Showing 1–32 of 32 results
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Research | | Open
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Amendments and Corrections |
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Research | | Open
Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action
- James M. McFarland
- , Brenton R. Paolella
- , Allison Warren
- , Kathryn Geiger-Schuller
- , Tsukasa Shibue
- , Michael Rothberg
- , Olena Kuksenko
- , William N. Colgan
- , Andrew Jones
- , Emily Chambers
- , Danielle Dionne
- , Samantha Bender
- , Brian M. Wolpin
- , Mahmoud Ghandi
- , Itay Tirosh
- , Orit Rozenblatt-Rosen
- , Jennifer A. Roth
- , Todd R. Golub
- , Aviv Regev
- , Andrew J. Aguirre
- , Francisca Vazquez
- & Aviad Tsherniak
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Amendments and Corrections | | Open
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Research |
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Research | | Open
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Amendments and Corrections |
Erratum: Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
- Glenn S Cowley
- , Barbara A Weir
- , Francisca Vazquez
- , Pablo Tamayo
- , Justine A Scott
- , Scott Rusin
- , Alexandra East-Seletsky
- , Levi D Ali
- , William F.J Gerath
- , Sarah E Pantel
- , Patrick H Lizotte
- , Guozhi Jiang
- , Jessica Hsiao
- , Aviad Tsherniak
- , Elizabeth Dwinell
- , Simon Aoyama
- , Michael Okamoto
- , William Harrington
- , Ellen Gelfand
- , Thomas M Green
- , Mark J Tomko
- , Shuba Gopal
- , Terence C Wong
- , Hubo Li
- , Sara Howell
- , Nicolas Stransky
- , Ted Liefeld
- , Dongkeun Jang
- , Jonathan Bistline
- , Barbara Hill Meyers
- , Scott A Armstrong
- , Ken C Anderson
- , Kimberly Stegmaier
- , Michael Reich
- , David Pellman
- , Jesse S Boehm
- , Jill P Mesirov
- , Todd R Golub
- , David E Root
- & William C Hahn
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Research |
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Research |
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Research |
Discovering the anticancer potential of non-oncology drugs by systematic viability profiling
- Steven M. Corsello
- , Rohith T. Nagari
- , Ryan D. Spangler
- , Jordan Rossen
- , Mustafa Kocak
- , Jordan G. Bryan
- , Ranad Humeidi
- , David Peck
- , Xiaoyun Wu
- , Andrew A. Tang
- , Vickie M. Wang
- , Samantha A. Bender
- , Evan Lemire
- , Rajiv Narayan
- , Philip Montgomery
- , Uri Ben-David
- , Colin W. Garvie
- , Yejia Chen
- , Matthew G. Rees
- , Nicholas J. Lyons
- , James M. McFarland
- , Bang T. Wong
- , Li Wang
- , Nancy Dumont
- , Patrick J. O’Hearn
- , Eric Stefan
- , John G. Doench
- , Caitlin N. Harrington
- , Heidi Greulich
- , Matthew Meyerson
- , Francisca Vazquez
- , Aravind Subramanian
- , Jennifer A. Roth
- , Joshua A. Bittker
- , Jesse S. Boehm
- , Christopher C. Mader
- , Aviad Tsherniak
- & Todd R. Golub
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Research |
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Research | | Open
Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets
- Joshua M. Dempster
- , Clare Pacini
- , Sasha Pantel
- , Fiona M. Behan
- , Thomas Green
- , John Krill-Burger
- , Charlotte M. Beaver
- , Scott T. Younger
- , Victor Zhivich
- , Hanna Najgebauer
- , Felicity Allen
- , Emanuel Gonçalves
- , Rebecca Shepherd
- , John G. Doench
- , Kosuke Yusa
- , Francisca Vazquez
- , Leopold Parts
- , Jesse S. Boehm
- , Todd R. Golub
- , William C. Hahn
- , David E. Root
- , Mathew J. Garnett
- , Aviad Tsherniak
- & Francesco Iorio
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Research | | Open
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Research |
Next-generation characterization of the Cancer Cell Line Encyclopedia
- Mahmoud Ghandi
- , Franklin W. Huang
