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2 October 2008
Cystic fibrosis: Ferreting with fibroblasts for cystic fibrosis
- U Griesenbach
- & E W F W Alton
Gene Therapy 16 , 1–2

Rights & permissionsfor article Cystic fibrosis: Ferreting with fibroblasts for cystic fibrosis . Opens in a new window.
Editorial | 29 April 1998
Towards gene therapy for cystic fibrosis: a clinical progress report
- E W F W Alton
- , DM Geddes
- , DR Gill
- , CF Higgins
- , SC Hyde
- , JA Innes
- & DJ Porteous
Gene Therapy 5 , 291–292

Rights & permissionsfor article Towards gene therapy for cystic fibrosis: a clinical progress report . Opens in a new window.
Amendments and Corrections | 30 April 1998
Erratum: Safety of a single aerosol administration of escalating doses of the cationic lipid GL-67/DOPE/DMPE-PEG₅₀₀₀ formulation to the lungs of normal volunteers
- SL Chadwick
- , HD Kingston
- , M Stern
- , RM Cook
- , BJ O’Connor
- , M Lukasson
- , RP Balfour
- , M Rosenberg
- , SH Cheng
- , AE Smith
- , DP Meeker
- , DM Geddes
- & E W F W Alton
Gene Therapy 5 , 569–569

Rights & permissionsfor article Erratum: Safety of a single aerosol administration of escalating doses of the cationic lipid GL-67/DOPE/DMPE-PEG5000 formulation to the lungs of normal volunteers . Opens in a new window.
Research | 7 November 2013
Toxicology study assessing efficacy and safety of repeated administration of lipid/DNA complexes to mouse lung
- E W F W Alton
- , A C Boyd
- , S H Cheng
- , J C Davies
- , L A Davies
- , A Dayan
- , D R Gill
- , U Griesenbach
- , T Higgins
- , S C Hyde
- , J A Innes
- , G McLachlan
- , D Porteous
- , I Pringle
- , R K Scheule
- & S Sumner-Jones
Gene Therapy 21 , 89–95

Rights & permissionsfor article Toxicology study assessing efficacy and safety of repeated administration of lipid/DNA complexes to mouse lung . Opens in a new window.
28 July 2008
Poly (D, L-lactide-co-glycolide)/DNA microspheres to facilitate prolonged transgene expression in airway epithelium in vitro, ex vivo and in vivo
- M Stern
- , K Ulrich
- , D M Geddes
- & E W F W Alton
Gene Therapy 10 , 1282–1288

Rights & permissionsfor article Poly (D, L-lactide-co-glycolide)/DNA microspheres to facilitate prolonged transgene expression in airway epithelium in vitro, ex vivo and in vivo . Opens in a new window.
24 June 2004
Effects of intramyocardial pVEGF₁₆₅ delivery on regional myocardial blood flow: evidence for a spatial ‘delivery–efficacy’ mismatch
- P W Radke
- , A Heinl-Green
- , O M Frass
- , U Griesenbach
- , S Ferrari
- , D M Geddes
- & E W F W Alton
Gene Therapy 11 , 1249–1255

Rights & permissionsfor article Effects of intramyocardial pVEGF165 delivery on regional myocardial blood flow: evidence for a spatial ‘delivery–efficacy’ mismatch . Opens in a new window.
29 July 2004
A defective nontransmissible recombinant Sendai virus mediates efficient gene transfer to airway epithelium in vivo
- S Ferrari
- , U Griesenbach
- , T Shiraki-Iida
- , T Shu
- , T Hironaka
- , X Hou
- , J Williams
- , J Zhu
- , P K Jeffery
- , D M Geddes
- , M Hasegawa
- & E W F W Alton
Gene Therapy 11 , 1659–1664

Rights & permissionsfor article A defective nontransmissible recombinant Sendai virus mediates efficient gene transfer to airway epithelium in vivo . Opens in a new window.
Research | 15 February 2007
Use of ultrasound to enhance nonviral lung gene transfer in vivo
- S Xenariou
- , U Griesenbach
- , H-D Liang
- , J Zhu
- , R Farley
- , L Somerton
- , C Singh
- , P K Jeffery
- , S Ferrari
- , R K Scheule
- , S H Cheng
- , D M Geddes
- , M Blomley
- & E W F W Alton
Gene Therapy 14 , 768–774

