nature.com search

Loading Filters

Showing 1–50 of 55 results

Loading Filters

Research | 21 January 2021 | Open
The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein
- Shan Lu
- , Qiaozhen Ye
- , Digvijay Singh
- , Yong Cao
- , Jolene K. Diedrich
- , John R. Yates III
- , Elizabeth Villa
- , Don W. Cleveland
- & Kevin D. Corbett
Nature Communications 12 , 1–15

Rights & permissionsfor article The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein . Opens in a new window.
Research | 23 December 2020
Chromothripsis drives the evolution of gene amplification in cancer
- Ofer Shoshani
- , Simon F. Brunner
- , Rona Yaeger
- , Peter Ly
- , Yael Nechemia-Arbely
- , Dong Hyun Kim
- , Rongxin Fang
- , Guillaume A. Castillon
- , Miao Yu
- , Julia S. Z. Li
- , Ying Sun
- , Mark H. Ellisman
- , Bing Ren
- , Peter J. Campbell
- & Don W. Cleveland
Nature , 1–5

Rights & permissionsfor article Chromothripsis drives the evolution of gene amplification in cancer . Opens in a new window.
Amendments and Corrections | 29 July 2020
Author Correction: Reversing a model of Parkinson’s disease with in situ converted nigral neurons
- Hao Qian
- , Xinjiang Kang
- , Jing Hu
- , Dongyang Zhang
- , Zhengyu Liang
- , Fan Meng
- , Xuan Zhang
- , Yuanchao Xue
- , Roy Maimon
- , Steven F. Dowdy
- , Neal K. Devaraj
- , Zhuan Zhou
- , William C. Mobley
- , Don W. Cleveland
- & Xiang-Dong Fu
Nature 584 , E17–E17

Rights & permissionsfor article Author Correction: Reversing a model of Parkinson’s disease with in situ converted nigral neurons . Opens in a new window.
News and Views | 16 December 2016
Gene-editing therapy for neurological disease
- Moira A. McMahon
- & Don W. Cleveland
Nature Reviews Neurology 13 , 7–9

Rights & permissionsfor article Gene-editing therapy for neurological disease . Opens in a new window.
News and Views | 1 October 2006
Intercellular miscommunication in polyglutamine pathogenesis
- Christopher A Ross
- & Don W Cleveland
Nature Neuroscience 9 , 1205–1206

Rights & permissionsfor article Intercellular miscommunication in polyglutamine pathogenesis . Opens in a new window.
News and Views | 1 July 2008
The curious ways of ALS
- Magdalini Polymenidou
- & Don W. Cleveland
Nature 454 , 284–285

Rights & permissionsfor article The curious ways of ALS . Opens in a new window.
News and Views | 1 December 2000
Oxidation versus aggregation — how do SOD1 mutants cause ALS?
- Don W. Cleveland
- & Jian Liu
Nature Medicine 6 , 1320–1321

Rights & permissionsfor article Oxidation versus aggregation — how do SOD1 mutants cause ALS? . Opens in a new window.
1 September 2006
Amyotrophic lateral sclerosis and gene therapy
Nature Reviews Neurology 2 , 462–463

Rights & permissionsfor article Amyotrophic lateral sclerosis and gene therapy . Opens in a new window.
News and Views | 1 January 2005
VEGF: multitasking in ALS
- Christine Vande Velde
- & Don W Cleveland
Nature Neuroscience 8 , 5–7

Rights & permissionsfor article VEGF: multitasking in ALS . Opens in a new window.
29 March 1990
Tubulin site interpretation
Nature 344 , 389–389

Rights & permissionsfor article Tubulin site interpretation . Opens in a new window.
News and Views | 25 August 2010
An expansion in ALS genetics
- Clotilde Lagier-Tourenne
- & Don W. Cleveland
Nature 466 , 1052–1053

Rights & permissionsfor article An expansion in ALS genetics . Opens in a new window.
News and Views | 1 June 2001
Hypoxia and Lou Gehrig
- JH Pate Skene
- & Don W Cleveland
Nature Genetics 28 , 107–108

