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Research | 9 March 2020
Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia
- Robert J. Autry
- , Steven W. Paugh
- , Robert Carter
- , Lei Shi
- , Jingjing Liu
- , Daniel C. Ferguson
- , Calvin E. Lau
- , Erik J. Bonten
- , Wenjian Yang
- , J. Robert McCorkle
- , Jordan A. Beard
- , John C. Panetta
- , Jonathan D. Diedrich
- , Kristine R. Crews
- , Deqing Pei
- , Christopher J. Coke
- , Sivaraman Natarajan
- , Alireza Khatamian
- , Seth E. Karol
- , Elixabet Lopez-Lopez
- , Barthelemy Diouf
- , Colton Smith
- , Yoshihiro Gocho
- , Kohei Hagiwara
- , Kathryn G. Roberts
- , Stanley Pounds
- , Steven M. Kornblau
- , Wendy Stock
- , Elisabeth M. Paietta
- , Mark R. Litzow
- , Hiroto Inaba
- , Charles G. Mullighan
- , Sima Jeha
- , Ching-Hon Pui
- , Cheng Cheng
- , Daniel Savic
- , Jiyang Yu
- , Charles Gawad
- , Mary V. Relling
- , Jun J. Yang
- & William E. Evans
Nature Cancer 1 , 329–344

Rights & permissionsfor article Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia . Opens in a new window.
Research | 25 September 2011
Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells
- Barthelemy Diouf
- , Qing Cheng
- , Natalia F Krynetskaia
- , Wenjian Yang
- , Meyling Cheok
- , Deqing Pei
- , Yiping Fan
- , Cheng Cheng
- , Evgeny Y Krynetskiy
- , Hui Geng
- , Siying Chen
- , William E Thierfelder
- , Charles G Mullighan
- , James R Downing
- , Peggy Hsieh
- , Ching-Hon Pui
- , Mary V Relling
- & William E Evans
Nature Medicine 17 , 1298–1303

Rights & permissionsfor article Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells . Opens in a new window.
Research | 29 March 2019
Genomic subtyping and therapeutic targeting of acute erythroleukemia
- Ilaria Iacobucci
- , Ji Wen
- , Manja Meggendorfer
- , John K. Choi
- , Lei Shi
- , Stanley B. Pounds
- , Catherine L. Carmichael
- , Katherine E. Masih
- , Sarah M. Morris
- , R. Coleman Lindsley
- , Laura J. Janke
- , Thomas B. Alexander
- , Guangchun Song
- , Chunxu Qu
- , Yongjin Li
- , Debbie Payne-Turner
- , Daisuke Tomizawa
- , Nobutaka Kiyokawa
- , Marcus Valentine
- , Virginia Valentine
- , Giuseppe Basso
- , Franco Locatelli
- , Eric J. Enemark
- , Shirley K. Y. Kham
- , Allen E. J. Yeoh
- , Xiaotu Ma
- , Xin Zhou
- , Edgar Sioson
- , Michael Rusch
- , Rhonda E. Ries
- , Elliot Stieglitz
- , Stephen P. Hunger
- , Andrew H. Wei
- , L Bik To
- , Ian D. Lewis
- , Richard J. D’Andrea
- , Benjamin T. Kile
- , Anna L. Brown
- , Hamish S. Scott
- , Christopher N. Hahn
- , Paula Marlton
- , Deqing Pei
- , Cheng Cheng
- , Mignon L. Loh
- , Benjamin L. Ebert
- , Soheil Meshinchi
- , Torsten Haferlach
- & Charles G. Mullighan
Nature Genetics 51 , 694–704

