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Amendments and Corrections | 20 June 2018
Author Correction: Pancreas regeneration
- Qiao Zhou
- & Douglas A. Melton
Nature 560 , E34–E34

Rights & permissionsfor article Author Correction: Pancreas regeneration . Opens in a new window.
Amendments and Corrections | 4 August 2016 | Open
Correction: Corrigendum: Generation of stem cell-derived β-cells from patients with type 1 diabetes
Nature Communications 7 , 1–1

Rights & permissionsfor article Correction: Corrigendum: Generation of stem cell-derived β-cells from patients with type 1 diabetes . Opens in a new window.
13 May 2013
A protocol to improve pluripotent stem cell differentiation
Protocol Exchange

Rights & permissionsfor article A protocol to improve pluripotent stem cell differentiation . Opens in a new window.
Amendments and Corrections | 6 April 2016
Correction: Corrigendum: Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice
- Arturo J Vegas
- , Omid Veiseh
- , Madsörtler G
- , Jeffrey R Millman
- , Felicia W Pagliuca
- , Andrew R Bader
- , Joshua C Doloff
- , Jie Li
- , Michael Chen
- , Karsten Olejnik
- , Hok Hei Tam
- , Siddharth Jhunjhunwala
- , Erin Langan
- , Stephanie Aresta-Dasilva
- , Srujan Gandham
- , James J McGarrigle
- , Matthew A Bochenek
- , Jennifer Hollister-Lock
- , Jose Oberholzer
- , Dale L Greiner
- , Gordon C Weir
- , Douglas A Melton
- , Robert Langer
- & Daniel G Anderson
Nature Medicine 22 , 446–446

Rights & permissionsfor article Correction: Corrigendum: Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice . Opens in a new window.
Research | 17 February 2008
Marked differences in differentiation propensity among human embryonic stem cell lines
- Kenji Osafune
- , Leslie Caron
- , Malgorzata Borowiak
- , Rita J Martinez
- , Claire S Fitz-Gerald
- , Yasunori Sato
- , Chad A Cowan
- , Kenneth R Chien
- & Douglas A Melton
Nature Biotechnology 26 , 313–315

Rights & permissionsfor article Marked differences in differentiation propensity among human embryonic stem cell lines . Opens in a new window.
Research | 27 July 2020
Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes
- Erica P. Cai
- , Yuki Ishikawa
- , Wei Zhang
- , Nayara C. Leite
- , Jian Li
- , Shurong Hou
- , Badr Kiaf
- , Jennifer Hollister-Lock
- , Nese Kurt Yilmaz
- , Celia A. Schiffer
- , Douglas A. Melton
- , Stephan Kissler
- & Peng Yi
Nature Metabolism 2 , 934–945

Rights & permissionsfor article Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes . Opens in a new window.
Reviews | 18 February 2019
Regenerating the field of cardiovascular cell therapy
Nature Biotechnology 37 , 232–237

Rights & permissionsfor article Regenerating the field of cardiovascular cell therapy . Opens in a new window.
Research | 7 May 2020 | Open
A method for the generation of human stem cell-derived alpha cells
- Quinn P. Peterson
- , Adrian Veres
- , Lihua Chen
- , Michael Q. Slama
- , Jennifer H. R. Kenty
- , Shaimaa Hassoun
- , Matthew R. Brown
- , Haiqiang Dou
- , Caden D. Duffy
- , Quan Zhou
- , Aleksey V. Matveyenko
- , Björn Tyrberg
- , Maria Sörhede-Winzell
- , Patrik Rorsman
- & Douglas A. Melton
Nature Communications 11 , 1–14

Rights & permissionsfor article A method for the generation of human stem cell-derived alpha cells . Opens in a new window.
Research | 12 March 2020 | Open
Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice
- Ryan G. Walker
- , Ornella Barrandon
- , Tommaso Poggioli
- , Sezin Dagdeviren
- , Shannon H. Carroll
- , Melanie J. Mills
- , Kourtney R. Mendello
- , Yanet Gomez
- , Francesco S. Loffredo
- , James R. Pancoast
- , Claudio Macias-Trevino
- , Colin Marts
- , Katherine B. LeClair
- , Hye-Lim Noh
- , Taekyoon Kim
- , Alexander S. Banks
- , Jason K. Kim
- , David E. Cohen
- , Amy J. Wagers
- , Douglas A. Melton
- & Richard T. Lee
Scientific Reports 10 , 1–13

Rights & permissionsfor article Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice . Opens in a new window.
Research | 14 April 2013
A simple tool to improve pluripotent stem cell differentiation
Nature Methods 10 , 553–556

Rights & permissionsfor article A simple tool to improve pluripotent stem cell differentiation . Opens in a new window.
Research | 28 January 2007
Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver
Nature 445 , 886–891

Rights & permissionsfor article Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver . Opens in a new window.
Research | 26 February 2012
Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3
- Barak Blum
- , Siniša Hrvatin
- , Christian Schuetz
- , Claire Bonal
- , Alireza Rezania
- & Douglas A Melton
Nature Biotechnology 30 , 261–264

Rights & permissionsfor article Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3 . Opens in a new window.
Research | 7 October 2012
Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme
Nature 491 , 765–768

