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Research | 12 January 2021 | Open
Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation
- Xihao Chang
- , Jiayin Zhang
- , Lingzi Peng
- & Chang Guo
Nature Communications 12 , 1–9

Rights & permissionsfor article Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation . Opens in a new window.
Research | 22 October 2020 | Open
Research on multi-effect evaporation salt prediction based on feature extraction
- Bo-Lun Chen
- , Yong Hua
- , Guo-Chang Zhu
- , Min Ji
- , Hong-Fei Zhu
- & Yong-Tao Yu
Scientific Reports 10 , 1–12

Rights & permissionsfor article Research on multi-effect evaporation salt prediction based on feature extraction . Opens in a new window.
Research | 23 June 2020 | Open
DREAM-in-CDM Approach and Identification of a New Generation of Anti-inflammatory Drugs Targeting mPGES-1
- Shuo Zhou
- , Ziyuan Zhou
- , Kai Ding
- , Yaxia Yuan
- , Charles Loftin
- , Fang Zheng
- & Chang-Guo Zhan
Scientific Reports 10 , 1–9

Rights & permissionsfor article DREAM-<i>in</i>-CDM Approach and Identification of a New Generation of Anti-inflammatory Drugs Targeting mPGES-1 . Opens in a new window.
Research | 9 June 2020 | Open
Effects of Cebranopadol on Cocaine-induced Hyperactivity and Cocaine Pharmacokinetics in Rats
- Huimei Wei
- , Linyue Shang
- , Chang-Guo Zhan
- & Fang Zheng
Scientific Reports 10 , 1–10

Rights & permissionsfor article Effects of Cebranopadol on Cocaine-induced Hyperactivity and Cocaine Pharmacokinetics in Rats . Opens in a new window.
Amendments and Corrections | 16 November 2018 | Open
Author Correction: Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity
- Katherine E. Larrimore
- , I. Can Kazan
- , Latha Kannan
- , R. Player Kendle
- , Tameem Jamal
- , Matthew Barcus
- , Ashini Bolia
- , Stephen Brimijoin
- , Chang-Guo Zhan
- , S. Banu Ozkan
- & Tsafrir S. Mor
Scientific Reports 8 , 1–2

Rights & permissionsfor article Author Correction: Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity . Opens in a new window.
Research | 23 April 2019 | Open
Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish
- Yanqi Xie
- , Liliia M. Kril
- , Tianxin Yu
- , Wen Zhang
- , Mykhaylo S. Frasinyuk
- , Svitlana P. Bondarenko
- , Kostyantyn M. Kondratyuk
- , Elizabeth Hausman
- , Zachary M. Martin
- , Przemyslaw P. Wyrebek
- , Xifu Liu
- , Agripina Deaciuc
- , Linda P. Dwoskin
- , Jing Chen
- , Haining Zhu
- , Chang-Guo Zhan
- , Vitaliy M. Sviripa
- , Jessica Blackburn
- , David S. Watt
- & Chunming Liu
Scientific Reports 9 , 1–15

Rights & permissionsfor article Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish . Opens in a new window.
Research | 7 March 2019 | Open
Mutational effects of human dopamine transporter at tyrosine88, lysine92, and histidine547 on basal and HIV-1 Tat-inhibited dopamine transport
- Wei-Lun Sun
- , Pamela M. Quizon
- , Yaxia Yuan
- , Matthew J. Strauss
- , Richard McCain Jr.
- , Chang-Guo Zhan
- & Jun Zhu
Scientific Reports 9 , 1–13

Rights & permissionsfor article Mutational effects of human dopamine transporter at tyrosine88, lysine92, and histidine547 on basal and HIV-1 Tat-inhibited dopamine transport . Opens in a new window.
Research | 13 November 2018 | Open
Blocking drug activation as a therapeutic strategy to attenuate acute toxicity and physiological effects of heroin
- Ting Zhang
- , Xirong Zheng
- , Kyungbo Kim
- , Fang Zheng
- & Chang-Guo Zhan
Scientific Reports 8 , 1–6

Rights & permissionsfor article Blocking drug activation as a therapeutic strategy to attenuate acute toxicity and physiological effects of heroin . Opens in a new window.
Research | 23 September 2020
Targeted inhibition of calpain in mitochondria alleviates oxidative stress-induced myocardial injury
- Dong Zheng
- , Ting Cao
- , Lu-lu Zhang
- , Guo-chang Fan
- , Jun Qiu
- & Tian-qing Peng
Acta Pharmacologica Sinica , 1–12

