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Research | 21 August 2020 | Open
Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer
- Emanuela Gadaleta
- , Pauline Fourgoux
- , Stefano Pirró
- , Graeme J. Thorn
- , Rachel Nelan
- , Alastair Ironside
- , Vinothini Rajeeve
- , Pedro R. Cutillas
- , Anna E. Lobley
- , Jun Wang
- , Esteban Gea
- , Helen Ross-Adams
- , Conrad Bessant
- , Nicholas R. Lemoine
- , Louise J. Jones
- & Claude Chelala
npj Breast Cancer 6 , 1–12

Rights & permissionsfor article Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer . Opens in a new window.
Research | 19 July 2019 | Open
SMAC, a computational system to link literature, biomedical and expression data
Scientific Reports 9 , 1–7

Rights & permissionsfor article SMAC, a computational system to link literature, biomedical and expression data . Opens in a new window.
Amendments and Corrections | 23 March 2019
Correction: Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma
- Shamzah Araf
- , Jun Wang
- , Koorosh Korfi
- , Celine Pangault
- , Eleni Kotsiou
- , Ana Rio-Machin
- , Tahrima Rahim
- , James Heward
- , Andrew Clear
- , Sameena Iqbal
- , Jeff K. Davies
- , Peter Johnson
- , Maria Calaminici
- , Silvia Montoto
- , Rebecca Auer
- , Claude Chelala
- , John G. Gribben
- , Trevor A. Graham
- , Thierry Fest
- , Jude Fitzgibbon
- & Jessica Okosun
Leukemia 33 , 1540–1540

Rights & permissionsfor article Correction: Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma . Opens in a new window.
Research | 8 February 2018 | Open
Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma
- Shamzah Araf
- , Jun Wang
- , Koorosh Korfi
- , Celine Pangault
- , Eleni Kotsiou
- , Ana Rio-Machin
- , Tahrima Rahim
- , James Heward
- , Andrew Clear
- , Sameena Iqbal
- , Jeff K. Davies
- , Peter Johnson
- , Maria Calaminici
- , Silvia Montoto
- , Rebecca Auer
- , Claude Chelala
- , John G. Gribben
- , Trevor A. Graham
- , Thierry Fest
- , Jude Fitzgibbon
- & Jessica Okosun
Leukemia 32 , 1261–1265

Rights & permissionsfor article Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma . Opens in a new window.
Research | 14 May 2018 | Open
MicroRNA and transcriptome analysis in periocular Sebaceous Gland Carcinoma
Scientific Reports 8 , 1–8

Rights & permissionsfor article MicroRNA and transcriptome analysis in periocular Sebaceous Gland Carcinoma . Opens in a new window.
17 May 2017
Recurrent somatic JAK-STAT pathway variants within a RUNX1-mutated pedigree
- Kiran Tawana
- , Jun Wang
- , Péter A Király
- , Krisztián Kállay
- , Gábor Benyó
- , Marianna Zombori
- , Judit Csomor
- , Ahad Al Seraihi
- , Ana Rio-Machin
- , András Matolcsy
- , Claude Chelala
- , Jamie Cavenagh
- , Jude Fitzgibbon
- & Csaba Bödör
European Journal of Human Genetics 25 , 1020–1024

Rights & permissionsfor article Recurrent somatic JAK-STAT pathway variants within a RUNX1-mutated pedigree . Opens in a new window.
Amendments and Corrections | 27 May 2016
Correction: Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
- Jessica Okosun
- , Rachel L Wolfson
- , Jun Wang
- , Shamzah Araf
- , Lucy Wilkins
- , Brian M Castellano
- , Leire Escudero-Ibarz
- , Ahad Fahad Al Seraihi
- , Julia Richter
- , Stephan H Bernhart
- , Alejo Efeyan
- , Sameena Iqbal
- , Janet Matthews
- , Andrew Clear
- , José Afonso Guerra-Assunção
- , Csaba Bödör
- , Hilmar Quentmeier
- , Christopher Mansbridge
- , Peter Johnson
- , Andrew Davies
- , Jonathan C Strefford
- , Graham Packham
- , Sharon Barrans
- , Andrew Jack
- , Ming-Qing Du
- , Maria Calaminici
- , T Andrew Lister
- , Rebecca Auer
- , Silvia Montoto
- , John G Gribben
- , Reiner Siebert
- , Claude Chelala
- , Roberto Zoncu
- , David M Sabatini
- & Jude Fitzgibbon
Nature Genetics 48 , 700–700