Rights & permissionsfor article Genomic subtyping and therapeutic targeting of acute erythroleukemia . Opens in a new window.
Research | 14 January 2019
PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia
- Zhaohui Gu
- , Michelle L. Churchman
- , Kathryn G. Roberts
- , Ian Moore
- , Xin Zhou
- , Joy Nakitandwe
- , Kohei Hagiwara
- , Stephane Pelletier
- , Sebastien Gingras
- , Hartmut Berns
- , Debbie Payne-Turner
- , Ashley Hill
- , Ilaria Iacobucci
- , Lei Shi
- , Stanley Pounds
- , Cheng Cheng
- , Deqing Pei
- , Chunxu Qu
- , Scott Newman
- , Meenakshi Devidas
- , Yunfeng Dai
- , Shalini C. Reshmi
- , Julie Gastier-Foster
- , Elizabeth A. Raetz
- , Michael J. Borowitz
- , Brent L. Wood
- , William L. Carroll
- , Patrick A. Zweidler-McKay
- , Karen R. Rabin
- , Leonard A. Mattano
- , Kelly W. Maloney
- , Alessandro Rambaldi
- , Orietta Spinelli
- , Jerald P. Radich
- , Mark D. Minden
- , Jacob M. Rowe
- , Selina Luger
- , Mark R. Litzow
- , Martin S. Tallman
- , Janis Racevskis
- , Yanming Zhang
- , Ravi Bhatia
- , Jessica Kohlschmidt
- , Krzysztof Mrózek
- , Clara D. Bloomfield
- , Wendy Stock
- , Steven Kornblau
- , Hagop M. Kantarjian
- , Marina Konopleva
- , Williams E. Evans
- , Sima Jeha
- , Ching-Hon Pui
- , Jun Yang
- , Elisabeth Paietta
- , James R. Downing
- , Mary V. Relling
- , Jinghui Zhang
- , Mignon L. Loh
- , Stephen P. Hunger
- & Charles G. Mullighan
Nature Genetics 51 , 296–307

Rights & permissionsfor article <i>PAX5</i>-driven subtypes of B-progenitor acute lymphoblastic leukemia . Opens in a new window.
Research | 12 September 2018
The genetic basis and cell of origin of mixed phenotype acute leukaemia
- Thomas B. Alexander
- , Zhaohui Gu
- , Ilaria Iacobucci
- , Kirsten Dickerson
- , John K. Choi
- , Beisi Xu
- , Debbie Payne-Turner
- , Hiroki Yoshihara
- , Mignon L. Loh
- , John Horan
- , Barbara Buldini
- , Giuseppe Basso
- , Sarah Elitzur
- , Valerie de Haas
- , C. Michel Zwaan
- , Allen Yeoh
- , Dirk Reinhardt
- , Daisuke Tomizawa
- , Nobutaka Kiyokawa
- , Tim Lammens
- , Barbara De Moerloose
- , Daniel Catchpoole
- , Hiroki Hori
- , Anthony Moorman
- , Andrew S. Moore
- , Ondrej Hrusak
- , Soheil Meshinchi
- , Etan Orgel
- , Meenakshi Devidas
- , Michael Borowitz
- , Brent Wood
- , Nyla A. Heerema
- , Andrew Carrol
- , Yung-Li Yang
- , Malcolm A. Smith
- , Tanja M. Davidsen
- , Leandro C. Hermida
- , Patee Gesuwan
- , Marco A. Marra
- , Yussanne Ma
- , Andrew J. Mungall
- , Richard A. Moore
- , Steven J. M. Jones
- , Marcus Valentine
- , Laura J. Janke
- , Jeffrey E. Rubnitz
- , Ching-Hon Pui
- , Liang Ding
- , Yu Liu
- , Jinghui Zhang
- , Kim E. Nichols
- , James R. Downing
- , Xueyuan Cao
- , Lei Shi
- , Stanley Pounds
- , Scott Newman
- , Deqing Pei
- , Jaime M. Guidry Auvil
- , Daniela S. Gerhard
- , Stephen P. Hunger
- , Hiroto Inaba
- & Charles G. Mullighan
Nature 562 , 373–379

Rights & permissionsfor article The genetic basis and cell of origin of mixed phenotype acute leukaemia . Opens in a new window.
Research | 3 July 2017
The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia
- Yu Liu
- , John Easton
- , Ying Shao
- , Jamie Maciaszek
- , Zhaoming Wang
- , Mark R Wilkinson
- , Kelly McCastlain
- , Michael Edmonson
- , Stanley B Pounds
- , Lei Shi
- , Xin Zhou
- , Xiaotu Ma
- , Edgar Sioson
- , Yongjin Li
- , Michael Rusch
- , Pankaj Gupta
- , Deqing Pei
- , Cheng Cheng
- , Malcolm A Smith
- , Jaime Guidry Auvil
- , Daniela S Gerhard
- , Mary V Relling
- , Naomi J Winick
- , Andrew J Carroll
- , Nyla A Heerema
- , Elizabeth Raetz
- , Meenakshi Devidas
- , Cheryl L Willman
- , Richard C Harvey
- , William L Carroll
- , Kimberly P Dunsmore
- , Stuart S Winter
- , Brent L Wood
- , Brian P Sorrentino
- , James R Downing
- , Mignon L Loh
- , Stephen P Hunger
- , Jinghui Zhang
- & Charles G Mullighan
Nature Genetics 49 , 1211–1218

