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Research | 1 April 1997
Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression
- Ralf C. Bargou
- , Karsten Jürchott
- , Christian Wagener
- , Stephan Bergmann
- , Sylvia Metzner
- , Kurt Bommert
- , Markus Y. Mapara
- , Klaus-Jürgen Winzer
- , Manfred Dietel
- , Bernd Dörken
- & Hans-Dieter Royer
Nature Medicine 3 , 447–450

Rights & permissionsfor article Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression . Opens in a new window.
17 May 2001
Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance
Oncogene 20 , 2749–2760

Rights & permissionsfor article Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance . Opens in a new window.
11 April 2005
Recurrent chromosomal aberrations in INK4a/ARF defective primary lymphomas predict drug responses in vivo
- Anne Helmrich
- , Soyoung Lee
- , Patricia O'Brien
- , Bernd Dörken
- , Scott W Lowe
- , Evelin Schröck
- & Clemens A Schmitt
Oncogene 24 , 4174–4182

Rights & permissionsfor article Recurrent chromosomal aberrations in INK4a/ARF defective primary lymphomas predict drug responses in vivo . Opens in a new window.
Research | 28 March 2018 | Open
The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma
- Nikolai Schleussner
- , Olaf Merkel
- , Mariantonia Costanza
- , Huan-Chang Liang
- , Franziska Hummel
- , Chiara Romagnani
- , Pawel Durek
- , Ioannis Anagnostopoulos
- , Michael Hummel
- , Korinna Jöhrens
- , Antonia Niedobitek
- , Patrick R. Griffin
- , Roberto Piva
- , Henrike L. Sczakiel
- , Wilhelm Woessmann
- , Christine Damm-Welk
- , Christian Hinze
- , Dagmar Stoiber
- , Bernd Gillissen
- , Suzanne D. Turner
- , Eva Kaergel
- , Linda von Hoff
- , Michael Grau
- , Georg Lenz
- , Bernd Dörken
- , Claus Scheidereit
- , Lukas Kenner
- , Martin Janz
- & Stephan Mathas
Leukemia 32 , 1994–2007

Rights & permissionsfor article The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma . Opens in a new window.
Research | 1 March 2018
Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis
- Christopher Maximilian Arends
- , Joel Galan-Sousa
- , Kaja Hoyer
- , Willy Chan
- , Marten Jäger
- , Kenichi Yoshida
- , Ricarda Seemann
- , Daniel Noerenberg
- , Nils Waldhueter
- , Helga Fleischer-Notter
- , Friederike Christen
- , Clemens A. Schmitt
- , Bernd Dörken
- , Uwe Pelzer
- , Marianne Sinn
- , Tomasz Zemojtel
- , Seishi Ogawa
- , Sven Märdian
- , Adrian Schreiber
- , Annegret Kunitz
- , Ulrike Krüger
- , Lars Bullinger
- , Elena Mylonas
- , Mareike Frick
- & Frederik Damm
Leukemia 32 , 1908–1919

Rights & permissionsfor article Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis . Opens in a new window.
Research | 20 December 2017
Senescence-associated reprogramming promotes cancer stemness
- Maja Milanovic
- , Dorothy N. Y. Fan
- , Dimitri Belenki
- , J. Henry M. Däbritz
- , Zhen Zhao
- , Yong Yu
- , Jan R. Dörr
- , Lora Dimitrova
- , Dido Lenze
- , Ines A. Monteiro Barbosa
- , Marco A. Mendoza-Parra
- , Tamara Kanashova
- , Marlen Metzner
- , Katharina Pardon
- , Maurice Reimann
- , Andreas Trumpp
- , Bernd Dörken
- , Johannes Zuber
- , Hinrich Gronemeyer
- , Michael Hummel
- , Gunnar Dittmar
- , Soyoung Lee
- & Clemens A. Schmitt
Nature 553 , 96–100

