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Amendments and Corrections | 30 May 2018
Author Correction: High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
- Semir Beyaz
- , Miyeko D. Mana
- , Jatin Roper
- , Dmitriy Kedrin
- , Assieh Saadatpour
- , Sue-Jean Hong
- , Khristian E. Bauer-Rowe
- , Michael E. Xifaras
- , Adam Akkad
- , Erika Arias
- , Luca Pinello
- , Yarden Katz
- , Shweta Shinagare
- , Monther Abu-Remaileh
- , Maria M. Mihaylova
- , Dudley W. Lamming
- , Rizkullah Dogum
- , Guoji Guo
- , George W. Bell
- , Martin Selig
- , G. Petur Nielsen
- , Nitin Gupta
- , Cristina R. Ferrone
- , Vikram Deshpande
- , Guo-Cheng Yuan
- , Stuart H. Orkin
- , David M. Sabatini
- & Ömer H. Yilmaz
Nature 560 , E26–E26

Rights & permissionsfor article Author Correction: High-fat diet enhances stemness and tumorigenicity of intestinal progenitors . Opens in a new window.
Correspondence | 10 July 2018 | Open
Quantitative integration of epigenomic variation and transcription factor binding using MAmotif toolkit identifies an important role of IRF2 as transcription activator at gene promoters
- Hongduo Sun
- , Jiawei Wang
- , Zhaohui Gong
- , Jiaying Yao
- , Yuangao Wang
- , Jian Xu
- , Guo-cheng Yuan
- , Yijing Zhang
- & Zhen Shao
Cell Discovery 4 , 1–4

Rights & permissionsfor article Quantitative integration of epigenomic variation and transcription factor binding using MAmotif toolkit identifies an important role of IRF2 as transcription activator at gene promoters . Opens in a new window.
Amendments and Corrections | 2 June 2017
Erratum: A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations
- Xiaoping Han
- , Hao Yu
- , Daosheng Huang
- , Yang Xu
- , Assieh Saadatpour
- , Xia Li
- , Lengmei Wang
- , Jie Yu
- , Luca Pinello
- , Shujing Lai
- , Mengmeng Jiang
- , Xueying Tian
- , Fen Zhang
- , Yanhong Cen
- , Yuko Fujiwara
- , Wei Zhu
- , Bin Zhou
- , Tianhua Zhou
- , Hongwei Ouyang
- , Jianan Wang
- , Guo-Cheng Yuan
- , Shumin Duan
- , Stuart H Orkin
- & Guoji Guo
Cell Research 27 , 843–843

Rights & permissionsfor article Erratum: A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations . Opens in a new window.
Amendments and Corrections | 2 June 2017
Erratum: A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations
- Xiaoping Han
- , Hao Yu
- , Daosheng Huang
- , Yang Xu
- , Assieh Saadatpour
- , Xia Li
- , Lengmei Wang
- , Jie Yu
- , Luca Pinello
- , Shujing Lai
- , Mengmeng Jiang
- , Xueying Tian
- , Fen Zhang
- , Yanhong Cen
- , Yuko Fujiwara
- , Wei Zhu
- , Bin Zhou
- , Tianhua Zhou
- , Hongwei Ouyang
- , Jianan Wang
- , Guo-Cheng Yuan
- , Shumin Duan
- , Stuart H Orkin
- & Guoji Guo
Cell Research 27 , 842–842

Rights & permissionsfor article Erratum: A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations . Opens in a new window.
Correspondence | 12 July 2016
Analyzing CRISPR genome-editing experiments with CRISPResso
- Luca Pinello
- , Matthew C Canver
- , Megan D Hoban
- , Stuart H Orkin
- , Donald B Kohn
- , Daniel E Bauer
- & Guo-Cheng Yuan
Nature Biotechnology 34 , 695–697