Rights & permissionsfor article Targeted inhibition of calpain in mitochondria alleviates oxidative stress-induced myocardial injury . Opens in a new window.
Research | 26 March 2018 | Open
Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs
- Kai Ding
- , Ziyuan Zhou
- , Shurong Hou
- , Yaxia Yuan
- , Shuo Zhou
- , Xirong Zheng
- , Jianzhong Chen
- , Charles Loftin
- , Fang Zheng
- & Chang-Guo Zhan
Scientific Reports 8 , 1–9

Rights & permissionsfor article Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs . Opens in a new window.
Research | 10 November 2017 | Open
Clinical Potential of an Enzyme-based Novel Therapy for Cocaine Overdose
- Ting Zhang
- , Xirong Zheng
- , Ziyuan Zhou
- , Xiabin Chen
- , Zhenyu Jin
- , Jing Deng
- , Chang-Guo Zhan
- & Fang Zheng
Scientific Reports 7 , 1–9

Rights & permissionsfor article Clinical Potential of an Enzyme-based Novel Therapy for Cocaine Overdose . Opens in a new window.
Research | 16 June 2017 | Open
Allosteric modulatory effects of SRI-20041 and SRI-30827 on cocaine and HIV-1 Tat protein binding to human dopamine transporter
- Wei-Lun Sun
- , Pamela M. Quizon
- , Yaxia Yuan
- , Wei Zhang
- , Subramaniam Ananthan
- , Chang-Guo Zhan
- & Jun Zhu
Scientific Reports 7 , 1–12

Rights & permissionsfor article Allosteric modulatory effects of SRI-20041 and SRI-30827 on cocaine and HIV-1 Tat protein binding to human dopamine transporter . Opens in a new window.
Research | 5 September 2017 | Open
Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity
- Katherine E. Larrimore
- , I. Can Kazan
- , Latha Kannan
- , R. Player Kendle
- , Tameem Jamal
- , Matthew Barcus
- , Ashini Bolia
- , Stephen Brimijoin
- , Chang-Guo Zhan
- , S. Banu Ozkan
- & Tsafrir S. Mor
Scientific Reports 7 , 1–14

Rights & permissionsfor article Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity . Opens in a new window.
Research | 1 August 2016 | Open
Extracorporeal delivery of a therapeutic enzyme
- Chun Zhang
- , Jun Pu
- , Xiaolan Yang
- , Tao Feng
- , Fang Liu
- , Deqiang Wang
- , Xiaolei Hu
- , Ang Gao
- , Hongbo Liu
- , Chang-Guo Zhan
- & Fei Liao
Scientific Reports 6 , 1–8

Rights & permissionsfor article Extracorporeal delivery of a therapeutic enzyme . Opens in a new window.
Research | 29 February 2016 | Open
Unexpected Reaction Pathway for butyrylcholinesterase-catalyzed inactivation of “hunger hormone” ghrelin
- Jianzhuang Yao
- , Yaxia Yuan
- , Fang Zheng
- & Chang-Guo Zhan
Scientific Reports 6 , 1–10

Rights & permissionsfor article Unexpected Reaction Pathway for butyrylcholinesterase-catalyzed inactivation of “hunger hormone” ghrelin . Opens in a new window.
Research | 2 June 2016 | Open
Role of Histidine 547 of Human Dopamine Transporter in Molecular Interaction with HIV-1 Tat and Dopamine Uptake
- Yaxia Yuan
- , Pamela M. Quizon
- , Wei-Lun Sun
- , Jianzhuang Yao
- , Jun Zhu
- & Chang-Guo Zhan
Scientific Reports 6 , 1–10

Rights & permissionsfor article Role of Histidine 547 of Human Dopamine Transporter in Molecular Interaction with HIV-1 Tat and Dopamine Uptake . Opens in a new window.
Research | 14 December 2016 | Open
Molecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tat protein-inhibited dopamine transport
- Pamela M. Quizon
- , Wei-Lun Sun
- , Yaxia Yuan
- , Narasimha M. Midde
- , Chang-Guo Zhan
- & Jun Zhu
Scientific Reports 6 , 1–14

Rights & permissionsfor article Molecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tat protein-inhibited dopamine transport . Opens in a new window.
Research | 3 February 2017 | Open
The molecular basis of talin2’s high affinity toward β1-integrin
- Yaxia Yuan
- , Liqing Li
- , Yanyan Zhu
- , Lei Qi
- , Latifeh Azizi
- , Vesa P. Hytönen
- , Chang-Guo Zhan
- & Cai Huang
Scientific Reports 7 , 1–12

