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Research | 4 January 2021 | Open
Homeostatic regulation of STING by retrograde membrane traffic to the ER
- Kojiro Mukai
- , Emari Ogawa
- , Rei Uematsu
- , Yoshihiko Kuchitsu
- , Fumika Kiku
- , Takefumi Uemura
- , Satoshi Waguri
- , Takehiro Suzuki
- , Naoshi Dohmae
- , Hiroyuki Arai
- , Anthony K. Shum
- & Tomohiko Taguchi
Nature Communications 12 , 1–9

Rights & permissionsfor article Homeostatic regulation of STING by retrograde membrane traffic to the ER . Opens in a new window.
Research | 14 October 2020 | Open
Changes in patient subjective happiness and satisfaction with cataract surgery
- Erisa Yotsukura
- , Masahiko Ayaki
- , Naohisa Nezu
- , Hidemasa Torii
- , Hiroyuki Arai
- , Keiko Sakatani
- , Kazuo Tsubota
- & Kazuno Negishi
Scientific Reports 10 , 1–8

Rights & permissionsfor article Changes in patient subjective happiness and satisfaction with cataract surgery . Opens in a new window.
Amendments and Corrections | 7 September 2012
Erratum: Vitamin E decreases bone mass by stimulating osteoclast fusion
- Koji Fujita
- , Makiko Iwasaki
- , Hiroki Ochi
- , Toru Fukuda
- , Chengshan Ma
- , Takeshi Miyamoto
- , Kimitaka Takitani
- , Takako Negishi-Koga
- , Satoko Sunamura
- , Tatsuhiko Kodama
- , Hiroshi Takayanagi
- , Hiroshi Tamai
- , Shigeaki Kato
- , Hiroyuki Arai
- , Kenichi Shinomiya
- , Hiroshi Itoh
- , Atsushi Okawa
- & Shu Takeda
Nature Medicine 18 , 1445–1445

Rights & permissionsfor article Erratum: Vitamin E decreases bone mass by stimulating osteoclast fusion . Opens in a new window.
Research | 11 September 2019 | Open
One-year clinical evaluation of rotationally asymmetric multifocal intraocular lens with +1.5 diopters near addition
- Tetsuro Oshika
- , Hiroyuki Arai
- , Yoshifumi Fujita
- , Mikio Inamura
- , Yasushi Inoue
- , Toru Noda
- & Kazunori Miyata
Scientific Reports 9 , 1–8

Rights & permissionsfor article One-year clinical evaluation of rotationally asymmetric multifocal intraocular lens with +1.5 diopters near addition . Opens in a new window.
Research | 11 February 2016 | Open
Randomized, Multicenter, Double–Blind Study of the Safety and Efficacy of 1%D-3-Hydroxybutyrate eye drops for Dry Eye Disease
- Tetsuya Kawakita
- , Miki Uchino
- , Kazumi Fukagawa
- , Kenichi Yoshino
- , Seika Shimazaki
- , Ikuko Toda
- , Mari Tanaka
- , Hiroyuki Arai
- , Keiko Sakatani
- , Seiichiro Hata
- , Takashi Okano
- & Kazuo Tsubota
Scientific Reports 6 , 1–8

Rights & permissionsfor article Randomized, Multicenter, Double–Blind Study of the Safety and Efficacy of 1%D-3-Hydroxybutyrate eye drops for Dry Eye Disease . Opens in a new window.
Research | 11 June 2015 | Open
Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut
- Jun Kunisawa
- , Makoto Arita
- , Takahiro Hayasaka
- , Takashi Harada
- , Ryo Iwamoto
- , Risa Nagasawa
- , Shiori Shikata
- , Takahiro Nagatake
- , Hidehiko Suzuki
- , Eri Hashimoto
- , Yosuke Kurashima
- , Yuji Suzuki
- , Hiroyuki Arai
- , Mitsutoshi Setou
- & Hiroshi Kiyono
Scientific Reports 5 , 1–8

Rights & permissionsfor article Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut . Opens in a new window.
Research | 21 July 1994
Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor
Nature 370 , 216–218

Rights & permissionsfor article Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor . Opens in a new window.
Research | 2 January 1997
Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer
- Yew S. Ho
- , Lora Swenson
- , Urszula Derewenda
- , Laurence Serre
- , Yunyi Wei
- , Zbyszek Dauter
- , Mitsuharu Hattori
- , Tomoya Adachi
- , Junken Aoki
- , Hiroyuki Arai
- , Keizo Inoue
- & Zygmunt S. Derewenda
Nature 385 , 89–93

Rights & permissionsfor article Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer . Opens in a new window.
Research | 5 May 2005
LPA₃-mediated lysophosphatidic acid signalling in embryo implantation and spacing
- Xiaoqin Ye
- , Kotaro Hama
- , James J. A. Contos
- , Brigitte Anliker
- , Asuka Inoue
- , Michael K. Skinner
- , Hiroshi Suzuki
- , Tomokazu Amano
- , Grace Kennedy
- , Hiroyuki Arai
- , Junken Aoki
- & Jerold Chun
Nature 435 , 104–108