Rights & permissionsfor article Use of ultrasound to enhance nonviral lung gene transfer in vivo . Opens in a new window.
Research | 24 January 2008
Bactofection of lung epithelial cells in vitro and in vivo using a genetically modified Escherichia coli
- M D B Larsen
- , U Griesenbach
- , S Goussard
- , D C Gruenert
- , D M Geddes
- , R K Scheule
- , S H Cheng
- , P Courvalin
- , C Grillot-Courvalin
- & E W F W Alton
Gene Therapy 15 , 434–442

Rights & permissionsfor article Bactofection of lung epithelial cells in vitro and in vivo using a genetically modified Escherichia coli . Opens in a new window.
17 February 2000
Cationic lipid-mediated gene transfer to the growing murine and human airway
- A Jaffé
- , D Judd
- , C Ratcliffe
- , S H Cheng
- , A Bush
- , D M Geddes
- & E W F W Alton
Gene Therapy 7 , 273–278

Rights & permissionsfor article Cationic lipid-mediated gene transfer to the growing murine and human airway . Opens in a new window.
29 September 2004
Gene therapy for cystic fibrosis: an example for lung gene therapy
Gene Therapy 11 , S43–S50

Rights & permissionsfor article Gene therapy for cystic fibrosis: an example for lung gene therapy . Opens in a new window.
Research | 27 September 2007
Expression and maturation of Sendai virus vector-derived CFTR protein: functional and biochemical evidence using a GFP-CFTR fusion protein
- H Ban
- , M Inoue
- , U Griesenbach
- , F Munkonge
- , M Chan
- , A Iida
- , E W F W Alton
- & M Hasegawa
Gene Therapy 14 , 1688–1694

Rights & permissionsfor article Expression and maturation of Sendai virus vector-derived CFTR protein: functional and biochemical evidence using a GFP-CFTR fusion protein . Opens in a new window.
1 September 1997
Safety of a single aerosol administration of escalating doses of the cationic lipid GL-67/DOPE/DMPE-PEG₅₀₀₀ formulation to the lungs of normal volunteers
- SL Chadwick
- , HD Kingston
- , M Stern
- , RM Cook
- , BJ O’Connor
- , M Lukasson
- , RP Balfour
- , M Rosenberg
- , SH Cheng
- , AE Smith
- , DP Meeker
- , DM Geddes
- & E W F W Alton
Gene Therapy 4 , 937–942

Rights & permissionsfor article Safety of a single aerosol administration of escalating doses of the cationic lipid GL-67/DOPE/DMPE-PEG5000 formulation to the lungs of normal volunteers . Opens in a new window.
Research | 1 June 2006
Using magnetic forces to enhance non-viral gene transfer to airway epithelium in vivo
- S Xenariou
- , U Griesenbach
- , S Ferrari
- , P Dean
- , R K Scheule
- , S H Cheng
- , D M Geddes
- , C Plank
- & E W F W Alton
Gene Therapy 13 , 1545–1552

Rights & permissionsfor article Using magnetic forces to enhance non-viral gene transfer to airway epithelium in vivo . Opens in a new window.
3 October 2002
Gene Therapy Progress and Prospects: Cystic fibrosis
- U Griesenbach
- , S Ferrari
- , D M Geddes
- & E W F W Alton
Gene Therapy 9 , 1344–1350

Rights & permissionsfor article Gene Therapy Progress and Prospects: Cystic fibrosis . Opens in a new window.
4 March 1998
The effect of mucolytic agents on gene transfer across a CF sputum barrier in vitro
- M Stern
- , NJ Caplen
- , JE Browning
- , U Griesenbach
- , F Sorgi
- , L Huang
- , DC Gruenert
- , C Marriot
- , RG Crystal
- , DM Geddes
- & E W F W Alton
Gene Therapy 5 , 91–98

Rights & permissionsfor article The effect of mucolytic agents on gene transfer across a CF sputum barrier in vitro . Opens in a new window.
Research | 22 June 2006
Intravenously administered oligonucleotides can be delivered to conducting airway epithelium via the bronchial circulation
- E Holder
- , U Griesenbach
- , S Li
- , L Huang
- , D F Rogers
- , P K Jeffery
- , D M Geddes
- & E W F W Alton
Gene Therapy 13 , 1628–1638