Rights & permissionsfor article The molecular basis of talin2’s high affinity toward β1-integrin . Opens in a new window.
Research | 14 September 2014
Arylquins target vimentin to trigger Par-4 secretion for tumor cell apoptosis
- Ravshan Burikhanov
- , Vitaliy M Sviripa
- , Nikhil Hebbar
- , Wen Zhang
- , W John Layton
- , Adel Hamza
- , Chang-Guo Zhan
- , David S Watt
- , Chunming Liu
- & Vivek M Rangnekar
Nature Chemical Biology 10 , 924–926

Rights & permissionsfor article Arylquins target vimentin to trigger Par-4 secretion for tumor cell apoptosis . Opens in a new window.
Research | 18 March 2014
A highly efficient cocaine-detoxifying enzyme obtained by computational design
- Fang Zheng
- , Liu Xue
- , Shurong Hou
- , Junjun Liu
- , Max Zhan
- , Wenchao Yang
- & Chang-Guo Zhan
Nature Communications 5 , 1–8

Rights & permissionsfor article A highly efficient cocaine-detoxifying enzyme obtained by computational design . Opens in a new window.
Research | 22 March 2019 | Open
Overcoming the thermodynamic equilibrium of an isomerization reaction through oxidoreductive reactions for biotransformation
- Jing-Jing Liu
- , Guo-Chang Zhang
- , Suryang Kwak
- , Eun Joong Oh
- , Eun Ju Yun
- , Kulika Chomvong
- , Jamie H. D. Cate
- & Yong-Su Jin
Nature Communications 10 , 1–8

Rights & permissionsfor article Overcoming the thermodynamic equilibrium of an isomerization reaction through oxidoreductive reactions for biotransformation . Opens in a new window.
Editorial | 2 April 2018
Extracellular vesicles as novel biomarkers and pharmaceutic targets of diseases
Acta Pharmacologica Sinica 39 , 499–500

Rights & permissionsfor article Extracellular vesicles as novel biomarkers and pharmaceutic targets of diseases . Opens in a new window.
Research | 23 February 2016 | Open
Reduced soluble RAGE is associated with disease severity of axonal Guillain-Barré syndrome
- Da-Qi Zhang
- , Rong Wang
- , Ting Li
- , Jian-Ping Zhou
- , Guo-Qiang Chang
- , Ning Zhao
- , Li-Na Yang
- , Hui Zhai
- & Li Yang
Scientific Reports 6 , 1–9

Rights & permissionsfor article Reduced soluble RAGE is associated with disease severity of axonal Guillain-Barré syndrome . Opens in a new window.
Research | 31 August 2015
Switchable selectivity in an NHC-catalysed dearomatizing annulation reaction
Nature Chemistry 7 , 842–847

Rights & permissionsfor article Switchable selectivity in an NHC-catalysed dearomatizing annulation reaction . Opens in a new window.
1 June 2001
Bcl-2 over-expression and activation of protein kinase C suppress the Trail-induced apoptosis in Jurkat T cells
- Ben Chang GUO
- & Yong Hua XU
Cell Research 11 , 101–106

Rights & permissionsfor article Bcl-2 over-expression and activation of protein kinase C suppress the Trail-induced apoptosis in Jurkat T cells . Opens in a new window.
Research | 25 July 2019 | Open
Glycine, serine and threonine metabolism confounds efficacy of complement-mediated killing
- Zhi-xue Cheng
- , Chang Guo
- , Zhuang-gui Chen
- , Tian-ci Yang
- , Jian-ying Zhang
- , Jie Wang
- , Jia-xin Zhu
- , Dan Li
- , Tian-tuo Zhang
- , Hui Li
- , Bo Peng
- & Xuan-xian Peng
Nature Communications 10 , 1–17

Rights & permissionsfor article Glycine, serine and threonine metabolism confounds efficacy of complement-mediated killing . Opens in a new window.
Reviews | 31 August 2017
Versatile effects of bacterium-released membrane vesicles on mammalian cells and infectious/inflammatory diseases
Acta Pharmacologica Sinica 39 , 514–533

Rights & permissionsfor article Versatile effects of bacterium-released membrane vesicles on mammalian cells and infectious/inflammatory diseases . Opens in a new window.
Research | 14 February 2014 | Open
IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling
- Ding-Sheng Jiang
- , Xiang Wei
- , Xiao-Fei Zhang
- , Yu Liu
- , Yan Zhang
- , Ke Chen
- , Lu Gao
- , Heng Zhou
- , Xue-Hai Zhu
- , Peter P. Liu
- , Wayne Bond Lau
- , Xinliang Ma
- , Yunzeng Zou
- , Xiao-Dong Zhang
- , Guo-Chang Fan
- & Hongliang Li
Nature Communications 5 , 1–14

