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Correspondence | 1 December 2003
Reply to “Proteomic alterations of cancer-cell mitochondria: driver or bystander?”
Nature Reviews Cancer 3 , 796–796

Rights & permissionsfor article Reply to “Proteomic alterations of cancer-cell mitochondria: driver or bystander?” . Opens in a new window.
Amendments and Corrections | 1 October 2004
Correction: Corrigendum: CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer
- Zhongmin Guo
- , Jürgen F Linn
- , Guojun Wu
- , Sarah L Anzick
- , Claus F Eisenberger
- , Sarel Halachmi
- , Yoram Cohen
- , Alexey Fomenkov
- , Mohammad O Hoque
- , Kenji Okami
- , Gabriel Steiner
- , James M Engles
- , Motonabu Osada
- , Chulso Moon
- , Edward Ratovitski
- , Jeffrey M Trent
- , Paul S Meltzer
- , William H Westra
- , Lambertus A Kiemeney
- , Mark P Schoenberg
- , David Sidransky
- & Barry Trink
Nature Medicine 10 , 1139–1139

Rights & permissionsfor article Correction: Corrigendum: <i>CDC91L1</i> (PIG-U) is a newly discovered oncogene in human bladder cancer . Opens in a new window.
Correspondence | 2 January 2008
Slow development impedes the uptake of diagnostics
Nature 451 , 16–16

Rights & permissionsfor article Slow development impedes the uptake of diagnostics . Opens in a new window.
Amendments and Corrections | 26 June 2017 | Open
Correction: Corrigendum: A dual specificity kinase, DYRK1A, as a potential therapeutic target for head and neck squamous cell carcinoma
Scientific Reports 7 , 1–2

Rights & permissionsfor article Correction: Corrigendum: A dual specificity kinase, DYRK1A, as a potential therapeutic target for head and neck squamous cell carcinoma . Opens in a new window.
Research | 22 May 2017 | Open
In silico analysis of pathways activation landscape in oral squamous cell carcinoma and oral leukoplakia
- Eugene Makarev
- , Adrian D Schubert
- , Riya R Kanherkar
- , Nyall London
- , Mahder Teka
- , Ivan Ozerov
- , Ksenia Lezhnina
- , Atul Bedi
- , Rajani Ravi
- , Rannee Mehra
- , Mohammad O Hoque
- , Ido Sloma
- , Daria A Gaykalova
- , Antonei B Csoka
- , David Sidransky
- , Alex Zhavoronkov
- & Evgeny Izumchenko
Cell Death Discovery 3 , 1–7

Rights & permissionsfor article <i>In silico</i> analysis of pathways activation landscape in oral squamous cell carcinoma and oral leukoplakia . Opens in a new window.
News and Views | 1 September 1996
Is human patched the gatekeeper of common skin cancers?
- David Sidransky
Nature Genetics 14 , 7–8

Rights & permissionsfor article Is human <i>patched</i> the gatekeeper of common skin cancers? . Opens in a new window.
Research | 4 June 2004
The V599E BRAF mutation is uncommon in biliary tract cancers
- David Goldenberg
- , Eli Rosenbaum
- , Pedram Argani
- , Ignacio I Wistuba
- , David Sidransky
- , Paul J Thuluvath
- , Manuel Hidalgo
- , Joseph Califano
- & Anirban Maitra
Modern Pathology 17 , 1386–1391

Rights & permissionsfor article The V599E <i>BRAF</i> mutation is uncommon in biliary tract cancers . Opens in a new window.
Reviews | 1 December 2003
Proteomic analysis of cancer-cell mitochondria
Nature Reviews Cancer 3 , 789–795

Rights & permissionsfor article Proteomic analysis of cancer-cell mitochondria . Opens in a new window.
22 June 2001
Distinct pattern of p53 phosphorylation in human tumors
Oncogene 20 , 3341–3347

Rights & permissionsfor article Distinct pattern of p53 phosphorylation in human tumors . Opens in a new window.
Research | 1 September 1996
Microsatellite alterations in serum DNA of head and neck cancer patients
- Homaira Nawroz
- , Wayne Koch
- , Philippe Anker
- , Maurice Stroun
- & David Sidransky
Nature Medicine 2 , 1035–1037

