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Research | 13 January 2021
Loop extrusion mediates physiological Igh locus contraction for RAG scanning
- Hai-Qiang Dai
- , Hongli Hu
- , Jiangman Lou
- , Adam Yongxin Ye
- , Zhaoqing Ba
- , Xuefei Zhang
- , Yiwen Zhang
- , Lijuan Zhao
- , Hye Suk Yoon
- , Aimee M. Chapdelaine-Williams
- , Nia Kyritsis
- , Huan Chen
- , Kerstin Johnson
- , Sherry Lin
- , Andrea Conte
- , Rafael Casellas
- , Cheng-Sheng Lee
- & Frederick W. Alt
Nature , 1–6

Rights & permissionsfor article Loop extrusion mediates physiological <i>Igh</i> locus contraction for RAG scanning . Opens in a new window.
Amendments and Corrections | 1 August 2004
Erratum: Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
- Jayanta Chaudhuri
- & Frederick W. Alt
Nature Reviews Immunology 4 , 655–655

Rights & permissionsfor article Erratum: Class-switch recombination: interplay of transcription, DNA deamination and DNA repair . Opens in a new window.
Research Highlights | 31 August 2018
Guiding a mutator in antibody diversification
- Ming Tian
- & Frederick W. Alt
Cell Research 28 , 963–964

Rights & permissionsfor article Guiding a mutator in antibody diversification . Opens in a new window.
Protocols | 10 August 2020
Direct analysis of brain phenotypes via neural blastocyst complementation
Nature Protocols 15 , 3154–3181

Rights & permissionsfor article Direct analysis of brain phenotypes via neural blastocyst complementation . Opens in a new window.
News and Views | 1 June 2004
V(D)J recombinational accessibility—heading in the opposite direction?
Nature Immunology 5 , 561–562

Rights & permissionsfor article V(D)J recombinational accessibility—heading in the opposite direction? . Opens in a new window.
News and Views | 21 May 1987
Circular T-cell receptor gene recombination products
- Frederick W. Alt
- & George D. Yancopoulos
Nature 327 , 189–190

Rights & permissionsfor article Circular T-cell receptor gene recombination products . Opens in a new window.
News and Views | 6 December 1984
Immunology: Exclusive immunoglobulin genes
- Frederick W. Alt
Nature 312 , 502–503

Rights & permissionsfor article Immunology: Exclusive immunoglobulin genes . Opens in a new window.
News and Views | 4 March 2004
Case of mistaken identity
- Craig H. Bassing
- & Frederick W. Alt
Nature 428 , 29–31

Rights & permissionsfor article Case of mistaken identity . Opens in a new window.
News and Views | 1 December 2004
Antibody diversity: one enzyme to rule them all
- Michel C Nussenzweig
- & Frederick W Alt
Nature Medicine 10 , 1304–1305

Rights & permissionsfor article Antibody diversity: one enzyme to rule them all . Opens in a new window.
News and Views | 28 August 1986
Antibody diversity: New mechanism revealed
- Frederick W. Alt
Nature 322 , 772–773

Rights & permissionsfor article Antibody diversity: New mechanism revealed . Opens in a new window.
News and Views | 7 September 2000
RNA editing meets DNA shuffling
- Ming Tian
- & Frederick W. Alt
Nature 407 , 31–33

Rights & permissionsfor article RNA editing meets DNA shuffling . Opens in a new window.
Research | 27 July 2020
CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning
- Zhaoqing Ba
- , Jiangman Lou
- , Adam Yongxin Ye
- , Hai-Qiang Dai
- , Edward W. Dring
- , Sherry G. Lin
- , Suvi Jain
- , Nia Kyritsis
- , Kyong-Rim Kieffer-Kwon
- , Rafael Casellas
- & Frederick W. Alt
Nature 586 , 305–310

Rights & permissionsfor article CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning . Opens in a new window.
Research | 6 May 2020
BCR selection and affinity maturation in Peyer’s patch germinal centres
- Huan Chen
- , Yuxiang Zhang
- , Adam Yongxin Ye
- , Zhou Du
- , Mo Xu
- , Cheng-Sheng Lee
- , Joyce K. Hwang
- , Nia Kyritsis
- , Zhaoqing Ba
- , Donna Neuberg
- , Dan R. Littman
- & Frederick W. Alt
Nature 582 , 421–425

Rights & permissionsfor article BCR selection and affinity maturation in Peyer’s patch germinal centres . Opens in a new window.
19 October 2018
CRISPR/Cas9-mediated genome editing in mouse embryonic stem cells and direct analysis of brain phenotypes via neural blastocyst complementation
Protocol Exchange