Rights & permissionsfor article Senescence-associated reprogramming promotes cancer stemness . Opens in a new window.
Research | 14 August 2013
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
- Jan R. Dörr
- , Yong Yu
- , Maja Milanovic
- , Gregor Beuster
- , Christin Zasada
- , J. Henry M. Däbritz
- , Jan Lisec
- , Dido Lenze
- , Anne Gerhardt
- , Katharina Schleicher
- , Susanne Kratzat
- , Bettina Purfürst
- , Stefan Walenta
- , Wolfgang Mueller-Klieser
- , Markus Gräler
- , Michael Hummel
- , Ulrich Keller
- , Andreas K. Buck
- , Bernd Dörken
- , Lothar Willmitzer
- , Maurice Reimann
- , Stefan Kempa
- , Soyoung Lee
- & Clemens A. Schmitt
Nature 501 , 421–425

Rights & permissionsfor article Synthetic lethal metabolic targeting of cellular senescence in cancer therapy . Opens in a new window.
Research | 22 December 2013
Pharmacological and genomic profiling identifies NF-κB–targeted treatment strategies for mantle cell lymphoma
- Rami Rahal
- , Mareike Frick
- , Rodrigo Romero
- , Joshua M Korn
- , Robert Kridel
- , Fong Chun Chan
- , Barbara Meissner
- , Hyo-eun Bhang
- , Dave Ruddy
- , Audrey Kauffmann
- , Ali Farsidjani
- , Adnan Derti
- , Daniel Rakiec
- , Tara Naylor
- , Estelle Pfister
- , Steve Kovats
- , Sunkyu Kim
- , Kerstin Dietze
- , Bernd Dörken
- , Christian Steidl
- , Alexandar Tzankov
- , Michael Hummel
- , John Monahan
- , Michael P Morrissey
- , Christine Fritsch
- , William R Sellers
- , Vesselina G Cooke
- , Randy D Gascoyne
- , Georg Lenz
- & Frank Stegmeier
Nature Medicine 20 , 87–92

Rights & permissionsfor article Pharmacological and genomic profiling identifies NF-κB–targeted treatment strategies for mantle cell lymphoma . Opens in a new window.
Research | 30 September 2014
Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ
- Armin Rehm
- , Marcel Gätjen
- , Kerstin Gerlach
- , Florian Scholz
- , Angela Mensen
- , Marleen Gloger
- , Kristina Heinig
- , Björn Lamprecht
- , Stephan Mathas
- , Valérie Bégay
- , Achim Leutz
- , Martin Lipp
- , Bernd Dörken
- & Uta E. Höpken
Nature Communications 5 , 1–14

Rights & permissionsfor article Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ . Opens in a new window.
8 February 1999
Molecular mechanisms of constitutive NF-κB/Rel activation in Hodgkin/Reed-Sternberg cells
Oncogene 18 , 943–953

Rights & permissionsfor article Molecular mechanisms of constitutive NF-κB/Rel activation in Hodgkin/Reed-Sternberg cells . Opens in a new window.
Research | 24 July 2002
Adenovirus-mediated gene transfer of P16INK4/CDKN2 into bax-negative colon cancer cells induces apoptosis and tumor regression in vivo
- Ingo Tamm
- , Axel Schumacher
- , Leonid Karawajew
- , Velia Ruppert
- , Wolfgang Arnold
- , Andreas K Nüssler
- , Peter Neuhaus
- , Bernd Dörken
- & Gerhard Wolff
Cancer Gene Therapy 9 , 641–650

Rights & permissionsfor article Adenovirus-mediated gene transfer of P16INK4/CDKN2 into bax-negative colon cancer cells induces apoptosis and tumor regression in vivo . Opens in a new window.
5 April 2004
Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-x_L in a strictly caspase-3-dependent manner in human carcinoma cells
Oncogene 23 , 4523–4535

Rights & permissionsfor article Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-xL in a strictly caspase-3-dependent manner in human carcinoma cells . Opens in a new window.
4 April 2005
TRAIL sensitizes for ionizing irradiation-induced apoptosis through an entirely Bax-dependent mitochondrial cell death pathway
- Jana Wendt
- , Clarissa von Haefen
- , Philipp Hemmati
- , Claus Belka
- , Bernd Dörken
- & Peter T Daniel
Oncogene 24 , 4052–4064