Rights & permissionsfor article LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing . Opens in a new window.
Research | 4 March 2012
Vitamin E decreases bone mass by stimulating osteoclast fusion
- Koji Fujita
- , Makiko Iwasaki
- , Hiroki Ochi
- , Toru Fukuda
- , Chengshan Ma
- , Takeshi Miyamoto
- , Kimitaka Takitani
- , Takako Negishi-Koga
- , Satoko Sunamura
- , Tatsuhiko Kodama
- , Hiroshi Takayanagi
- , Hiroshi Tamai
- , Shigeaki Kato
- , Hiroyuki Arai
- , Kenichi Shinomiya
- , Hiroshi Itoh
- , Atsushi Okawa
- & Shu Takeda
Nature Medicine 18 , 589–594

Rights & permissionsfor article Vitamin E decreases bone mass by stimulating osteoclast fusion . Opens in a new window.
Research | 1 February 1995
Ataxia with isolated vitamin E deficiency is caused by mutations in the α–tocopherol transfer protein
- Karim Ouahchi
- , Makoto Arita
- , Herbert Kayden
- , Fayçal Hentati
- , Mongi Ben Hamida
- , Ronald Sokol
- , Hiroyuki Arai
- , Keizo Inoue
- , Jean-Louis Mandel
- & Michel Koenig
Nature Genetics 9 , 141–145

Rights & permissionsfor article Ataxia with isolated vitamin E deficiency is caused by mutations in the α–tocopherol transfer protein . Opens in a new window.
5 March 2003
Elimination of the vertebrate Escherichia coli Ras-like protein homologue leads to cell cycle arrest at G1 phase and apoptosis
- Jin Gohda
- , Yukiko Nomura
- , Hisayo Suzuki
- , Hiroyuki Arai
- , Taishin Akiyama
- & Jun-ichiro Inoue
Oncogene 22 , 1340–1348

Rights & permissionsfor article Elimination of the vertebrate Escherichia coli Ras-like protein homologue leads to cell cycle arrest at G1 phase and apoptosis . Opens in a new window.
Amendments and Corrections | 4 August 1994
Erratum: Miller-Dicker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase
Nature 370 , 391–391

Rights & permissionsfor article Erratum: Miller-Dicker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase . Opens in a new window.
15 October 2008
GAB2 is not associated with late-onset Alzheimer's disease in Japanese
- Akinori Miyashita
- , Hiroyuki Arai
- , Takashi Asada
- , Masaki Imagawa
- , Mikio Shoji
- , Susumu Higuchi
- , Katsuya Urakami
- , Shinichi Toyabe
- , Kohei Akazawa
- , Ichiro Kanazawa
- , Yasuo Ihara
- & Ryozo Kuwano
European Journal of Human Genetics 17 , 682–686

Rights & permissionsfor article GAB2 is not associated with late-onset Alzheimer's disease in Japanese . Opens in a new window.
Research | 24 January 2020 | Open
YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology
- Hikari Tanaka
- , Hidenori Homma
- , Kyota Fujita
- , Kanoh Kondo
- , Shingo Yamada
- , Xiaocen Jin
- , Masaaki Waragai
- , Gaku Ohtomo
- , Atsushi Iwata
- , Kazuhiko Tagawa
- , Naoki Atsuta
- , Masahisa Katsuno
- , Naoki Tomita
- , Katsutoshi Furukawa
- , Yuko Saito
- , Takashi Saito
- , Ayaka Ichise
- , Shinsuke Shibata
- , Hiroyuki Arai
- , Takaomi Saido
- , Marius Sudol
- , Shin-ichi Muramatsu
- , Hideyuki Okano
- , Elliott J. Mufson
- , Gen Sobue
- , Shigeo Murayama
- & Hitoshi Okazawa
Nature Communications 11 , 1–22

Rights & permissionsfor article YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology . Opens in a new window.
Research | 1 November 2017 | Open
Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells
- Tatsuyuki Matsudaira
- , Kojiro Mukai
- , Taishin Noguchi
- , Junya Hasegawa
- , Tomohisa Hatta
- , Shun-ichiro Iemura
- , Tohru Natsume
- , Norio Miyamura
- , Hiroshi Nishina
- , Jun Nakayama
- , Kentaro Semba
- , Takuya Tomita
- , Shigeo Murata
- , Hiroyuki Arai
- & Tomohiko Taguchi
Nature Communications 8 , 1–11

Rights & permissionsfor article Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells . Opens in a new window.
Research | 9 October 2017
Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation
- Hiroyuki Arai and colleagues characterize a new...
- Yuta Shimanaka
- , Nozomu Kono
- , Yoshitaka Taketomi
- , Makoto Arita
- , Yoshimichi Okayama
- , Yuki Tanaka
- , Yasumasa Nishito
- , Tatsuki Mochizuki
- , Hiroyuki Kusuhara
- , Alexander Adibekian
- , Benjamin F Cravatt
- , Makoto Murakami
- & Hiroyuki Arai
Nature Medicine 23 , 1287–1297

