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Research |
Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale
- Xihao Li
- , Zilin Li
- , Hufeng Zhou
- , Sheila M. Gaynor
- , Yaowu Liu
- , Han Chen
- , Ryan Sun
- , Rounak Dey
- , Donna K. Arnett
- , Stella Aslibekyan
- , Christie M. Ballantyne
- , Lawrence F. Bielak
- , John Blangero
- , Eric Boerwinkle
- , Donald W. Bowden
- , Jai G. Broome
- , Matthew P. Conomos
- , Adolfo Correa
- , L. Adrienne Cupples
- , Joanne E. Curran
- , Barry I. Freedman
- , Xiuqing Guo
- , George Hindy
- , Marguerite R. Irvin
- , Sharon L. R. Kardia
- , Sekar Kathiresan
- , Alyna T. Khan
- , Charles L. Kooperberg
- , Cathy C. Laurie
- , X. Shirley Liu
- , Michael C. Mahaney
- , Ani W. Manichaikul
- , Lisa W. Martin
- , Rasika A. Mathias
- , Stephen T. McGarvey
- , Braxton D. Mitchell
- , May E. Montasser
- , Jill E. Moore
- , Alanna C. Morrison
- , Jeffrey R. O’Connell
- , Nicholette D. Palmer
- , Akhil Pampana
- , Juan M. Peralta
- , Patricia A. Peyser
- , Bruce M. Psaty
- , Susan Redline
- , Kenneth M. Rice
- , Stephen S. Rich
- , Jennifer A. Smith
- , Hemant K. Tiwari
- , Michael Y. Tsai
- , Ramachandran S. Vasan
- , Fei Fei Wang
- , Daniel E. Weeks
- , Zhiping Weng
- , James G. Wilson
- , Lisa R. Yanek
- , Namiko Abe
- , Gonçalo R. Abecasis
- , Francois Aguet
- , Christine Albert
- , Laura Almasy
- , Alvaro Alonso
- , Seth Ament
- , Peter Anderson
- , Pramod Anugu
- , Deborah Applebaum-Bowden
- , Kristin Ardlie
- , Dan Arking
- , Donna K. Arnett
- , Allison Ashley-Koch
- , Stella Aslibekyan
- , Tim Assimes
- , Paul Auer
- , Dimitrios Avramopoulos
- , John Barnard
- , Kathleen Barnes
- , R. Graham Barr
- , Emily Barron-Casella
- , Lucas Barwick
- , Terri Beaty
- , Gerald Beck
- , Diane Becker
- , Lewis Becker
- , Rebecca Beer
- , Amber Beitelshees
- , Emelia Benjamin
- , Takis Benos
- , Marcos Bezerra
- , Lawrence F. Bielak
- , Joshua Bis
- , Thomas Blackwell
- , John Blangero
- , Eric Boerwinkle
- , Donald W. Bowden
- , Russell Bowler
- , Jennifer Brody
- , Ulrich Broeckel
- , Jai G. Broome
- , Karen Bunting
- , Esteban Burchard
- , Carlos Bustamante
- , Erin Buth
- , Brian Cade
- , Jonathan Cardwell
- , Vincent Carey
- , Cara Carty
- , Richard Casaburi
- , James Casella
- , Peter Castaldi
- , Mark Chaffin
- , Christy Chang
- , Yi-Cheng Chang
- , Daniel Chasman
- , Sameer Chavan
- , Bo-Juen Chen
- , Wei-Min Chen
- , Yii-Der Ida Chen
- , Michael Cho
- , Seung Hoan Choi
- , Lee-Ming Chuang
- , Mina Chung
- , Ren-Hua Chung
- , Clary Clish
- , Suzy Comhair
- , Matthew P. Conomos
- , Elaine Cornell
- , Adolfo Correa
- , Carolyn Crandall
- , James Crapo
- , L. Adrienne Cupples
- , Joanne E. Curran
- , Jeffrey Curtis
- , Brian Custer
- , Coleen Damcott
- , Dawood Darbar
- , Sayantan Das