Rights & permissionsfor article TRAIL sensitizes for ionizing irradiation-induced apoptosis through an entirely Bax-dependent mitochondrial cell death pathway . Opens in a new window.
26 July 2004
Tumor necrosis factor α sensitizes malignant cells to chemotherapeutic drugs via the mitochondrial apoptosis pathway independently of caspase-8 and NF-κB
- Karin Schmelz
- , Thomas Wieder
- , Ingo Tamm
- , Antje Müller
- , Frank Essmann
- , Christoph-C Geilen
- , Klaus Schulze-Osthoff
- , Bernd Dörken
- & Peter-T Daniel
Oncogene 23 , 6743–6759

Rights & permissionsfor article Tumor necrosis factor α sensitizes malignant cells to chemotherapeutic drugs via the mitochondrial apoptosis pathway independently of caspase-8 and NF-κB . Opens in a new window.
7 May 2002
Adenovirus-mediated overexpression of p14^ARF induces p53 and Bax-independent apoptosis
- Philipp G Hemmati
- , Bernhard Gillissen
- , Clarissa von Haefen
- , Jana Wendt
- , Lilian Stärck
- , Dilek Güner
- , Bernd Dörken
- & Peter T Daniel
Oncogene 21 , 3149–3161

Rights & permissionsfor article Adenovirus-mediated overexpression of p14ARF induces p53 and Bax-independent apoptosis . Opens in a new window.
5 June 2002
Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells
- Clarissa von Haefen
- , Thomas Wieder
- , Bernd Gillissen
- , Lilian Stärck
- , Vilma Graupner
- , Bernd Dörken
- & Peter T Daniel
Oncogene 21 , 4009–4019

Rights & permissionsfor article Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells . Opens in a new window.
24 January 2005
Arsenic trioxide triggers a regulated form of caspase-independent necrotic cell death via the mitochondrial death pathway
Oncogene 24 , 1904–1913

Rights & permissionsfor article Arsenic trioxide triggers a regulated form of caspase-independent necrotic cell death via the mitochondrial death pathway . Opens in a new window.
Research | 4 August 2005
Oncogene-induced senescence as an initial barrier in lymphoma development
Nature 436 , 660–665

Rights & permissionsfor article Oncogene-induced senescence as an initial barrier in lymphoma development . Opens in a new window.
Research | 2 May 2010
Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma
- Björn Lamprecht
- , Korden Walter
- , Stephan Kreher
- , Raman Kumar
- , Michael Hummel
- , Dido Lenze
- , Karl Köchert
- , Mohamed Amine Bouhlel
- , Julia Richter
- , Eric Soler
- , Ralph Stadhouders
- , Korinna Jöhrens
- , Kathrin D Wurster
- , David F Callen
- , Michael F Harte
- , Maciej Giefing
- , Rachael Barlow
- , Harald Stein
- , Ioannis Anagnostopoulos
- , Martin Janz
- , Peter N Cockerill
- , Reiner Siebert
- , Bernd Dörken
- , Constanze Bonifer
- & Stephan Mathas
Nature Medicine 16 , 571–579

Rights & permissionsfor article Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma . Opens in a new window.
11 December 2003
Induction of apoptosis by enediyne antibiotic calicheamicin ϑII proceeds through a caspase-mediated mitochondrial amplification loop in an entirely Bax-dependent manner
- Aram Prokop
- , Wolf Wrasidlo
- , Holger Lode
- , Ralf Herold
- , Florian Lang
- , Günter Henze
- , Bernd Dörken
- , Thomas Wieder
- & Peter T Daniel
Oncogene 22 , 9107–9120

Rights & permissionsfor article Induction of apoptosis by enediyne antibiotic calicheamicin ϑII proceeds through a caspase-mediated mitochondrial amplification loop in an entirely Bax-dependent manner . Opens in a new window.
Research | 20 December 2005
Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma
- Stephan Mathas
- , Martin Janz
- , Franziska Hummel
- , Michael Hummel
- , Brigitte Wollert-Wulf
- , Simone Lusatis
- , Ioannis Anagnostopoulos
- , Andreas Lietz
- , Mikael Sigvardsson
- , Franziska Jundt
- , Korinna Jöhrens
- , Kurt Bommert
- , Harald Stein
- & Bernd Dörken
Nature Immunology 7 , 207–215

