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Amendments and Corrections | 21 February 2008
Erratum: Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA
- Di Yu
- , Andy Hee-Meng Tan
- , Xin Hu
- , Vicki Athanasopoulos
- , Nicholas Simpson
- , Diego G. Silva
- , Andreas Hutloff
- , Keith M. Giles
- , Peter J. Leedman
- , Kong Peng Lam
- , Christopher C. Goodnow
- & Carola G. Vinuesa
Nature 451 , 1022–1022

Rights & permissionsfor article Erratum: Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA . Opens in a new window.
Amendments and Corrections | 1 January 2010
Correction: Corrigendum: Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection
- Andy L Johnson
- , L Aravind
- , Natalia Shulzhenko
- , Andre Morgun
- , See-Young Choi
- , Tanya L Crockford
- , Teresa Lambe
- , Heather Domaschenz
- , Edyta M Kucharska
- , Lixin Zheng
- , Carola G Vinuesa
- , Michael J Lenardo
- , Christopher C Goodnow
- , Richard J Cornall
- & Ronald H Schwartz
Nature Immunology 11 , 97–97

Rights & permissionsfor article Correction: Corrigendum: <i>Themis</i> is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection . Opens in a new window.
Research | 17 July 1997
Differential activation of transcription factors induced by Ca²⁺ response amplitude and duration
Nature 388 , 308–308

Rights & permissionsfor article Differential activation of transcription factors induced by Ca<sup>2+</sup> response amplitude and duration . Opens in a new window.
Amendments and Corrections | 21 September 2000
Erratum: How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis
Nature 407 , 413–413

Rights & permissionsfor article Erratum: How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis . Opens in a new window.
Amendments and Corrections | 13 January 2016
Erratum: Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation
- Ingrid E. Wertz
- , Kim Newton
- , Dhaya Seshasayee
- , Saritha Kusam
- , Cynthia Lam
- , Juan Zhang
- , Nataliya Popovych
- , Elizabeth Helgason
- , Allyn Schoeffler
- , Surinder Jeet
- , Nandhini Ramamoorthi
- , Lorna Kategaya
- , Robert J. Newman
- , Keisuke Horikawa
- , Debra Dugger
- , Wendy Sandoval
- , Susmith Mukund
- , Anuradha Zindal
- , Flavius Martin
- , Clifford Quan
- , Jeffrey Tom
- , Wayne J. Fairbrother
- , Michael Townsend
- , Søren Warming
- , Jason DeVoss
- , Jinfeng Liu
- , Erin Dueber
- , Patrick Caplazi
- , Wyne P. Lee
- , Christopher C. Goodnow
- , Mercedesz Balazs
- , Kebing Yu
- , Ganesh Kolumam
- & Vishva M. Dixit
Nature 532 , 402–402

Rights & permissionsfor article Erratum: Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation . Opens in a new window.
Research | 16 April 2015 | Open
A deleterious RNF43 germline mutation in a severely affected serrated polyposis kindred
- Douglas Taupin
- , Wesley Lam
- , David Rangiah
- , Larissa McCallum
- , Belinda Whittle
- , Yafei Zhang
- , Daniel Andrews
- , Matthew Field
- , Christopher C Goodnow
- & Matthew C Cook
Human Genome Variation 2 , 1–3

Rights & permissionsfor article A deleterious <i>RNF43</i> germline mutation in a severely affected serrated polyposis kindred . Opens in a new window.
News and Views | 11 April 2002
DNA drives autoimmunity
- Carola G. Vinuesa
- & Christopher C. Goodnow
Nature 416 , 595–597

Rights & permissionsfor article DNA drives autoimmunity . Opens in a new window.
Amendments and Corrections | 1 July 2010
Correction: Corrigendum: Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production
- Katrina L Randall
- , Teresa Lambe
- , Andy Johnson
- , Bebhinn Treanor
- , Edyta Kucharska
- , Heather Domaschenz
- , Belinda Whittle
- , Lina E Tze
- , Anselm Enders
- , Tanya L Crockford
- , Tiphaine Bouriez-Jones
- , Duncan Alston
- , Jason G Cyster
- , Michael J Lenardo
- , Fabienne Mackay
- , Elissa K Deenick
- , Stuart G Tangye
- , Tyani D Chan
- , Tahra Camidge
- , Robert Brink
- , Carola G Vinuesa
- , Facundo D Batista
- , Richard J Cornall
- & Christopher C Goodnow
Nature Immunology 11 , 644–644

Rights & permissionsfor article Correction: Corrigendum: <i>Dock8</i> mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production . Opens in a new window.
Research | 15 February 2001
A genomic view of immunology
Nature 409 , 836–838

Rights & permissionsfor article A genomic view of immunology . Opens in a new window.
Research | 13 July 1995
CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4⁺T cells
Nature 376 , 181–184

