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Correspondence | 26 February 2020
Serial evaluation of CD19 surface expression in pediatric B-cell malignancies following CD19-targeted therapy
- Diane Libert
- , Constance M. Yuan
- , Katherine E. Masih
- , Pallavi Galera
- , Dalia Salem
- , Haneen Shalabi
- , Bonnie Yates
- , Cindy Delbrook
- , Jack F. Shern
- , Terry J. Fry
- , Javed Khan
- , Maryalice Stetler-Stevenson
- & Nirali N. Shah
Leukemia 34 , 3064–3069

Rights & permissionsfor article Serial evaluation of CD19 surface expression in pediatric B-cell malignancies following CD19-targeted therapy . Opens in a new window.
Research | 23 July 2020 | Open
Transcriptome analysis of desmoplastic small round cell tumors identifies actionable therapeutic targets: a report from the Children’s Oncology Group
- Pooja Hingorani
- , Valentin Dinu
- , Xiyuan Zhang
- , Haiyan Lei
- , Jack F. Shern
- , Jin Park
- , Jason Steel
- , Femina Rauf
- , David Parham
- , Julie Gastier-Foster
- , David Hall
- , Douglas S. Hawkins
- , Stephen X. Skapek
- , Joshua Labaer
- & Troy A. McEachron
Scientific Reports 10 , 1–12

Rights & permissionsfor article Transcriptome analysis of desmoplastic small round cell tumors identifies actionable therapeutic targets: a report from the Children’s Oncology Group . Opens in a new window.
Research | 14 February 2020 | Open
CASZ1 induces skeletal muscle and rhabdomyosarcoma differentiation through a feed-forward loop with MYOD and MYOG
- Zhihui Liu
- , Xiyuan Zhang
- , Haiyan Lei
- , Norris Lam
- , Sakereh Carter
- , Oliver Yockey
- , Max Xu
- , Arnulfo Mendoza
- , Edjay R. Hernandez
- , Jun S. Wei
- , Javed Khan
- , Marielle E. Yohe
- , Jack F. Shern
- & Carol J. Thiele
Nature Communications 11 , 1–16

Rights & permissionsfor article CASZ1 induces skeletal muscle and rhabdomyosarcoma differentiation through a feed-forward loop with MYOD and MYOG . Opens in a new window.
Research | 29 November 2019
Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma
- Berkley E. Gryder
- , Silvia Pomella
- , Carly Sayers
- , Xiaoli S. Wu
- , Young Song
- , Anna M. Chiarella
- , Sukriti Bagchi
- , Hsien-Chao Chou
- , Ranu S. Sinniah
- , Ashley Walton
- , Xinyu Wen
- , Rossella Rota
- , Nathaniel A. Hathaway
- , Keji Zhao
- , Jiji Chen
- , Christopher R. Vakoc
- , Jack F. Shern
- , Benjamin Z. Stanton
- & Javed Khan
Nature Genetics 51 , 1714–1722

Rights & permissionsfor article Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma . Opens in a new window.
Research | 8 July 2019 | Open
Chemical genomics reveals histone deacetylases are required for core regulatory transcription
- Berkley E. Gryder
- , Lei Wu
- , Girma M. Woldemichael
- , Silvia Pomella
- , Taylor R. Quinn
- , Paul M. C. Park
- , Abigail Cleveland
- , Benjamin Z. Stanton
- , Young Song
- , Rossella Rota
- , Olaf Wiest
- , Marielle E. Yohe
- , Jack F. Shern
- , Jun Qi
- & Javed Khan
Nature Communications 10 , 1–12

Rights & permissionsfor article Chemical genomics reveals histone deacetylases are required for core regulatory transcription . Opens in a new window.
Research | 28 February 2018
Functional screening of FGFR4-driven tumorigenesis identifies PI3K/mTOR inhibition as a therapeutic strategy in rhabdomyosarcoma
- Timothy McKinnon
- , Rosemarie Venier
- , Marielle Yohe
- , Sivasish Sindiri
- , Berkley E. Gryder
- , Jack F. Shern
- , Leah Kabaroff
- , Brendan Dickson
- , Krista Schleicher
- , Guillaume Chouinard-Pelletier
- , Serena Menezes
- , Abha Gupta
- , Xiaohu Zhang
- , Rajarashi Guha
- , Marc Ferrer
- , Craig J. Thomas
- , Yuhong Wei
- , Dariush Davani
- , Cynthia J. Guidos
- , Javed Khan
- & Rebecca A. Gladdy
Oncogene 37 , 2630–2644

Rights & permissionsfor article Functional screening of FGFR4-driven tumorigenesis identifies PI3K/mTOR inhibition as a therapeutic strategy in rhabdomyosarcoma . Opens in a new window.
Research | 18 September 2017
KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis
- Meera Murgai
- , Wei Ju
- , Matthew Eason
- , Jessica Kline
- , Daniel W Beury
- , Sabina Kaczanowska
- , Markku M Miettinen
- , Michael Kruhlak
- , Haiyan Lei
- , Jack F Shern
- , Olga A Cherepanova
- , Gary K Owens
- & Rosandra N Kaplan
Nature Medicine 23 , 1176–1190

Rights & permissionsfor article KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis . Opens in a new window.
Research | 20 November 2017
CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy
- Terry J Fry
- , Nirali N Shah
- , Rimas J Orentas
- , Maryalice Stetler-Stevenson
- , Constance M Yuan
- , Sneha Ramakrishna
- , Pamela Wolters
- , Staci Martin
- , Cindy Delbrook
- , Bonnie Yates
- , Haneen Shalabi
- , Thomas J Fountaine
- , Jack F Shern
- , Robbie G Majzner
- , David F Stroncek
- , Marianna Sabatino
- , Yang Feng
- , Dimiter S Dimitrov
- , Ling Zhang
- , Sang Nguyen
- , Haiying Qin
- , Boro Dropulic
- , Daniel W Lee
- & Crystal L Mackall
Nature Medicine 24 , 20–28

Rights & permissionsfor article CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy . Opens in a new window.
Research | 27 July 2016 | Open
CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity
- Elad Jacoby
- , Sang M. Nguyen
- , Thomas J. Fountaine
- , Kathryn Welp
- , Berkley Gryder
- , Haiying Qin
- , Yinmeng Yang
- , Christopher D. Chien
- , Alix E. Seif
- , Haiyan Lei
- , Young K. Song
- , Javed Khan
- , Daniel W. Lee
- , Crystal L. Mackall
- , Rebecca A. Gardner
- , Michael C. Jensen
- , Jack F. Shern
- & Terry J. Fry
Nature Communications 7 , 1–10

Rights & permissionsfor article CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity . Opens in a new window.
Research | 4 May 2015
4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors
- Adrienne H Long
- , Waleed M Haso
- , Jack F Shern
- , Kelsey M Wanhainen
- , Meera Murgai
- , Maria Ingaramo
- , Jillian P Smith
- , Alec J Walker
- , M Eric Kohler
- , Vikas R Venkateshwara
- , Rosandra N Kaplan
- , George H Patterson
- , Terry J Fry
- , Rimas J Orentas
- & Crystal L Mackall
Nature Medicine 21 , 581–590

Rights & permissionsfor article 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors . Opens in a new window.

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