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Research | 11 January 2021 | Open
Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML
- Toshihiko Oki
- , Francois Mercier
- , Hiroki Kato
- , Yookyung Jung
- , Thomas O. McDonald
- , Joel A. Spencer
- , Michael C. Mazzola
- , Nick van Gastel
- , Charles P. Lin
- , Franziska Michor
- , Toshio Kitamura
- & David T. Scadden
Nature Communications 12 , 1–13

Rights & permissionsfor article Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML . Opens in a new window.
Correspondence | 29 October 2018
Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution
Nature Genetics 50 , 1620–1623

Rights & permissionsfor article Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution . Opens in a new window.
Research | 11 June 2020 | Open
Accelerating massively parallel hemodynamic models of coarctation of the aorta using neural networks
- Bradley Feiger
- , John Gounley
- , Dale Adler
- , Jane A. Leopold
- , Erik W. Draeger
- , Rafeed Chaudhury
- , Justin Ryan
- , Girish Pathangey
- , Kevin Winarta
- , David Frakes
- , Franziska Michor
- & Amanda Randles
Scientific Reports 10 , 1–13

Rights & permissionsfor article Accelerating massively parallel hemodynamic models of coarctation of the aorta using neural networks . Opens in a new window.
Research | 11 May 2020 | Open
Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer
- Jennifer Y. Ge
- , Shaokun Shu
- , Mijung Kwon
- , Bojana Jovanović
- , Katherine Murphy
- , Anushree Gulvady
- , Anne Fassl
- , Anne Trinh
- , Yanan Kuang
- , Grace A. Heavey
- , Adrienne Luoma
- , Cloud Paweletz
- , Aaron R. Thorner
- , Kai W. Wucherpfennig
- , Jun Qi
- , Myles Brown
- , Piotr Sicinski
- , Thomas O. McDonald
- , David Pellman
- , Franziska Michor
- & Kornelia Polyak
Nature Communications 11 , 1–17

Rights & permissionsfor article Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer . Opens in a new window.
Research | 26 July 2016 | Open
ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells
- Boyoung Wee
- , Alexander Pietras
- , Tatsuya Ozawa
- , Elena Bazzoli
- , Ondrej Podlaha
- , Christophe Antczak
- , Bengt Westermark
- , Sven Nelander
- , Lene Uhrbom
- , Karin Forsberg-Nilsson
- , Hakim Djaballah
- , Franziska Michor
- & Eric C. Holland
Scientific Reports 6 , 1–9

Rights & permissionsfor article ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells . Opens in a new window.
News and Views | 1 April 2014
Understanding tissue context influences on intratumour heterogeneity
- Franziska Michor
- & Valerie M. Weaver
Nature Cell Biology 16 , 301–302

Rights & permissionsfor article Understanding tissue context influences on intratumour heterogeneity . Opens in a new window.
Research | 30 June 2005
Dynamics of chronic myeloid leukaemia
- Franziska Michor
- , Timothy P. Hughes
- , Yoh Iwasa
- , Susan Branford
- , Neil P. Shah
- , Charles L. Sawyers
- & Martin A. Nowak
Nature 435 , 1267–1270

Rights & permissionsfor article Dynamics of chronic myeloid leukaemia . Opens in a new window.
Correspondence | 8 November 2012
Analyzing the association of SCNA boundaries with replication timing
- Subhajyoti De
- & Franziska Michor
Nature Biotechnology 30 , 1045–1046

Rights & permissionsfor article Analyzing the association of SCNA boundaries with replication timing . Opens in a new window.
6 November 2012
The sciences converge to fight cancer
- David B. Agus
- & Franziska Michor
Nature Physics 8 , 773–774

Rights & permissionsfor article The sciences converge to fight cancer . Opens in a new window.
Research | 11 May 2011
A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia
- Apostolos Klinakis
- , Camille Lobry
- , Omar Abdel-Wahab
- , Philmo Oh
- , Hiroshi Haeno
- , Silvia Buonamici
- , Inge van De Walle
- , Severine Cathelin
- , Thomas Trimarchi
- , Elisa Araldi
- , Cynthia Liu
- , Sherif Ibrahim
- , Miroslav Beran
- , Jiri Zavadil
- , Argiris Efstratiadis
- , Tom Taghon
- , Franziska Michor
- , Ross L. Levine
- & Iannis Aifantis
Nature 473 , 230–233

