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Research | 10 September 2020
Structural mechanism of cGAS inhibition by the nucleosome
- andrea.ablasser@epfl.ch
- Ganesh R. Pathare
- , Alexiane Decout
- , Selene Glück
- , Simone Cavadini
- , Kristina Makasheva
- , Ruud Hovius
- , Georg Kempf
- , Joscha Weiss
- , Zuzanna Kozicka
- , Baptiste Guey
- , Pauline Melenec
- , Beat Fierz
- , Nicolas H. Thomä
- & Andrea Ablasser
Nature 587 , 668–672

Rights & permissionsfor article Structural mechanism of cGAS inhibition by the nucleosome . Opens in a new window.
News & Views | 6 March 2019
Structures of STING protein illuminate this key regulator of inflammation
- andrea.ablasser@epfl.ch
- Andrea Ablasser
Nature 567 , 321–322

Rights & permissionsfor article Structures of STING protein illuminate this key regulator of inflammation . Opens in a new window.
Research | 5 September 2017 | Open
Signalling strength determines proapoptotic functions of STING
- andrea.ablasser@epfl.ch
- Muhammet F. Gulen
- , Ute Koch
- , Simone M. Haag
- , Fabian Schuler
- , Lionel Apetoh
- , Andreas Villunger
- , Freddy Radtke
- & Andrea Ablasser
Nature Communications 8 , 1–10

Rights & permissionsfor article Signalling strength determines proapoptotic functions of STING . Opens in a new window.
Research | 31 July 2017
Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
- andrea.ablasser@epfl.ch
- Selene Glück
- , Baptiste Guey
- , Muhammet Fatih Gulen
- , Katharina Wolter
- , Tae-Won Kang
- , Niklas Arndt Schmacke
- , Anne Bridgeman
- , Jan Rehwinkel
- , Lars Zender
- & Andrea Ablasser
Nature Cell Biology 19 , 1061–1070

Rights & permissionsfor article Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence . Opens in a new window.
News & Views | 22 March 2016
ReGLUation of cGAS
- andrea.ablasser@epfl.ch
- Andrea Ablasser
Nature Immunology 17 , 347–349

Rights & permissionsfor article ReGLUation of cGAS . Opens in a new window.
News & Views | 10 October 2019
A carrier for cyclic dinucleotides
- andrea.ablasser@epfl.ch
- Baptiste Guey
- & Andrea Ablasser
Nature Immunology 20 , 1418–1420

Rights & permissionsfor article A carrier for cyclic dinucleotides . Opens in a new window.
Reviews | 18 July 2014
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids
- Andrea Ablasser completed her medical studies at...
Nature Reviews Immunology 14 , 521–528

Rights & permissionsfor article OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids . Opens in a new window.
Research | 4 July 2018
Targeting STING with covalent small-molecule inhibitors
- andrea.ablasser@epfl.ch
- Simone M. Haag
- , Muhammet F. Gulen
- , Luc Reymond
- , Antoine Gibelin
- , Laurence Abrami
- , Alexiane Decout
- , Michael Heymann
- , F. Gisou van der Goot
- , Gerardo Turcatti
- , Rayk Behrendt
- & Andrea Ablasser
Nature 559 , 269–273

Rights & permissionsfor article Targeting STING with covalent small-molecule inhibitors . Opens in a new window.
News & Views | 20 June 2011
Where, in antiviral defense, does IFIT1 fit?
- Andrea Ablasser and Veit Hornung are with...
- Andrea Ablasser
- & Veit Hornung
Nature Immunology 12 , 588–590

Rights & permissionsfor article Where, in antiviral defense, does IFIT1 fit? . Opens in a new window.
Reviews | 9 December 2019
Regulation of cGAS- and RLR-mediated immunity to nucleic acids
- andrea.ablasser@epfl.ch
- Andrea Ablasser
- & Sun Hur
Nature Immunology 21 , 17–29

Rights & permissionsfor article Regulation of cGAS- and RLR-mediated immunity to nucleic acids . Opens in a new window.
Research | 30 May 2013
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
- andrea.ablasser@uni-bonn.de
- Andrea Ablasser
- , Marion Goldeck
- , Taner Cavlar
- , Tobias Deimling
- , Gregor Witte
- , Ingo Röhl
- , Karl-Peter Hopfner
- , Janos Ludwig
- & Veit Hornung
Nature 498 , 380–384

Rights & permissionsfor article cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING . Opens in a new window.

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