- , Judit Jané-Valbuena
- , Gregory V. Kryukov
- , Christopher C. Lo
- , E. Robert McDonald III
- , Jordi Barretina
- , Ellen T. Gelfand
- , Craig M. Bielski
- , Haoxin Li
- , Kevin Hu
- , Alexander Y. Andreev-Drakhlin
- , Jaegil Kim
- , Julian M. Hess
- , Brian J. Haas
- , François Aguet
- , Barbara A. Weir
- , Michael V. Rothberg
- , Brenton R. Paolella
- , Michael S. Lawrence
- , Rehan Akbani
- , Yiling Lu
- , Hong L. Tiv
- , Prafulla C. Gokhale
- , Antoine de Weck
- , Ali Amin Mansour
- , Coyin Oh
- , Juliann Shih
- , Kevin Hadi
- , Yanay Rosen
- , Jonathan Bistline
- , Kavitha Venkatesan
- , Anupama Reddy
- , Dmitriy Sonkin
- , Manway Liu
- , Joseph Lehar
- , Joshua M. Korn
- , Dale A. Porter
- , Michael D. Jones
- , Javad Golji
- , Giordano Caponigro
- , Jordan E. Taylor
- , Caitlin M. Dunning
- , Amanda L. Creech
- , Allison C. Warren
- , James M. McFarland
- , Mahdi Zamanighomi
- , Audrey Kauffmann
- , Nicolas Stransky
- , Marcin Imielinski
- , Yosef E. Maruvka
- , Andrew D. Cherniack
- , Aviad Tsherniak
- , Francisca Vazquez
- , Jacob D. Jaffe
- , Andrew A. Lane
- , David M. Weinstock
- , Cory M. Johannessen
- , Michael P. Morrissey
- , Frank Stegmeier
- , Robert Schlegel
- , William C. Hahn
- , Gad Getz
- , Gordon B. Mills
- , Jesse S. Boehm
- , Todd R. Golub
- , Levi A. Garraway
- & William R. Sellers
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Research | | Open
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma
- Pratiti Bandopadhayay
- , Federica Piccioni
- , Ryan O’Rourke
- , Patricia Ho
- , Elizabeth M. Gonzalez
- , Graham Buchan
- , Kenin Qian
- , Gabrielle Gionet
- , Emily Girard
- , Margo Coxon
- , Matthew G. Rees
- , Lisa Brenan
- , Frank Dubois
- , Ofer Shapira
- , Noah F. Greenwald
- , Melanie Pages
- , Amanda Balboni Iniguez
- , Brenton R. Paolella
- , Alice Meng
- , Claire Sinai
- , Giovanni Roti
- , Neekesh V. Dharia
- , Amanda Creech
- , Benjamin Tanenbaum
- , Prasidda Khadka
- , Adam Tracy
- , Hong L. Tiv
- , Andrew L. Hong
- , Shannon Coy
- , Rumana Rashid
- , Jia-Ren Lin
- , Glenn S. Cowley
- , Fred C. Lam
- , Amy Goodale
- , Yenarae Lee
- , Kathleen Schoolcraft
- , Francisca Vazquez
- , William C. Hahn
- , Aviad Tsherniak
- , James E. Bradner
- , Michael B. Yaffe
- , Till Milde
- , Stefan M. Pfister
- , Jun Qi
- , Monica Schenone
- , Steven A. Carr
- , Keith L. Ligon
- , Mark W. Kieran
- , Sandro Santagata
- , James M. Olson
- , Prafulla C. Gokhale
- , Jacob D. Jaffe
- , David E. Root
- , Kimberly Stegmaier
- , Cory M. Johannessen
- & Rameen Beroukhim
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Research |
The landscape of cancer cell line metabolism
- Haoxin Li
- , Shaoyang Ning
- , Mahmoud Ghandi
- , Gregory V. Kryukov
- , Shuba Gopal
- , Amy Deik
- , Amanda Souza
- , Kerry Pierce
- , Paula Keskula
- , Desiree Hernandez
- , Julie Ann
- , Dojna Shkoza
- , Verena Apfel
- , Yilong Zou
- , Francisca Vazquez
- , Jordi Barretina
- , Raymond A. Pagliarini
- , Giorgio G. Galli
- , David E. Root
- , William C. Hahn
- , Aviad Tsherniak
- , Marios Giannakis
- , Stuart L. Schreiber
- , Clary B. Clish
- , Levi A. Garraway
- & William R. Sellers
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Research |
Small-molecule targeting of brachyury transcription factor addiction in chordoma
- Tanaz Sharifnia
- , Mathias J. Wawer
- , Ting Chen
- , Qing-Yuan Huang
- , Barbara A. Weir
- , Ann Sizemore
- , Matthew A. Lawlor
- , Amy Goodale
- , Glenn S. Cowley
- , Francisca Vazquez
- , Christopher J. Ott
- , Joshua M. Francis
- , Slim Sassi
- , Patricia Cogswell
- , Hadley E. Sheppard
- , Tinghu Zhang
- , Nathanael S. Gray
- , Paul A. Clarke
- , Julian Blagg
- , Paul Workman
- , Josh Sommer
- , Francis Hornicek
- , David E. Root
- , William C. Hahn
- , James E. Bradner
- , Kwok K. Wong
- , Paul A. Clemons