Rights & permissionsfor article Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme . Opens in a new window.
Research | 22 June 2008
Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
- Danwei Huangfu
- , René Maehr
- , Wenjun Guo
- , Astrid Eijkelenboom
- , Melinda Snitow
- , Alice E Chen
- & Douglas A Melton
Nature Biotechnology 26 , 795–797

Rights & permissionsfor article Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds . Opens in a new window.
Research | 6 May 2004
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Nature 429 , 41–46

Rights & permissionsfor article Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation . Opens in a new window.
Research | 12 October 2008
Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2
- Danwei Huangfu
- , Kenji Osafune
- , René Maehr
- , Wenjun Guo
- , Astrid Eijkelenboom
- , Shuibing Chen
- , Whitney Muhlestein
- & Douglas A Melton
Nature Biotechnology 26 , 1269–1275

Rights & permissionsfor article Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2 . Opens in a new window.
Research | 8 May 2019
Charting cellular identity during human in vitro β-cell differentiation
- Adrian Veres
- , Aubrey L. Faust
- , Henry L. Bushnell
- , Elise N. Engquist
- , Jennifer Hyoje-Ryu Kenty
- , George Harb
- , Yeh-Chuin Poh
- , Elad Sintov
- , Mads Gürtler
- , Felicia W. Pagliuca
- , Quinn P. Peterson
- & Douglas A. Melton
Nature 569 , 368–373

Rights & permissionsfor article Charting cellular identity during human in vitro β-cell differentiation . Opens in a new window.
Research | 1 April 2019 | Open
YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells
Nature Communications 10 , 1–11

Rights & permissionsfor article YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells . Opens in a new window.
Reviews | 16 May 2018
Pancreas regeneration
- Qiao Zhou
- & Douglas A. Melton
Nature 557 , 351–358

Rights & permissionsfor article Pancreas regeneration . Opens in a new window.
Research | 10 May 2016 | Open
Generation of stem cell-derived β-cells from patients with type 1 diabetes
Nature Communications 7 , 1–9

Rights & permissionsfor article Generation of stem cell-derived β-cells from patients with type 1 diabetes . Opens in a new window.
Research | 25 January 2016
Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice
- Arturo J Vegas
- , Omid Veiseh
- , Mads Gürtler
- , Jeffrey R Millman
- , Felicia W Pagliuca
- , Andrew R Bader
- , Joshua C Doloff
- , Jie Li
- , Michael Chen
- , Karsten Olejnik
- , Hok Hei Tam
- , Siddharth Jhunjhunwala
- , Erin Langan
- , Stephanie Aresta-Dasilva
- , Srujan Gandham
- , James J McGarrigle
- , Matthew A Bochenek
- , Jennifer Hollister-Lock
- , Jose Oberholzer
- , Dale L Greiner
- , Gordon C Weir
- , Douglas A Melton
- , Robert Langer
- & Daniel G Anderson
Nature Medicine 22 , 306–311

Rights & permissionsfor article Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice . Opens in a new window.
Reviews | 1 June 2003
Endothelial signaling during development
- Ondine Cleaver
- & Douglas A Melton
Nature Medicine 9 , 661–668

Rights & permissionsfor article Endothelial signaling during development . Opens in a new window.
Research | 4 October 2011
Reprogramming within hours following nuclear transfer into mouse but not human zygotes
- Dieter Egli
- , Alice E. Chen
- , Genevieve Saphier
- , Justin Ichida
- , Claire Fitzgerald
- , Kathryn J. Go
- , Nicole Acevedo
- , Jay Patel
- , Manfred Baetscher
- , William G. Kearns
- , Robin Goland
- , Rudolph L. Leibel
- , Douglas A. Melton
- & Kevin Eggan
Nature Communications 2 , 1–10

Rights & permissionsfor article Reprogramming within hours following nuclear transfer into mouse but not human zygotes . Opens in a new window.
Research | 15 October 1992
A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos
- Ali Hemmati-Brivanlou
- & Douglas A. Melton
Nature 359 , 609–614

Rights & permissionsfor article A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos . Opens in a new window.
Research | 27 August 2008
In vivo reprogramming of adult pancreatic exocrine cells to β-cells
Nature 455 , 627–632

Rights & permissionsfor article In vivo reprogramming of adult pancreatic exocrine cells to β-cells . Opens in a new window.

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Author Correction: Pancreas regeneration

Correction: Corrigendum: Generation of stem cell-derived β-cells from patients with type 1 diabetes

A protocol to improve pluripotent stem cell differentiation

Correction: Corrigendum: Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

Marked differences in differentiation propensity among human embryonic stem cell lines

Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes

Regenerating the field of cardiovascular cell therapy

A method for the generation of human stem cell-derived alpha cells

Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice

A simple tool to improve pluripotent stem cell differentiation

Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3

Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation

Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2

Charting cellular identity during human in vitro β-cell differentiation

YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells

Pancreas regeneration

Generation of stem cell-derived β-cells from patients with type 1 diabetes

Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

Endothelial signaling during development

Reprogramming within hours following nuclear transfer into mouse but not human zygotes

A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

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