Rights & permissionsfor article Analyzing CRISPR genome-editing experiments with CRISPResso . Opens in a new window.
Research | 6 June 2016
Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases
- Jing Ni
- , Shakti H Ramkissoon
- , Shaozhen Xie
- , Shom Goel
- , Daniel G Stover
- , Hanbing Guo
- , Victor Luu
- , Eugenio Marco
- , Lori A Ramkissoon
- , Yun Jee Kang
- , Marika Hayashi
- , Quang-De Nguyen
- , Azra H Ligon
- , Rose Du
- , Elizabeth B Claus
- , Brian M Alexander
- , Guo-Cheng Yuan
- , Zhigang C Wang
- , J Dirk Iglehart
- , Ian E Krop
- , Thomas M Roberts
- , Eric P Winer
- , Nancy U Lin
- , Keith L Ligon
- & Jean J Zhao
Nature Medicine 22 , 723–726

Rights & permissionsfor article Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases . Opens in a new window.
Research | 30 January 2020 | Open
Two faces of bivalent domain regulate VEGFA responsiveness and angiogenesis
- Jiahuan Chen
- , Xiaodong Liang
- , Shasha Zhang
- , Shiyan Wang
- , Sara P. Garcia
- , Pengyi Yan
- , Huijing Yu
- , Zixuan Li
- , Li Liu
- , Fang Zhang
- , Weiting Wei
- , Huangying Le
- , Yan Zhang
- , Guo-cheng Yuan
- , Sun Chen
- , Yingwei Chen
- , Kun Sun
- , William T. Pu
- & Bing Zhang
Cell Death & Disease 11 , 1–15

Rights & permissionsfor article Two faces of bivalent domain regulate VEGFA responsiveness and angiogenesis . Opens in a new window.
Reviews | 9 October 2019 | Open
The human body at cellular resolution: the NIH Human Biomolecular Atlas Program
- Michael P. Snyder
- , Shin Lin
- , Amanda Posgai
- , Mark Atkinson
- , Aviv Regev
- , Jennifer Rood
- , Orit Rozenblatt-Rosen
- , Leslie Gaffney
- , Anna Hupalowska
- , Rahul Satija
- , Nils Gehlenborg
- , Jay Shendure
- , Julia Laskin
- , Pehr Harbury
- , Nicholas A. Nystrom
- , Jonathan C. Silverstein
- , Ziv Bar-Joseph
- , Kun Zhang
- , Katy Börner
- , Yiing Lin
- , Richard Conroy
- , Dena Procaccini
- , Ananda L. Roy
- , Ajay Pillai
- , Marishka Brown
- , Zorina S. Galis
- , Long Cai
- , Jay Shendure
- , Cole Trapnell
- , Shin Lin
- , Dana Jackson
- , Michael P. Snyder
- , Garry Nolan
- , William James Greenleaf
- , Yiing Lin
- , Sylvia Plevritis
- , Sara Ahadi
- , Stephanie A. Nevins
- , Hayan Lee
- , Christian Martijn Schuerch
- , Sarah Black
- , Vishal Gautham Venkataraaman
- , Ed Esplin
- , Aaron Horning
- , Amir Bahmani
- , Kun Zhang
- , Xin Sun
- , Sanjay Jain
- , James Hagood
- , Gloria Pryhuber
- , Peter Kharchenko
- , Mark Atkinson
- , Bernd Bodenmiller
- , Todd Brusko
- , Michael Clare-Salzler
- , Harry Nick
- , Kevin Otto
- , Amanda Posgai
- , Clive Wasserfall
- , Marda Jorgensen
- , Maigan Brusko
- , Sergio Maffioletti
- , Richard M. Caprioli
- , Jeffrey M. Spraggins
- , Danielle Gutierrez
- , Nathan Heath Patterson
- , Elizabeth K. Neumann
- , Raymond Harris
- , Mark deCaestecker
- , Agnes B. Fogo
- , Raf van de Plas
- , Ken Lau
- , Long Cai
- , Guo-Cheng Yuan
- , Qian Zhu
- , Ruben Dries
- , Peng Yin
- , Sinem K. Saka
- , Jocelyn Y. Kishi
- , Yu Wang
- , Isabel Goldaracena
- , Julia Laskin
- , DongHye Ye
- , Kristin E. Burnum-Johnson
- , Paul D. Piehowski
- , Charles Ansong
- , Ying Zhu
- , Pehr Harbury
- , Tushar Desai
- , Jay Mulye
- , Peter Chou
- , Monica Nagendran
- , Ziv Bar-Joseph
- , Sarah A. Teichmann
- , Benedict Paten
- , Robert F. Murphy
- , Jian Ma
- , Vladimir Yu. Kiselev
- , Carl Kingsford
- , Allyson Ricarte
- , Maria Keays
- , Sushma A. Akoju
- , Matthew Ruffalo
- , Nils Gehlenborg
- , Peter Kharchenko
- , Margaret Vella
- , Chuck McCallum
- , Katy Börner
- , Leonard E. Cross
- , Samuel H. Friedman
- , Randy Heiland
- , Bruce Herr II
- , Paul Macklin
- , Ellen M. Quardokus
- , Lisel Record
- , James P. Sluka
- , Griffin M. Weber
- , Nicholas A. Nystrom
- , Jonathan C. Silverstein
- , Philip D. Blood
- , Alexander J. Ropelewski
- , William E. Shirey
- , Robin M. Scibek
- , Paula Mabee
- , W. Christopher Lenhardt
- , Kimberly Robasky
- , Stavros Michailidis
- , Rahul Satija
- , John Marioni
- , Aviv Regev
- , Andrew Butler
- , Tim Stuart
- , Eyal Fisher
- , Shila Ghazanfar
- , Jennifer Rood
- , Leslie Gaffney
- , Gokcen Eraslan
- , Tommaso Biancalani
- , Eeshit D. Vaishnav
- , Richard Conroy
- , Dena Procaccini
- , Ananda Roy
- , Ajay Pillai
- , Marishka Brown
- , Zorina Galis
- , Pothur Srinivas
- , Aaron Pawlyk
- , Salvatore Sechi
- , Elizabeth Wilder
- & James Anderson
Nature 574 , 187–192

