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Research | 1 December 2020 | Open
Multiple proteases are involved in mesothelin shedding by cancer cells
- Xiufen Liu
- , Alexander Chan
- , Chin-Hsien Tai
- , Thorkell Andresson
- & Ira Pastan
Communications Biology 3 , 1–9

Rights & permissionsfor article Multiple proteases are involved in mesothelin shedding by cancer cells . Opens in a new window.
Research | 15 September 1971
On the Mechanism of Action of lac Repressor
Nature New Biology 233 , 67–70

Rights & permissionsfor article On the Mechanism of Action of lac Repressor . Opens in a new window.
28 June 1972
N⁶,O²′-Dibutyryl Adenosine 3′,5′-Monophosphate induces Pigment Production in Melanoma Cells
- GEORGE S. JOHNSON
- & IRA PASTAN
Nature New Biology 237 , 267–268

Rights & permissionsfor article N6,O2′-Dibutyryl Adenosine 3′,5′-Monophosphate induces Pigment Production in Melanoma Cells . Opens in a new window.
26 April 1972
Cyclic AMP increases the Adhesion of Fibroblasts to Substratum
- GEORGE S. JOHNSON
- & IRA PASTAN
Nature New Biology 236 , 247–249

Rights & permissionsfor article Cyclic AMP increases the Adhesion of Fibroblasts to Substratum . Opens in a new window.
21 March 1973
Cyclic AMP and Growth of Fibroblasts: Effect of Environmental pH
Nature New Biology 242 , 78–80

Rights & permissionsfor article Cyclic AMP and Growth of Fibroblasts: Effect of Environmental pH . Opens in a new window.
Research | 27 May 2019 | Open
Possible role of complement factor H in podocytes in clearing glomerular subendothelial immune complex deposits
- Takeshi Zoshima
- , Satoshi Hara
- , Masakazu Yamagishi
- , Ira Pastan
- , Taiji Matsusaka
- , Mitsuhiro Kawano
- & Michio Nagata
Scientific Reports 9 , 1–9

Rights & permissionsfor article Possible role of complement factor H in podocytes in clearing glomerular subendothelial immune complex deposits . Opens in a new window.
Research | 20 July 2018 | Open
Moxetumomab pasudotox in relapsed/refractory hairy cell leukemia
- Robert J. Kreitman
- , Claire Dearden
- , Pier Luigi Zinzani
- , Julio Delgado
- , Lionel Karlin
- , Tadeusz Robak
- , Douglas E. Gladstone
- , Philipp le Coutre
- , Sascha Dietrich
- , Mirjana Gotic
- , Loree Larratt
- , Fritz Offner
- , Gary Schiller
- , Ronan Swords
- , Larry Bacon
- , Monica Bocchia
- , Krimo Bouabdallah
- , Dimitri A. Breems
- , Agostino Cortelezzi
- , Shira Dinner
- , Michael Doubek
- , Bjorn Tore Gjertsen
- , Marco Gobbi
- , Andrzej Hellmann
- , Stephane Lepretre
- , Frederic Maloisel
- , Farhad Ravandi
- , Philippe Rousselot
- , Mathias Rummel
- , Tanya Siddiqi
- , Tamar Tadmor
- , Xavier Troussard
- , Cecilia Arana Yi
- , Giuseppe Saglio
- , Gail J. Roboz
- , Kemal Balic
- , Nathan Standifer
- , Peng He
- , Shannon Marshall
- , Wyndham Wilson
- , Ira Pastan
- , Nai-Shun Yao
- & Francis Giles
Leukemia 32 , 1768–1777

Rights & permissionsfor article Moxetumomab pasudotox in relapsed/refractory hairy cell leukemia . Opens in a new window.
Research | 26 June 2015 | Open
Quantification of recombinant immunotoxin delivery to solid tumors allows for direct comparison of in vivo and in vitro results
Scientific Reports 5 , 1–10

Rights & permissionsfor article Quantification of recombinant immunotoxin delivery to solid tumors allows for direct comparison of in vivo and in vitro results . Opens in a new window.
Research | 18 May 2000
Attenuating the growth of tumors by intratumoral administration of DNA encoding Pseudomonas exotoxin via cationic liposomes
- Noga Yerushalmi
- , Ulrich Brinkmann
- , Elisabeth Brinkmann
- , Lee Pai
- & Ira Pastan
Cancer Gene Therapy 7 , 91–96

