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Research | 4 December 2020 | Open
A substrate binding model for the KEOPS tRNA modifying complex
- Jonah Beenstock
- , Samara Mishelle Ona
- , Jennifer Porat
- , Stephen Orlicky
- , Leo C. K. Wan
- , Derek F. Ceccarelli
- , Pierre Maisonneuve
- , Rachel K. Szilard
- , Zhe Yin
- , Dheva Setiaputra
- , Daniel Y. L. Mao
- , Morgan Khan
- , Shaunak Raval
- , David C. Schriemer
- , Mark A. Bayfield
- , Daniel Durocher
- & Frank Sicheri
Nature Communications 11 , 1–17

Rights & permissionsfor article A substrate binding model for the KEOPS tRNA modifying complex . Opens in a new window.
Research | 10 August 2020
Functional characterization of a PROTAC directed against BRAF mutant V600E
- Ganna Posternak
- , Xiaojing Tang
- , Pierre Maisonneuve
- , Ting Jin
- , Hugo Lavoie
- , Salima Daou
- , Stephen Orlicky
- , Theo Goullet de Rugy
- , Lauren Caldwell
- , Kin Chan
- , Ahmed Aman
- , Michael Prakesch
- , Gennady Poda
- , Pavel Mader
- , Cassandra Wong
- , Stefan Maier
- , Julia Kitaygorodsky
- , Brett Larsen
- , Karen Colwill
- , Zhe Yin
- , Derek F. Ceccarelli
- , Robert A. Batey
- , Mikko Taipale
- , Igor Kurinov
- , David Uehling
- , Jeff Wrana
- , Daniel Durocher
- , Anne-Claude Gingras
- , Rima Al-Awar
- , Marc Therrien
- & Frank Sicheri
Nature Chemical Biology 16 , 1170–1178

Rights & permissionsfor article Functional characterization of a PROTAC directed against BRAF mutant V600E . Opens in a new window.
Amendments and Corrections | 14 November 2018
Author Correction: Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome
- Tenzin Gayden
- , Fernando E. Sepulveda
- , Dong-Anh Khuong-Quang
- , Jonathan Pratt
- , Elvis T. Valera
- , Alexandrine Garrigue
- , Susan Kelso
- , Frank Sicheri
- , Leonie G. Mikael
- , Nancy Hamel
- , Andrea Bajic
- , Rola Dali
- , Shriya Deshmukh
- , Dzana Dervovic
- , Daniel Schramek
- , Frédéric Guerin
- , Mikko Taipale
- , Hamid Nikbakht
- , Jacek Majewski
- , Despina Moshous
- , Janie Charlebois
- , Sharon Abish
- , Christine Bole-Feysot
- , Patrick Nitschke
- , Brigitte Bader-Meunier
- , David Mitchell
- , Catherine Thieblemont
- , Maxime Battistella
- , Simon Gravel
- , Van-Hung Nguyen
- , Rachel Conyers
- , Jean-Sebastien Diana
- , Chris McCormack
- , H. Miles Prince
- , Marianne Besnard
- , Stephane Blanche
- , Paul G. Ekert
- , Sylvie Fraitag
- , William D. Foulkes
- , Alain Fischer
- , Bénédicte Neven
- , David Michonneau
- , Geneviève de Saint Basile
- & Nada Jabado
Nature Genetics 51 , 196–196

Rights & permissionsfor article Author Correction: Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome . Opens in a new window.
News and Views | 6 December 2017
Vivid views of the PINK1 protein
- Salima Daou
- & Frank Sicheri
Nature 552 , 38–39

Rights & permissionsfor article Vivid views of the PINK1 protein . Opens in a new window.
Research | 1 January 1999
The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization
- David Stapleton
- , Inga Balan
- , Tony Pawson
- & Frank Sicheri
Nature Structural & Molecular Biology 6 , 44–49