Rights & permissionsfor article The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia . Opens in a new window.
Research | 24 October 2016
Deregulation of DUX4 and ERG in acute lymphoblastic leukemia
- Jinghui Zhang
- , Kelly McCastlain
- , Hiroki Yoshihara
- , Beisi Xu
- , Yunchao Chang
- , Michelle L Churchman
- , Gang Wu
- , Yongjin Li
- , Lei Wei
- , Ilaria Iacobucci
- , Yu Liu
- , Chunxu Qu
- , Ji Wen
- , Michael Edmonson
- , Debbie Payne-Turner
- , Kerstin B Kaufmann
- , Shin-ichiro Takayanagi
- , Erno Wienholds
- , Esmé Waanders
- , Panagiotis Ntziachristos
- , Sofia Bakogianni
- , Jingjing Wang
- , Iannis Aifantis
- , Kathryn G Roberts
- , Jing Ma
- , Guangchun Song
- , John Easton
- , Heather L Mulder
- , Xiang Chen
- , Scott Newman
- , Xiaotu Ma
- , Michael Rusch
- , Pankaj Gupta
- , Kristy Boggs
- , Bhavin Vadodaria
- , James Dalton
- , Yanling Liu
- , Marcus L Valentine
- , Li Ding
- , Charles Lu
- , Robert S Fulton
- , Lucinda Fulton
- , Yashodhan Tabib
- , Kerri Ochoa
- , Meenakshi Devidas
- , Deqing Pei
- , Cheng Cheng
- , Jun Yang
- , William E Evans
- , Mary V Relling
- , Ching-Hon Pui
- , Sima Jeha
- , Richard C Harvey
- , I-Ming L Chen
- , Cheryl L Willman
- , Guido Marcucci
- , Clara D Bloomfield
- , Jessica Kohlschmidt
- , Krzysztof Mrózek
- , Elisabeth Paietta
- , Martin S Tallman
- , Wendy Stock
- , Matthew C Foster
- , Janis Racevskis
- , Jacob M Rowe
- , Selina Luger
- , Steven M Kornblau
- , Sheila A Shurtleff
- , Susana C Raimondi
- , Elaine R Mardis
- , Richard K Wilson
- , John E Dick
- , Stephen P Hunger
- , Mignon L Loh
- , James R Downing
- & Charles G Mullighan
Nature Genetics 48 , 1481–1489

Rights & permissionsfor article Deregulation of <i>DUX4</i> and <i>ERG</i> in acute lymphoblastic leukemia . Opens in a new window.
Research | 1 August 2016 | Open
Msh2 deficiency leads to dysmyelination of the corpus callosum, impaired locomotion and altered sensory function in mice
- Barthelemy Diouf
- , Prakash Devaraju
- , Laura J. Janke
- , Yiping Fan
- , Sharon Frase
- , Donnie Eddins
- , Jennifer L. Peters
- , Jieun Kim
- , Deqing Pei
- , Cheng Cheng
- , Stanislav S. Zakharenko
- & William E. Evans
Scientific Reports 6 , 1–10