- , Sean David
- , Colleen Davis
- , Michelle Daya
- , Mariza de Andrade
- , Lisa de las Fuentes
- , Michael DeBaun
- , Ranjan Deka
- , Dawn DeMeo
- , Scott Devine
- , Qing Duan
- , Ravi Duggirala
- , Jon Peter Durda
- , Susan Dutcher
- , Charles Eaton
- , Lynette Ekunwe
- , Adel El Boueiz
- , Patrick Ellinor
- , Leslie Emery
- , Serpil Erzurum
- , Charles Farber
- , Tasha Fingerlin
- , Matthew Flickinger
- , Myriam Fornage
- , Nora Franceschini
- , Chris Frazar
- , Mao Fu
- , Stephanie M. Fullerton
- , Lucinda Fulton
- , Stacey Gabriel
- , Weiniu Gan
- , Shanshan Gao
- , Yan Gao
- , Margery Gass
- , Bruce Gelb
- , Xiaoqi (Priscilla) Geng
- , Mark Geraci
- , Soren Germer
- , Robert Gerszten
- , Auyon Ghosh
- , Richard Gibbs
- , Chris Gignoux
- , Mark Gladwin
- , David Glahn
- , Stephanie Gogarten
- , Da-Wei Gong
- , Harald Goring
- , Sharon Graw
- , Daniel Grine
- , C. Charles Gu
- , Yue Guan
- , Xiuqing Guo
- , Namrata Gupta
- , Jeff Haessler
- , Michael Hall
- , Daniel Harris
- , Nicola L. Hawley
- , Jiang He
- , Susan Heckbert
- , Ryan Hernandez
- , David Herrington
- , Craig Hersh
- , Bertha Hidalgo
- , James Hixson
- , Brian Hobbs
- , John Hokanson
- , Elliott Hong
- , Karin Hoth
- , Chao (Agnes) Hsiung
- , Yi-Jen Hung
- , Haley Huston
- , Chii Min Hwu
- , Marguerite R. Irvin
- , Rebecca Jackson
- , Deepti Jain
- , Cashell Jaquish
- , Min A. Jhun
- , Jill Johnsen
- , Andrew Johnson
- , Craig Johnson
- , Rich Johnston
- , Kimberly Jones
- , Hyun Min Kang
- , Robert Kaplan
- , Sharon L. R. Kardia
- , Sekar Kathiresan
- , Shannon Kelly
- , Eimear Kenny
- , Michael Kessler
- , Alyna T. Khan
- , Wonji Kim
- , Greg Kinney
- , Barbara Konkle
- , Charles L. Kooperberg
- , Holly Kramer
- , Christoph Lange
- , Ethan Lange
- , Leslie Lange
- , Cathy C. Laurie
- , Cecelia Laurie
- , Meryl LeBoff
- , Jiwon Lee
- , Seunggeun Shawn Lee
- , Wen-Jane Lee
- , Jonathon LeFaive
- , David Levine
- , Dan Levy
- , Joshua Lewis
- , Xiaohui Li
- , Yun Li
- , Henry Lin
- , Honghuang Lin
- , Keng Han Lin
- , Xihong Lin
- , Simin Liu
- , Yongmei Liu
- , Yu Liu
- , Ruth J. F. Loos
- , Steven Lubitz
- , Kathryn Lunetta
- , James Luo
- , Michael C. Mahaney
- , Barry Make
- , Ani W. Manichaikul
- , JoAnn Manson
- , Lauren Margolin
- , Lisa W. Martin
- , Susan Mathai
- , Rasika A. Mathias
- , Susanne May
- , Patrick McArdle
- , Merry-Lynn McDonald
- , Sean McFarland
- , Stephen T. McGarvey
- , Daniel McGoldrick
- , Caitlin McHugh
- , Hao Mei
- , Luisa Mestroni
- , Deborah A. Meyers
- , Julie Mikulla
- , Nancy Min
- , Mollie Minear
- , Ryan L. Minster
- , Braxton D. Mitchell
- , Matt Moll
- , May E. Montasser
- , Courtney Montgomery
- , Arden Moscati
- , Solomon Musani
- , Stanford Mwasongwe
- , Josyf C. Mychaleckyj
- , Girish Nadkarni
- , Rakhi Naik