Rights & permissionsfor article Hypoxia and Lou Gehrig . Opens in a new window.
Research | 16 August 2006
Nondisjunction, aneuploidy and tetraploidy
Nature 442 , E9–E10

Rights & permissionsfor article Nondisjunction, aneuploidy and tetraploidy . Opens in a new window.
News and Views | 1 October 2003
Has gene therapy for ALS arrived?
- Timothy M Miller
- & Don W Cleveland
Nature Medicine 9 , 1256–1257

Rights & permissionsfor article Has gene therapy for ALS arrived? . Opens in a new window.
News and Views | 28 November 2012
TDP-43 toxicity and the usefulness of junk
- Shuying Sun
- & Don W Cleveland
Nature Genetics 44 , 1289–1291

Rights & permissionsfor article TDP-43 toxicity and the usefulness of junk . Opens in a new window.
Research | 24 June 2020
Reversing a model of Parkinson’s disease with in situ converted nigral neurons
- Hao Qian
- , Xinjiang Kang
- , Jing Hu
- , Dongyang Zhang
- , Zhengyu Liang
- , Fan Meng
- , Xuan Zhang
- , Yuanchao Xue
- , Roy Maimon
- , Steven F. Dowdy
- , Neal K. Devaraj
- , Zhuan Zhou
- , William C. Mobley
- , Don W. Cleveland
- & Xiang-Dong Fu
Nature 582 , 550–556

Rights & permissionsfor article Reversing a model of Parkinson’s disease with in situ converted nigral neurons . Opens in a new window.
Research | 13 April 2020
Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72
- Qiang Zhu
- , Jie Jiang
- , Tania F. Gendron
- , Melissa McAlonis-Downes
- , Lulin Jiang
- , Amy Taylor
- , Sandra Diaz Garcia
- , Somasish Ghosh Dastidar
- , Maria J. Rodriguez
- , Patrick King
- , Yongjie Zhang
- , Albert R. La Spada
- , Huaxi Xu
- , Leonard Petrucelli
- , John Ravits
- , Sandrine Da Cruz
- , Clotilde Lagier-Tourenne
- & Don W. Cleveland
Nature Neuroscience 23 , 615–624

Rights & permissionsfor article Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in <i>C9orf72</i> . Opens in a new window.
Research | 29 July 2004
Structural determinants for generating centromeric chromatin
Nature 430 , 578–582

Rights & permissionsfor article Structural determinants for generating centromeric chromatin . Opens in a new window.
Reviews | 26 October 2007
Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease
- Christian S Lobsiger
- & Don W Cleveland
Nature Neuroscience 10 , 1355–1360

Rights & permissionsfor article Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease . Opens in a new window.
23 November 1995
Toxic mutants in Charcot's sclerosis
Nature 378 , 342–343

Rights & permissionsfor article Toxic mutants in Charcot's sclerosis . Opens in a new window.
Research | 3 February 2008
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
Nature Neuroscience 11 , 251–253

Rights & permissionsfor article Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis . Opens in a new window.
Research | 1 January 1999
Slowing of axonal transport is a very early event in the toxicity of ALS–linked SOD1 mutants to motor neurons
- Toni L. Williamson
- & Don W. Cleveland
Nature Neuroscience 2 , 50–56

Rights & permissionsfor article Slowing of axonal transport is a very early event in the toxicity of ALS–linked SOD1 mutants to motor neurons . Opens in a new window.
Research | 11 March 2002
Mutant SOD1 causes motor neuron disease independent of copper chaperone–mediated copper loading
Nature Neuroscience 5 , 301–307

Rights & permissionsfor article Mutant SOD1 causes motor neuron disease independent of copper chaperone–mediated copper loading . Opens in a new window.
Research | 18 August 1988
Autoregulated instability of β-tubulin mRNAs by recognition of the nascent amino terminus of βtubulin
Nature 334 , 580–585