Rights & permissionsfor article The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization . Opens in a new window.
Research | 23 September 2002
The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization
- Genie C. Leung
- , John W. Hudson
- , Anna Kozarova
- , Alan Davidson
- , James W. Dennis
- & Frank Sicheri
Nature Structural & Molecular Biology 9 , 719–724

Rights & permissionsfor article The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization . Opens in a new window.
Research | 2 September 2009
A dimerization-dependent mechanism drives RAF catalytic activation
Nature 461 , 542–545

Rights & permissionsfor article A dimerization-dependent mechanism drives RAF catalytic activation . Opens in a new window.
Research | 29 October 2001
Structural and biochemical characterization of the type III secretion chaperones CesT and SigE
- Yu Luo
- , Michela G. Bertero
- , Elizabeth A. Frey
- , Richard A. Pfuetzner
- , Markus R. Wenk
- , Louise Creagh
- , Sandra L. Marcus
- , Daniel Lim
- , Frank Sicheri
- , Cyril Kay
- , Charles Haynes
- , B. Brett Finlay
- & Natalie C.J. Strynadka
Nature Structural & Molecular Biology 8 , 1031–1036

Rights & permissionsfor article Structural and biochemical characterization of the type III secretion chaperones CesT and SigE . Opens in a new window.
Research | 27 June 2010
An allosteric inhibitor of substrate recognition by the SCF^Cdc4 ubiquitin ligase
- Stephen Orlicky
- , Xiaojing Tang
- , Victor Neduva
- , Nadine Elowe
- , Eric D Brown
- , Frank Sicheri
- & Mike Tyers
Nature Biotechnology 28 , 733–737

Rights & permissionsfor article An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase . Opens in a new window.
News and Views | 1 August 2009
Grb-ing hold of insulin signaling
- Derek F J Ceccarelli
- & Frank Sicheri
Nature Structural & Molecular Biology 16 , 803–804

Rights & permissionsfor article Grb-ing hold of insulin signaling . Opens in a new window.
Research | 30 October 2003
Bone recognition mechanism of porcine osteocalcin from crystal structure
Nature 425 , 977–980

Rights & permissionsfor article Bone recognition mechanism of porcine osteocalcin from crystal structure . Opens in a new window.
Research | 13 February 1997
Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement
- Ismail Moarefi
- , Michelle LaFevre-Bernt
- , Frank Sicheri
- , Morgan Huse
- , Chi-Hon Lee
- , John Kuriyan
- & W. Todd Miller
Nature 385 , 650–653

Rights & permissionsfor article Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement . Opens in a new window.
Research | 11 March 2019 | Open
The ubiquitin interacting motifs of USP37 act on the proximal Ub of a di-Ub chain to enhance catalytic efficiency
- Noah Manczyk
- , Gianluca Veggiani
- , Joan Teyra
- , Amy W. Strilchuk
- , Sachdev S. Sidhu
- & Frank Sicheri
Scientific Reports 9 , 1–11

Rights & permissionsfor article The ubiquitin interacting motifs of USP37 act on the proximal Ub of a di-Ub chain to enhance catalytic efficiency . Opens in a new window.
Research | 22 October 2018 | Open
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
- Salima Daou
- , Haithem Barbour
- , Oumaima Ahmed
- , Louis Masclef
- , Caroline Baril
- , Nadine Sen Nkwe
- , Daméhan Tchelougou
- , Maxime Uriarte
- , Eric Bonneil
- , Derek Ceccarelli
- , Nazar Mashtalir
- , Mika Tanji
- , Jean-Yves Masson
- , Pierre Thibault
- , Frank Sicheri
- , Haining Yang
- , Michele Carbone
- , Marc Therrien
- & El Bachir Affar
Nature Communications 9 , 1–21

Rights & permissionsfor article Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1 . Opens in a new window.
Research | 27 August 2018
Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase
- Roger W. Hunter
- , Curtis C. Hughey
- , Louise Lantier
- , Elias I. Sundelin
- , Mark Peggie
- , Elton Zeqiraj
- , Frank Sicheri
- , Niels Jessen
- , David H. Wasserman
- & Kei Sakamoto
Nature Medicine 24 , 1395–1406