Rights & permissionsfor article Microsatellite alterations in serum DNA of head and neck cancer patients . Opens in a new window.
Research | 1 October 1995
Frequency of homozygous deletion at p16/CDKN2 in primary human tumours
- Paul Cairns
- , Thomas J. Polascik
- , Yolanda Eby
- , Kaori Tokino
- , Joseph Califano
- , Adrian Merlo
- , Li Mao
- , John Herath
- , Robert Jenkins
- , William Westra
- , Joni L. Rutter
- , Alan Buckler
- , Edward Gabrielson
- , Mel Tockman
- , Kathleen R. Cho
- , Lora Hedrick
- , G. Steven Bova
- , William Isaacs
- , Wayne Koch
- , Donna Schwab
- & David Sidransky
Nature Genetics 11 , 210–212

Rights & permissionsfor article Frequency of homozygous deletion at <i>p16/CDKN2</i> in primary human tumours . Opens in a new window.
Research | 1 July 2003
Molecular Analysis of Peritoneal Fluid in Ovarian Cancer Patients
Modern Pathology 16 , 636–640

Rights & permissionsfor article Molecular Analysis of Peritoneal Fluid in Ovarian Cancer Patients . Opens in a new window.
2 October 2003
Involvement of aquaporins in colorectal carcinogenesis
- Chulso Moon
- , Jean-Charles Soria
- , Se Jin Jang
- , Juna Lee
- , Mohammad Obaidul Hoque
- , Mathilde Sibony
- , Barry Trink
- , Yoon Soo Chang
- , David Sidransky
- & Li Mao
Oncogene 22 , 6699–6703

Rights & permissionsfor article Involvement of aquaporins in colorectal carcinogenesis . Opens in a new window.
9 October 2003
Biallelic inactivation of the RIZ1 gene in human gastric cancer
- Yutaka Tokumaru
- , Shuji Nomoto
- , Carmen Jerónimo
- , Rui Henrique
- , Susan Harden
- , Barry Trink
- & David Sidransky
Oncogene 22 , 6954–6958

Rights & permissionsfor article Biallelic inactivation of the RIZ1 gene in human gastric cancer . Opens in a new window.
17 June 1998
Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers
- Paul Cairns
- , Ella Evron
- , Kenji Okami
- , Naomi Halachmi
- , Manel Esteller
- , James G Herman
- , Shikha Bose
- , Steven I Wang
- , Ramon Parsons
- & David Sidransky
Oncogene 16 , 3215–3218

Rights & permissionsfor article Point mutation and homozygous deletion of <i>PTEN/MMAC1</i> in primary bladder cancers . Opens in a new window.
23 October 1997
Functional analysis of wild-type and malignant glioma derived CDKN2Aβ alleles: Evidence for an RB-independent growth suppressive pathway
- Wadih Arap
- , Erik Knudsen
- , Duane A Sewell
- , David Sidransky
- , Jean YJ Wang
- , H-J Su Huang
- & Webster K Cavenee
Oncogene 15 , 2013–2020

Rights & permissionsfor article Functional analysis of wild-type and malignant glioma derived CDKN2Aβ alleles: Evidence for an RB-independent growth suppressive pathway . Opens in a new window.
Research | 27 February 1992
Clonal expansion of p53 mutant cells is associated with brain tumour progression
Nature 355 , 846–847

Rights & permissionsfor article Clonal expansion of p53 mutant cells is associated with brain tumour progression . Opens in a new window.
Research | 11 June 2004
BRAF mutations in anaplastic thyroid carcinoma: implications for tumor origin, diagnosis and treatment
- Shahnaz Begum
- , Eli Rosenbaum
- , Rui Henrique
- , Yoram Cohen
- , David Sidransky
- & William H Westra
Modern Pathology 17 , 1359–1363

Rights & permissionsfor article <i>BRAF</i> mutations in anaplastic thyroid carcinoma: implications for tumor origin, diagnosis and treatment . Opens in a new window.
Research | 1 October 1996
Selective radiosensitization of p53–deficient cells by caffeine–mediated activation of p34^cdc2 kinase
- Siu-Long Yao
- , Adil J. Akhtar
- , Karen A. Mckenna
- , Gauri C. Bedi
- , David Sidransky
- , Mack Mabry
- , Rajani Ravi
- , Michael I. Collector
- , Richard J. Jones
- , Saul J. Sharkis
- , Ephraim J. Fuchs
- & Atul Bedi
Nature Medicine 2 , 1140–1143