Rights & permissionsfor article CRISPR/Cas9-mediated genome editing in mouse embryonic stem cells and direct analysis of brain phenotypes via neural blastocyst complementation . Opens in a new window.
Research | 21 August 2013
Microbial colonization influences early B-lineage development in the gut lamina propria
Nature 501 , 112–115

Rights & permissionsfor article Microbial colonization influences early B-lineage development in the gut lamina propria . Opens in a new window.
Research | 19 February 2020 | Open
Immune checkpoint modulation enhances HIV-1 antibody induction
- Todd Bradley
- , Masayuki Kuraoka
- , Chen-Hao Yeh
- , Ming Tian
- , Huan Chen
- , Derek W. Cain
- , Xuejun Chen
- , Cheng Cheng
- , Ali H. Ellebedy
- , Robert Parks
- , Maggie Barr
- , Laura L. Sutherland
- , Richard M. Scearce
- , Cindy M. Bowman
- , Hilary Bouton-Verville
- , Sampa Santra
- , Kevin Wiehe
- , Mark G. Lewis
- , Ane Ogbe
- , Persephone Borrow
- , David Montefiori
- , Mattia Bonsignori
- , M. Anthony Moody
- , Laurent Verkoczy
- , Kevin O. Saunders
- , Rafi Ahmed
- , John R. Mascola
- , Garnett Kelsoe
- , Frederick W. Alt
- & Barton F. Haynes
Nature Communications 11 , 1–16

Rights & permissionsfor article Immune checkpoint modulation enhances HIV-1 antibody induction . Opens in a new window.
Research | 15 December 2010
ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks
- Shan Zha
- , Chunguang Guo
- , Cristian Boboila
- , Valentyn Oksenych
- , Hwei-Ling Cheng
- , Yu Zhang
- , Duane R. Wesemann
- , Grace Yuen
- , Harin Patel
- , Peter H. Goff
- , Richard L. Dubois
- & Frederick W. Alt
Nature 469 , 250–254

Rights & permissionsfor article ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks . Opens in a new window.
Research | 22 January 2003
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
- Kwok-Kin Wong
- , Richard S. Maser
- , Robert M. Bachoo
- , Jayant Menon
- , Daniel R. Carrasco
- , Yansong Gu
- , Frederick W. Alt
- & Ronald A. DePinho
Nature 421 , 643–648

Rights & permissionsfor article Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing . Opens in a new window.
Research | 22 August 2007
IgH class switching and translocations use a robust non-classical end-joining pathway
- Catherine T. Yan
- , Cristian Boboila
- , Ellen Kris Souza
- , Sonia Franco
- , Thomas R. Hickernell
- , Michael Murphy
- , Sunil Gumaste
- , Mark Geyer
- , Ali A. Zarrin
- , John P. Manis
- , Klaus Rajewsky
- & Frederick W. Alt
Nature 449 , 478–482

Rights & permissionsfor article IgH class switching and translocations use a robust non-classical end-joining pathway . Opens in a new window.
Special Features | 1 July 2003
Chromatin dynamics and locus accessibility in the immune system
Nature Immunology 4 , 603–606

Rights & permissionsfor article Chromatin dynamics and locus accessibility in the immune system . Opens in a new window.
Research | 9 April 2003
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
- Jayanta Chaudhuri
- , Ming Tian
- , Chan Khuong
- , Katrin Chua
- , Eric Pinaud
- & Frederick W. Alt
Nature 422 , 726–730

Rights & permissionsfor article Transcription-targeted DNA deamination by the AID antibody diversification enzyme . Opens in a new window.
Research | 26 September 1985
Regulated progression of a cultured pre-B-cell line to the B-cell stage
Nature 317 , 353–355

Rights & permissionsfor article Regulated progression of a cultured pre-B-cell line to the B-cell stage . Opens in a new window.
Research | 25 October 1984
Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells
Nature 311 , 752–755

Rights & permissionsfor article Insertion of <i>N</i> regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells . Opens in a new window.
Research | 27 February 1986
Differential expression of myc family genes during murine development
Nature 319 , 780–783

Rights & permissionsfor article Differential expression of <i>myc</i> family genes during murine development . Opens in a new window.
Research | 10 July 1986
A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes
Nature 322 , 179–181

Rights & permissionsfor article A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes . Opens in a new window.
8 October 2001
DNA double strand break repair and chromosomal translocation: Lessons from animal models
- David O Ferguson
- & Frederick W Alt
Oncogene 20 , 5572–5579

Rights & permissionsfor article DNA double strand break repair and chromosomal translocation: Lessons from animal models . Opens in a new window.
Research | 19 October 1995
Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene
Nature 377 , 635–638