Rights & permissionsfor article Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation . Opens in a new window.
Research | 21 June 2016 | Open
Activation of STING requires palmitoylation at the Golgi
- Kojiro Mukai
- , Hiroyasu Konno
- , Tatsuya Akiba
- , Takefumi Uemura
- , Satoshi Waguri
- , Toshihide Kobayashi
- , Glen N. Barber
- , Hiroyuki Arai
- & Tomohiko Taguchi
Nature Communications 7 , 1–10

Rights & permissionsfor article Activation of STING requires palmitoylation at the Golgi . Opens in a new window.
Research | 16 June 2016 | Open
Endomembrane-associated RSD-3 is important for RNAi induced by extracellular silencing RNA in both somatic and germ cells of Caenorhabditis elegans
Scientific Reports 6 , 1–14

Rights & permissionsfor article Endomembrane-associated RSD-3 is important for RNAi induced by extracellular silencing RNA in both somatic and germ cells of Caenorhabditis elegans . Opens in a new window.
Research | 18 February 2016 | Open
Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase
- Junko Morita
- , Kuniyuki Kano
- , Kazuki Kato
- , Hiroyuki Takita
- , Hideki Sakagami
- , Yasuo Yamamoto
- , Emiko Mihara
- , Hirofumi Ueda
- , Takanao Sato
- , Hidetoshi Tokuyama
- , Hiroyuki Arai
- , Hiroaki Asou
- , Junichi Takagi
- , Ryuichiro Ishitani
- , Hiroshi Nishimasu
- , Osamu Nureki
- & Junken Aoki
Scientific Reports 6 , 1–14

Rights & permissionsfor article Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase . Opens in a new window.
Research | 1 November 2013 | Open
Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth
- Aki Yamashita
- , Kei Kawana
- , Kensuke Tomio
- , Ayumi Taguchi
- , Yosuke Isobe
- , Ryo Iwamoto
- , Koji Masuda
- , Hitomi Furuya
- , Takeshi Nagamatsu
- , Kazunori Nagasaka
- , Takahide Arimoto
- , Katsutoshi Oda
- , Osamu Wada-Hiraike
- , Takahiro Yamashita
- , Yuji Taketani
- , Jing X. Kang
- , Shiro Kozuma
- , Hiroyuki Arai
- , Makoto Arita
- , Yutaka Osuga
- & Tomoyuki Fujii
Scientific Reports 3 , 1–7

Rights & permissionsfor article Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth . Opens in a new window.
Research | 16 September 2012
TGFα shedding assay: an accurate and versatile method for detecting GPCR activation
- Asuka Inoue
- , Jun Ishiguro
- , Hajime Kitamura
- , Naoaki Arima
- , Michiyo Okutani
- , Akira Shuto
- , Shigeki Higashiyama
- , Tomohiko Ohwada
- , Hiroyuki Arai
- , Kumiko Makide
- & Junken Aoki
Nature Methods 9 , 1021–1029

Rights & permissionsfor article TGFα shedding assay: an accurate and versatile method for detecting GPCR activation . Opens in a new window.
28 June 2004
Aberrant expression of lysophosphatidic acid (LPA) receptors in human colorectal cancer
- Dai Shida
- , Toshiaki Watanabe
- , Junken Aoki
- , Kotaro Hama
- , Joji Kitayama
- , Hirofumi Sonoda
- , Yasuhiro Kishi
- , Hironori Yamaguchi
- , Shin Sasaki
- , Akihiro Sako
- , Tsuyoshi Konishi
- , Hiroyuki Arai
- & Hirokazu Nagawa
Laboratory Investigation 84 , 1352–1362

Rights & permissionsfor article Aberrant expression of lysophosphatidic acid (LPA) receptors in human colorectal cancer . Opens in a new window.

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Homeostatic regulation of STING by retrograde membrane traffic to the ER

Changes in patient subjective happiness and satisfaction with cataract surgery

Erratum: Vitamin E decreases bone mass by stimulating osteoclast fusion

One-year clinical evaluation of rotationally asymmetric multifocal intraocular lens with +1.5 diopters near addition

Randomized, Multicenter, Double–Blind Study of the Safety and Efficacy of 1%D-3-Hydroxybutyrate eye drops for Dry Eye Disease

Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut

Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor

Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer

LPA₃-mediated lysophosphatidic acid signalling in embryo implantation and spacing

Vitamin E decreases bone mass by stimulating osteoclast fusion

Ataxia with isolated vitamin E deficiency is caused by mutations in the α–tocopherol transfer protein

Elimination of the vertebrate Escherichia coli Ras-like protein homologue leads to cell cycle arrest at G1 phase and apoptosis

Erratum: Miller-Dicker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase

GAB2 is not associated with late-onset Alzheimer's disease in Japanese

YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology

Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells

Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation

Activation of STING requires palmitoylation at the Golgi

Endomembrane-associated RSD-3 is important for RNAi induced by extracellular silencing RNA in both somatic and germ cells of Caenorhabditis elegans

Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase

Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth

TGFα shedding assay: an accurate and versatile method for detecting GPCR activation

Aberrant expression of lysophosphatidic acid (LPA) receptors in human colorectal cancer

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