Rights & permissionsfor article A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia . Opens in a new window.
Books and Arts | 19 December 2002
Immunology tomorrow
- Franziska Michor
- & Martin A. Nowak
Nature 420 , 741–742

Rights & permissionsfor article Immunology tomorrow . Opens in a new window.
News and Views | 17 October 2002
The good, the bad and the lonely
- Franziska Michor
- & Martin A. Nowak
Nature 419 , 677–679

Rights & permissionsfor article The good, the bad and the lonely . Opens in a new window.
Research | 3 July 2011
DNA secondary structures and epigenetic determinants of cancer genome evolution
- Subhajyoti De
- & Franziska Michor
Nature Structural & Molecular Biology 18 , 950–955

Rights & permissionsfor article DNA secondary structures and epigenetic determinants of cancer genome evolution . Opens in a new window.
Research | 20 November 2011
DNA replication timing and long-range DNA interactions predict mutational landscapes of cancer genomes
- Subhajyoti De
- & Franziska Michor
Nature Biotechnology 29 , 1103–1108

Rights & permissionsfor article DNA replication timing and long-range DNA interactions predict mutational landscapes of cancer genomes . Opens in a new window.
Research | 1 July 2019
Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments
- Michalina Janiszewska
- , Doris P. Tabassum
- , Zafira Castaño
- , Simona Cristea
- , Kimiyo N. Yamamoto
- , Natalie L. Kingston
- , Katherine C. Murphy
- , Shaokun Shu
- , Nicholas W. Harper
- , Carlos Gil Del Alcazar
- , Maša Alečković
- , Muhammad B. Ekram
- , Ofir Cohen
- , Minsuk Kwak
- , Yuanbo Qin
- , Tyler Laszewski
- , Adrienne Luoma
- , Andriy Marusyk
- , Kai W. Wucherpfennig
- , Nikhil Wagle
- , Rong Fan
- , Franziska Michor
- , Sandra S. McAllister
- & Kornelia Polyak
Nature Cell Biology 21 , 879–888

Rights & permissionsfor article Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments . Opens in a new window.
Research | 18 December 2018 | Open
Hidden heterogeneity and circadian-controlled cell fate inferred from single cell lineages
Nature Communications 9 , 1–13

Rights & permissionsfor article Hidden heterogeneity and circadian-controlled cell fate inferred from single cell lineages . Opens in a new window.
Research | 4 September 2018 | Open
Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq
Nature Communications 9 , 1–10

Rights & permissionsfor article Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq . Opens in a new window.
Research | 26 September 2018 | Open
Fitness variation in isogenic populations leads to a novel evolutionary mechanism for crossing fitness valleys
Communications Biology 1 , 1–9

Rights & permissionsfor article Fitness variation in isogenic populations leads to a novel evolutionary mechanism for crossing fitness valleys . Opens in a new window.
Research | 4 May 2018 | Open
Phase II study of ruxolitinib, a selective JAK1/2 inhibitor, in patients with metastatic triple-negative breast cancer
- Daniel G. Stover
- , Carlos R. Gil Del Alcazar
- , Jane Brock
- , Hao Guo
- , Beth Overmoyer
- , Justin Balko
- , Qiong Xu
- , Aditya Bardia
- , Sara M. Tolaney
- , Rebecca Gelman
- , Maxwell Lloyd
- , Yu Wang
- , Yaomin Xu
- , Franziska Michor
- , Vivian Wang
- , Eric P. Winer
- , Kornelia Polyak
- & Nancy U. Lin
npj Breast Cancer 4 , 1–9

