jennifer R. Hamilton
- , Ariana Hirsh
- , Megan L. Hochstrasser
- , Dirk Hockemeyer
- , Netravathi Krishnappa
- , Azra Lari
- , Hanqin Li
- , Enrique Lin-Shiao
- , Tianlin Lu
- , Elijah F. Lyons
- , Kevin G. Mark
- , Lisa Argento Martell
- , A. Raquel O. Martins
- , Shana L. McDevitt
- , Patrick S. Mitchell
- , Erica A. Moehle
- , Christine Naca
- , Divya Nandakumar
- , Elizabeth O’Brien
- , Derek J. Pappas
- , Kathleen Pestal
- , Diana L. Quach
- , Benjamin E. Rubin
- , Rohan Sachdeva
- , Elizabeth C. Stahl
- , Abdullah Muhammad Syed
- , I-Li Tan
- , Amy L. Tollner
- , Connor A. Tsuchida
- , C. Kimberly Tsui
- , Timothy K. Turkalo
- , Fyodor D. Urnov
- , M. Bryan Warf
- , Oscar N. Whitney
- & Lea B. Witkowsky
Nature Biotechnology 38 , 791–797

Rights & permissionsfor article Blueprint for a pop-up SARS-CoV-2 testing lab . Opens in a new window.
Amendments and Corrections | 3 April 2019
Author Correction: CasX enzymes comprise a distinct family of RNA-guided genome editors
- Jun-Jie Liu
- , Natalia Orlova
- , Benjamin L. Oakes
- , Enbo Ma
- , Hannah B. Spinner
- , Katherine L. M. Baney
- , Jonathan Chuck
- , Dan Tan
- , Gavin J. Knott
- , Lucas B. Harrington
- , Basem Al-Shayeb
- , Alexander Wagner
- , Julian Brötzmann
- , Brett T. Staahl
- , Kian L. Taylor
- , John Desmarais
- , Eva Nogales
- & Jennifer A. Doudna
Nature 568 , E8–E10

Rights & permissionsfor article Author Correction: CasX enzymes comprise a distinct family of RNA-guided genome editors . Opens in a new window.
Research | 7 September 2020
Massively parallel kinetic profiling of natural and engineered CRISPR nucleases
Nature Biotechnology 39 , 84–93

Rights & permissionsfor article Massively parallel kinetic profiling of natural and engineered CRISPR nucleases . Opens in a new window.
7 July 2016
Foreign DNA capture during CRISPR–Cas adaptive immunity
Nature 534 , S13–S14

Rights & permissionsfor article Foreign DNA capture during CRISPR–Cas adaptive immunity . Opens in a new window.
News and Views | 3 July 2013
Activating silent Argonautes
- Mary Anne Kidwell
- & Jennifer A Doudna
Nature Structural & Molecular Biology 20 , 769–771

Rights & permissionsfor article Activating silent Argonautes . Opens in a new window.
1 November 2005
Chemical biology at the crossroads of molecular structure and mechanism
- Jennifer A Doudna
Nature Chemical Biology 1 , 300–303

Rights & permissionsfor article Chemical biology at the crossroads of molecular structure and mechanism . Opens in a new window.
News and Views | 28 August 1997
A molecular contortionist
- Jennifer A. Doudna
Nature 388 , 830–831

Rights & permissionsfor article A molecular contortionist . Opens in a new window.
News and Views | 6 March 2013
Rewriting a genome
- Emmanuelle Charpentier
- & Jennifer A. Doudna
Nature 495 , 50–51

Rights & permissionsfor article Rewriting a genome . Opens in a new window.
Research | 16 March 2020
Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity
- Michelle F. Richter
- , Kevin T. Zhao
- , Elliot Eton
- , Audrone Lapinaite
- , Gregory A. Newby
- , Benjamin W. Thuronyi
- , Christopher Wilson
- , Luke W. Koblan
- , Jing Zeng
- , Daniel E. Bauer
- , Jennifer A. Doudna
- & David R. Liu
Nature Biotechnology 38 , 883–891

Rights & permissionsfor article Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity . Opens in a new window.
Research | 14 September 2016 | Open
Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9
Nature Communications 7 , 1–8