Rights & permissionsfor article Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene . Opens in a new window.
Research | 26 October 2005
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation
- Uttiya Basu
- , Jayanta Chaudhuri
- , Craig Alpert
- , Shilpee Dutt
- , Sheila Ranganath
- , Gang Li
- , Jason Patrick Schrum
- , John P. Manis
- & Frederick W. Alt
Nature 438 , 508–511

Rights & permissionsfor article The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation . Opens in a new window.
News and Views | 1 August 2009
Mre11: roles in DNA repair beyond homologous recombination
Nature Structural & Molecular Biology 16 , 798–800

Rights & permissionsfor article Mre11: roles in DNA repair beyond homologous recombination . Opens in a new window.
Research | 1 June 2000
Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule
Nature 405 , 583–586

Rights & permissionsfor article Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule . Opens in a new window.
Research | 30 March 1995
Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene
Nature 374 , 470–473

Rights & permissionsfor article Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene . Opens in a new window.
Research | 22 April 2002
Essential roles of the κ light chain intronic enhancer and 3′ enhancer in κ rearrangement and demethylation
- Matthew Inlay
- , Frederick W. Alt
- , David Baltimore
- & Yang Xu
Nature Immunology 3 , 463–468

Rights & permissionsfor article Essential roles of the κ light chain intronic enhancer and 3′ enhancer in κ rearrangement and demethylation . Opens in a new window.
Research | 1 September 2000
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation
- Kwok-Kin Wong
- , Sandy Chang
- , Sarah R. Weiler
- , Shridar Ganesan
- , Jayanta Chaudhuri
- , Chengming Zhu
- , Steven E. Artandi
- , Karl Lenhard Rudolph
- , Geoffrey J. Gottlieb
- , Lynda Chin
- , Frederick W. Alt
- & Ronald A. DePinho
Nature Genetics 26 , 85–88

Rights & permissionsfor article Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation . Opens in a new window.
Research | 18 January 2009
Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner
- Frédéric Van Gool
- , Mara Gallí
- , Cyril Gueydan
- , Véronique Kruys
- , Pierre-Paul Prevot
- , Antonio Bedalov
- , Raul Mostoslavsky
- , Frederick W Alt
- , Thibaut De Smedt
- & Oberdan Leo
Nature Medicine 15 , 206–210

Rights & permissionsfor article Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner . Opens in a new window.
Research | 10 December 2009
Long-range oncogenic activation of Igh–c-myc translocations by the Igh 3′ regulatory region
Nature 462 , 803–807

Rights & permissionsfor article Long-range oncogenic activation of <i>Igh–c-myc</i> translocations by the <i>Igh</i> 3′ regulatory region . Opens in a new window.
Research | 20 April 2000
Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development
- Yijie Gao
- , David O. Ferguson
- , Wei Xie
- , John P. Manis
- , JoAnn Sekiguchi
- , Karen M. Frank
- , Jayanta Chaudhuri
- , James Horner
- , Ronald A. DePinho
- & Frederick W. Alt
Nature 404 , 897–900

Rights & permissionsfor article Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development . Opens in a new window.
News and Views | 28 December 1989
Making antigen-receptor genes
Nature 342 , 863–864

Rights & permissionsfor article Making antigen-receptor genes . Opens in a new window.
Research | 15 September 1994
An early haematopoietic defect in mice lacking the transcription factor GATA-2
- Fong-Ying Tsai
- , Gordon Keller
- , Frank C. Kuo
- , Mitchell Weiss
- , Jianzhou Chen
- , Margery Rosenblatt
- , Frederick W. Alt
- & Stuart H. Orkin
Nature 371 , 221–226

Rights & permissionsfor article An early haematopoietic defect in mice lacking the transcription factor GATA-2 . Opens in a new window.
Research | 12 November 1998
Late embryonic lethality and impaired V (D)J recombination in mice lacking DNA ligase IV
Nature 396 , 173–177

Rights & permissionsfor article Late embryonic lethality and impaired <i>V</i> (<i>D</i>)<i>J</i> recombination in mice lacking DNA ligase IV . Opens in a new window.
Research | 11 December 1986
Recombination between immunoglobulin variable region gene segments is enhanced by transcription
Nature 324 , 585–589

Rights & permissionsfor article Recombination between immunoglobulin variable region gene segments is enhanced by transcription . Opens in a new window.
Research | 30 October 2019
Fundamental roles of chromatin loop extrusion in antibody class switching
- Xuefei Zhang
- , Yu Zhang
- , Zhaoqing Ba
- , Nia Kyritsis
- , Rafael Casellas
- & Frederick W. Alt
Nature 575 , 385–389