Rights & permissionsfor article Attenuating the growth of tumors by intratumoral administration of DNA encoding Pseudomonas exotoxin via cationic liposomes . Opens in a new window.
Research | 1 July 1999
Interleukin-4 receptor-directed cytotoxin therapy of AIDS-associated Kaposi's sarcoma tumors in xenograft model
Nature Medicine 5 , 817–822

Rights & permissionsfor article Interleukin-4 receptor-directed cytotoxin therapy of AIDS-associated Kaposi's sarcoma tumors in xenograft model . Opens in a new window.
Research | 1 July 1994
Efficient Expression of Drug-selectable Genes in Retroviral Vectors Under Control of an Internal Ribosome Entry Site
Nature Biotechnology 12 , 694–698

Rights & permissionsfor article Efficient Expression of Drug-selectable Genes in Retroviral Vectors Under Control of an Internal Ribosome Entry Site . Opens in a new window.
Research | 3 June 1976
Diminished content of plasma membrane-associated myosin in transformed fibroblasts
Nature 261 , 414–415

Rights & permissionsfor article Diminished content of plasma membrane-associated myosin in transformed fibroblasts . Opens in a new window.
Research | 2 March 1978
Decreased binding of epidermal growth factor to BALB/c 3T3 mutant cells defective in glycoprotein synthesis
- ROBERT M. PRATT
- & IRA PASTAN
Nature 272 , 68–70

Rights & permissionsfor article Decreased binding of epidermal growth factor to BALB/c 3T3 mutant cells defective in glycoprotein synthesis . Opens in a new window.
1 June 1992
Renaturation of a Single–Chain Immunotoxin Facilitated by Chaperones and Protein Disulfide Isomerase
Nature Biotechnology 10 , 682–685

Rights & permissionsfor article Renaturation of a Single–Chain Immunotoxin Facilitated by Chaperones and Protein Disulfide Isomerase . Opens in a new window.
Research | 1 February 1979
Amines inhibit the clustering of α₂-macroglobulin and EGF on the fibroblast cell surface
Nature 277 , 661–663

Rights & permissionsfor article Amines inhibit the clustering of α2-macroglobulin and EGF on the fibroblast cell surface . Opens in a new window.
Research | 23 August 1969
Cyclic AMP regulates Catabolite and Transient Repression in E. coli
Nature 223 , 810–812

Rights & permissionsfor article Cyclic AMP regulates Catabolite and Transient Repression in E. coli . Opens in a new window.
Research | 22 September 1988
Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein
Nature 335 , 369–372

Rights & permissionsfor article Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein . Opens in a new window.
Research | 28 February 1973
Effect of Rho on Transcription of Bacterial Operons
Nature New Biology 241 , 260–264

Rights & permissionsfor article Effect of Rho on Transcription of Bacterial Operons . Opens in a new window.
Research | 1 March 1996
Treatment of advanced solid tumors with immunotoxin LMB–1: An antibody linked to Pseudomonas exotoxin
- Lee H. Pai
- , Robert Wittes
- , Ann Setser
- , Mark C. Willingham
- & Ira Pastan
Nature Medicine 2 , 350–353

Rights & permissionsfor article Treatment of advanced solid tumors with immunotoxin LMB–1: An antibody linked to Pseudomonas exotoxin . Opens in a new window.
1 November 1988
Purification and Partial Characterization of an Interleukin 2-Pseudomonas Exotoxin Fusion Protein
- Pascal Bailon
- , David V. Weber
- , Maurice Gately
- , John E. Smart
- , Haya Lorberboum-Galski
- , David Fitzgerald
- & Ira Pastan
Nature Biotechnology 6 , 1326–1329

Rights & permissionsfor article Purification and Partial Characterization of an Interleukin 2-Pseudomonas Exotoxin Fusion Protein . Opens in a new window.
Research | 7 January 1972
Regulation of Cell Motility by Cyclic AMP
Nature 235 , 54–56

Rights & permissionsfor article Regulation of Cell Motility by Cyclic AMP . Opens in a new window.
1 June 1999
Improving antibody affinity by mimicking somatic hypermutation in vitro
- Partha S. Chowdhury
- & Ira Pastan
Nature Biotechnology 17 , 568–572