Rights & permissionsfor article Phase II study of ruxolitinib, a selective JAK1/2 inhibitor, in patients with metastatic triple-negative breast cancer . Opens in a new window.
Research | 6 August 2018 | Open
A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine
- Hyun Jung Jun
- , Vicky A. Appleman
- , Hua-Jun Wu
- , Christopher M. Rose
- , Javier J. Pineda
- , Alan T. Yeo
- , Bethany Delcuze
- , Charlotte Lee
- , Aron Gyuris
- , Haihao Zhu
- , Steve Woolfenden
- , Agnieszka Bronisz
- , Ichiro Nakano
- , Ennio A. Chiocca
- , Roderick T. Bronson
- , Keith L. Ligon
- , Jann N. Sarkaria
- , Steve P. Gygi
- , Franziska Michor
- , Timothy J. Mitchison
- & Al Charest
Nature Communications 9 , 1–13

Rights & permissionsfor article A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine . Opens in a new window.
Research | 11 September 2017
Analysis of somatic microsatellite indels identifies driver events in human tumors
- Yosef E Maruvka
- , Kent W Mouw
- , Rosa Karlic
- , Prasanna Parasuraman
- , Atanas Kamburov
- , Paz Polak
- , Nicholas J Haradhvala
- , Julian M Hess
- , Esther Rheinbay
- , Yehuda Brody
- , Amnon Koren
- , Lior Z Braunstein
- , Alan D'Andrea
- , Michael S Lawrence
- , Adam Bass
- , Andre Bernards
- , Franziska Michor
- & Gad Getz
Nature Biotechnology 35 , 951–959

Rights & permissionsfor article Analysis of somatic microsatellite indels identifies driver events in human tumors . Opens in a new window.
Research | 20 September 2017
Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer
- ...cancer. Here, Alexander Meissner, Franziska Michor and colleagues determine genome-wide...
- Zachary D. Smith
- , Jiantao Shi
- , Hongcang Gu
- , Julie Donaghey
- , Kendell Clement
- , Davide Cacchiarelli
- , Andreas Gnirke
- , Franziska Michor
- & Alexander Meissner
Nature 549 , 543–547

Rights & permissionsfor article Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer . Opens in a new window.
Research | 2 October 2017
Nuclear topology modulates the mutational landscapes of cancer genomes
- Kyle S Smith
- , Lin L Liu
- , Shridar Ganesan
- , Franziska Michor
- & Subhajyoti De
Nature Structural & Molecular Biology 24 , 1000–1006

Rights & permissionsfor article Nuclear topology modulates the mutational landscapes of cancer genomes . Opens in a new window.
Research | 15 August 2016
Punctuated copy number evolution and clonal stasis in triple-negative breast cancer
- Ruli Gao
- , Alexander Davis
- , Thomas O McDonald
- , Emi Sei
- , Xiuqing Shi
- , Yong Wang
- , Pei-Ching Tsai
- , Anna Casasent
- , Jill Waters
- , Hong Zhang
- , Funda Meric-Bernstam
- , Franziska Michor
- & Nicholas E Navin
Nature Genetics 48 , 1119–1130

Rights & permissionsfor article Punctuated copy number evolution and clonal stasis in triple-negative breast cancer . Opens in a new window.
Research | 13 April 2015
Studying clonal dynamics in response to cancer therapy using high-complexity barcoding
- Hyo-eun C Bhang
- , David A Ruddy
- , Viveksagar Krishnamurthy Radhakrishna
- , Justina X Caushi
- , Rui Zhao
- , Matthew M Hims
- , Angad P Singh
- , Iris Kao
- , Daniel Rakiec
- , Pamela Shaw
- , Marissa Balak
- , Alina Raza
- , Elizabeth Ackley
- , Nicholas Keen
- , Michael R Schlabach
- , Michael Palmer
- , Rebecca J Leary
- , Derek Y Chiang
- , William R Sellers
- , Franziska Michor
- , Vesselina G Cooke
- , Joshua M Korn
- & Frank Stegmeier
Nature Medicine 21 , 440–448