Rights & permissionsfor article <i>Msh2</i> deficiency leads to dysmyelination of the corpus callosum, impaired locomotion and altered sensory function in mice . Opens in a new window.
Research | 8 November 2016 | Open
Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia
- Zhaohui Gu
- , Michelle Churchman
- , Kathryn Roberts
- , Yongjin Li
- , Yu Liu
- , Richard C. Harvey
- , Kelly McCastlain
- , Shalini C. Reshmi
- , Debbie Payne-Turner
- , Ilaria Iacobucci
- , Ying Shao
- , I-Ming Chen
- , Marcus Valentine
- , Deqing Pei
- , Karen L. Mungall
- , Andrew J. Mungall
- , Yussanne Ma
- , Richard Moore
- , Marco Marra
- , Eileen Stonerock
- , Julie M. Gastier-Foster
- , Meenakshi Devidas
- , Yunfeng Dai
- , Brent Wood
- , Michael Borowitz
- , Eric E. Larsen
- , Kelly Maloney
- , Leonard A. Mattano Jr
- , Anne Angiolillo
- , Wanda L. Salzer
- , Michael J. Burke
- , Francesca Gianni
- , Orietta Spinelli
- , Jerald P. Radich
- , Mark D. Minden
- , Anthony V. Moorman
- , Bella Patel
- , Adele K. Fielding
- , Jacob M. Rowe
- , Selina M. Luger
- , Ravi Bhatia
- , Ibrahim Aldoss
- , Stephen J. Forman
- , Jessica Kohlschmidt
- , Krzysztof Mrózek
- , Guido Marcucci
- , Clara D. Bloomfield
- , Wendy Stock
- , Steven Kornblau
- , Hagop M. Kantarjian
- , Marina Konopleva
- , Elisabeth Paietta
- , Cheryl L. Willman
- , Mignon L. Loh
- , Stephen P. Hunger
- & Charles G. Mullighan
Nature Communications 7 , 1–10

Rights & permissionsfor article Genomic analyses identify recurrent <i>MEF2D</i> fusions in acute lymphoblastic leukaemia . Opens in a new window.
Research | 2 March 2015
The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias
- Anna K Andersson
- , Jing Ma
- , Jianmin Wang
- , Xiang Chen
- , Amanda Larson Gedman
- , Jinjun Dang
- , Joy Nakitandwe
- , Linda Holmfeldt
- , Matthew Parker
- , John Easton
- , Robert Huether
- , Richard Kriwacki
- , Michael Rusch
- , Gang Wu
- , Yongjin Li
- , Heather Mulder
- , Susana Raimondi
- , Stanley Pounds
- , Guolian Kang
- , Lei Shi
- , Jared Becksfort
- , Pankaj Gupta
- , Debbie Payne-Turner
- , Bhavin Vadodaria
- , Kristy Boggs
- , Donald Yergeau
- , Jayanthi Manne
- , Guangchun Song
- , Michael Edmonson
- , Panduka Nagahawatte
- , Lei Wei
- , Cheng Cheng
- , Deqing Pei
- , Rosemary Sutton
- , Nicola C Venn
- , Albert Chetcuti
- , Amanda Rush
- , Daniel Catchpoole
- , Jesper Heldrup
- , Thoas Fioretos
- , Charles Lu
- , Li Ding
- , Ching-Hon Pui
- , Sheila Shurtleff
- , Charles G Mullighan
- , Elaine R Mardis
- , Richard K Wilson
- , Tanja A Gruber
- , Jinghui Zhang
- & James R Downing
Nature Genetics 47 , 330–337

Rights & permissionsfor article The landscape of somatic mutations in infant <i>MLL</i>-rearranged acute lymphoblastic leukemias . Opens in a new window.
Research | 20 October 2013
Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse
- Virginia Perez-Andreu
- , Kathryn G Roberts
- , Richard C Harvey
- , Wenjian Yang
- , Cheng Cheng
- , Deqing Pei
- , Heng Xu
- , Julie Gastier-Foster
- , Shuyu E
- , Joshua Yew-Suang Lim
- , I-Ming Chen
- , Yiping Fan
- , Meenakshi Devidas
- , Michael J Borowitz
- , Colton Smith
- , Geoffrey Neale
- , Esteban G Burchard
- , Dara G Torgerson
- , Federico Antillon Klussmann
- , Cesar Rolando Najera Villagran
- , Naomi J Winick
- , Bruce M Camitta
- , Elizabeth Raetz
- , Brent Wood
- , Feng Yue
- , William L Carroll
- , Eric Larsen
- , W Paul Bowman
- , Mignon L Loh
- , Michael Dean
- , Deepa Bhojwani
- , Ching-Hon Pui
- , William E Evans
- , Mary V Relling
- , Stephen P Hunger
- , Cheryl L Willman
- , Charles G Mullighan
- & Jun J Yang
Nature Genetics 45 , 1494–1498