Rights & permissionsfor article Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9 . Opens in a new window.
Research | 11 August 2013
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
- Vikram Pattanayak
- , Steven Lin
- , John P Guilinger
- , Enbo Ma
- , Jennifer A Doudna
- & David R Liu
Nature Biotechnology 31 , 839–843

Rights & permissionsfor article High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity . Opens in a new window.
Research | 21 October 2015
Foreign DNA capture during CRISPR–Cas adaptive immunity
Nature 527 , 535–538

Rights & permissionsfor article Foreign DNA capture during CRISPR–Cas adaptive immunity . Opens in a new window.
Reviews | 12 February 2020
The promise and challenge of therapeutic genome editing
- Jennifer A. Doudna
Nature 578 , 229–236

Rights & permissionsfor article The promise and challenge of therapeutic genome editing . Opens in a new window.
Research | 12 February 2020 | Open
Clades of huge phages from across Earth’s ecosystems
- Basem Al-Shayeb
- , Rohan Sachdeva
- , Lin-Xing Chen
- , Fred Ward
- , Patrick Munk
- , Audra Devoto
- , Cindy J. Castelle
- , Matthew R. Olm
- , Keith Bouma-Gregson
- , Yuki Amano
- , Christine He
- , Raphaël Méheust
- , Brandon Brooks
- , Alex Thomas
- , Adi Lavy
- , Paula Matheus-Carnevali
- , Christine Sun
- , Daniela S. A. Goltsman
- , Mikayla A. Borton
- , Allison Sharrar
- , Alexander L. Jaffe
- , Tara C. Nelson
- , Rose Kantor
- , Ray Keren
- , Katherine R. Lane
- , Ibrahim F. Farag
- , Shufei Lei
- , Kari Finstad
- , Ronald Amundson
- , Karthik Anantharaman
- , Jinglie Zhou
- , Alexander J. Probst
- , Mary E. Power
- , Susannah G. Tringe
- , Wen-Jun Li
- , Kelly Wrighton
- , Sue Harrison
- , Michael Morowitz
- , David A. Relman
- , Jennifer A. Doudna
- , Anne-Catherine Lehours
- , Lesley Warren
- , Jamie H. D. Cate
- , Joanne M. Santini
- & Jillian F. Banfield
Nature 578 , 425–431

Rights & permissionsfor article Clades of huge phages from across Earth’s ecosystems . Opens in a new window.
Research | 16 September 2007
Structural determinants of RNA recognition and cleavage by Dicer
Nature Structural & Molecular Biology 14 , 934–940

Rights & permissionsfor article Structural determinants of RNA recognition and cleavage by Dicer . Opens in a new window.
Reviews | 1 November 2000
Structural genomics of RNA
- Jennifer A. Doudna
Nature Structural & Molecular Biology 7 , 954–956

Rights & permissionsfor article Structural genomics of RNA . Opens in a new window.
Research | 24 January 2010
Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation
Nature Structural & Molecular Biology 17 , 238–240

Rights & permissionsfor article Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation . Opens in a new window.
Research | 1 April 2002
Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation
Nature Structural & Molecular Biology 9 , 370–374

Rights & permissionsfor article Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation . Opens in a new window.
Research | 1 April 2001
A universal mode of helix packing in RNA
Nature Structural & Molecular Biology 8 , 339–343

Rights & permissionsfor article A universal mode of helix packing in RNA . Opens in a new window.
Research | 1 November 1998
A specific monovalent metal ion integral to the AA platform of the RNA tetraloop receptor
Nature Structural & Molecular Biology 5 , 986–992

Rights & permissionsfor article A specific monovalent metal ion integral to the AA platform of the RNA tetraloop receptor . Opens in a new window.
Research | 15 March 2009
The pathway of hepatitis C virus mRNA recruitment to the human ribosome
Nature Structural & Molecular Biology 16 , 397–404

Rights & permissionsfor article The pathway of hepatitis C virus mRNA recruitment to the human ribosome . Opens in a new window.
Research | 15 June 1989
RNA-catalysed synthesis of complementary-strand RNA
- Jennifer A. Doudna
- & Jack W. Szostak
Nature 339 , 519–522