Rights & permissionsfor article The human body at cellular resolution: the NIH Human Biomolecular Atlas Program . Opens in a new window.
Research | 28 October 2019 | Open
A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers
- Brynn N. Akerberg
- , Fei Gu
- , Nathan J. VanDusen
- , Xiaoran Zhang
- , Rui Dong
- , Kai Li
- , Bing Zhang
- , Bin Zhou
- , Isha Sethi
- , Qing Ma
- , Lauren Wasson
- , Tong Wen
- , Jinhua Liu
- , Kunzhe Dong
- , Frank L. Conlon
- , Jiliang Zhou
- , Guo-Cheng Yuan
- , Pingzhu Zhou
- & William T. Pu
Nature Communications 10 , 1–16

Rights & permissionsfor article A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers . Opens in a new window.
Research | 13 August 2019
LSD1 suppresses invasion, migration and metastasis of luminal breast cancer cells via activation of GATA3 and repression of TRIM37 expression
- Xin Hu
- , Dongxi Xiang
- , Ying Xie
- , Luwei Tao
- , Yu Zhang
- , Yue Jin
- , Luca Pinello
- , Youzhong Wan
- , Guo-Cheng Yuan
- & Zhe Li
Oncogene 38 , 7017–7034

Rights & permissionsfor article LSD1 suppresses invasion, migration and metastasis of luminal breast cancer cells via activation of GATA3 and repression of TRIM37 expression . Opens in a new window.
Research | 5 July 2019 | Open
Accurate estimation of cell-type composition from gene expression data
- Daphne Tsoucas
- , Rui Dong
- , Haide Chen
- , Qian Zhu
- , Guoji Guo
- & Guo-Cheng Yuan
Nature Communications 10 , 1–9

Rights & permissionsfor article Accurate estimation of cell-type composition from gene expression data . Opens in a new window.
Research | 7 August 2019
BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells
- David N. Debruyne
- , Ruben Dries
- , Satyaki Sengupta
- , Davide Seruggia
- , Yang Gao
- , Bandana Sharma
- , Hao Huang
- , Lisa Moreau
- , Michael McLane
- , Daniel S. Day
- , Eugenio Marco
- , Ting Chen
- , Nathanael S. Gray
- , Kwok-Kin Wong
- , Stuart H. Orkin
- , Guo-Cheng Yuan
- , Richard A. Young
- & Rani E. George
Nature 572 , 676–680