Rights & permissionsfor article Improving antibody affinity by mimicking somatic hypermutation in vitro . Opens in a new window.
Research | 28 November 1970
Effects of Calcium on ACTH Stimulation of the Adrenal: Separation of Hormone Binding from Adenyl Cyclase Activation
Nature 228 , 864–866

Rights & permissionsfor article Effects of Calcium on ACTH Stimulation of the Adrenal: Separation of Hormone Binding from Adenyl Cyclase Activation . Opens in a new window.
Research | 2 June 1971
Lac DNA, RNA Polymerase and Cyclic AMP Receptor Protein, Cyclic AMP, Lac Repressor and Inducer are the Essential Elements for Controlled Lac Transcription
- BENOIT de CROMBRUGGHE
- , BEATRICE CHEN
- , WAYNE ANDERSON
- , PETER NISSLEY
- , MAX GOTTESMAN
- , IRA PASTAN
- & ROBERT PERLMAN
Nature New Biology 231 , 139–142

Rights & permissionsfor article Lac DNA, RNA Polymerase and Cyclic AMP Receptor Protein, Cyclic AMP, Lac Repressor and Inducer are the Essential Elements for Controlled Lac Transcription . Opens in a new window.
Reviews | 1 July 2006
Immunotoxin therapy of cancer
Nature Reviews Cancer 6 , 559–565

Rights & permissionsfor article Immunotoxin therapy of cancer . Opens in a new window.
Research | 21 September 1978
Adenylate cyclase in a fibroblast mutant defective in glycolipid and glycoprotein synthesis
Nature 275 , 223–224

Rights & permissionsfor article Adenylate cyclase in a fibroblast mutant defective in glycolipid and glycoprotein synthesis . Opens in a new window.
Research | 1 June 1989
A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin
Nature 339 , 394–397

Rights & permissionsfor article A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin . Opens in a new window.
Research | 24 April 2019
Lipoprotein modulation of proteinuric renal injury
- Yohei Tsuchida
- , Jianyong Zhong
- , Tadashi Otsuka
- , Anna Dikalova
- , Ira Pastan
- , G. M. Anantharamaiah
- , MacRae F. Linton
- , Patricia G. Yancey
- , T. Alp Ikizler
- , Agnes B. Fogo
- , Haichun Yang
- & Valentina Kon
Laboratory Investigation 99 , 1107–1116

Rights & permissionsfor article Lipoprotein modulation of proteinuric renal injury . Opens in a new window.
Research | 7 March 2017 | Open
Specific CpG hyper-methylation leads to Ankrd26 gene down-regulation in white adipose tissue of a mouse model of diet-induced obesity
- Gregory A. Raciti
- , Rosa Spinelli
- , Antonella Desiderio
- , Michele Longo
- , Luca Parrillo
- , Cecilia Nigro
- , Vittoria D’Esposito
- , Paola Mirra
- , Francesca Fiory
- , Vincenzo Pilone
- , Pietro Forestieri
- , Pietro Formisano
- , Ira Pastan
- , Claudia Miele
- & Francesco Beguinot
Scientific Reports 7 , 1–13

Rights & permissionsfor article Specific CpG hyper-methylation leads to Ankrd26 gene down-regulation in white adipose tissue of a mouse model of diet-induced obesity . Opens in a new window.
19 October 2015
Elimination of murine and human T-cell epitopes in recombinant immunotoxin eliminates neutralizing and anti-drug antibodies in vivo
- Ronit Mazor
- , Devorah Crown
- , Selamawit Addissie
- , Youjin Jang
- , Gilad Kaplan
- & Ira Pastan
Cellular & Molecular Immunology 14 , 432–442

Rights & permissionsfor article Elimination of murine and human T-cell epitopes in recombinant immunotoxin eliminates neutralizing and anti-drug antibodies in vivo . Opens in a new window.
Research | 21 May 2015 | Open
New High Affinity Monoclonal Antibodies Recognize Non-Overlapping Epitopes On Mesothelin For Monitoring And Treating Mesothelioma
- Yi-Fan Zhang
- , Yen Phung
- , Wei Gao
- , Seiji Kawa
- , Raffit Hassan
- , Ira Pastan
- & Mitchell Ho
Scientific Reports 5 , 1–14