Rights & permissionsfor article Selective radiosensitization of p53–deficient cells by caffeine–mediated activation of p34<sup>cdc2</sup> kinase . Opens in a new window.
27 June 2001
Adenomatous polyposis coli gene promoter hypermethylation in non-small cell lung cancer is associated with survival
- Jan Brabender
- , Henning Usadel
- , Kathleen D Danenberg
- , Ralf Metzger
- , Paul M Schneider
- , Reginald V Lord
- , Kumari Wickramasinghe
- , Christopher E Lum
- , JiMin Park
- , Dennis Salonga
- , Jonathan Singer
- , David Sidransky
- , Arnulf H Hölscher
- , Stephen J Meltzer
- & Peter V Danenberg
Oncogene 20 , 3528–3532

Rights & permissionsfor article Adenomatous polyposis coli gene promoter hypermethylation in non-small cell lung cancer is associated with survival . Opens in a new window.
Research | 16 May 2008
Profiling the expression pattern of GPI transamidase complex subunits in human cancer
- Jatin K Nagpal
- , Santanu Dasgupta
- , Sana Jadallah
- , Young K Chae
- , Edward A Ratovitski
- , Antoun Toubaji
- , George J Netto
- , Toby Eagle
- , Aviram Nissan
- , David Sidransky
- & Barry Trink
Modern Pathology 21 , 979–991

Rights & permissionsfor article Profiling the expression pattern of GPI transamidase complex subunits in human cancer . Opens in a new window.
Research | 1 June 1997
Detection of bladder cancer recurrence by microsatellite analysis of urine
- Gabriel Steiner
- , Mark P. Schoenberg
- , Jurgen F. Linn
- , Li Mao
- & David Sidransky
Nature Medicine 3 , 621–624

Rights & permissionsfor article Detection of bladder cancer recurrence by microsatellite analysis of urine . Opens in a new window.
15 October 2002
Molecular detection approaches for smoking associated tumors
Oncogene 21 , 7289–7297

Rights & permissionsfor article Molecular detection approaches for smoking associated tumors . Opens in a new window.
1 July 1998
A new human p53 homologue
- Barry Trink
- , Kenji Okami
- , Li Wu
- , Virote Sriuranpong
- , Jin Jen
- & David Sidransky
Nature Medicine 4 , 747–748

Rights & permissionsfor article A new human p53 homologue . Opens in a new window.
28 August 2001
Mitochondrial mutations in early stage prostate cancer and bodily fluids
- Carmen Jerónimo
- , Shuji Nomoto
- , Otávia L Caballero
- , Henning Usadel
- , Rui Henrique
- , Graça Varzim
- , Jorge Oliveira
- , Carlos Lopes
- , Makiko S Fliss
- & David Sidransky
Oncogene 20 , 5195–5198

Rights & permissionsfor article Mitochondrial mutations in early stage prostate cancer and bodily fluids . Opens in a new window.
Research | 6 August 2004
Mutational activation of BRAF is not a major event in sporadic childhood papillary thyroid carcinoma
- Eli Rosenbaum
- , Gregory Hosler
- , Marianna Zahurak
- , Yoram Cohen
- , David Sidransky
- & William H Westra
Modern Pathology 18 , 898–902

Rights & permissionsfor article Mutational activation of <i>BRAF</i> is not a major event in sporadic childhood papillary thyroid carcinoma . Opens in a new window.
7 May 2002
Interaction and colocalization of PGP9.5 with JAB1 and p27^Kip1
- Otávia L Caballero
- , Vicente Resto
- , Meera Patturajan
- , Daoud Meerzaman
- , Ming Zhou Guo
- , James Engles
- , Robert Yochem
- , Edward Ratovitski
- , David Sidransky
- & Jin Jen
Oncogene 21 , 3003–3010

Rights & permissionsfor article Interaction and colocalization of PGP9.5 with JAB1 and p27<sup>Kip1</sup> . Opens in a new window.
Comments and Opinion | 1 February 2011
An accelerated pathway for targeted cancer therapies
- Mark McClellan
- , Joshua Benner
- , Richard Schilsky
- , David Epstein
- , Ray Woosley
- , Stephen Friend
- , David Sidransky
- , Cindy Geoghegan
- & David Kessler
Nature Reviews Drug Discovery 10 , 79–80

Rights & permissionsfor article An accelerated pathway for targeted cancer therapies . Opens in a new window.
Research | 1 January 1995
Microsatellite instability in primary neoplasms from HIV+ patients
Nature Medicine 1 , 65–68