Rights & permissionsfor article Studying clonal dynamics in response to cancer therapy using high-complexity barcoding . Opens in a new window.
Research | 26 April 2013 | Open
A physical sciences network characterization of non-tumorigenic and metastatic cells
- David B. Agus
- , Jenolyn F. Alexander
- , Wadih Arap
- , Shashanka Ashili
- , Joseph E. Aslan
- , Robert H. Austin
- , Vadim Backman
- , Kelly J. Bethel
- , Richard Bonneau
- , Wei-Chiang Chen
- , Chira Chen-Tanyolac
- , Nathan C. Choi
- , Steven A. Curley
- , Matthew Dallas
- , Dhwanil Damania
- , Paul C. W. Davies
- , Paolo Decuzzi
- , Laura Dickinson
- , Luis Estevez-Salmeron
- , Veronica Estrella
- , Mauro Ferrari
- , Claudia Fischbach
- , Jasmine Foo
- , Stephanie I. Fraley
- , Christian Frantz
- , Alexander Fuhrmann
- , Philippe Gascard
- , Robert A. Gatenby
- , Yue Geng
- , Sharon Gerecht
- , Robert J. Gillies
- , Biana Godin
- , William M. Grady
- , Alex Greenfield
- , Courtney Hemphill
- , Barbara L. Hempstead
- , Abigail Hielscher
- , W. Daniel Hillis
- , Eric C. Holland
- , Arig Ibrahim-Hashim
- , Tyler Jacks
- , Roger H. Johnson
- , Ahyoung Joo
- , Jonathan E. Katz
- , Laimonas Kelbauskas
- , Carl Kesselman
- , Michael R. King
- , Konstantinos Konstantopoulos
- , Casey M. Kraning-Rush
- , Peter Kuhn
- , Kevin Kung
- , Brian Kwee
- , Johnathon N. Lakins
- , Guillaume Lambert
- , David Liao
- , Jonathan D. Licht
- , Jan T. Liphardt
- , Liyu Liu
- , Mark C. Lloyd
- , Anna Lyubimova
- , Parag Mallick
- , John Marko
- , Owen J. T. McCarty
- , Deirdre R. Meldrum
- , Franziska Michor
- , Shannon M. Mumenthaler
- , Vivek Nandakumar
- , Thomas V. O’Halloran
- , Steve Oh
- , Renata Pasqualini
- , Matthew J. Paszek
- , Kevin G. Philips
- , Christopher S. Poultney
- , Kuldeepsinh Rana
- , Cynthia A. Reinhart-King
- , Robert Ros
- , Gregg L. Semenza
- , Patti Senechal
- , Michael L. Shuler
- , Srimeenakshi Srinivasan
- , Jack R. Staunton
- , Yolanda Stypula
- , Hariharan Subramanian
- , Thea D. Tlsty
- , Garth W. Tormoen
- , Yiider Tseng
- , Alexander van Oudenaarden
- , Scott S. Verbridge
- , Jenny C. Wan
- , Valerie M. Weaver
- , Jonathan Widom
- , Christine Will
- , Denis Wirtz
- , Jonathan Wojtkowiak
- & Pei-Hsun Wu
Scientific Reports 3 , 1–12

Rights & permissionsfor article A physical sciences network characterization of non-tumorigenic and metastatic cells . Opens in a new window.
Research | 30 July 2014
Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity
Nature 514 , 54–58

Rights & permissionsfor article Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity . Opens in a new window.
Research | 30 July 2014
Clonal evolution in breast cancer revealed by single nucleus genome sequencing
- Yong Wang
- , Jill Waters
- , Marco L. Leung
- , Anna Unruh
- , Whijae Roh
- , Xiuqing Shi
- , Ken Chen
- , Paul Scheet
- , Selina Vattathil
- , Han Liang
- , Asha Multani
- , Hong Zhang
- , Rui Zhao
- , Franziska Michor
- , Funda Meric-Bernstam
- & Nicholas E. Navin
Nature 512 , 155–160