Rights & permissionsfor article Intravenously administered oligonucleotides can be delivered to conducting airway epithelium via the bronchial circulation . Opens in a new window.
Research | 9 August 1999
Effects of altering dosing on cationic liposome-mediated gene transfer to the respiratory epithelium
- E Hillery
- , S H Cheng
- , D M Geddes
- & E W F W Alton
Gene Therapy 6 , 1313–1316

Rights & permissionsfor article Effects of altering dosing on cationic liposome-mediated gene transfer to the respiratory epithelium . Opens in a new window.
21 May 1998
The effects of jet nebulisation on cationic liposome-mediated gene transfer in vitro
- M Stern
- , F Sorgi
- , C Hughes
- , NJ Caplen
- , JE Browning
- , PG Middleton
- , DC Gruenert
- , SJ Farr
- , L Huang
- , DM Geddes
- & E W F W Alton
Gene Therapy 5 , 583–593

Rights & permissionsfor article The effects of jet nebulisation on cationic liposome-mediated gene transfer in vitro . Opens in a new window.
4 July 2006
Gene therapy progress and prospects: cystic fibrosis
Gene Therapy 13 , 1061–1067

Rights & permissionsfor article Gene therapy progress and prospects: cystic fibrosis . Opens in a new window.
17 February 2000
Anti-inflammatory gene therapy directed at the airway epithelium
- U Griesenbach
- , P Scheid
- , E Hillery
- , R de Martin
- , L Huang
- , D M Geddes
- & E W F W Alton
Gene Therapy 7 , 306–313

Rights & permissionsfor article Anti-inflammatory gene therapy directed at the airway epithelium . Opens in a new window.
Research | 1 December 2005
Effect of tolerance induction to immunodominant T-cell epitopes of Sendai virus on gene expression following repeat administration to lung
- U Griesenbach
- , R J Boyton
- , L Somerton
- , S E Garcia
- , S Ferrari
- , T Owaki
- , Z Ya-Fen
- , D M Geddes
- , M Hasegawa
- , D M Altmann
- & E W F W Alton
Gene Therapy 13 , 449–456

Rights & permissionsfor article Effect of tolerance induction to immunodominant T-cell epitopes of Sendai virus on gene expression following repeat administration to lung . Opens in a new window.
7 April 1999
The extra- and intracellular barriers to lipid and adenovirus-mediated pulmonary gene transfer in native sheep airway epithelium
- C Kitson
- , B Angel
- , D Judd
- , S Rothery
- , N J Severs
- , A Dewar
- , L Huang
- , S C Wadsworth
- , S H Cheng
- , D M Geddes
- & E W F W Alton
Gene Therapy 6 , 534–546

Rights & permissionsfor article The extra- and intracellular barriers to lipid and adenovirus-mediated pulmonary gene transfer in native sheep airway epithelium . Opens in a new window.
Research | 21 April 2011
Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung
- G McLachlan
- , H Davidson
- , E Holder
- , L A Davies
- , I A Pringle
- , S G Sumner-Jones
- , A Baker
- , P Tennant
- , C Gordon
- , C Vrettou
- , R Blundell
- , L Hyndman
- , B Stevenson
- , A Wilson
- , A Doherty
- , D J Shaw
- , R L Coles
- , H Painter
- , S H Cheng
- , R K Scheule
- , J C Davies
- , J A Innes
- , S C Hyde
- , U Griesenbach
- , E W F W Alton
- , A C Boyd
- , D J Porteous
- , D R Gill
- & D D S Collie
Gene Therapy 18 , 996–1005

Rights & permissionsfor article Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung . Opens in a new window.
Research | 1 October 1993
Non–invasive liposome–mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice
- E. W. F. W. Alton
- , P. G. Middleton
- , N. J. Caplen
- , S. N. Smith
- , D. M. Steel
- , F. M. Munkonge
- , P. K. Jeffery
- , D. M. Geddes
- , S. L. Hart
- , R. Williamson
- , K. I. Fasold
- , A. D. Miller
- , P. Dickinson
- , B. J. Stevenson
- , G. McLachlan
- , J. R. Dorin
- & D. J. Porteous
Nature Genetics 5 , 135–142

Rights & permissionsfor article Non–invasive liposome–mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice . Opens in a new window.
25 April 2002
Characterisation of LMD virus-like nanoparticles self-assembled from cationic liposomes, adenovirus core peptide μ (mu) and plasmid DNA
- T Tagawa
- , M Manvell
- , N Brown
- , M Keller
- , E Perouzel
- , K D Murray
- , R P Harbottle
- , M Tecle
- , F Booy
- , M C Brahimi-Horn
- , C Coutelle
- , N R Lemoine
- , E W F W Alton
- & A D Miller
Gene Therapy 9 , 564–576