- , Take Naseri
- , Pradeep Natarajan
- , Sergei Nekhai
- , Sarah C. Nelson
- , Bonnie Neltner
- , Deborah Nickerson
- , Kari North
- , Jeffrey R. O’Connell
- , Tim O’Connor
- , Heather Ochs-Balcom
- , David Paik
- , Nicholette D. Palmer
- , James Pankow
- , George Papanicolaou
- , Afshin Parsa
- , Juan M. Peralta
- , Marco Perez
- , James Perry
- , Ulrike Peters
- , Patricia A. Peyser
- , Lawrence S. Phillips
- , Toni Pollin
- , Wendy Post
- , Julia Powers Becker
- , Meher Preethi Boorgula
- , Michael Preuss
- , Bruce M. Psaty
- , Pankaj Qasba
- , Dandi Qiao
- , Zhaohui Qin
- , Nicholas Rafaels
- , Laura Raffield
- , Ramachandran S. Vasan
- , D. C. Rao
- , Laura Rasmussen-Torvik
- , Aakrosh Ratan
- , Susan Redline
- , Robert Reed
- , Elizabeth Regan
- , Alex Reiner
- , Muagututi‘a Sefuiva Reupena
- , Kenneth M. Rice
- , Stephen S. Rich
- , Dan Roden
- , Carolina Roselli
- , Jerome I. Rotter
- , Ingo Ruczinski
- , Pamela Russell
- , Sarah Ruuska
- , Kathleen Ryan
- , Ester Cerdeira Sabino
- , Danish Saleheen
- , Shabnam Salimi
- , Steven Salzberg
- , Kevin Sandow
- , Vijay G. Sankaran
- , Christopher Scheller
- , Ellen Schmidt
- , Karen Schwander
- , David Schwartz
- , Frank Sciurba
- , Christine Seidman
- , Jonathan Seidman
- , Vivien Sheehan
- , Stephanie L. Sherman
- , Amol Shetty
- , Aniket Shetty
- , Wayne Hui-Heng Sheu
- , M. Benjamin Shoemaker
- , Brian Silver
- , Edwin Silverman
- , Jennifer A. Smith
- , Josh Smith
- , Nicholas Smith
- , Tanja Smith
- , Sylvia Smoller
- , Beverly Snively
- , Michael Snyder
- , Tamar Sofer
- , Nona Sotoodehnia
- , Adrienne M. Stilp
- , Garrett Storm
- , Elizabeth Streeten
- , Jessica Lasky Su
- , Yun Ju Sung
- , Jody Sylvia
- , Adam Szpiro
- , Carole Sztalryd
- , Daniel Taliun
- , Hua Tang
- , Margaret Taub
- , Kent D. Taylor
- , Matthew Taylor
- , Simeon Taylor
- , Marilyn Telen
- , Timothy A. Thornton
- , Machiko Threlkeld
- , Lesley Tinker
- , David Tirschwell
- , Sarah Tishkoff
- , Hemant K. Tiwari
- , Catherine Tong
- , Russell Tracy
- , Michael Y. Tsai
- , Dhananjay Vaidya
- , David Van Den Berg
- , Peter VandeHaar
- , Scott Vrieze
- , Tarik Walker
- , Robert Wallace
- , Avram Walts
- , Fei Fei Wang
- , Heming Wang
- , Karol Watson
- , Daniel E. Weeks
- , Bruce Weir
- , Scott Weiss
- , Lu-Chen Weng
- , Jennifer Wessel
- , Cristen J. Willer
- , Kayleen Williams
- , L. Keoki Williams
- , Carla Wilson
- , James G. Wilson
- , Quenna Wong
- , Joseph Wu
- , Huichun Xu
- , Lisa R. Yanek
- , Ivana Yang
- , Rongze Yang
- , Norann Zaghloul
- , Maryam Zekavat
- , Yingze Zhang
- , Snow Xueyan Zhao
- , Wei Zhao
- , Degui Zhi
- , Xiang Zhou
- , Xiaofeng Zhu
- , Michael Zody
- , Sebastian Zoellner
- , Moustafa Abdalla
- , Gonçalo R. Abecasis
- , Donna K. Arnett
- , Stella Aslibekyan