Rights & permissionsfor article Clonal evolution in breast cancer revealed by single nucleus genome sequencing . Opens in a new window.
Research | 24 August 2015
In situ single-cell analysis identifies heterogeneity for PIK3CA mutation and HER2 amplification in HER2-positive breast cancer
- Kornelia Polyak, Franziska Michor and colleagues report a novel...
- Michalina Janiszewska
- , Lin Liu
- , Vanessa Almendro
- , Yanan Kuang
- , Cloud Paweletz
- , Rita A Sakr
- , Britta Weigelt
- , Ariella B Hanker
- , Sarat Chandarlapaty
- , Tari A King
- , Jorge S Reis-Filho
- , Carlos L Arteaga
- , So Yeon Park
- , Franziska Michor
- & Kornelia Polyak
Nature Genetics 47 , 1212–1219

Rights & permissionsfor article In situ single-cell analysis identifies heterogeneity for PIK3CA mutation and HER2 amplification in HER2-positive breast cancer . Opens in a new window.
Reviews | 24 November 2015
The mathematics of cancer: integrating quantitative models
Nature Reviews Cancer 15 , 730–745

Rights & permissionsfor article The mathematics of cancer: integrating quantitative models . Opens in a new window.
Research | 2 March 2015
Polyploidy can drive rapid adaptation in yeast
- Anna M. Selmecki
- , Yosef E. Maruvka
- , Phillip A. Richmond
- , Marie Guillet
- , Noam Shoresh
- , Amber L. Sorenson
- , Subhajyoti De
- , Roy Kishony
- , Franziska Michor
- , Robin Dowell
- & David Pellman
Nature 519 , 349–352

Rights & permissionsfor article Polyploidy can drive rapid adaptation in yeast . Opens in a new window.
Research | 19 February 2013
DNA replication timing and higher-order nuclear organization determine single-nucleotide substitution patterns in cancer genomes
Nature Communications 4 , 1–9

Rights & permissionsfor article DNA replication timing and higher-order nuclear organization determine single-nucleotide substitution patterns in cancer genomes . Opens in a new window.
Reviews | 1 March 2004
Dynamics of cancer progression
Nature Reviews Cancer 4 , 197–205

Rights & permissionsfor article Dynamics of cancer progression . Opens in a new window.
Reviews | 18 August 2011
What does physics have to do with cancer?
Nature Reviews Cancer 11 , 657–670

Rights & permissionsfor article What does physics have to do with cancer? . Opens in a new window.

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Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML

Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution

Accelerating massively parallel hemodynamic models of coarctation of the aorta using neural networks

Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer

ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells

Understanding tissue context influences on intratumour heterogeneity

Dynamics of chronic myeloid leukaemia

Analyzing the association of SCNA boundaries with replication timing

The sciences converge to fight cancer

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia

Immunology tomorrow

The good, the bad and the lonely

DNA secondary structures and epigenetic determinants of cancer genome evolution

DNA replication timing and long-range DNA interactions predict mutational landscapes of cancer genomes

Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments

Hidden heterogeneity and circadian-controlled cell fate inferred from single cell lineages

Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq

Fitness variation in isogenic populations leads to a novel evolutionary mechanism for crossing fitness valleys

Phase II study of ruxolitinib, a selective JAK1/2 inhibitor, in patients with metastatic triple-negative breast cancer

A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine

Analysis of somatic microsatellite indels identifies driver events in human tumors

Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer

Nuclear topology modulates the mutational landscapes of cancer genomes

Punctuated copy number evolution and clonal stasis in triple-negative breast cancer

Studying clonal dynamics in response to cancer therapy using high-complexity barcoding

A physical sciences network characterization of non-tumorigenic and metastatic cells

Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity

Clonal evolution in breast cancer revealed by single nucleus genome sequencing

In situ single-cell analysis identifies heterogeneity for PIK3CA mutation and HER2 amplification in HER2-positive breast cancer

The mathematics of cancer: integrating quantitative models

Polyploidy can drive rapid adaptation in yeast

DNA replication timing and higher-order nuclear organization determine single-nucleotide substitution patterns in cancer genomes

Dynamics of cancer progression

What does physics have to do with cancer?

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