Rights & permissionsfor article Microsatellite instability in primary neoplasms from HIV+ patients . Opens in a new window.
21 October 1999
Inactivation of the INK4A/ARF locus frequently coexists with TP53 mutations in non-small cell lung cancer
- Montserrat Sanchez-Cespedes
- , Andre L Reed
- , Martin Buta
- , Li Wu
- , William H Westra
- , James G Herman
- , Stephen C Yang
- , Jin Jen
- & David Sidransky
Oncogene 18 , 5843–5849

Rights & permissionsfor article Inactivation of the INK4A/ARF locus frequently coexists with TP53 mutations in non-small cell lung cancer . Opens in a new window.
4 June 1998
Absence of TSG101 transcript abnormalities in human cancers
- Barry Trink
- , Sara I Pai
- , Sheri L Spunt
- , Venu Raman
- , Paul Cairns
- , Jin Jen
- , Ed Gabrielson
- , Saraswati Sukumar
- & David Sidransky
Oncogene 16 , 2815–2818

Rights & permissionsfor article Absence of TSG101 transcript abnormalities in human cancers . Opens in a new window.
Research | 11 December 2019 | Open
MAP2K1 is a potential therapeutic target in erlotinib resistant head and neck squamous cell carcinoma
- Ankit P. Jain
- , Krishna Patel
- , Sneha Pinto
- , Aneesha Radhakrishnan
- , Vishalakshi Nanjappa
- , Manish Kumar
- , Remya Raja
- , Arun H. Patil
- , Anjali Kumari
- , Malini Manoharan
- , Coral Karunakaran
- , Saktivel Murugan
- , T. S. Keshava Prasad
- , Xiaofei Chang
- , Premendu Prakash Mathur
- , Prashant Kumar
- , Ravi Gupta
- , Rohit Gupta
- , Arati Khanna-Gupta
- , David Sidransky
- , Aditi Chatterjee
- & Harsha Gowda
Scientific Reports 9 , 1–12

Rights & permissionsfor article MAP2K1 is a potential therapeutic target in erlotinib resistant head and neck squamous cell carcinoma . Opens in a new window.
Research | 21 February 2018 | Open
Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy
- Rajani Ravi
- , Kimberly A. Noonan
- , Vui Pham
- , Rishi Bedi
- , Alex Zhavoronkov
- , Ivan V. Ozerov
- , Eugene Makarev
- , Artem V. Artemov
- , Piotr T. Wysocki
- , Ranee Mehra
- , Sridhar Nimmagadda
- , Luigi Marchionni
- , David Sidransky
- , Ivan M. Borrello
- , Evgeny Izumchenko
- & Atul Bedi
Nature Communications 9 , 1–14

Rights & permissionsfor article Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy . Opens in a new window.
Research | 4 May 2018 | Open
Cigarette smoke and chewing tobacco alter expression of different sets of miRNAs in oral keratinocytes
Scientific Reports 8 , 1–13

Rights & permissionsfor article Cigarette smoke and chewing tobacco alter expression of different sets of miRNAs in oral keratinocytes . Opens in a new window.
Research | 24 November 2017 | Open
NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis
- Suraj Peri
- , Evgeny Izumchenko
- , Adrian D. Schubert
- , Michael J. Slifker
- , Karen Ruth
- , Ilya G. Serebriiskii
- , Theresa Guo
- , Barbara A. Burtness
- , Ranee Mehra
- , Eric A. Ross
- , David Sidransky
- & Erica A. Golemis
Nature Communications 8 , 1–10

Rights & permissionsfor article <i>NSD1</i>- and <i>NSD2</i>-damaging mutations define a subset of laryngeal tumors with favorable prognosis . Opens in a new window.
24 January 2017 | Open
Comparative mutational landscape analysis of patient-derived tumour xenografts
- Mariana Brait
- , Evgeny Izumchenko
- , Luciane T Kagohara
- , Samuel Long
- , Piotr T Wysocki
- , Brian Faherty
- , Elana J Fertig
- , Tin Oo Khor
- , Elizabeth Bruckheimer
- , Gilson Baia
- , Daniel Ciznadija
- , Ido Sloma
- , Ido Ben-Zvi
- , Keren Paz
- & David Sidransky
British Journal of Cancer 116 , 515–523

Rights & permissionsfor article Comparative mutational landscape analysis of patient-derived tumour xenografts . Opens in a new window.
Research | 16 November 2016 | Open
In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development
- Ivan V. Ozerov
- , Ksenia V. Lezhnina
- , Evgeny Izumchenko
- , Artem V. Artemov
- , Sergey Medintsev
- , Quentin Vanhaelen
- , Alexander Aliper
- , Jan Vijg
- , Andreyan N. Osipov
- , Ivan Labat
- , Michael D. West
- , Anton Buzdin
- , Charles R. Cantor
- , Yuri Nikolsky
- , Nikolay Borisov
- , Irina Irincheeva
- , Edward Khokhlovich
- , David Sidransky
- , Miguel Luiz Camargo
- & Alex Zhavoronkov
Nature Communications 7 , 1–11