Rights & permissionsfor article BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells . Opens in a new window.
Research | 15 April 2019 | Open
CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation
- Malgorzata Krajewska
- , Ruben Dries
- , Andrew V. Grassetti
- , Sofia Dust
- , Yang Gao
- , Hao Huang
- , Bandana Sharma
- , Daniel S. Day
- , Nicholas Kwiatkowski
- , Monica Pomaville
- , Oliver Dodd
- , Edmond Chipumuro
- , Tinghu Zhang
- , Arno L. Greenleaf
- , Guo-Cheng Yuan
- , Nathanael S. Gray
- , Richard A. Young
- , Matthias Geyer
- , Scott A. Gerber
- & Rani E. George
Nature Communications 10 , 1–16

Rights & permissionsfor article CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation . Opens in a new window.
Research | 23 April 2019 | Open
Single-cell trajectories reconstruction, exploration and mapping of omics data with STREAM
- Huidong Chen
- , Luca Albergante
- , Jonathan Y. Hsu
- , Caleb A. Lareau
- , Giosuè Lo Bosco
- , Jihong Guan
- , Shuigeng Zhou
- , Alexander N. Gorban
- , Daniel E. Bauer
- , Martin J. Aryee
- , David M. Langenau
- , Andrei Zinovyev
- , Jason D. Buenrostro
- , Guo-Cheng Yuan
- & Luca Pinello
Nature Communications 10 , 1–14

Rights & permissionsfor article Single-cell trajectories reconstruction, exploration and mapping of omics data with STREAM . Opens in a new window.
Research | 25 March 2019
Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH+
- Chee-Huat Linus Eng
- , Michael Lawson
- , Qian Zhu
- , Ruben Dries
- , Noushin Koulena
- , Yodai Takei
- , Jina Yun
- , Christopher Cronin
- , Christoph Karp
- , Guo-Cheng Yuan
- & Long Cai
Nature 568 , 235–239

Rights & permissionsfor article Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH+ . Opens in a new window.
Research | 29 October 2018
Identification of spatially associated subpopulations by combining scRNAseq and sequential fluorescence in situ hybridization data
- Qian Zhu
- , Sheel Shah
- , Ruben Dries
- , Long Cai
- & Guo-Cheng Yuan
Nature Biotechnology 36 , 1183–1190

Rights & permissionsfor article Identification of spatially associated subpopulations by combining scRNAseq and sequential fluorescence in situ hybridization data . Opens in a new window.
Research | 21 September 2018 | Open
Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor
- Yuxuan Guo
- , Blake D. Jardin
- , Pingzhu Zhou
- , Isha Sethi
- , Brynn N. Akerberg
- , Christopher N Toepfer
- , Yulan Ai
- , Yifei Li
- , Qing Ma
- , Silvia Guatimosim
- , Yongwu Hu
- , Grigor Varuzhanyan
- , Nathan J. VanDusen
- , Donghui Zhang
- , David C. Chan
- , Guo-Cheng Yuan
- , Christine E. Seidman
- , Jonathan G. Seidman
- & William T. Pu
Nature Communications 9 , 1–16

Rights & permissionsfor article Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor . Opens in a new window.
Research | 24 August 2018 | Open
Integrative epigenomic analysis in differentiated human primary bronchial epithelial cells exposed to cigarette smoke
- Kimberly Glass
- , Derek Thibault
- , Feng Guo
- , Jennifer A. Mitchel
- , Betty Pham
- , Weiliang Qiu
- , Yan Li
- , Zhiqiang Jiang
- , Peter J. Castaldi
- , Edwin K. Silverman
- , Benjamin Raby
- , Jin-Ah Park
- , Guo-Cheng Yuan
- & Xiaobo Zhou
Scientific Reports 8 , 1–11

Rights & permissionsfor article Integrative epigenomic analysis in differentiated human primary bronchial epithelial cells exposed to cigarette smoke . Opens in a new window.
Protocols | 12 April 2018
Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments
- Matthew C Canver
- , Maximilian Haeussler
- , Daniel E Bauer
- , Stuart H Orkin
- , Neville E Sanjana
- , Ophir Shalem
- , Guo-Cheng Yuan
- , Feng Zhang
- , Jean-Paul Concordet
- & Luca Pinello
Nature Protocols 13 , 946–986