- , Tim Assimes
- , Elizabeth Atkinson
- , Christie M. Ballantyne
- , Amber Beitelshees
- , Lawrence F. Bielak
- , Joshua Bis
- , Corneliu Bodea
- , Eric Boerwinkle
- , Donald W. Bowden
- , Jennifer Brody
- , Brian Cade
- , Jenna Carlson
- , I-Shou Chang
- , Yii-Der Ida Chen
- , Sung Chun
- , Ren-Hua Chung
- , Matthew P. Conomos
- , Adolfo Correa
- , L. Adrienne Cupples
- , Coleen Damcott
- , Paul de Vries
- , Ron Do
- , Amanda Elliott
- , Mao Fu
- , Andrea Ganna
- , Da-Wei Gong
- , Sarah Graham
- , Mary Haas
- , Bernhard Haring
- , Jiang He
- , Susan Heckbert
- , Blanca Himes
- , James Hixson
- , Marguerite R. Irvin
- , Deepti Jain
- , Gail Jarvik
- , Min A. Jhun
- , Jicai Jiang
- , Goo Jun
- , Rita Kalyani
- , Sharon L. R. Kardia
- , Sekar Kathiresan
- , Amit Khera
- , Derek Klarin
- , Charles L. Kooperberg
- , Brian Kral
- , Leslie Lange
- , Cathy C. Laurie
- , Cecelia Laurie
- , Rozenn Lemaitre
- , Zilin Li
- , Xihao Li
- , Xihong Lin
- , Michael C. Mahaney
- , Ani W. Manichaikul
- , Lisa W. Martin
- , Rasika A. Mathias
- , Ravi Mathur
- , Stephen T. McGarvey
- , Caitlin McHugh
- , John McLenithan
- , Julie Mikulla
- , Braxton D. Mitchell
- , May E. Montasser
- , Andrew Moran
- , Alanna C. Morrison
- , Tetsushi Nakao
- , Pradeep Natarajan
- , Deborah Nickerson
- , Kari North
- , Jeffrey R. O’Connell
- , Christopher O’Donnell
- , Nicholette D. Palmer
- , Akhil Pampana
- , Aniruddh Patel
- , Gina M. Peloso
- , James Perry
- , Ulrike Peters
- , Patricia A. Peyser
- , James Pirruccello
- , Toni Pollin
- , Michael Preuss
- , Bruce M. Psaty
- , D. C. Rao
- , Susan Redline
- , Robert Reed
- , Alex Reiner
- , Stephen S. Rich
- , Samantha Rosenthal
- , Jerome I. Rotter
- , Jenny Schoenberg
- , Margaret Sunitha Selvaraj
- , Wayne Hui-Heng Sheu
- , Jennifer A. Smith
- , Tamar Sofer
- , Adrienne M. Stilp
- , Shamil R. Sunyaev
- , Ida Surakka
- , Carole Sztalryd
- , Hua Tang
- , Kent D. Taylor
- , Michael Y. Tsai
- , Md Mesbah Uddin
- , Sarah Urbut
- , Marie Verbanck
- , Ann Von Holle
- , Heming Wang
- , Fei Fei Wang
- , Kerri Wiggins
- , Cristen J. Willer
- , James G. Wilson
- , Brooke Wolford
- , Huichun Xu
- , Lisa R. Yanek
- , Norann Zaghloul
- , Maryam Zekavat
- , Jingwen Zhang
- , Benjamin M. Neale
- , Shamil R. Sunyaev
- , Gonçalo R. Abecasis
- , Jerome I. Rotter
- , Cristen J. Willer
- , Gina M. Peloso
- , Pradeep Natarajan
- & Xihong Lin
-
Amendments and Corrections |
Erratum: Genome-wide association studies identify genetic loci for low von Willebrand factor levels
- Janine van Loon
- , Abbas Dehghan
- , Tang Weihong
- , Stella Trompet
- , Wendy L McArdle
- , Folkert W Asselbergs
- , Ming-Huei Chen
- , Lorna M Lopez
- , Jennifer E Huffman
- , Frank W G Leebeek
- , Saonli Basu
- , David J Stott
- , Ann Rumley