Rights & permissionsfor article Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase . Opens in a new window.
Research | 29 October 2018
Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome
- Tenzin Gayden
- , Fernando E. Sepulveda
- , Dong-Anh Khuong-Quang
- , Jonathan Pratt
- , Elvis T. Valera
- , Alexandrine Garrigue
- , Susan Kelso
- , Frank Sicheri
- , Leonie G. Mikael
- , Nancy Hamel
- , Andrea Bajic
- , Rola Dali
- , Shriya Deshmukh
- , Dzana Dervovic
- , Daniel Schramek
- , Frédéric Guerin
- , Mikko Taipale
- , Hamid Nikbakht
- , Jacek Majewski
- , Despina Moshous
- , Janie Charlebois
- , Sharon Abish
- , Christine Bole-Feysot
- , Patrick Nitschke
- , Brigitte Bader-Meunier
- , David Mitchell
- , Catherine Thieblemont
- , Maxime Battistella
- , Simon Gravel
- , Van-Hung Nguyen
- , Rachel Conyers
- , Jean-Sebastien Diana
- , Chris McCormack
- , H. Miles Prince
- , Marianne Besnard
- , Stephane Blanche
- , Paul G. Ekert
- , Sylvie Fraitag
- , William D. Foulkes
- , Alain Fischer
- , Bénédicte Neven
- , David Michonneau
- , Geneviève de Saint Basile
- & Nada Jabado
Nature Genetics 50 , 1650–1657

Rights & permissionsfor article Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome . Opens in a new window.
Research | 29 August 2018 | Open
A feed forward loop enforces YAP/TAZ signaling during tumorigenesis
- Mandeep K. Gill
- , Tania Christova
- , Ying Y. Zhang
- , Alex Gregorieff
- , Liang Zhang
- , Masahiro Narimatsu
- , Siyuan Song
- , Shawn Xiong
- , Amber L. Couzens
- , Jiefei Tong
- , Jonathan R. Krieger
- , Michael F. Moran
- , Alexandre R. Zlotta
- , Theodorus H. van der Kwast
- , Anne-Claude Gingras
- , Frank Sicheri
- , Jeffrey L. Wrana
- & Liliana Attisano
Nature Communications 9 , 1–13

Rights & permissionsfor article A feed forward loop enforces YAP/TAZ signaling during tumorigenesis . Opens in a new window.
Research | 12 February 2018
MEK drives BRAF activation through allosteric control of KSR proteins
- Hugo Lavoie
- , Malha Sahmi
- , Pierre Maisonneuve
- , Sara A. Marullo
- , Neroshan Thevakumaran
- , Ting Jin
- , Igor Kurinov
- , Frank Sicheri
- & Marc Therrien
Nature 554 , 549–553

Rights & permissionsfor article MEK drives BRAF activation through allosteric control of KSR proteins . Opens in a new window.
Research | 27 November 2017
Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency
- Marella D Canny
- , Nathalie Moatti
- , Leo C K Wan
- , Amélie Fradet-Turcotte
- , Danielle Krasner
- , Pedro A Mateos-Gomez
- , Michal Zimmermann
- , Alexandre Orthwein
- , Yu-Chi Juang
- , Wei Zhang
- , Sylvie M Noordermeer
- , Eduardo Seclen
- , Marcus D Wilson
- , Andrew Vorobyov
- , Meagan Munro
- , Andreas Ernst
- , Timothy F Ng
- , Tiffany Cho
- , Paula M Cannon
- , Sachdev S Sidhu
- , Frank Sicheri
- & Daniel Durocher
Nature Biotechnology 36 , 95–102