- , Charles Y. Lin
- , Joanne D. Kotz
- & Stuart L. Schreiber
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Research |
WRN helicase is a synthetic lethal target in microsatellite unstable cancers
- Edmond M. Chan
- , Tsukasa Shibue
- , James M. McFarland
- , Benjamin Gaeta
- , Mahmoud Ghandi
- , Nancy Dumont
- , Alfredo Gonzalez
- , Justine S. McPartlan
- , Tianxia Li
- , Yanxi Zhang
- , Jie Bin Liu
- , Jean-Bernard Lazaro
- , Peili Gu
- , Cortt G. Piett
- , Annie Apffel
- , Syed O. Ali
- , Rebecca Deasy
- , Paula Keskula
- , Raymond W. S. Ng
- , Emma A. Roberts
- , Elizaveta Reznichenko
- , Lisa Leung
- , Maria Alimova
- , Monica Schenone
- , Mirazul Islam
- , Yosef E. Maruvka
- , Yang Liu
- , Jatin Roper
- , Srivatsan Raghavan
- , Marios Giannakis
- , Yuen-Yi Tseng
- , Zachary D. Nagel
- , Alan D’Andrea
- , David E. Root
- , Jesse S. Boehm
- , Gad Getz
- , Sandy Chang
- , Todd R. Golub
- , Aviad Tsherniak
- , Francisca Vazquez
- & Adam J. Bass
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Research |
Mutational processes shape the landscape of TP53 mutations in human cancer
- Andrew O. Giacomelli
- , Xiaoping Yang
- , Robert E. Lintner
- , James M. McFarland
- , Marc Duby
- , Jaegil Kim
- , Thomas P. Howard
- , David Y. Takeda
- , Seav Huong Ly
- , Eejung Kim
- , Hugh S. Gannon
- , Brian Hurhula
- , Ted Sharpe
- , Amy Goodale
- , Briana Fritchman
- , Scott Steelman
- , Francisca Vazquez
- , Aviad Tsherniak
- , Andrew J. Aguirre
- , John G. Doench
- , Federica Piccioni
- , Charles W. M. Roberts
- , Matthew Meyerson
- , Gad Getz
- , Cory M. Johannessen
- , David E. Root
- & William C. Hahn
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Research |
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Research | | Open
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Research | | Open
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Research |
Genetic and transcriptional evolution alters cancer cell line drug response
- Uri Ben-David
- , Benjamin Siranosian
- , Gavin Ha
- , Helen Tang
- , Yaara Oren
- , Kunihiko Hinohara
- , Craig A. Strathdee
- , Joshua Dempster
- , Nicholas J. Lyons
- , Robert Burns
- , Anwesha Nag
- , Guillaume Kugener
- , Beth Cimini
- , Peter Tsvetkov
- , Yosef E. Maruvka
- , Ryan O’Rourke
- , Anthony Garrity
- , Andrew A. Tubelli
- , Pratiti Bandopadhayay
- , Aviad Tsherniak
- , Francisca Vazquez
- , Bang Wong
- , Chet Birger
- , Mahmoud Ghandi
- , Aaron R. Thorner
- , Joshua A. Bittker
- , Matthew Meyerson
- , Gad Getz
- , Rameen Beroukhim
- & Todd R. Golub
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Research | | Open
Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models
- Samuel Y. Ng
- , Noriaki Yoshida
- , Amanda L. Christie
- , Mahmoud Ghandi
- , Neekesh V. Dharia
- , Joshua Dempster
- , Mark Murakami
- , Kay Shigemori
- , Sara N. Morrow
- , Alexandria Van Scoyk
- , Nicolas A. Cordero
- , Kristen E. Stevenson
- , Maneka Puligandla
- , Brian Haas
- , Christopher Lo
- , Robin Meyers
- , Galen Gao
- , Andrew Cherniack
- , Abner Louissaint Jr
- , Valentina Nardi
- , Aaron R. Thorner
- , Henry Long
- , Xintao Qiu
- , Elizabeth A. Morgan
- , David M. Dorfman
- , Danilo Fiore
- , Julie Jang
- , Alan L. Epstein
- , Ahmet Dogan
- , Yanming Zhang
- , Steven M. Horwitz
- , Eric D. Jacobsen
- , Solimar Santiago
- , Jian-Guo Ren
- , Vincent Guerlavais
- , D. Allen Annis
- , Manuel Aivado
- , Mansoor N. Saleh
- , Amitkumar Mehta
- , Aviad Tsherniak
- , David Root
- , Francisca Vazquez
- , William C. Hahn
- , Giorgio Inghirami
- , Jon C. Aster
- , David M. Weinstock
- & Raphael Koch
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Research |
Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer
- Srinivas R. Viswanathan
- , Marina F. Nogueira
- , Colin G. Buss
- , John M. Krill-Burger
- , Mathias J. Wawer
