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Reviews | 26 October 2020
The critical roles of somatic mutations and environmental tumor-promoting agents in cancer risk
- Allan Balmain
Nature Genetics 52 , 1139–1143

Rights & permissionsfor article The critical roles of somatic mutations and environmental tumor-promoting agents in cancer risk . Opens in a new window.
Research | 28 September 2020
The mutational signature profile of known and suspected human carcinogens in mice
- Laura Riva
- , Arun R. Pandiri
- , Yun Rose Li
- , Alastair Droop
- , James Hewinson
- , Michael A. Quail
- , Vivek Iyer
- , Rebecca Shepherd
- , Ronald A. Herbert
- , Peter J. Campbell
- , Robert C. Sills
- , Ludmil B. Alexandrov
- , Allan Balmain
- & David J. Adams
Nature Genetics 52 , 1189–1197

Rights & permissionsfor article The mutational signature profile of known and suspected human carcinogens in mice . Opens in a new window.
Research | 12 May 2020 | Open
Integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility
- Angel A. Ku
- , Hsien-Ming Hu
- , Xin Zhao
- , Khyati N. Shah
- , Sameera Kongara
- , Di Wu
- , Frank McCormick
- , Allan Balmain
- & Sourav Bandyopadhyay
Nature Communications 11 , 1–12

Rights & permissionsfor article Integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility . Opens in a new window.
Research | 20 January 2020 | Open
Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice
- Yun Rose Li
- , Kyle D. Halliwill
- , Cassandra J. Adams
- , Vivek Iyer
- , Laura Riva
- , Rashid Mamunur
- , Kuang-Yu Jen
- , Reyno del Rosario
- , Erik Fredlund
- , Gillian Hirst
- , Ludmil B. Alexandrov
- , David Adams
- & Allan Balmain
Nature Communications 11 , 1–15

Rights & permissionsfor article Mutational signatures in tumours induced by high and low energy radiation in <i>Trp53</i> deficient mice . Opens in a new window.
Research | 1 July 2002
Metastasis is driven by sequential elevation of H-ras and Smad2 levels
Nature Cell Biology 4 , 487–494

Rights & permissionsfor article Metastasis is driven by sequential elevation of H-ras and Smad2 levels . Opens in a new window.
22 August 2005
Genomic instability in radiation-induced mouse lymphoma from p53 heterozygous mice
- Jiang-Hua Mao
- , Jiangzhen Li
- , Tao Jiang
- , Qian Li
- , Di Wu
- , Jesus Perez-Losada
- , Reyno DelRosario
- , Leif Peterson
- , Allan Balmain
- & Wei-Wen Cai
Oncogene 24 , 7924–7934

Rights & permissionsfor article Genomic instability in radiation-induced mouse lymphoma from p53 heterozygous mice . Opens in a new window.
News and Views | 16 May 2002
New-age tumour suppressors
- Allan Balmain
Nature 417 , 235–237

Rights & permissionsfor article New-age tumour suppressors . Opens in a new window.
Reviews | 28 July 2009
Systems genetics analysis of cancer susceptibility: from mouse models to humans
- David Quigley
- & Allan Balmain
Nature Reviews Genetics 10 , 651–657

Rights & permissionsfor article Systems genetics analysis of cancer susceptibility: from mouse models to humans . Opens in a new window.
Research | 11 January 2009
Genetic architecture of mouse skin inflammation and tumour susceptibility
Nature 458 , 505–508

Rights & permissionsfor article Genetic architecture of mouse skin inflammation and tumour susceptibility . Opens in a new window.
Research | 18 May 2000
Targeting gene expression to tumor cells with loss of wild-type p53 function
- Jingde Zhu
- , Baomei Gao
- , Jiangqin Zhao
- & Allan Balmain
Cancer Gene Therapy 7 , 4–12

Rights & permissionsfor article Targeting gene expression to tumor cells with loss of wild-type p53 function . Opens in a new window.
News and Views | 18 March 2004
Dangerous liaisons
- Allan Balmain
- & Rosemary J. Akhurst
Nature 428 , 271–272

Rights & permissionsfor article Dangerous liaisons . Opens in a new window.
Research | 1 April 2002
Genome-wide detection of chromosomal imbalances in tumors using BAC microarrays
- Wei-Wen Cai
- , Jian-Hua Mao
- , Chi-Wen Chow
- , Shamsha Damani
- , Allan Balmain
- & Allan Bradley
Nature Biotechnology 20 , 393–396

Rights & permissionsfor article Genome-wide detection of chromosomal imbalances in tumors using BAC microarrays . Opens in a new window.
Research | 9 December 2004
Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene
- Jian-Hua Mao
- , Jesus Perez-losada
- , Di Wu
- , Reyno DelRosario
- , Ryosuke Tsunematsu
- , Keiichi I. Nakayama
- , Ken Brown
- , Sheila Bryson
- & Allan Balmain
Nature 432 , 775–779