- , Ron T Gansevoort
- , Gail Davies
- , James J F Wilson
- , Jacqueline C M Witteman
- , Xiting Cao
- , Anton J M de Craen
- , Stephan J L Bakker
- , Bruce M Psaty
- , John M Starr
- , Albert Hofman
- , J Wouter Jukema
- , Ian J Deary
- , Caroline Hayward
- , Pim van der Harst
- , Gordon D O Lowe
- , Aaron R Folsom
- , David P Strachan
- , Nicolas Smith
- , Moniek P M de Maat
- & Christopher O'Donnell
-
Research |
Genome-wide association studies identify genetic loci for low von Willebrand factor levels
- Janine van Loon
- , Abbas Dehghan
- , Tang Weihong
- , Stella Trompet
- , Wendy L McArdle
- , Folkert F W Asselbergs
- , Ming-Huei Chen
- , Lorna M Lopez
- , Jennifer E Huffman
- , Frank W G Leebeek
- , Saonli Basu
- , David J Stott
- , Ann Rumley
- , Ron T Gansevoort
- , Gail Davies
- , James J F Wilson
- , Jacqueline C M Witteman
- , Xiting Cao
- , Anton J M de Craen
- , Stephan J L Bakker
- , Bruce M Psaty
- , John M Starr
- , Albert Hofman
- , J Wouter Jukema
- , Ian J Deary
- , Caroline Hayward
- , Pim van der Harst
- , Gordon D O Lowe
- , Aaron R Folsom
- , David P Strachan
- , Nicolas Smith
- , Moniek P M de Maat
- & Christopher O'Donnell
-
Protocols |
High-throughput phenotyping with electronic medical record data using a common semi-supervised approach (PheCAP)
- Yichi Zhang
- , Tianrun Cai
- , Sheng Yu
- , Kelly Cho
- , Chuan Hong
- , Jiehuan Sun
- , Jie Huang
- , Yuk-Lam Ho
- , Ashwin N. Ananthakrishnan
- , Zongqi Xia
- , Stanley Y. Shaw
- , Vivian Gainer
- , Victor Castro
- , Nicholas Link
- , Jacqueline Honerlaw
- , Sicong Huang
- , David Gagnon
- , Elizabeth W. Karlson
- , Robert M. Plenge
- , Peter Szolovits
- , Guergana Savova
- , Susanne Churchill
- , Christopher O’Donnell
- , Shawn N. Murphy
- , J. Michael Gaziano
- , Isaac Kohane
- , Tianxi Cai
- & Katherine P. Liao
-
Research |
Large-scale association analysis identifies new risk loci for coronary artery disease
- Panos Deloukas
- , Stavroula Kanoni
- , Christina Willenborg
- , Martin Farrall
- , Themistocles L Assimes
- , John R Thompson
- , Erik Ingelsson
- , Danish Saleheen
- , Jeanette Erdmann
- , Benjamin A Goldstein
- , Kathleen Stirrups
- , Inke R König
- , Jean-Baptiste Cazier
- , Åsa Johansson
- , Alistair S Hall
- , Jong-Young Lee
- , Cristen J Willer
- , John C Chambers
- , Tõnu Esko
- , Lasse Folkersen
- , Anuj Goel
- , Elin Grundberg
- , Aki S Havulinna
- , Weang K Ho
- , Jemma C Hopewell
- , Niclas Eriksson
- , Marcus E Kleber
- , Kati Kristiansson
- , Per Lundmark
- , Leo-Pekka Lyytikäinen
- , Suzanne Rafelt
- , Dmitry Shungin
- , Rona J Strawbridge
- , Gudmar Thorleifsson
- , Emmi Tikkanen
- , Natalie Van Zuydam
- , Benjamin F Voight
- , Lindsay L Waite
- , Weihua Zhang
- , Andreas Ziegler
- , Devin Absher
- , David Altshuler
- , Anthony J Balmforth