Rights & permissionsfor article Correction: Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma . Opens in a new window.
Research | 29 June 2016 | Open
Introducing SEARCHBreast: a virtual resource to facilitate sharing of surplus animal material developed for breast cancer research
- Bethny Morrissey
- , Ingunn Holen
- , Claude Chelala
- , Phil Carter
- , Louise Jones
- , Karen Blyth
- & Valerie Speirs
npj Breast Cancer 2 , 1–1

Rights & permissionsfor article Introducing SEARCHBreast: a virtual resource to facilitate sharing of surplus animal material developed for breast cancer research . Opens in a new window.
Research | 21 May 2006
Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism
- Valérie Senée
- , Claude Chelala
- , Sabine Duchatelet
- , Daorong Feng
- , Hervé Blanc
- , Jack-Christophe Cossec
- , Céline Charon
- , Marc Nicolino
- , Pascal Boileau
- , Douglas R Cavener
- , Pierre Bougnères
- , Doris Taha
- & Cécile Julier
Nature Genetics 38 , 682–687

Rights & permissionsfor article Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism . Opens in a new window.
Research | 6 February 2020 | Open
Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis
Nature Communications 11 , 1–15

Rights & permissionsfor article Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis . Opens in a new window.
Research | 22 October 2019 | Open
MLH1 deficiency leads to deregulated mitochondrial metabolism
- Sukaina Rashid
- , Marta O. Freitas
- , Danilo Cucchi
- , Gemma Bridge
- , Zhi Yao
- , Laura Gay
- , Marc Williams
- , Jun Wang
- , Nirosha Suraweera
- , Andrew Silver
- , Stuart A. C. McDonald
- , Claude Chelala
- , Gyorgy Szabadkai
- & Sarah A. Martin
Cell Death & Disease 10 , 1–11

Rights & permissionsfor article MLH1 deficiency leads to deregulated mitochondrial metabolism . Opens in a new window.
Research | 12 March 2019 | Open
Tumor microenvironment defines the invasive phenotype of AIP-mutation-positive pituitary tumors
- Sayka Barry
- , Eivind Carlsen
- , Pedro Marques
- , Craig E. Stiles
- , Emanuela Gadaleta
- , Dan M. Berney
- , Federico Roncaroli
- , Claude Chelala
- , Antonia Solomou
- , Maria Herincs
- , Francisca Caimari
- , Ashley B. Grossman
- , Tatjana Crnogorac-Jurcevic
- , Oliver Haworth
- , Carles Gaston-Massuet
- & Márta Korbonits
Oncogene 38 , 5381–5395

Rights & permissionsfor article Tumor microenvironment defines the invasive phenotype of AIP-mutation-positive pituitary tumors . Opens in a new window.
Research | 10 September 2018 | Open
The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature
- Gareth J. Inman
- , Jun Wang
- , Ai Nagano
- , Ludmil B. Alexandrov
- , Karin J. Purdie
- , Richard G. Taylor
- , Victoria Sherwood
- , Jason Thomson
- , Sarah Hogan
- , Lindsay C. Spender
- , Andrew P. South
- , Michael Stratton
- , Claude Chelala
- , Catherine A. Harwood
- , Charlotte M. Proby
- & Irene M. Leigh
Nature Communications 9 , 1–14

Rights & permissionsfor article The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature . Opens in a new window.
Research | 7 June 2017 | Open
Splice variants as novel targets in pancreatic ductal adenocarcinoma
- Jun Wang
- , Laurent Dumartin
- , Andrea Mafficini
- , Pinar Ulug
- , Ajanthah Sangaralingam
- , Namaa Audi Alamiry
- , Tomasz P. Radon
- , Roberto Salvia
- , Rita T. Lawlor
- , Nicholas R. Lemoine
- , Aldo Scarpa
- , Claude Chelala
- & Tatjana Crnogorac-Jurcevic
Scientific Reports 7 , 1–13

Rights & permissionsfor article Splice variants as novel targets in pancreatic ductal adenocarcinoma . Opens in a new window.
Research | 25 August 2016 | Open
Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma
- Patrizia Cammareri
- , Aidan M. Rose
- , David F. Vincent
- , Jun Wang
- , Ai Nagano
- , Silvana Libertini
- , Rachel A. Ridgway
- , Dimitris Athineos
- , Philip J. Coates
- , Angela McHugh
- , Celine Pourreyron
- , Jasbani H. S. Dayal
- , Jonas Larsson
- , Simone Weidlich
- , Lindsay C. Spender
- , Gopal P. Sapkota
- , Karin J. Purdie
- , Charlotte M. Proby
- , Catherine A. Harwood
- , Irene M. Leigh
- , Hans Clevers
- , Nick Barker
- , Stefan Karlsson
- , Catrin Pritchard
- , Richard Marais
- , Claude Chelala
- , Andrew P. South
- , Owen J. Sansom
- & Gareth J. Inman
Nature Communications 7 , 1–14