Rights & permissionsfor article Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency . Opens in a new window.
Research | 3 January 2017 | Open
An allosteric conduit facilitates dynamic multisite substrate recognition by the SCF^Cdc4 ubiquitin ligase
- Veronika Csizmok
- , Stephen Orlicky
- , Jing Cheng
- , Jianhui Song
- , Alaji Bah
- , Neda Delgoshaie
- , Hong Lin
- , Tanja Mittag
- , Frank Sicheri
- , Hue Sun Chan
- , Mike Tyers
- & Julie D. Forman-Kay
Nature Communications 8 , 1–14

Rights & permissionsfor article An allosteric conduit facilitates dynamic multisite substrate recognition by the SCFCdc4 ubiquitin ligase . Opens in a new window.
Research | 7 November 2016
Inhibition of RAS function through targeting an allosteric regulatory site
- Russell Spencer-Smith
- , Akiko Koide
- , Yong Zhou
- , Raphael R Eguchi
- , Fern Sha
- , Priyanka Gajwani
- , Dianicha Santana
- , Ankit Gupta
- , Miranda Jacobs
- , Erika Herrero-Garcia
- , Jacqueline Cobbert
- , Hugo Lavoie
- , Matthew Smith
- , Thanashan Rajakulendran
- , Evan Dowdell
- , Mustafa Nazir Okur
- , Irina Dementieva
- , Frank Sicheri
- , Marc Therrien
- , John F Hancock
- , Mitsuhiko Ikura
- , Shohei Koide
- & John P O'Bryan
Nature Chemical Biology 13 , 62–68

Rights & permissionsfor article Inhibition of RAS function through targeting an allosteric regulatory site . Opens in a new window.
Research | 27 July 2016
The structural basis of modified nucleosome recognition by 53BP1
Nature 536 , 100–103

Rights & permissionsfor article The structural basis of modified nucleosome recognition by 53BP1 . Opens in a new window.
Research | 28 August 2014
Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors
- Mario Sanches
- , Nicole M. Duffy
- , Manisha Talukdar
- , Nero Thevakumaran
- , David Chiovitti
- , Marella D. Canny
- , Kenneth Lee
- , Igor Kurinov
- , David Uehling
- , Rima Al-awar
- , Gennadiy Poda
- , Michael Prakesch
- , Brian Wilson
- , Victor Tam
- , Colleen Schweitzer
- , Andras Toro
- , Julie L. Lucas
- , Danka Vuga
- , Lynn Lehmann
- , Daniel Durocher
- , Qingping Zeng
- , John B. Patterson
- & Frank Sicheri
Nature Communications 5 , 1–16

Rights & permissionsfor article Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors . Opens in a new window.
Research | 19 May 2013
Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization
- Hugo Lavoie
- , Neroshan Thevakumaran
- , Gwenaëlle Gavory
- , John J Li
- , Abbas Padeganeh
- , Sébastien Guiral
- , Jean Duchaine
- , Daniel Y L Mao
- , Michel Bouvier
- , Frank Sicheri
- & Marc Therrien
Nature Chemical Biology 9 , 428–436

Rights & permissionsfor article Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization . Opens in a new window.
Research | 1 December 2014
Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation
- ...dimer configuration. Marc Therrien, Frank Sicheri and colleagues now report a...
- Neroshan Thevakumaran
- , Hugo Lavoie
- , David A Critton
- , Andrew Tebben
- , Anne Marinier
- , Frank Sicheri
- & Marc Therrien
Nature Structural & Molecular Biology 22 , 37–43

Rights & permissionsfor article Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation . Opens in a new window.
Research | 12 June 2013
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark
Nature 499 , 50–54

Rights & permissionsfor article 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark . Opens in a new window.
Research | 24 May 2013
The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis
- Elena Rivkin
- , Stephanie M. Almeida
- , Derek F. Ceccarelli
- , Yu-Chi Juang
- , Teresa A. MacLean
- , Tharan Srikumar
- , Hao Huang
- , Wade H. Dunham
- , Ryutaro Fukumura
- , Gang Xie
- , Yoichi Gondo
- , Brian Raught
- , Anne-Claude Gingras
- , Frank Sicheri
- & Sabine P. Cordes
Nature 498 , 318–324

