nature.com search

Loading Filters

Showing 1–16 of 16 results

Loading Filters

Amendments and Corrections | 2 October 2013
Erratum: Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers
- Georgia Hatzivassiliou
- , Jacob R. Haling
- , Huifen Chen
- , Kyung Song
- , Steve Price
- , Robert Heald
- , Joanne F. M. Hewitt
- , Mark Zak
- , Ariana Peck
- , Christine Orr
- , Mark Merchant
- , Klaus P. Hoeflich
- , Jocelyn Chan
- , Shiuh-Ming Luoh
- , Daniel J. Anderson
- , Mary J. C. Ludlam
- , Christian Wiesmann
- , Mark Ultsch
- , Lori S. Friedman
- , Shiva Malek
- & Marcia Belvin
Nature 502 , 258–258

Rights & permissionsfor article Erratum: Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers . Opens in a new window.
Amendments and Corrections | 15 January 2020
Author Correction: Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex
- Dirksen E. Bussiere
- , Lili Xie
- , Honnappa Srinivas
- , Wei Shu
- , Ashley Burke
- , Celine Be
- , Junping Zhao
- , Adarsh Godbole
- , Dan King
- , Rajeshri G. Karki
- , Viktor Hornak
- , Fangmin Xu
- , Jennifer Cobb
- , Nathalie Carte
- , Andreas O. Frank
- , Alexandra Frommlet
- , Patrick Graff
- , Mark Knapp
- , Aleem Fazal
- , Barun Okram
- , Songchun Jiang
- , Pierre-Yves Michellys
- , Rohan Beckwith
- , Hans Voshol
- , Christian Wiesmann
- , Jonathan M. Solomon
- & Joshiawa Paulk
Nature Chemical Biology 16 , 361–361

Rights & permissionsfor article Author Correction: Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex . Opens in a new window.
Research | 15 June 2016 | Open
Structure of neprilysin in complex with the active metabolite of sacubitril
- Nikolaus Schiering
- , Allan D’Arcy
- , Frederic Villard
- , Paul Ramage
- , Claude Logel
- , Frederic Cumin
- , Gary M. Ksander
- , Christian Wiesmann
- , Rajeshri G. Karki
- & Muneto Mogi
Scientific Reports 6 , 1–5

Rights & permissionsfor article Structure of neprilysin in complex with the active metabolite of sacubitril . Opens in a new window.
Research | 11 August 2013
Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers
- Georgia Hatzivassiliou
- , Jacob R. Haling
- , Huifen Chen
- , Kyung Song
- , Steve Price
- , Robert Heald
- , Joanne F. M. Hewitt
- , Mark Zak
- , Ariana Peck
- , Christine Orr
- , Mark Merchant
- , Klaus P. Hoeflich
- , Jocelyn Chan
- , Shiuh-Ming Luoh
- , Daniel J. Anderson
- , Mary J. C. Ludlam
- , Christian Wiesmann
- , Mark Ultsch
- , Lori S. Friedman
- , Shiva Malek
- & Marcia Belvin
Nature 501 , 232–236

Rights & permissionsfor article Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers . Opens in a new window.
Research | 3 February 2003
In situ assembly of enzyme inhibitors using extended tethering
- Daniel A. Erlanson
- , Joni W. Lam
- , Christian Wiesmann
- , Tinh N. Luong
- , Robert L. Simmons
- , Warren L. DeLano
- , Ingrid C. Choong
- , Matthew T. Burdett
- , W. Michael Flanagan
- , Dennis Lee
- , Eric M. Gordon
- & Tom O'Brien
Nature Biotechnology 21 , 308–314

Rights & permissionsfor article <i>In situ</i> assembly of enzyme inhibitors using extended tethering . Opens in a new window.
Research | 1 March 2009
Inhibition of Wnt signaling by Dishevelled PDZ peptides
- Yingnan Zhang
- , Brent A Appleton
- , Christian Wiesmann
- , Ted Lau
- , Mike Costa
- , Rami N Hannoush
- & Sachdev S Sidhu
Nature Chemical Biology 5 , 217–219

Rights & permissionsfor article Inhibition of Wnt signaling by Dishevelled PDZ peptides . Opens in a new window.
News and Views | 1 June 2000
Variations on ligand–receptor complexes
- Christian Wiesmann
- & Abraham M. de Vos
Nature Structural & Molecular Biology 7 , 440–442

Rights & permissionsfor article Variations on ligand–receptor complexes . Opens in a new window.
Research | 18 July 2004
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
- Ingrid E. Wertz
- , Karen M. O'Rourke
- , Honglin Zhou
- , Michael Eby
- , L. Aravind
- , Somasekar Seshagiri
- , Ping Wu
- , Christian Wiesmann
- , Rohan Baker
- , David L. Boone
- , Averil Ma
- , Eugene V. Koonin
- & Vishva M. Dixit
Nature 430 , 694–699