- , Edyta Malolepsza
- , Ashton C. Berger
- , Peter S. Choi
- , Juliann Shih
- , Alison M. Taylor
- , Benjamin Tanenbaum
- , Chandra Sekhar Pedamallu
- , Andrew D. Cherniack
- , Pablo Tamayo
- , Craig A. Strathdee
- , Kasper Lage
- , Steven A. Carr
- , Monica Schenone
- , Sangeeta N. Bhatia
- , Francisca Vazquez
- , Aviad Tsherniak
- , William C. Hahn
- & Matthew Meyerson
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Research |
Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells
- Robin M Meyers
- , Jordan G Bryan
- , James M McFarland
- , Barbara A Weir
- , Ann E Sizemore
- , Han Xu
- , Neekesh V Dharia
- , Phillip G Montgomery
- , Glenn S Cowley
- , Sasha Pantel
- , Amy Goodale
- , Yenarae Lee
- , Levi D Ali
- , Guozhi Jiang
- , Rakela Lubonja
- , William F Harrington
- , Matthew Strickland
- , Ting Wu
- , Derek C Hawes
- , Victor A Zhivich
- , Meghan R Wyatt
- , Zohra Kalani
- , Jaime J Chang
- , Michael Okamoto
- , Kimberly Stegmaier
- , Todd R Golub
- , Jesse S Boehm
- , Francisca Vazquez
- , David E Root
- , William C Hahn
- & Aviad Tsherniak
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Research |
Characterizing genomic alterations in cancer by complementary functional associations
- Jong Wook Kim
- , Olga B Botvinnik
- , Omar Abudayyeh
- , Chet Birger
- , Joseph Rosenbluh
- , Yashaswi Shrestha
- , Mohamed E Abazeed
- , Peter S Hammerman
- , Daniel DiCara
- , David J Konieczkowski
- , Cory M Johannessen
- , Arthur Liberzon
- , Amir Reza Alizad-Rahvar
- , Gabriela Alexe
- , Andrew Aguirre
- , Mahmoud Ghandi
- , Heidi Greulich
- , Francisca Vazquez
- , Barbara A Weir
- , Eliezer M Van Allen
- , Aviad Tsherniak
- , Diane D Shao
- , Travis I Zack
- , Michael Noble
- , Gad Getz
- , Rameen Beroukhim
- , Levi A Garraway
- , Masoud Ardakani
- , Chiara Romualdi
- , Gabriele Sales
- , David A Barbie
- , Jesse S Boehm
- , William C Hahn
- , Jill P Mesirov
- & Pablo Tamayo
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Research | | Open
Integrated genetic and pharmacologic interrogation of rare cancers
- Andrew L. Hong
- , Yuen-Yi Tseng
- , Glenn S. Cowley
- , Oliver Jonas
- , Jaime H. Cheah
- , Bryan D. Kynnap
- , Mihir B. Doshi
- , Coyin Oh
- , Stephanie C. Meyer
- , Alanna J. Church
- , Shubhroz Gill
- , Craig M. Bielski
- , Paula Keskula
- , Alma Imamovic
- , Sara Howell
- , Gregory V. Kryukov
- , Paul A. Clemons
- , Aviad Tsherniak
- , Francisca Vazquez
- , Brian D. Crompton
- , Alykhan F. Shamji
- , Carlos Rodriguez-Galindo
- , Katherine A. Janeway
- , Charles W. M. Roberts
- , Kimberly Stegmaier
- , Paul van Hummelen
- , Michael J. Cima
- , Robert S. Langer
- , Levi A. Garraway
- , Stuart L. Schreiber
- , David E. Root
- , William C. Hahn
- & Jesse S. Boehm
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Research |
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Research |
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Research |
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Research | | Open
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
- Glenn S Cowley
- , Barbara A Weir
- , Francisca Vazquez
- , Pablo Tamayo
- , Justine A Scott
- , Scott Rusin
- , Alexandra East-Seletsky
- , Levi D Ali
- , William FJ Gerath
- , Sarah E Pantel
- , Patrick H Lizotte
- , Guozhi Jiang
- , Jessica Hsiao
- , Aviad Tsherniak
- , Elizabeth Dwinell
- , Simon Aoyama
- , Michael Okamoto
- , William Harrington
- , Ellen Gelfand
- , Thomas M Green
- , Mark J Tomko
- , Shuba Gopal
- , Terence C Wong
- , Hubo Li
- , Sara Howell
- , Nicolas Stransky
- , Ted Liefeld
- , Dongkeun Jang
- , Jonathan Bistline
- , Barbara Hill Meyers
- , Scott A Armstrong
- , Ken C Anderson
- , Kimberly Stegmaier
- , Michael Reich
- , David Pellman
- , Jesse S Boehm
- , Jill P Mesirov
- , Todd R Golub
- , David E Root
- & William C Hahn