Rights & permissionsfor article Inherited <i>GATA3</i> variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse . Opens in a new window.
Research | 11 January 2012 | Open
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
- Jinghui Zhang
- , Li Ding
- , Linda Holmfeldt
- , Gang Wu
- , Sue L. Heatley
- , Debbie Payne-Turner
- , John Easton
- , Xiang Chen
- , Jianmin Wang
- , Michael Rusch
- , Charles Lu
- , Shann-Ching Chen
- , Lei Wei
- , J. Racquel Collins-Underwood
- , Jing Ma
- , Kathryn G. Roberts
- , Stanley B. Pounds
- , Anatoly Ulyanov
- , Jared Becksfort
- , Pankaj Gupta
- , Robert Huether
- , Richard W. Kriwacki
- , Matthew Parker
- , Daniel J. McGoldrick
- , David Zhao
- , Daniel Alford
- , Stephen Espy
- , Kiran Chand Bobba
- , Guangchun Song
- , Deqing Pei
- , Cheng Cheng
- , Stefan Roberts
- , Michael I. Barbato
- , Dario Campana
- , Elaine Coustan-Smith
- , Sheila A. Shurtleff
- , Susana C. Raimondi
- , Maria Kleppe
- , Jan Cools
- , Kristin A. Shimano
- , Michelle L. Hermiston
- , Sergei Doulatov
- , Kolja Eppert
- , Elisa Laurenti
- , Faiyaz Notta
- , John E. Dick
- , Giuseppe Basso
- , Stephen P. Hunger
- , Mignon L. Loh
- , Meenakshi Devidas
- , Brent Wood
- , Stuart Winter
- , Kimberley P. Dunsmore
- , Robert S. Fulton
- , Lucinda L. Fulton
- , Xin Hong
- , Christopher C. Harris
- , David J. Dooling
- , Kerri Ochoa
- , Kimberly J. Johnson
- , John C. Obenauer
- , William E. Evans
- , Ching-Hon Pui
- , Clayton W. Naeve
- , Timothy J. Ley
- , Elaine R. Mardis
- , Richard K. Wilson
- , James R. Downing
- & Charles G. Mullighan
Nature 481 , 157–163

Rights & permissionsfor article The genetic basis of early T-cell precursor acute lymphoblastic leukaemia . Opens in a new window.
Research | 20 January 2013
The genomic landscape of hypodiploid acute lymphoblastic leukemia
- Linda Holmfeldt
- , Lei Wei
- , Ernesto Diaz-Flores
- , Michael Walsh
- , Jinghui Zhang
- , Li Ding
- , Debbie Payne-Turner
- , Michelle Churchman
- , Anna Andersson
- , Shann-Ching Chen
- , Kelly McCastlain
- , Jared Becksfort
- , Jing Ma
- , Gang Wu
- , Samir N Patel
- , Susan L Heatley
- , Letha A Phillips
- , Guangchun Song
- , John Easton
- , Matthew Parker
- , Xiang Chen
- , Michael Rusch
- , Kristy Boggs
- , Bhavin Vadodaria
- , Erin Hedlund
- , Christina Drenberg
- , Sharyn Baker
- , Deqing Pei
- , Cheng Cheng
- , Robert Huether
- , Charles Lu
- , Robert S Fulton
- , Lucinda L Fulton
- , Yashodhan Tabib
- , David J Dooling
- , Kerri Ochoa
- , Mark Minden
- , Ian D Lewis
- , L Bik To
- , Paula Marlton
- , Andrew W Roberts
- , Gordana Raca
- , Wendy Stock
- , Geoffrey Neale
- , Hans G Drexler
- , Ross A Dickins
- , David W Ellison
- , Sheila A Shurtleff
- , Ching-Hon Pui
- , Raul C Ribeiro
- , Meenakshi Devidas
- , Andrew J Carroll
- , Nyla A Heerema
- , Brent Wood
- , Michael J Borowitz
- , Julie M Gastier-Foster
- , Susana C Raimondi
- , Elaine R Mardis
- , Richard K Wilson
- , James R Downing
- , Stephen P Hunger
- , Mignon L Loh
- & Charles G Mullighan
Nature Genetics 45 , 242–252

Rights & permissionsfor article The genomic landscape of hypodiploid acute lymphoblastic leukemia . Opens in a new window.

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