Rights & permissionsfor article <i>In silico</i> Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development . Opens in a new window.
Research | 31 October 2016 | Open
A dual specificity kinase, DYRK1A, as a potential therapeutic target for head and neck squamous cell carcinoma
Scientific Reports 6 , 1–13

Rights & permissionsfor article A dual specificity kinase, DYRK1A, as a potential therapeutic target for head and neck squamous cell carcinoma . Opens in a new window.
Research | 28 August 2015 | Open
An integrated genome-wide approach to discover deregulated microRNAs in non-small cell lung cancer: Clinical significance of miR-23b-3p deregulation
- Shahnaz Begum
- , Masamichi Hayashi
- , Takenori Ogawa
- , Fayez J. Jabboure
- , Mariana Brait
- , Evgeny Izumchenko
- , Sarit Tabak
- , Steven A. Ahrendt
- , William H. Westra
- , Wayne Koch
- , David Sidransky
- & Mohammad O. Hoque
Scientific Reports 5 , 1–16

Rights & permissionsfor article An integrated genome-wide approach to discover deregulated microRNAs in non-small cell lung cancer: Clinical significance of <i>miR-23b-3p</i> deregulation . Opens in a new window.
Research | 2 April 2015 | Open
Pathway activation strength is a novel independent prognostic biomarker for cetuximab sensitivity in colorectal cancer patients
- ...A research team led by David Sidransky from Johns Hopkins University School...
- Qingsong Zhu
- , Evgeny Izumchenko
- , Alexander M Aliper
- , Evgeny Makarev
- , Keren Paz
- , Anton A Buzdin
- , Alex A Zhavoronkov
- & David Sidransky
Human Genome Variation 2 , 1–9

Rights & permissionsfor article Pathway activation strength is a novel independent prognostic biomarker for cetuximab sensitivity in colorectal cancer patients . Opens in a new window.
Research | 16 September 2015 | Open
Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA
- Evgeny Izumchenko
- , Xiaofei Chang
- , Mariana Brait
- , Elana Fertig
- , Luciane T. Kagohara
- , Atul Bedi
- , Luigi Marchionni
- , Nishant Agrawal
- , Rajani Ravi
- , Sian Jones
- , Mohammad O. Hoque
- , William H. Westra
- & David Sidransky
Nature Communications 6 , 1–13

Rights & permissionsfor article Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA . Opens in a new window.
Reviews | 1 March 2002
Emerging molecular markers of cancer
- David Sidransky
Nature Reviews Cancer 2 , 210–219

Rights & permissionsfor article Emerging molecular markers of cancer . Opens in a new window.
25 April 2005
Oxidized guanine lesions and hOgg1 activity in lung cancer
Oncogene 24 , 4496–4508

Rights & permissionsfor article Oxidized guanine lesions and hOgg1 activity in lung cancer . Opens in a new window.
Research | 1 July 1995
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
- Adrian Merlo
- , James G. Herman
- , Li Mao
- , Daniel J. Lee
- , Edward Gabrielson
- , Peter C. Burger
- , Stephen B. Baylin
- & David Sidransky
Nature Medicine 1 , 686–692

Rights & permissionsfor article 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor <i>p16/CDKN2/MTS1</i> in human cancers . Opens in a new window.
Research | 14 March 2004
CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer
- Zhongmin Guo
- , Jürgen F. Linn
- , Guojun Wu
- , Sarah L Anzick
- , Claus F Eisenberger
- , Sarel Halachmi
- , Yoram Cohen
- , Alexey Fomenkov
- , Mohammad Obaidul Hoque
- , Kenji Okami
- , Gabriel Steiner
- , James M Engles
- , Motonabu Osada
- , Chulso Moon
- , Edward Ratovitski
- , Jeffrey M Trent
- , Paul S Meltzer
- , William H Westra
- , Lambertus A Kiemeney
- , Mark P Schoenberg
- , David Sidransky
- & Barry Trink
Nature Medicine 10 , 374–381

Rights & permissionsfor article <i>CDC91L1</i> (PIG-U) is a newly discovered oncogene in human bladder cancer . Opens in a new window.

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