Rights & permissionsfor article Autoregulated instability of β-tubulin mRNAs by recognition of the nascent amino terminus of βtubulin . Opens in a new window.
Research | 16 March 2008
ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration
- Zhihui Zhong
- , Rashid Deane
- , Zarina Ali
- , Margaret Parisi
- , Yuriy Shapovalov
- , M Kerry O'Banion
- , Konstantin Stojanovic
- , Abhay Sagare
- , Severine Boillee
- , Don W Cleveland
- & Berislav V Zlokovic
Nature Neuroscience 11 , 420–422

Rights & permissionsfor article ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration . Opens in a new window.
Research | 5 March 1992
γ-Tubulin is a centrosomal protein required for cell cycle-dependent microtubule nucleation
Nature 356 , 80–83

Rights & permissionsfor article γ-Tubulin is a centrosomal protein required for cell cycle-dependent microtubule nucleation . Opens in a new window.
Research | 7 May 2007
An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS
Nature Medicine 13 , 754–759

Rights & permissionsfor article An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS . Opens in a new window.
Research | 20 October 1983
Elevation of tubulin levels by microinjection suppresses new tubulin synthesis
Nature 305 , 738–740

Rights & permissionsfor article Elevation of tubulin levels by microinjection suppresses new tubulin synthesis . Opens in a new window.
Research | 23 December 2019
Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS
- Mariana Bravo-Hernandez
- , Takahiro Tadokoro
- , Michael R. Navarro
- , Oleksandr Platoshyn
- , Yoshiomi Kobayashi
- , Silvia Marsala
- , Atsushi Miyanohara
- , Stefan Juhas
- , Jana Juhasova
- , Helena Skalnikova
- , Zoltan Tomori
- , Ivo Vanicky
- , Hana Studenovska
- , Vladimir Proks
- , PeiXi Chen
- , Noe Govea-Perez
- , Dara Ditsworth
- , Joseph D. Ciacci
- , Shang Gao
- , Wenlian Zhu
- , Eric T. Ahrens
- , Shawn P. Driscoll
- , Thomas D. Glenn
- , Melissa McAlonis-Downes
- , Sandrine Da Cruz
- , Samuel L. Pfaff
- , Brian K. Kaspar
- , Don W. Cleveland
- & Martin Marsala
Nature Medicine 26 , 118–130

Rights & permissionsfor article Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS . Opens in a new window.
Research | 14 June 2019
BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules
- Yuejia Huang
- , Lin Lin
- , Xing Liu
- , Sheng Ye
- , Phil Y. Yao
- , Wenwen Wang
- , Fengrui Yang
- , Xinjiao Gao
- , Junying Li
- , Yin Zhang
- , Jiancun Zhang
- , Zhihong Yang
- , Xu Liu
- , Zhenye Yang
- , Jianye Zang
- , Maikun Teng
- , Zhiyong Wang
- , Ke Ruan
- , Xia Ding
- , Lin Li
- , Don W. Cleveland
- , Rongguang Zhang
- & Xuebiao Yao
Cell Research 29 , 562–578

Rights & permissionsfor article BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules . Opens in a new window.
Research | 3 June 2019
DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres
- Yael Nechemia-Arbely
- , Karen H. Miga
- , Ofer Shoshani
- , Aaron Aslanian
- , Moira A. McMahon
- , Ah Young Lee
- , Daniele Fachinetti
- , John R. Yates III
- , Bing Ren
- & Don W. Cleveland
Nature Cell Biology 21 , 743–754

Rights & permissionsfor article DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres . Opens in a new window.
Research | 4 March 2019
Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements
- Peter Ly
- , Simon F. Brunner
- , Ofer Shoshani
- , Dong Hyun Kim
- , Weijie Lan
- , Tatyana Pyntikova
- , Adrienne M. Flanagan
- , Sam Behjati
- , David C. Page
- , Peter J. Campbell
- & Don W. Cleveland
Nature Genetics 51 , 705–715

Rights & permissionsfor article Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements . Opens in a new window.
Research | 14 January 2019
Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration
- Ze’ev Melamed
- , Jone López-Erauskin
- , Michael W. Baughn
- , Ouyang Zhang
- , Kevin Drenner
- , Ying Sun
- , Fernande Freyermuth
- , Moira A. McMahon
- , Melinda S. Beccari
- , Jon W. Artates
- , Takuya Ohkubo
- , Maria Rodriguez
- , Nianwei Lin
- , Dongmei Wu
- , C. Frank Bennett
- , Frank Rigo
- , Sandrine Da Cruz
- , John Ravits
- , Clotilde Lagier-Tourenne
- & Don W. Cleveland
Nature Neuroscience 22 , 180–190