- , Inês Barroso
- , Peter S Braund
- , Christof Burgdorf
- , Simone Claudi-Boehm
- , David Cox
- , Maria Dimitriou
- , Ron Do
- , Alex S F Doney
- , NourEddine El Mokhtari
- , Per Eriksson
- , Krista Fischer
- , Pierre Fontanillas
- , Anders Franco-Cereceda
- , Bruna Gigante
- , Leif Groop
- , Stefan Gustafsson
- , Jörg Hager
- , Göran Hallmans
- , Bok-Ghee Han
- , Sarah E Hunt
- , Hyun M Kang
- , Thomas Illig
- , Thorsten Kessler
- , Joshua W Knowles
- , Genovefa Kolovou
- , Johanna Kuusisto
- , Claudia Langenberg
- , Cordelia Langford
- , Karin Leander
- , Marja-Liisa Lokki
- , Anders Lundmark
- , Mark I McCarthy
- , Christa Meisinger
- , Olle Melander
- , Evelin Mihailov
- , Seraya Maouche
- , Andrew D Morris
- , Martina Müller-Nurasyid
- , Kjell Nikus
- , John F Peden
- , N William Rayner
- , Asif Rasheed
- , Silke Rosinger
- , Diana Rubin
- , Moritz P Rumpf
- , Arne Schäfer
- , Mohan Sivananthan
- , Ci Song
- , Alexandre F R Stewart
- , Sian-Tsung Tan
- , Gudmundur Thorgeirsson
- , C Ellen van der Schoot
- , Peter J Wagner
- , George A Wells
- , Philipp S Wild
- , Tsun-Po Yang
- , Philippe Amouyel
- , Dominique Arveiler
- , Hanneke Basart
- , Michael Boehnke
- , Eric Boerwinkle
- , Paolo Brambilla
- , Francois Cambien
- , Adrienne L Cupples
- , Ulf de Faire
- , Abbas Dehghan
- , Patrick Diemert
- , Stephen E Epstein
- , Alun Evans
- , Marco M Ferrario
- , Jean Ferrières
- , Dominique Gauguier
- , Alan S Go
- , Alison H Goodall
- , Villi Gudnason
- , Stanley L Hazen
- , Hilma Holm
- , Carlos Iribarren
- , Yangsoo Jang
- , Mika Kähönen
- , Frank Kee
- , Hyo-Soo Kim
- , Norman Klopp
- , Wolfgang Koenig
- , Wolfgang Kratzer
- , Kari Kuulasmaa
- , Markku Laakso
- , Reijo Laaksonen
- , Ji-Young Lee
- , Lars Lind
- , Willem H Ouwehand
- , Sarah Parish
- , Jeong E Park
- , Nancy L Pedersen
- , Annette Peters
- , Thomas Quertermous
- , Daniel J Rader
- , Veikko Salomaa
- , Eric Schadt
- , Svati H Shah
- , Juha Sinisalo
- , Klaus Stark
- , Kari Stefansson
- , David-Alexandre Trégouët
- , Jarmo Virtamo
- , Lars Wallentin
- , Nicholas Wareham
- , Martina E Zimmermann
- , Markku S Nieminen
- , Christian Hengstenberg
- , Manjinder S Sandhu
- , Tomi Pastinen
- , Ann-Christine Syvänen
- , G Kees Hovingh
- , George Dedoussis
- , Paul W Franks
- , Terho Lehtimäki
- , Andres Metspalu
- , Pierre A Zalloua
- , Agneta Siegbahn
- , Stefan Schreiber
- , Samuli Ripatti
- , Stefan S Blankenberg
- , Markus Perola
- , Robert Clarke
- , Bernhard O Boehm
- , Christopher O'Donnell
- , Muredach P Reilly
- , Winfried März
- , Rory Collins
- , Sekar Kathiresan
- , Anders Hamsten
- , Jaspal S Kooner
- , Unnur Thorsteinsdottir
- , John Danesh
- , Colin N A Palmer
- , Robert Roberts
- , Hugh Watkins
- , Heribert Schunkert
- & Nilesh J Samani