Rights & permissionsfor article IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling . Opens in a new window.
Research | 28 November 2013 | Open
TRAF1 is a critical regulator of cerebral ischaemia–reperfusion injury and neuronal death
- Yan-Yun Lu
- , Zuo-Zhi Li
- , Ding-Sheng Jiang
- , Lang Wang
- , Yan Zhang
- , Ke Chen
- , Xiao-Fei Zhang
- , Yi Liu
- , Guo-Chang Fan
- , Yingjie Chen
- , Qinglin Yang
- , Yan Zhou
- , Xiao-Dong Zhang
- , De-Pei Liu
- & Hongliang Li
Nature Communications 4 , 1–13

Rights & permissionsfor article TRAF1 is a critical regulator of cerebral ischaemia–reperfusion injury and neuronal death . Opens in a new window.
Research | 8 September 2015 | Open
Exosomal miR-223 Contributes to Mesenchymal Stem Cell-Elicited Cardioprotection in Polymicrobial Sepsis
- Xiaohong Wang
- , Haitao Gu
- , Dongze Qin
- , Liwang Yang
- , Wei Huang
- , Kobina Essandoh
- , Yigang Wang
- , Charles C. Caldwell
- , Tianqing Peng
- , Basilia Zingarelli
- & Guo-Chang Fan
Scientific Reports 5 , 1–16

Rights & permissionsfor article Exosomal miR-223 Contributes to Mesenchymal Stem Cell-Elicited Cardioprotection in Polymicrobial Sepsis . Opens in a new window.
Research | 9 April 2006
Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior
- Guoqing Sheng
- , Guo-qing Chang
- , John Y Lin
- , Zhao-Xue Yu
- , Zhi-Hui Fang
- , Juan Rong
- , Stuart A Lipton
- , Shi-Hua Li
- , Gang Tong
- , Sarah F Leibowitz
- & Xiao-Jiang Li
Nature Medicine 12 , 526–533

Rights & permissionsfor article Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior . Opens in a new window.

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Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation

Research on multi-effect evaporation salt prediction based on feature extraction

DREAM-in-CDM Approach and Identification of a New Generation of Anti-inflammatory Drugs Targeting mPGES-1

Effects of Cebranopadol on Cocaine-induced Hyperactivity and Cocaine Pharmacokinetics in Rats

Author Correction: Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity

Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish

Mutational effects of human dopamine transporter at tyrosine88, lysine92, and histidine547 on basal and HIV-1 Tat-inhibited dopamine transport

Blocking drug activation as a therapeutic strategy to attenuate acute toxicity and physiological effects of heroin

Targeted inhibition of calpain in mitochondria alleviates oxidative stress-induced myocardial injury

Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs

Clinical Potential of an Enzyme-based Novel Therapy for Cocaine Overdose

Allosteric modulatory effects of SRI-20041 and SRI-30827 on cocaine and HIV-1 Tat protein binding to human dopamine transporter

Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity

Extracorporeal delivery of a therapeutic enzyme

Unexpected Reaction Pathway for butyrylcholinesterase-catalyzed inactivation of “hunger hormone” ghrelin

Role of Histidine 547 of Human Dopamine Transporter in Molecular Interaction with HIV-1 Tat and Dopamine Uptake

Molecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tat protein-inhibited dopamine transport

The molecular basis of talin2’s high affinity toward β1-integrin

Arylquins target vimentin to trigger Par-4 secretion for tumor cell apoptosis

A highly efficient cocaine-detoxifying enzyme obtained by computational design

Overcoming the thermodynamic equilibrium of an isomerization reaction through oxidoreductive reactions for biotransformation

Extracellular vesicles as novel biomarkers and pharmaceutic targets of diseases

Reduced soluble RAGE is associated with disease severity of axonal Guillain-Barré syndrome

Switchable selectivity in an NHC-catalysed dearomatizing annulation reaction

Bcl-2 over-expression and activation of protein kinase C suppress the Trail-induced apoptosis in Jurkat T cells

Glycine, serine and threonine metabolism confounds efficacy of complement-mediated killing

Versatile effects of bacterium-released membrane vesicles on mammalian cells and infectious/inflammatory diseases

IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling

TRAF1 is a critical regulator of cerebral ischaemia–reperfusion injury and neuronal death

Exosomal miR-223 Contributes to Mesenchymal Stem Cell-Elicited Cardioprotection in Polymicrobial Sepsis

Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior

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