Rights & permissionsfor article Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration . Opens in a new window.
Research | 11 January 2019 | Open
Phosphorylation of CENP-A on serine 7 does not control centromere function
Nature Communications 10 , 1–10

Rights & permissionsfor article Phosphorylation of CENP-A on serine 7 does not control centromere function . Opens in a new window.
Research | 19 October 2018 | Open
TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC
- Dong Hyun Kim
- , Joo Seok Han
- , Peter Ly
- , Qiaozhen Ye
- , Moira A. McMahon
- , Kyungjae Myung
- , Kevin D. Corbett
- & Don W. Cleveland
Nature Communications 9 , 1–11

Rights & permissionsfor article TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC . Opens in a new window.
Research | 9 June 2017 | Open
Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition
Nature Communications 8 , 1–15

Rights & permissionsfor article Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition . Opens in a new window.
Research | 17 January 2018
Chromosomal instability drives metastasis through a cytosolic DNA response
- Samuel F. Bakhoum
- , Bryan Ngo
- , Ashley M. Laughney
- , Julie-Ann Cavallo
- , Charles J. Murphy
- , Peter Ly
- , Pragya Shah
- , Roshan K. Sriram
- , Thomas B. K. Watkins
- , Neil K. Taunk
- , Mercedes Duran
- , Chantal Pauli
- , Christine Shaw
- , Kalyani Chadalavada
- , Vinagolu K. Rajasekhar
- , Giulio Genovese
- , Subramanian Venkatesan
- , Nicolai J. Birkbak
- , Nicholas McGranahan
- , Mark Lundquist
- , Quincey LaPlant
- , John H. Healey
- , Olivier Elemento
- , Christine H. Chung
- , Nancy Y. Lee
- , Marcin Imielenski
- , Gouri Nanjangud
- , Dana Pe’er
- , Don W. Cleveland
- , Simon N. Powell
- , Jan Lammerding
- , Charles Swanton
- & Lewis C. Cantley
Nature 553 , 467–472

Rights & permissionsfor article Chromosomal instability drives metastasis through a cytosolic DNA response . Opens in a new window.
Research | 4 January 2018 | Open
C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation
- Weiwei Cheng
- , Shaopeng Wang
- , Alexander A. Mestre
- , Chenglai Fu
- , Andres Makarem
- , Fengfan Xian
- , Lindsey R. Hayes
- , Rodrigo Lopez-Gonzalez
- , Kevin Drenner
- , Jie Jiang
- , Don W. Cleveland
- & Shuying Sun
Nature Communications 9 , 1–12

Rights & permissionsfor article C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation . Opens in a new window.
Research | 21 March 2016
C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins
- Yong-Jie Zhang
- , Tania F Gendron
- , Jonathan C Grima
- , Hiroki Sasaguri
- , Karen Jansen-West
- , Ya-Fei Xu
- , Rebecca B Katzman
- , Jennifer Gass
- , Melissa E Murray
- , Mitsuru Shinohara
- , Wen-Lang Lin
- , Aliesha Garrett
- , Jeannette N Stankowski
- , Lillian Daughrity
- , Jimei Tong
- , Emilie A Perkerson
- , Mei Yue
- , Jeannie Chew
- , Monica Castanedes-Casey
- , Aishe Kurti
- , Zizhao S Wang
- , Amanda M Liesinger
- , Jeremy D Baker
- , Jie Jiang
- , Clotilde Lagier-Tourenne
- , Dieter Edbauer
- , Don W Cleveland
- , Rosa Rademakers
- , Kevin B Boylan
- , Guojun Bu
- , Christopher D Link
- , Chad A Dickey
- , Jeffrey D Rothstein
- , Dennis W Dickson
- , John D Fryer
- & Leonard Petrucelli
Nature Neuroscience 19 , 668–677