Rights & permissionsfor article Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments . Opens in a new window.
Research | 5 March 2018 | Open
Dissecting super-enhancer hierarchy based on chromatin interactions
- Jialiang Huang
- , Kailong Li
- , Wenqing Cai
- , Xin Liu
- , Yuannyu Zhang
- , Stuart H. Orkin
- , Jian Xu
- & Guo-Cheng Yuan
Nature Communications 9 , 1–12

Rights & permissionsfor article Dissecting super-enhancer hierarchy based on chromatin interactions . Opens in a new window.
Research | 31 January 2017 | Open
The PRC2-binding long non-coding RNAs in human and mouse genomes are associated with predictive sequence features
- Shiqi Tu
- , Guo-Cheng Yuan
- & Zhen Shao
Scientific Reports 7 , 1–11

Rights & permissionsfor article The PRC2-binding long non-coding RNAs in human and mouse genomes are associated with predictive sequence features . Opens in a new window.
Research | 7 April 2017 | Open
Multi-scale chromatin state annotation using a hierarchical hidden Markov model
- Eugenio Marco
- , Wouter Meuleman
- , Jialiang Huang
- , Kimberly Glass
- , Luca Pinello
- , Jianrong Wang
- , Manolis Kellis
- & Guo-Cheng Yuan
Nature Communications 8 , 1–9

Rights & permissionsfor article Multi-scale chromatin state annotation using a hierarchical hidden Markov model . Opens in a new window.
Research | 20 February 2017
Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci
- Matthew C Canver
- , Samuel Lessard
- , Luca Pinello
- , Yuxuan Wu
- , Yann Ilboudo
- , Emily N Stern
- , Austen J Needleman
- , Frédéric Galactéros
- , Carlo Brugnara
- , Abdullah Kutlar
- , Colin McKenzie
- , Marvin Reid
- , Diane D Chen
- , Partha Pratim Das
- , Mitchel A Cole
- , Jing Zeng
- , Ryo Kurita
- , Yukio Nakamura
- , Guo-Cheng Yuan
- , Guillaume Lettre
- , Daniel E Bauer
- & Stuart H Orkin
Nature Genetics 49 , 625–634

Rights & permissionsfor article Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci . Opens in a new window.
Research | 27 January 2017
A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations
- Xiaoping Han
- , Hao Yu
- , Daosheng Huang
- , Yang Xu
- , Assieh Saadatpour
- , Xia Li
- , Lengmei Wang
- , Jie Yu
- , Luca Pinello
- , Shujing Lai
- , Mengmeng Jiang
- , Xueying Tian
- , Fen Zhang
- , Yanhong Cen
- , Yuko Fujiwara
- , Wei Zhu
- , Bin Zhou
- , Tianhua Zhou
- , Hongwei Ouyang
- , Jianan Wang
- , Guo-Cheng Yuan
- , Shumin Duan
- , Stuart H Orkin
- & Guoji Guo
Cell Research 27 , 386–401

Rights & permissionsfor article A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations . Opens in a new window.
Research | 19 December 2016
The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells
- Semir Beyaz
- , Ji Hyung Kim
- , Luca Pinello
- , Michael E Xifaras
- , Yu Hu
- , Jialiang Huang
- , Marc A Kerenyi
- , Partha P Das
- , R Anthony Barnitz
- , Aurelie Herault
- , Rizkullah Dogum
- , W Nicholas Haining
- , Ömer H Yilmaz
- , Emmanuelle Passegue
- , Guo-Cheng Yuan
- , Stuart H Orkin
- & Florian Winau
Nature Immunology 18 , 184–195