Rights & permissionsfor article CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4<sup>+</sup>T cells . Opens in a new window.
Research | 3 March 2003
Aire regulates negative selection of organ-specific T cells
Nature Immunology 4 , 350–354

Rights & permissionsfor article Aire regulates negative selection of organ-specific T cells . Opens in a new window.
Research | 23 May 1996
Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45
Nature 381 , 325–328

Rights & permissionsfor article Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45 . Opens in a new window.
Research | 8 August 1991
Breakdown of self-tolerance in anergic B lymphocytes
Nature 352 , 532–536

Rights & permissionsfor article Breakdown of self-tolerance in anergic B lymphocytes . Opens in a new window.
Research | 25 May 1995
Antigen-induced B-cell death and elimination during germinal-centre immune responses
- Kevan M. Shokat
- & Christopher C. Goodnow
Nature 375 , 334–338

Rights & permissionsfor article Antigen-induced B-cell death and elimination during germinal-centre immune responses . Opens in a new window.
Research | 10 February 2000
How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis
Nature 403 , 672–676

Rights & permissionsfor article How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis . Opens in a new window.
Research | 24 April 1997
Differential activation of transcription factors induced by Ca²⁺ response amplitude and duration
Nature 386 , 855–858

Rights & permissionsfor article Differential activation of transcription factors induced by Ca<sup>2+</sup> response amplitude and duration . Opens in a new window.
Research | 14 February 2008
Two levels of protection for the B cell genome during somatic hypermutation
Nature 451 , 841–845

Rights & permissionsfor article Two levels of protection for the B cell genome during somatic hypermutation . Opens in a new window.
Research | 24 October 1991
Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens
Nature 353 , 765–769

Rights & permissionsfor article Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens . Opens in a new window.
Research | 8 November 2007
Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA
- Di Yu
- , Andy Hee-Meng Tan
- , Xin Hu
- , Vicki Athanasopoulos
- , Nicholas Simpson
- , Diego G. Silva
- , Andreas Hutloff
- , Keith M. Giles
- , Peter J. Leedman
- , Kong Peng Lam
- , Christopher C. Goodnow
- & Carola G. Vinuesa
Nature 450 , 299–303

Rights & permissionsfor article Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA . Opens in a new window.
Research | 18 September 2019
Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity
- Nathan W. Zammit
- , Owen M. Siggs
- , Paul E. Gray
- , Keisuke Horikawa
- , David B. Langley
- , Stacey N. Walters
- , Stephen R. Daley
- , Claudia Loetsch
- , Joanna Warren
- , Jin Yan Yap
- , Daniele Cultrone
- , Amanda Russell
- , Elisabeth K. Malle
- , Jeanette E. Villanueva
- , Mark J. Cowley
- , Velimir Gayevskiy
- , Marcel E. Dinger
- , Robert Brink
- , David Zahra
- , Geeta Chaudhri
- , Gunasegaran Karupiah
- , Belinda Whittle
- , Carla Roots
- , Edward Bertram
- , Michiko Yamada
- , Yogesh Jeelall
- , Anselm Enders
- , Benjamin E. Clifton
- , Peter D. Mabbitt
- , Colin J. Jackson
- , Susan R. Watson
- , Craig N. Jenne
- , Lewis L. Lanier
- , Tim Wiltshire
- , Matthew H. Spitzer
- , Garry P. Nolan
- , Frank Schmitz
- , Alan Aderem
- , Benjamin T. Porebski
- , Ashley M. Buckle
- , Derek W. Abbott
- , John B. Ziegler
- , Maria E. Craig
- , Paul Benitez-Aguirre
- , Juliana Teo
- , Stuart G. Tangye
- , Cecile King
- , Melanie Wong
- , Murray P. Cox
- , Wilson Phung
- , Jia Tang
- , Wendy Sandoval
- , Ingrid E. Wertz
- , Daniel Christ
- , Christopher C. Goodnow
- & Shane T. Grey
Nature Immunology 20 , 1299–1310

Rights & permissionsfor article Denisovan, modern human and mouse <i>TNFAIP3</i> alleles tune A20 phosphorylation and immunity . Opens in a new window.
Research | 16 July 2019 | Open
High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes
- Mandeep Singh
- , Ghamdan Al-Eryani
- , Shaun Carswell
- , James M. Ferguson
- , James Blackburn
- , Kirston Barton
- , Daniel Roden
- , Fabio Luciani
- , Tri Giang Phan
- , Simon Junankar
- , Katherine Jackson
- , Christopher C. Goodnow
- , Martin A. Smith
- & Alexander Swarbrick
Nature Communications 10 , 1–13

Rights & permissionsfor article High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes . Opens in a new window.
Research | 24 April 2019
Deletion of self-reactive CCR7– thymocytes in the absence of MHC expression on thymic epithelial cells
Cell Death and Differentiation 26 , 2727–2739