Rights & permissionsfor article RNA-catalysed synthesis of complementary-strand RNA . Opens in a new window.
Research | 16 September 2012
RNA processing enables predictable programming of gene expression
- Lei Qi
- , Rachel E Haurwitz
- , Wenjun Shao
- , Jennifer A Doudna
- & Adam P Arkin
Nature Biotechnology 30 , 1002–1006

Rights & permissionsfor article RNA processing enables predictable programming of gene expression . Opens in a new window.
Research | 1 July 1997
A magnesium ion core at the heart of a ribozyme domain
Nature Structural & Molecular Biology 4 , 553–558

Rights & permissionsfor article A magnesium ion core at the heart of a ribozyme domain . Opens in a new window.
Research | 13 May 2004
A conformational switch controls hepatitis delta virus ribozyme catalysis
- Ailong Ke
- , Kaihong Zhou
- , Fang Ding
- , Jamie H. D. Cate
- & Jennifer A. Doudna
Nature 429 , 201–205

Rights & permissionsfor article A conformational switch controls hepatitis delta virus ribozyme catalysis . Opens in a new window.
News and Views | 1 May 1998
The parallel universe of RNA folding
- Robert T. Batey
- & Jennifer A. Doudna
Nature Structural & Molecular Biology 5 , 337–340

Rights & permissionsfor article The parallel universe of RNA folding . Opens in a new window.
Research | 21 September 2011
Structures of the RNA-guided surveillance complex from a bacterial immune system
Nature 477 , 486–489

Rights & permissionsfor article Structures of the RNA-guided surveillance complex from a bacterial immune system . Opens in a new window.
Research | 5 July 2019 | Open
Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble
Nature Communications 10 , 1–13

Rights & permissionsfor article Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble . Opens in a new window.
Research | 9 May 2019 | Open
Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs
- Kale Kundert
- , James E. Lucas
- , Kyle E. Watters
- , Christof Fellmann
- , Andrew H. Ng
- , Benjamin M. Heineike
- , Christina M. Fitzsimmons
- , Benjamin L. Oakes
- , Jiuxin Qu
- , Neha Prasad
- , Oren S. Rosenberg
- , David F. Savage
- , Hana El-Samad
- , Jennifer A. Doudna
- & Tanja Kortemme
Nature Communications 10 , 1–11

Rights & permissionsfor article Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs . Opens in a new window.
Research | 1 April 2019
Broad-spectrum enzymatic inhibition of CRISPR-Cas12a
Nature Structural & Molecular Biology 26 , 315–321

Rights & permissionsfor article Broad-spectrum enzymatic inhibition of CRISPR-Cas12a . Opens in a new window.
Research | 4 February 2019
CasX enzymes comprise a distinct family of RNA-guided genome editors
- Jun-Jie Liu
- , Natalia Orlova
- , Benjamin L. Oakes
- , Enbo Ma
- , Hannah B. Spinner
- , Katherine L. M. Baney
- , Jonathan Chuck
- , Dan Tan
- , Gavin J. Knott
- , Lucas B. Harrington
- , Basem Al-Shayeb
- , Alexander Wagner
- , Julian Brötzmann
- , Brett T. Staahl
- , Kian L. Taylor
- , John Desmarais
- , Eva Nogales
- & Jennifer A. Doudna
Nature 566 , 218–223

Rights & permissionsfor article CasX enzymes comprise a distinct family of RNA-guided genome editors . Opens in a new window.
Protocols | 17 December 2018
CRISPR–Cas9 genome engineering of primary CD4⁺ T cells for the interrogation of HIV–host factor interactions
Nature Protocols 14 , 1–27

Rights & permissionsfor article CRISPR–Cas9 genome engineering of primary CD4<sup>+</sup> T cells for the interrogation of HIV–host factor interactions . Opens in a new window.
Research | 8 December 2017 | Open
CRISPR-Cpf1 mediates efficient homology-directed repair and temperature-controlled genome editing
Nature Communications 8 , 1–9

Rights & permissionsfor article CRISPR-Cpf1 mediates efficient homology-directed repair and temperature-controlled genome editing . Opens in a new window.
Research | 20 September 2017
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
Nature 550 , 407–410