Rights & permissionsfor article The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells . Opens in a new window.
Research | 2 March 2016
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
- Semir Beyaz
- , Miyeko D. Mana
- , Jatin Roper
- , Dmitriy Kedrin
- , Assieh Saadatpour
- , Sue-Jean Hong
- , Khristian E. Bauer-Rowe
- , Michael E. Xifaras
- , Adam Akkad
- , Erika Arias
- , Luca Pinello
- , Yarden Katz
- , Shweta Shinagare
- , Monther Abu-Remaileh
- , Maria M. Mihaylova
- , Dudley W. Lamming
- , Rizkullah Dogum
- , Guoji Guo
- , George W. Bell
- , Martin Selig
- , G. Petur Nielsen
- , Nitin Gupta
- , Cristina R. Ferrone
- , Vikram Deshpande
- , Guo-Cheng Yuan
- , Stuart H. Orkin
- , David M. Sabatini
- & Ömer H. Yilmaz
Nature 531 , 53–58

Rights & permissionsfor article High-fat diet enhances stemness and tumorigenicity of intestinal progenitors . Opens in a new window.
Research | 11 January 2016
Mitochondrial iron chelation ameliorates cigarette smoke–induced bronchitis and emphysema in mice
- Suzanne M Cloonan
- , Kimberly Glass
- , Maria E Laucho-Contreras
- , Abhiram R Bhashyam
- , Morgan Cervo
- , Maria A Pabón
- , Csaba Konrad
- , Francesca Polverino
- , Ilias I Siempos
- , Elizabeth Perez
- , Kenji Mizumura
- , Manik C Ghosh
- , Harikrishnan Parameswaran
- , Niamh C Williams
- , Kristen T Rooney
- , Zhi-Hua Chen
- , Monica P Goldklang
- , Guo-Cheng Yuan
- , Stephen C Moore
- , Dawn L Demeo
- , Tracey A Rouault
- , Jeanine M D'Armiento
- , Eric A Schon
- , Giovanni Manfredi
- , John Quackenbush
- , Ashfaq Mahmood
- , Edwin K Silverman
- , Caroline A Owen
- & Augustine M K Choi
Nature Medicine 22 , 163–174

Rights & permissionsfor article Mitochondrial iron chelation ameliorates cigarette smoke–induced bronchitis and emphysema in mice . Opens in a new window.
Research | 16 September 2015
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
- Matthew C. Canver
- , Elenoe C. Smith
- , Falak Sher
- , Luca Pinello
- , Neville E. Sanjana
- , Ophir Shalem
- , Diane D. Chen
- , Patrick G. Schupp
- , Divya S. Vinjamur
- , Sara P. Garcia
- , Sidinh Luc
- , Ryo Kurita
- , Yukio Nakamura
- , Yuko Fujiwara
- , Takahiro Maeda
- , Guo-Cheng Yuan
- , Feng Zhang
- , Stuart H. Orkin
- & Daniel E. Bauer
Nature 527 , 192–197

Rights & permissionsfor article BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis . Opens in a new window.
Research | 31 January 2010
Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae
Nature Structural & Molecular Biology 17 , 251–257

Rights & permissionsfor article Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae . Opens in a new window.

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Author Correction: High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

Quantitative integration of epigenomic variation and transcription factor binding using MAmotif toolkit identifies an important role of IRF2 as transcription activator at gene promoters

Erratum: A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations

Erratum: A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations

Analyzing CRISPR genome-editing experiments with CRISPResso

Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases

Two faces of bivalent domain regulate VEGFA responsiveness and angiogenesis

The human body at cellular resolution: the NIH Human Biomolecular Atlas Program

A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers

LSD1 suppresses invasion, migration and metastasis of luminal breast cancer cells via activation of GATA3 and repression of TRIM37 expression

Accurate estimation of cell-type composition from gene expression data

BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

Single-cell trajectories reconstruction, exploration and mapping of omics data with STREAM

Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH+

Identification of spatially associated subpopulations by combining scRNAseq and sequential fluorescence in situ hybridization data

Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor

Integrative epigenomic analysis in differentiated human primary bronchial epithelial cells exposed to cigarette smoke

Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments

Dissecting super-enhancer hierarchy based on chromatin interactions

The PRC2-binding long non-coding RNAs in human and mouse genomes are associated with predictive sequence features

Multi-scale chromatin state annotation using a hierarchical hidden Markov model

Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci

A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations

The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

Mitochondrial iron chelation ameliorates cigarette smoke–induced bronchitis and emphysema in mice

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae

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