Rights & permissionsfor article Fundamental roles of chromatin loop extrusion in antibody class switching . Opens in a new window.
Research | 11 September 2019
The fundamental role of chromatin loop extrusion in physiological V(D)J recombination
- Yu Zhang
- , Xuefei Zhang
- , Zhaoqing Ba
- , Zhuoyi Liang
- , Edward W. Dring
- , Hongli Hu
- , Jiangman Lou
- , Nia Kyritsis
- , Jeffrey Zurita
- , Muhammad S. Shamim
- , Aviva Presser Aiden
- , Erez Lieberman Aiden
- & Frederick W. Alt
Nature 573 , 600–604

Rights & permissionsfor article The fundamental role of chromatin loop extrusion in physiological V(D)J recombination . Opens in a new window.
Research | 12 November 2018 | Open
Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
- Manasi Ratnaparkhe
- , John K. L. Wong
- , Pei-Chi Wei
- , Mario Hlevnjak
- , Thorsten Kolb
- , Milena Simovic
- , Daniel Haag
- , Yashna Paul
- , Frauke Devens
- , Paul Northcott
- , David T. W. Jones
- , Marcel Kool
- , Anna Jauch
- , Agata Pastorczak
- , Wojciech Mlynarski
- , Andrey Korshunov
- , Rajiv Kumar
- , Susanna M. Downing
- , Stefan M. Pfister
- , Marc Zapatka
- , Peter J. McKinnon
- , Frederick W. Alt
- , Peter Lichter
- & Aurélie Ernst
Nature Communications 9 , 1–13

Rights & permissionsfor article Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors . Opens in a new window.
Research | 10 October 2018
Neural blastocyst complementation enables mouse forebrain organogenesis
Nature 563 , 126–130

Rights & permissionsfor article Neural blastocyst complementation enables mouse forebrain organogenesis . Opens in a new window.
Research | 30 July 2018
DNA melting initiates the RAG catalytic pathway
- Heng Ru
- , Wei Mi
- , Pengfei Zhang
- , Frederick W. Alt
- , David G. Schatz
- , Maofu Liao
- & Hao Wu
Nature Structural & Molecular Biology 25 , 732–742

Rights & permissionsfor article DNA melting initiates the RAG catalytic pathway . Opens in a new window.
Research | 9 October 2017
Ectopic expression of RAD52 and dn53BP1 improves homology-directed repair during CRISPR–Cas9 genome editing
Nature Biomedical Engineering 1 , 878–888

Rights & permissionsfor article Ectopic expression of RAD52 and dn53BP1 improves homology-directed repair during CRISPR–Cas9 genome editing . Opens in a new window.
Research | 22 November 2017
Mechanism of tandem duplication formation in BRCA1-mutant cells
- Nicholas A. Willis
- , Richard L. Frock
- , Francesca Menghi
- , Erin E. Duffey
- , Arvind Panday
- , Virginia Camacho
- , E. Paul Hasty
- , Edison T. Liu
- , Frederick W. Alt
- & Ralph Scully
Nature 551 , 590–595

Rights & permissionsfor article Mechanism of tandem duplication formation in <i>BRCA1</i>-mutant cells . Opens in a new window.
Research | 15 February 2017
Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells
- Mara Compagno
- , Qi Wang
- , Chiara Pighi
- , Taek-Chin Cheong
- , Fei-Long Meng
- , Teresa Poggio
- , Leng-Siew Yeap
- , Elif Karaca
- , Rafael B. Blasco
- , Fernanda Langellotto
- , Chiara Ambrogio
- , Claudia Voena
- , Adrian Wiestner
- , Siddha N. Kasar
- , Jennifer R. Brown
- , Jing Sun
- , Catherine J. Wu
- , Monica Gostissa
- , Frederick W. Alt
- & Roberto Chiarle
Nature 542 , 489–493

Rights & permissionsfor article Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells . Opens in a new window.
Protocols | 31 March 2016
Detecting DNA double-stranded breaks in mammalian genomes by linear amplification–mediated high-throughput genome-wide translocation sequencing
- Jiazhi Hu
- , Robin M Meyers
- , Junchao Dong
- , Rohit A Panchakshari
- , Frederick W Alt
- & Richard L Frock
Nature Protocols 11 , 853–871

Rights & permissionsfor article Detecting DNA double-stranded breaks in mammalian genomes by linear amplification–mediated high-throughput genome-wide translocation sequencing . Opens in a new window.
Research | 15 December 2014
Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
- Richard L Frock
- , Jiazhi Hu
- , Robin M Meyers
- , Yu-Jui Ho
- , Erina Kii
- & Frederick W Alt
Nature Biotechnology 33 , 179–186

Rights & permissionsfor article Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases . Opens in a new window.

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