Rights & permissionsfor article <i>C9ORF72</i> poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins . Opens in a new window.
Reviews | 9 November 2016
Decoding ALS: from genes to mechanism
Nature 539 , 197–206

Rights & permissionsfor article Decoding ALS: from genes to mechanism . Opens in a new window.
Research | 5 December 2016
Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining
- Peter Ly
- , Levi S. Teitz
- , Dong H. Kim
- , Ofer Shoshani
- , Helen Skaletsky
- , Daniele Fachinetti
- , David C. Page
- & Don W. Cleveland
Nature Cell Biology 19 , 68–75

Rights & permissionsfor article Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining . Opens in a new window.
Research | 27 January 2015
ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP
- Shuying Sun
- , Shuo-Chien Ling
- , Jinsong Qiu
- , Claudio P. Albuquerque
- , Yu Zhou
- , Seiya Tokunaga
- , Hairi Li
- , Haiyan Qiu
- , Anh Bui
- , Gene W. Yeo
- , Eric J. Huang
- , Kevin Eggan
- , Huilin Zhou
- , Xiang-Dong Fu
- , Clotilde Lagier-Tourenne
- & Don W. Cleveland
Nature Communications 6 , 1–14

Rights & permissionsfor article ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP . Opens in a new window.
Research | 18 August 2013
Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips
Nature Cell Biology 15 , 1079–1088

Rights & permissionsfor article Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips . Opens in a new window.
Research | 2 March 2014
Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors
Nature Neuroscience 17 , 513–521

Rights & permissionsfor article Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors . Opens in a new window.
Research | 21 July 2013
A two-step mechanism for epigenetic specification of centromere identity and function
- Daniele Fachinetti
- , H. Diego Folco
- , Yael Nechemia-Arbely
- , Luis P. Valente
- , Kristen Nguyen
- , Alex J. Wong
- , Quan Zhu
- , Andrew J. Holland
- , Arshad Desai
- , Lars E. T. Jansen
- & Don W. Cleveland
Nature Cell Biology 15 , 1056–1066

Rights & permissionsfor article A two-step mechanism for epigenetic specification of centromere identity and function . Opens in a new window.
Reviews | 7 November 2012
Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements
- Andrew J Holland
- & Don W Cleveland
Nature Medicine 18 , 1630–1638

Rights & permissionsfor article Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements . Opens in a new window.
Research | 31 March 2013
Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis
- Shin H Kang
- , Ying Li
- , Masahiro Fukaya
- , Ileana Lorenzini
- , Don W Cleveland
- , Lyle W Ostrow
- , Jeffrey D Rothstein
- & Dwight E Bergles
Nature Neuroscience 16 , 571–579

Rights & permissionsfor article Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis . Opens in a new window.
Reviews | 1 July 2009
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
- Andrew J. Holland
- & Don W. Cleveland
Nature Reviews Molecular Cell Biology 10 , 478–487

Rights & permissionsfor article Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis . Opens in a new window.
Reviews | 1 November 2001
From charcot to lou gehrig: deciphering selective motor neuron death in als
- Don W. Cleveland
- & Jeffrey D. Rothstein
Nature Reviews Neuroscience 2 , 806–819

Rights & permissionsfor article From charcot to lou gehrig: deciphering selective motor neuron death in als . Opens in a new window.
Research | 30 September 2012
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs
- Clotilde Lagier-Tourenne
- , Magdalini Polymenidou
- , Kasey R Hutt
- , Anthony Q Vu
- , Michael Baughn
- , Stephanie C Huelga
- , Kevin M Clutario
- , Shuo-Chien Ling
- , Tiffany Y Liang
- , Curt Mazur
- , Edward Wancewicz
- , Aneeza S Kim
- , Andy Watt
- , Sue Freier
- , Geoffrey G Hicks
- , John Paul Donohue
- , Lily Shiue
- , C Frank Bennett
- , John Ravits
- , Don W Cleveland
- & Gene W Yeo
Nature Neuroscience 15 , 1488–1497

Rights & permissionsfor article Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs . Opens in a new window.

Quick links