Rights & permissionsfor article De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling . Opens in a new window.
Research | 9 September 1999
Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor
Nature 401 , 184–188

Rights & permissionsfor article Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor . Opens in a new window.
Research | 15 October 2006
Structure of C3b in complex with CRIg gives insights into regulation of complement activation
Nature 444 , 217–220

Rights & permissionsfor article Structure of C3b in complex with CRIg gives insights into regulation of complement activation . Opens in a new window.
Research | 9 December 2019
Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex
- Dirksen E. Bussiere
- , Lili Xie
- , Honnappa Srinivas
- , Wei Shu
- , Ashley Burke
- , Celine Be
- , Junping Zhao
- , Adarsh Godbole
- , Dan King
- , Rajeshri G. Karki
- , Viktor Hornak
- , Fangmin Xu
- , Jennifer Cobb
- , Nathalie Carte
- , Andreas O. Frank
- , Alexandra Frommlet
- , Patrick Graff
- , Mark Knapp
- , Aleem Fazal
- , Barun Okram
- , Songchun Jiang
- , Pierre-Yves Michellys
- , Rohan Beckwith
- , Hans Voshol
- , Christian Wiesmann
- , Jonathan M. Solomon
- & Joshiawa Paulk
Nature Chemical Biology 16 , 15–23

Rights & permissionsfor article Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex . Opens in a new window.
Research | 17 June 2019
A small-molecule inhibitor of C5 complement protein
- Keith Jendza
- , Mitsunori Kato
- , Michael Salcius
- , Honnappa Srinivas
- , Andrea De Erkenez
- , Anh Nguyen
- , Doug McLaughlin
- , Celine Be
- , Christian Wiesmann
- , Jason Murphy
- , Philippe Bolduc
- , Muneto Mogi
- , Jose Duca
- , Abdel Namil
- , Michael Capparelli
- , Veronique Darsigny
- , Erik Meredith
- , Ritesh Tichkule
- , Luciana Ferrara
- , Jessica Heyder
- , Fang Liu
- , Patricia A. Horton
- , Michael J. Romanowski
- , Markus Schirle
- , Nello Mainolfi
- , Karen Anderson
- & Gregory A. Michaud
Nature Chemical Biology 15 , 666–668

Rights & permissionsfor article A small-molecule inhibitor of C5 complement protein . Opens in a new window.
Reviews | 8 June 2018
Cryo-EM in drug discovery: achievements, limitations and prospects
Nature Reviews Drug Discovery 17 , 471–492

Rights & permissionsfor article Cryo-EM in drug discovery: achievements, limitations and prospects . Opens in a new window.
Research | 24 October 2016 | Open
Targeted inhibition of the COP9 signalosome for treatment of cancer
- Anita Schlierf
- , Eva Altmann
- , Jean Quancard
- , Anne B. Jefferson
- , René Assenberg
- , Martin Renatus
- , Matthew Jones
- , Ulrich Hassiepen
- , Michael Schaefer
- , Michael Kiffe
- , Andreas Weiss
- , Christian Wiesmann
- , Richard Sedrani
- , Jörg Eder
- & Bruno Martoglio
Nature Communications 7 , 1–10

Rights & permissionsfor article Targeted inhibition of the COP9 signalosome for treatment of cancer . Opens in a new window.
Research | 18 July 2014
The discovery of first-in-class drugs: origins and evolution
Nature Reviews Drug Discovery 13 , 577–587

Rights & permissionsfor article The discovery of first-in-class drugs: origins and evolution . Opens in a new window.
Research | 18 July 2004
Allosteric inhibition of protein tyrosine phosphatase 1B
- Christian Wiesmann
- , Kenneth J Barr
- , Jenny Kung
- , Jiang Zhu
- , Daniel A Erlanson
- , Wang Shen
- , Bruce J Fahr
- , Min Zhong
- , Lisa Taylor
- , Mike Randal
- , Robert S McDowell
- & Stig K Hansen
Nature Structural & Molecular Biology 11 , 730–737

Rights & permissionsfor article Allosteric inhibition of protein tyrosine phosphatase 1B . Opens in a new window.

Refine your results by…

Filters

Filter By:

Erratum: Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

Author Correction: Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex

Structure of neprilysin in complex with the active metabolite of sacubitril

Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

In situ assembly of enzyme inhibitors using extended tethering

Inhibition of Wnt signaling by Dishevelled PDZ peptides

Variations on ligand–receptor complexes

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor

Structure of C3b in complex with CRIg gives insights into regulation of complement activation

Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex

A small-molecule inhibitor of C5 complement protein

Cryo-EM in drug discovery: achievements, limitations and prospects

Targeted inhibition of the COP9 signalosome for treatment of cancer

The discovery of first-in-class drugs: origins and evolution

Allosteric inhibition of protein tyrosine phosphatase 1B

Quick links

Refine your results by…

Filters ​

Filter By:

Search

Quick links

Filters