Rights & permissionsfor article Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma . Opens in a new window.
Research | 21 December 2015
Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
- Jessica Okosun
- , Rachel L Wolfson
- , Jun Wang
- , Shamzah Araf
- , Lucy Wilkins
- , Brian M Castellano
- , Leire Escudero-Ibarz
- , Ahad Fahad Al Seraihi
- , Julia Richter
- , Stephan H Bernhart
- , Alejo Efeyan
- , Sameena Iqbal
- , Janet Matthews
- , Andrew Clear
- , José Afonso Guerra-Assunção
- , Csaba Bödör
- , Hilmar Quentmeier
- , Christopher Mansbridge
- , Peter Johnson
- , Andrew Davies
- , Jonathan C Strefford
- , Graham Packham
- , Sharon Barrans
- , Andrew Jack
- , Ming-Qing Du
- , Maria Calaminici
- , T Andrew Lister
- , Rebecca Auer
- , Silvia Montoto
- , John G Gribben
- , Reiner Siebert
- , Claude Chelala
- , Roberto Zoncu
- , David M Sabatini
- & Jude Fitzgibbon
Nature Genetics 48 , 183–188

Rights & permissionsfor article Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma . Opens in a new window.
Research | 18 November 2016 | Open
Gene expression profiling of breast cancer in Lebanese women
- Joelle Makoukji
- , Nadine J. Makhoul
- , Maya Khalil
- , Sally El-Sitt
- , Ehab Saad Aldin
- , Mark Jabbour
- , Fouad Boulos
- , Emanuela Gadaleta
- , Ajanthah Sangaralingam
- , Claude Chelala
- , Rose-Mary Boustany
- & Arafat Tfayli
Scientific Reports 6 , 1–13

Rights & permissionsfor article Gene expression profiling of breast cancer in Lebanese women . Opens in a new window.
Research | 6 January 2017 | Open
Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate
Scientific Reports 7 , 1–17

Rights & permissionsfor article Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate . Opens in a new window.
Research | 17 November 2016 | Open
Exosomes derived from embryonal and alveolar rhabdomyosarcoma carry differential miRNA cargo and promote invasion of recipient fibroblasts
- Sandra E. Ghayad
- , Ghina Rammal
- , Farah Ghamloush
- , Hussein Basma
- , Rihab Nasr
- , Mona Diab-Assaf
- , Claude Chelala
- & Raya Saab
Scientific Reports 6 , 1–15

Rights & permissionsfor article Exosomes derived from embryonal and alveolar rhabdomyosarcoma carry differential miRNA cargo and promote invasion of recipient fibroblasts . Opens in a new window.
Research | 22 December 2013
Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma
- Jessica Okosun
- , Csaba Bödör
- , Jun Wang
- , Shamzah Araf
- , Cheng-Yuan Yang
- , Chenyi Pan
- , Sören Boller
- , Davide Cittaro
- , Monika Bozek
- , Sameena Iqbal
- , Janet Matthews
- , David Wrench
- , Jacek Marzec
- , Kiran Tawana
- , Nikolay Popov
- , Ciaran O'Riain
- , Derville O'Shea
- , Emanuela Carlotti
- , Andrew Davies
- , Charles H Lawrie
- , András Matolcsy
- , Maria Calaminici
- , Andrew Norton
- , Richard J Byers
- , Charles Mein
- , Elia Stupka
- , T Andrew Lister
- , Georg Lenz
- , Silvia Montoto
- , John G Gribben
- , Yuhong Fan
- , Rudolf Grosschedl
- , Claude Chelala
- & Jude Fitzgibbon
Nature Genetics 46 , 176–181

Rights & permissionsfor article Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma . Opens in a new window.

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Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer

SMAC, a computational system to link literature, biomedical and expression data

Correction: Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma

Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma

MicroRNA and transcriptome analysis in periocular Sebaceous Gland Carcinoma

Recurrent somatic JAK-STAT pathway variants within a RUNX1-mutated pedigree

Correction: Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma

Introducing SEARCHBreast: a virtual resource to facilitate sharing of surplus animal material developed for breast cancer research

Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism

Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis

MLH1 deficiency leads to deregulated mitochondrial metabolism

Tumor microenvironment defines the invasive phenotype of AIP-mutation-positive pituitary tumors

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

Splice variants as novel targets in pancreatic ductal adenocarcinoma

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma

Gene expression profiling of breast cancer in Lebanese women

Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate

Exosomes derived from embryonal and alveolar rhabdomyosarcoma carry differential miRNA cargo and promote invasion of recipient fibroblasts

Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma

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