Rights & permissionsfor article New High Affinity Monoclonal Antibodies Recognize Non-Overlapping Epitopes On Mesothelin For Monitoring And Treating Mesothelioma . Opens in a new window.
1 October 1996
Engineering antibody Fv fragments for cancer detection and therapy: Bisulfide-stabilized Fv fragments
- Yoram Reiter
- , Ulrich Brinkmann
- , Byungkook Lee
- & Ira Pastan
Nature Biotechnology 14 , 1239–1245

Rights & permissionsfor article Engineering antibody Fv fragments for cancer detection and therapy: Bisulfide-stabilized Fv fragments . Opens in a new window.
Research | 28 June 1984
Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells
- Young-hua Xu
- , Shunsuke Ishii
- , Adrian J. L. Clark
- , Margery Sullivan
- , Richard K. Wilson
- , Din Pow Ma
- , Bruce A. Roe
- , Glenn T. Merlino
- & Ira Pastan
Nature 309 , 806–810

Rights & permissionsfor article Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells . Opens in a new window.
Reviews | 17 August 1978
Cellular transformation and the ‘morphologic phenotype’ of transformed cells
- Ira Pastan
- & Mark Willingham
Nature 274 , 645–650

Rights & permissionsfor article Cellular transformation and the ‘morphologic phenotype’ of transformed cells . Opens in a new window.

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Multiple proteases are involved in mesothelin shedding by cancer cells

On the Mechanism of Action of lac Repressor

N⁶,O²′-Dibutyryl Adenosine 3′,5′-Monophosphate induces Pigment Production in Melanoma Cells

Cyclic AMP increases the Adhesion of Fibroblasts to Substratum

Cyclic AMP and Growth of Fibroblasts: Effect of Environmental pH

Possible role of complement factor H in podocytes in clearing glomerular subendothelial immune complex deposits

Moxetumomab pasudotox in relapsed/refractory hairy cell leukemia

Quantification of recombinant immunotoxin delivery to solid tumors allows for direct comparison of in vivo and in vitro results

Attenuating the growth of tumors by intratumoral administration of DNA encoding Pseudomonas exotoxin via cationic liposomes

Interleukin-4 receptor-directed cytotoxin therapy of AIDS-associated Kaposi's sarcoma tumors in xenograft model

Efficient Expression of Drug-selectable Genes in Retroviral Vectors Under Control of an Internal Ribosome Entry Site

Diminished content of plasma membrane-associated myosin in transformed fibroblasts

Decreased binding of epidermal growth factor to BALB/c 3T3 mutant cells defective in glycoprotein synthesis

Renaturation of a Single–Chain Immunotoxin Facilitated by Chaperones and Protein Disulfide Isomerase

Amines inhibit the clustering of α₂-macroglobulin and EGF on the fibroblast cell surface

Cyclic AMP regulates Catabolite and Transient Repression in E. coli

Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein

Effect of Rho on Transcription of Bacterial Operons

Treatment of advanced solid tumors with immunotoxin LMB–1: An antibody linked to Pseudomonas exotoxin

Purification and Partial Characterization of an Interleukin 2-Pseudomonas Exotoxin Fusion Protein

Regulation of Cell Motility by Cyclic AMP

Improving antibody affinity by mimicking somatic hypermutation in vitro

Effects of Calcium on ACTH Stimulation of the Adrenal: Separation of Hormone Binding from Adenyl Cyclase Activation

Lac DNA, RNA Polymerase and Cyclic AMP Receptor Protein, Cyclic AMP, Lac Repressor and Inducer are the Essential Elements for Controlled Lac Transcription

Immunotoxin therapy of cancer

Adenylate cyclase in a fibroblast mutant defective in glycolipid and glycoprotein synthesis

A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin

Lipoprotein modulation of proteinuric renal injury

Specific CpG hyper-methylation leads to Ankrd26 gene down-regulation in white adipose tissue of a mouse model of diet-induced obesity

Elimination of murine and human T-cell epitopes in recombinant immunotoxin eliminates neutralizing and anti-drug antibodies in vivo

New High Affinity Monoclonal Antibodies Recognize Non-Overlapping Epitopes On Mesothelin For Monitoring And Treating Mesothelioma

Engineering antibody Fv fragments for cancer detection and therapy: Bisulfide-stabilized Fv fragments

Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells

Cellular transformation and the ‘morphologic phenotype’ of transformed cells

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