Rights & permissionsfor article Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma . Opens in a new window.
7 March 2005
Loss of p21 disrupts p14^ARF-induced G1 cell cycle arrest but augments p14^ARF-induced apoptosis in human carcinoma cells
- Philipp G Hemmati
- , Guillaume Normand
- , Berlinda Verdoodt
- , Clarissa von Haefen
- , Anne Hasenjäger
- , Dilek Güner
- , Jana Wendt
- , Bernd Dörken
- & Peter T Daniel
Oncogene 24 , 4114–4128

Rights & permissionsfor article Loss of p21 disrupts p14ARF-induced G1 cell cycle arrest but augments p14ARF-induced apoptosis in human carcinoma cells . Opens in a new window.
11 July 2005
Arsenic trioxide induces regulated, death receptor-independent cell death through a Bcl-2-controlled pathway
Oncogene 24 , 7031–7042

Rights & permissionsfor article Arsenic trioxide induces regulated, death receptor-independent cell death through a Bcl-2-controlled pathway . Opens in a new window.
27 September 2004
Multidomain Bcl-2 homolog Bax but not Bak mediates synergistic induction of apoptosis by TRAIL and 5-FU through the mitochondrial apoptosis pathway
- Clarissa von Haefen
- , Bernhard Gillissen
- , Philipp G Hemmati
- , Jana Wendt
- , Dilek Güner
- , Alicja Mrozek
- , Claus Belka
- , Bernd Dörken
- & Peter T Daniel
Oncogene 23 , 8320–8332

Rights & permissionsfor article Multidomain Bcl-2 homolog Bax but not Bak mediates synergistic induction of apoptosis by TRAIL and 5-FU through the mitochondrial apoptosis pathway . Opens in a new window.
1 November 2004
Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathway
Oncogene 23 , 9408–9418

Rights & permissionsfor article Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathway . Opens in a new window.
17 April 2003
Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop
Oncogene 22 , 2236–2247

Rights & permissionsfor article Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop . Opens in a new window.
24 January 2002
The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr-1-negative and Mdr-1-overexpressing breast cancer cell lines
Oncogene 21 , 227–238

Rights & permissionsfor article The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr-1-negative and Mdr-1-overexpressing breast cancer cell lines . Opens in a new window.

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Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression

Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance

Recurrent chromosomal aberrations in INK4a/ARF defective primary lymphomas predict drug responses in vivo

The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma

Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis

Senescence-associated reprogramming promotes cancer stemness

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

Pharmacological and genomic profiling identifies NF-κB–targeted treatment strategies for mantle cell lymphoma

Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ

Molecular mechanisms of constitutive NF-κB/Rel activation in Hodgkin/Reed-Sternberg cells

Adenovirus-mediated gene transfer of P16INK4/CDKN2 into bax-negative colon cancer cells induces apoptosis and tumor regression in vivo

Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-x_L in a strictly caspase-3-dependent manner in human carcinoma cells

TRAIL sensitizes for ionizing irradiation-induced apoptosis through an entirely Bax-dependent mitochondrial cell death pathway

Tumor necrosis factor α sensitizes malignant cells to chemotherapeutic drugs via the mitochondrial apoptosis pathway independently of caspase-8 and NF-κB

Adenovirus-mediated overexpression of p14^ARF induces p53 and Bax-independent apoptosis

Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells

Arsenic trioxide triggers a regulated form of caspase-independent necrotic cell death via the mitochondrial death pathway

Oncogene-induced senescence as an initial barrier in lymphoma development

Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma

Induction of apoptosis by enediyne antibiotic calicheamicin ϑII proceeds through a caspase-mediated mitochondrial amplification loop in an entirely Bax-dependent manner

Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma

Loss of p21 disrupts p14^ARF-induced G1 cell cycle arrest but augments p14^ARF-induced apoptosis in human carcinoma cells

Arsenic trioxide induces regulated, death receptor-independent cell death through a Bcl-2-controlled pathway

Multidomain Bcl-2 homolog Bax but not Bak mediates synergistic induction of apoptosis by TRAIL and 5-FU through the mitochondrial apoptosis pathway

Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathway

Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop

The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr-1-negative and Mdr-1-overexpressing breast cancer cell lines

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