Rights & permissionsfor article Characterisation of LMD virus-like nanoparticles self-assembled from cationic liposomes, adenovirus core peptide μ (mu) and plasmid DNA . Opens in a new window.
Research | 21 October 2010
Validation of recombinant Sendai virus in a non-natural host model
- U Griesenbach
- , G McLachlan
- , T Owaki
- , L Somerton
- , T Shu
- , A Baker
- , P Tennant
- , C Gordon
- , C Vrettou
- , E Baker
- , D D S Collie
- , M Hasegawa
- & E W F W Alton
Gene Therapy 18 , 182–188

Rights & permissionsfor article Validation of recombinant Sendai virus in a non-natural host model . Opens in a new window.
Research | 28 June 2007
Sendai virus-mediated CFTR gene transfer to the airway epithelium
- S Ferrari
- , U Griesenbach
- , A Iida
- , R Farley
- , A M Wright
- , J Zhu
- , F M Munkonge
- , S N Smith
- , J You
- , H Ban
- , M Inoue
- , M Chan
- , C Singh
- , B Verdon
- , B E Argent
- , B Wainwright
- , P K Jeffery
- , D M Geddes
- , D J Porteous
- , S C Hyde
- , M A Gray
- , M Hasegawa
- & E W F W Alton
Gene Therapy 14 , 1371–1379

Rights & permissionsfor article Sendai virus-mediated CFTR gene transfer to the airway epithelium . Opens in a new window.

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Cystic fibrosis: Ferreting with fibroblasts for cystic fibrosis

Towards gene therapy for cystic fibrosis: a clinical progress report

Erratum: Safety of a single aerosol administration of escalating doses of the cationic lipid GL-67/DOPE/DMPE-PEG₅₀₀₀ formulation to the lungs of normal volunteers

Toxicology study assessing efficacy and safety of repeated administration of lipid/DNA complexes to mouse lung

Poly (D, L-lactide-co-glycolide)/DNA microspheres to facilitate prolonged transgene expression in airway epithelium in vitro, ex vivo and in vivo

Effects of intramyocardial pVEGF₁₆₅ delivery on regional myocardial blood flow: evidence for a spatial ‘delivery–efficacy’ mismatch

A defective nontransmissible recombinant Sendai virus mediates efficient gene transfer to airway epithelium in vivo

Use of ultrasound to enhance nonviral lung gene transfer in vivo

Bactofection of lung epithelial cells in vitro and in vivo using a genetically modified Escherichia coli

Cationic lipid-mediated gene transfer to the growing murine and human airway

Gene therapy for cystic fibrosis: an example for lung gene therapy

Expression and maturation of Sendai virus vector-derived CFTR protein: functional and biochemical evidence using a GFP-CFTR fusion protein

Safety of a single aerosol administration of escalating doses of the cationic lipid GL-67/DOPE/DMPE-PEG₅₀₀₀ formulation to the lungs of normal volunteers

Using magnetic forces to enhance non-viral gene transfer to airway epithelium in vivo

Gene Therapy Progress and Prospects: Cystic fibrosis

The effect of mucolytic agents on gene transfer across a CF sputum barrier in vitro

Intravenously administered oligonucleotides can be delivered to conducting airway epithelium via the bronchial circulation

Effects of altering dosing on cationic liposome-mediated gene transfer to the respiratory epithelium

The effects of jet nebulisation on cationic liposome-mediated gene transfer in vitro

Gene therapy progress and prospects: cystic fibrosis

Anti-inflammatory gene therapy directed at the airway epithelium

Effect of tolerance induction to immunodominant T-cell epitopes of Sendai virus on gene expression following repeat administration to lung

The extra- and intracellular barriers to lipid and adenovirus-mediated pulmonary gene transfer in native sheep airway epithelium

Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung

Non–invasive liposome–mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice

Characterisation of LMD virus-like nanoparticles self-assembled from cationic liposomes, adenovirus core peptide μ (mu) and plasmid DNA

Validation of recombinant Sendai virus in a non-natural host model

Sendai virus-mediated CFTR gene transfer to the airway epithelium

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