Rights & permissionsfor article Deletion of self-reactive CCR7– thymocytes in the absence of MHC expression on thymic epithelial cells . Opens in a new window.
12 May 2017
IL-2 prevents deletion of developing T-regulatory cells in the thymus
Cell Death and Differentiation 24 , 1007–1016

Rights & permissionsfor article IL-2 prevents deletion of developing T-regulatory cells in the thymus . Opens in a new window.
Research | 9 December 2015
Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation
- Ingrid E. Wertz
- , Kim Newton
- , Dhaya Seshasayee
- , Saritha Kusam
- , Cynthia Lam
- , Juan Zhang
- , Nataliya Popovych
- , Elizabeth Helgason
- , Allyn Schoeffler
- , Surinder Jeet
- , Nandhini Ramamoorthi
- , Lorna Kategaya
- , Robert J. Newman
- , Keisuke Horikawa
- , Debra Dugger
- , Wendy Sandoval
- , Susmith Mukund
- , Anuradha Zindal
- , Flavius Martin
- , Clifford Quan
- , Jeffrey Tom
- , Wayne J. Fairbrother
- , Michael Townsend
- , Søren Warming
- , Jason DeVoss
- , Jinfeng Liu
- , Erin Dueber
- , Patrick Caplazi
- , Wyne P. Lee
- , Christopher C. Goodnow
- , Mercedesz Balazs
- , Kebing Yu
- , Ganesh Kolumam
- & Vishva M. Dixit
Nature 528 , 370–375

Rights & permissionsfor article Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation . Opens in a new window.
Research | 14 November 2016 | Open
CD45-mediated control of TCR tuning in naïve and memory CD8⁺ T cells
- Jae-Ho Cho
- , Hee-Ok Kim
- , Young-Jun Ju
- , Yoon-Chul Kye
- , Gil-Woo Lee
- , Sung-Woo Lee
- , Cheol-Heui Yun
- , Nunzio Bottini
- , Kylie Webster
- , Christopher C. Goodnow
- , Charles D. Surh
- , Cecile King
- & Jonathan Sprent
Nature Communications 7 , 1–15

Rights & permissionsfor article CD45-mediated control of TCR tuning in naïve and memory CD8<sup>+</sup> T cells . Opens in a new window.
Research | 10 November 2016 | Open
IgD attenuates the IgM-induced anergy response in transitional and mature B cells
- Zahra Sabouri
- , Samuel Perotti
- , Emily Spierings
- , Peter Humburg
- , Mehmet Yabas
- , Hannes Bergmann
- , Keisuke Horikawa
- , Carla Roots
- , Samantha Lambe
- , Clara Young
- , T. Dan Andrews
- , Matthew Field
- , Anselm Enders
- , Joanne H. Reed
- & Christopher C. Goodnow
Nature Communications 7 , 1–11

Rights & permissionsfor article IgD attenuates the IgM-induced anergy response in transitional and mature B cells . Opens in a new window.
Research | 16 September 2015
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
- Nobuhiko Kayagaki
- , Irma B. Stowe
- , Bettina L. Lee
- , Karen O’Rourke
- , Keith Anderson
- , Søren Warming
- , Trinna Cuellar
- , Benjamin Haley
- , Merone Roose-Girma
- , Qui T. Phung
- , Peter S. Liu
- , Jennie R. Lill
- , Hong Li
- , Jiansheng Wu
- , Sarah Kummerfeld
- , Juan Zhang
- , Wyne P. Lee
- , Scott J. Snipas
- , Guy S. Salvesen
- , Lucy X. Morris
- , Linda Fitzgerald
- , Yafei Zhang
- , Edward M. Bertram
- , Christopher C. Goodnow
- & Vishva M. Dixit
Nature 526 , 666–671

Rights & permissionsfor article Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling . Opens in a new window.
Research | 14 January 2002
Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory
- Stephen W. Martin
- & Christopher C. Goodnow
Nature Immunology 3 , 182–188

Rights & permissionsfor article Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory . Opens in a new window.
Research | 5 October 2008
The actin regulator coronin 1A is mutant in a thymic egress–deficient mouse strain and in a patient with severe combined immunodeficiency
- Lawrence R Shiow
- , David W Roadcap
- , Kenneth Paris
- , Susan R Watson
- , Irina L Grigorova
- , Tonya Lebet
- , Jinping An
- , Ying Xu
- , Craig N Jenne
- , Niko Föger
- , Ricardo U Sorensen
- , Christopher C Goodnow
- , James E Bear
- , Jennifer M Puck
- & Jason G Cyster
Nature Immunology 9 , 1307–1315