Rights & permissionsfor article Enhanced proofreading governs CRISPR–Cas9 targeting accuracy . Opens in a new window.
Research | 10 November 2017 | Open
A thermostable Cas9 with increased lifetime in human plasma
Nature Communications 8 , 1–8

Rights & permissionsfor article A thermostable Cas9 with increased lifetime in human plasma . Opens in a new window.
Reviews | 4 October 2017
The chemistry of Cas9 and its CRISPR colleagues
- Janice S. Chen
- & Jennifer A. Doudna
Nature Reviews Chemistry 1 , 1–15

Rights & permissionsfor article The chemistry of Cas9 and its CRISPR colleagues . Opens in a new window.
Research | 2 October 2017
Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair
- Kunwoo Lee
- , Michael Conboy
- , Hyo Min Park
- , Fuguo Jiang
- , Hyun Jin Kim
- , Mark A. Dewitt
- , Vanessa A. Mackley
- , Kevin Chang
- , Anirudh Rao
- , Colin Skinner
- , Tamanna Shobha
- , Melod Mehdipour
- , Hui Liu
- , Wen-chin Huang
- , Freeman Lan
- , Nicolas L. Bray
- , Song Li
- , Jacob E. Corn
- , Kazunori Kataoka
- , Jennifer A. Doudna
- , Irina Conboy
- & Niren Murthy
Nature Biomedical Engineering 1 , 889–901

Rights & permissionsfor article Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair . Opens in a new window.
Research | 11 September 2017
Guide-bound structures of an RNA-targeting A-cleaving CRISPR–Cas13a enzyme
Nature Structural & Molecular Biology 24 , 825–833

Rights & permissionsfor article Guide-bound structures of an RNA-targeting A-cleaving CRISPR–Cas13a enzyme . Opens in a new window.
Reviews | 15 February 2017
RNA-based recognition and targeting: sowing the seeds of specificity
Nature Reviews Molecular Cell Biology 18 , 215–228

Rights & permissionsfor article RNA-based recognition and targeting: sowing the seeds of specificity . Opens in a new window.
Research | 13 February 2017
Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes
Nature Biotechnology 35 , 431–434

Rights & permissionsfor article Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes . Opens in a new window.
Research | 27 July 2016
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
Nature 536 , 96–99

Rights & permissionsfor article eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation . Opens in a new window.
Reviews | 23 December 2016
Cornerstones of CRISPR–Cas in drug discovery and therapy
Nature Reviews Drug Discovery 16 , 89–100

Rights & permissionsfor article Cornerstones of CRISPR–Cas in drug discovery and therapy . Opens in a new window.
Reviews | 8 September 2016
Applications of CRISPR technologies in research and beyond
- Rodolphe Barrangou
- & Jennifer A Doudna
Nature Biotechnology 34 , 933–941

Rights & permissionsfor article Applications of CRISPR technologies in research and beyond . Opens in a new window.
Research | 2 May 2016
Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch
Nature Biotechnology 34 , 646–651

Rights & permissionsfor article Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch . Opens in a new window.
Research | 26 September 2016
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
Nature 538 , 270–273

Rights & permissionsfor article Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection . Opens in a new window.
Research | 17 October 2016
ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing
- Xingqi Chen
- , Ying Shen
- , Will Draper
- , Jason D Buenrostro
- , Ulrike Litzenburger
- , Seung Woo Cho
- , Ansuman T Satpathy
- , Ava C Carter
- , Rajarshi P Ghosh
- , Alexandra East-Seletsky
- , Jennifer A Doudna
- , William J Greenleaf
- , Jan T Liphardt
- & Howard Y Chang
Nature Methods 13 , 1013–1020

Rights & permissionsfor article ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing . Opens in a new window.
Research | 5 September 2016
Protecting genome integrity during CRISPR immune adaptation
- Addison V Wright
- & Jennifer A Doudna
Nature Structural & Molecular Biology 23 , 876–883

Rights & permissionsfor article Protecting genome integrity during CRISPR immune adaptation . Opens in a new window.

Quick links