Rights & permissionsfor article The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis . Opens in a new window.
Research | 15 December 2013
E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin
- Hao Huang
- , Derek F Ceccarelli
- , Stephen Orlicky
- , Daniel J St-Cyr
- , Amy Ziemba
- , Pankaj Garg
- , Serge Plamondon
- , Manfred Auer
- , Sachdev Sidhu
- , Anne Marinier
- , Gary Kleiger
- , Mike Tyers
- & Frank Sicheri
Nature Chemical Biology 10 , 156–163

Rights & permissionsfor article E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin . Opens in a new window.
Research | 13 July 2003
The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators
- Tzvi Aviv
- , Zhen Lin
- , Stefanie Lau
- , Laura M. Rendl
- , Frank Sicheri
- & Craig A Smibert
Nature Structural & Molecular Biology 10 , 614–621

Rights & permissionsfor article The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators . Opens in a new window.
Research | 19 August 2010
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1
- Shinichiro Nakada
- , Ikue Tai
- , Stephanie Panier
- , Abdallah Al-Hakim
- , Shun-ichiro Iemura
- , Yu-Chi Juang
- , Lara O’Donnell
- , Ayako Kumakubo
- , Meagan Munro
- , Frank Sicheri
- , Anne-Claude Gingras
- , Tohru Natsume
- , Toshio Suda
- & Daniel Durocher
Nature 466 , 941–946

Rights & permissionsfor article Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1 . Opens in a new window.
Research | 13 February 1997
Crystal structure of the Src family tyrosine kinase Hck
Nature 385 , 602–609

Rights & permissionsfor article Crystal structure of the Src family tyrosine kinase Hck . Opens in a new window.
Research | 22 January 2006
Sequence-specific recognition of RNA hairpins by the SAM domain of Vts1p
- Tzvi Aviv
- , Zhen Lin
- , Giora Ben-Ari
- , Craig A Smibert
- & Frank Sicheri
Nature Structural & Molecular Biology 13 , 168–176

Rights & permissionsfor article Sequence-specific recognition of RNA hairpins by the SAM domain of Vts1p . Opens in a new window.
Research | 29 November 2001
Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication
- Piers Nash
- , Xiaojing Tang
- , Stephen Orlicky
- , Qinghua Chen
- , Frank B. Gertler
- , Michael D. Mendenhall
- , Frank Sicheri
- , Tony Pawson
- & Mike Tyers
Nature 414 , 514–521

Rights & permissionsfor article Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication . Opens in a new window.

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A substrate binding model for the KEOPS tRNA modifying complex

Functional characterization of a PROTAC directed against BRAF mutant V600E

Author Correction: Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome

Vivid views of the PINK1 protein

The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization

The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization

A dimerization-dependent mechanism drives RAF catalytic activation

Structural and biochemical characterization of the type III secretion chaperones CesT and SigE

An allosteric inhibitor of substrate recognition by the SCF^Cdc4 ubiquitin ligase

Grb-ing hold of insulin signaling

Bone recognition mechanism of porcine osteocalcin from crystal structure

Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement

The ubiquitin interacting motifs of USP37 act on the proximal Ub of a di-Ub chain to enhance catalytic efficiency

Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome

A feed forward loop enforces YAP/TAZ signaling during tumorigenesis

MEK drives BRAF activation through allosteric control of KSR proteins

Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency

An allosteric conduit facilitates dynamic multisite substrate recognition by the SCF^Cdc4 ubiquitin ligase

Inhibition of RAS function through targeting an allosteric regulatory site

The structural basis of modified nucleosome recognition by 53BP1

Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors

Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization

Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis

E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin

The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

Crystal structure of the Src family tyrosine kinase Hck

Sequence-specific recognition of RNA hairpins by the SAM domain of Vts1p

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

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