Rights & permissionsfor article The actin regulator coronin 1A is mutant in a thymic egress–deficient mouse strain and in a patient with severe combined immunodeficiency . Opens in a new window.
Research | 7 June 2007
DNA repair is limiting for haematopoietic stem cells during ageing
- Anastasia Nijnik
- , Lisa Woodbine
- , Caterina Marchetti
- , Sara Dawson
- , Teresa Lambe
- , Cong Liu
- , Neil P. Rodrigues
- , Tanya L. Crockford
- , Erik Cabuy
- , Alessandro Vindigni
- , Tariq Enver
- , John I. Bell
- , Predrag Slijepcevic
- , Christopher C. Goodnow
- , Penelope A. Jeggo
- & Richard J. Cornall
Nature 447 , 686–690

Rights & permissionsfor article DNA repair is limiting for haematopoietic stem cells during ageing . Opens in a new window.
Research | 8 November 2009
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production
- Katrina L Randall
- , Teresa Lambe
- , Andy L Johnson
- , Bebhinn Treanor
- , Edyta Kucharska
- , Heather Domaschenz
- , Belinda Whittle
- , Lina E Tze
- , Anselm Enders
- , Tanya L Crockford
- , Tiphaine Bouriez-Jones
- , Duncan Alston
- , Jason G Cyster
- , Michael J Lenardo
- , Fabienne Mackay
- , Elissa K Deenick
- , Stuart G Tangye
- , Tyani D Chan
- , Tahra Camidge
- , Robert Brink
- , Carola G Vinuesa
- , Facundo D Batista
- , Richard J Cornall
- & Christopher C Goodnow
Nature Immunology 10 , 1283–1291

Rights & permissionsfor article <i>Dock8</i> mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production . Opens in a new window.
Research | 1 August 1988
Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice
Nature 334 , 676–682

Rights & permissionsfor article Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice . Opens in a new window.
Research | 29 September 1994
Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire
Nature 371 , 389–395

Rights & permissionsfor article Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire . Opens in a new window.
Research | 1 November 1989
Induction of self-tolerance in mature peripheral B lymphocytes
Nature 342 , 385–391

Rights & permissionsfor article Induction of self-tolerance in mature peripheral B lymphocytes . Opens in a new window.
Research | 11 May 2003
Resistance to CpG DNA–induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling
Nature Immunology 4 , 594–600

Rights & permissionsfor article Resistance to CpG DNA–induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling . Opens in a new window.
Reviews | 29 October 2003
Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling
- Jesse E Jun
- & Christopher C Goodnow
Nature Immunology 4 , 1057–1064

Rights & permissionsfor article Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling . Opens in a new window.
Research | 13 July 2009
Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection
- Andy L Johnson
- , L Aravind
- , Natalia Shulzhenko
- , Andre Morgun
- , See-Young Choi
- , Tanya L Crockford
- , Teresa Lambe
- , Heather Domaschenz
- , Edyta M Kucharska
- , Lixin Zheng
- , Carola G Vinuesa
- , Michael J Lenardo
- , Christopher C Goodnow
- , Richard J Cornall
- & Ronald H Schwartz
Nature Immunology 10 , 831–839

Rights & permissionsfor article <i>Themis</i> is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection . Opens in a new window.
Reviews | 1 June 2005
Cellular and genetic mechanisms of self tolerance and autoimmunity
Nature 435 , 590–597

Rights & permissionsfor article Cellular and genetic mechanisms of self tolerance and autoimmunity . Opens in a new window.
Research | 20 March 2011
ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes
- Mehmet Yabas
- , Charis E Teh
- , Sandra Frankenreiter
- , Dennis Lal
- , Carla M Roots
- , Belinda Whittle
- , Daniel T Andrews
- , Yafei Zhang
- , Narci C Teoh
- , Jonathan Sprent
- , Lina E Tze
- , Edyta M Kucharska
- , Jennifer Kofler
- , Geoffrey C Farell
- , Stefan Bröer
- , Christopher C Goodnow
- & Anselm Enders
Nature Immunology 12 , 441–449

Rights & permissionsfor article ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes . Opens in a new window.
Research | 26 May 2005
A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
- Carola G. Vinuesa
- , Matthew C. Cook
- , Constanza Angelucci
- , Vicki Athanasopoulos
- , Lixin Rui
- , Kim M. Hill
- , Di Yu
- , Heather Domaschenz
- , Belinda Whittle
- , Teresa Lambe
- , Ian S. Roberts
- , Richard R. Copley
- , John I. Bell
- , Richard J. Cornall
- & Christopher C. Goodnow
Nature 435 , 452–458

Rights & permissionsfor article A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity . Opens in a new window.
Reviews | 20 July 2010
Control systems and decision making for antibody production
Nature Immunology 11 , 681–688

Rights & permissionsfor article Control systems and decision making for antibody production . Opens in a new window.

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