Rights & permissionsfor article <i>Fbxw7</i>/<i>Cdc4</i> is a p53-dependent, haploinsufficient tumour suppressor gene . Opens in a new window.
Research | 1 September 1994
p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis
Nature Genetics 8 , 66–69

Rights & permissionsfor article <i>p53</i>-deficient mice are extremely susceptible to radiation-induced tumorigenesis . Opens in a new window.
Research | 3 July 1986
Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis
Nature 322 , 78–80

Rights & permissionsfor article Carcinogen-specific mutation and amplification of Ha-<i>ras</i> during mouse skin carcinogenesis . Opens in a new window.
Research | 5 May 1983
Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene
- Allan Balmain
- & Ian B. Pragnell
Nature 303 , 72–74

Rights & permissionsfor article Mouse skin carcinomas induced <i>in vivo</i> by chemical carcinogens have a transforming Harvey-<i>ras</i> oncogene . Opens in a new window.
Research | 22 August 2004
Genomic segmental polymorphisms in inbred mouse strains
- Jiangzhen Li
- , Tao Jiang
- , Jian-Hua Mao
- , Allan Balmain
- , Leif Peterson
- , Charles Harris
- , Pulivarthi H Rao
- , Paul Havlak
- , Richard Gibbs
- & Wei-Wen Cai
Nature Genetics 36 , 952–954

Rights & permissionsfor article Genomic segmental polymorphisms in inbred mouse strains . Opens in a new window.
Research | 16 February 1984
Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas
Nature 307 , 658–660

Rights & permissionsfor article Activation of the mouse cellular Harvey-<i>ras</i> gene in chemically induced benign skin papillomas . Opens in a new window.
20 June 2005
p63 and p73 do not contribute to p53-mediated lymphoma suppressor activity in vivo
- Jesus Perez-Losada
- , Di Wu
- , Reyno DelRosario
- , Allan Balmain
- & Jian-Hua Mao
Oncogene 24 , 5521–5524

Rights & permissionsfor article <i>p63</i> and <i>p73</i> do not contribute to p53-mediated lymphoma suppressor activity <i>in vivo</i> . Opens in a new window.
1 October 2001
Cancer genetics: from Boveri and Mendel to microarrays
- Allan Balmain
Nature Reviews Cancer 1 , 77–82

Rights & permissionsfor article Cancer genetics: from Boveri and Mendel to microarrays . Opens in a new window.
Research | 2 July 2006
A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2^LA2 mice
- Minh D To
- , Jesus Perez-Losada
- , Jian-Hua Mao
- , Jeff Hsu
- , Tyler Jacks
- & Allan Balmain
Nature Genetics 38 , 926–930

Rights & permissionsfor article A functional switch from lung cancer resistance to susceptibility at the <i>Pas1</i> locus in <i>Kras2</i><sup>LA2</sup> mice . Opens in a new window.
Research | 31 August 2008
Kras regulatory elements and exon 4A determine mutation specificity in lung cancer
- ...are common in skin tumors. Allan Balmain and colleagues use genetic engineering...
Nature Genetics 40 , 1240–1244

Rights & permissionsfor article <i>Kras</i> regulatory elements and exon 4A determine mutation specificity in lung cancer . Opens in a new window.
Research | 17 January 2007
Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice
- Yuichi Wakabayashi
- , Jian-Hua Mao
- , Ken Brown
- , Michael Girardi
- & Allan Balmain
Nature 445 , 761–765

Rights & permissionsfor article Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the <i>Patched</i> gene in FVB mice . Opens in a new window.
20 November 2003
Genetic interactions between Pten and p53 in radiation-induced lymphoma development
- Jian-Hua Mao
- , Di Wu
- , Jesus Perez-Losada
- , Hiroki Nagase
- , Reyno DelRosario
- & Allan Balmain
Oncogene 22 , 8379–8385

Rights & permissionsfor article Genetic interactions between <i>Pten</i> and p53 in radiation-induced lymphoma development . Opens in a new window.
Research | 11 December 2019
KRAS4A directly regulates hexokinase 1
- Caroline R. Amendola
- , James P. Mahaffey
- , Seth J. Parker
- , Ian M. Ahearn
- , Wei-Ching Chen
- , Mo Zhou
- , Helen Court
- , Jie Shi
- , Sebastian L. Mendoza
- , Michael J. Morten
- , Eli Rothenberg
- , Eyal Gottlieb
- , Youssef Z. Wadghiri
- , Richard Possemato
- , Stevan R. Hubbard
- , Allan Balmain
- , Alec C. Kimmelman
- & Mark R. Philips
Nature 576 , 482–486

Rights & permissionsfor article KRAS4A directly regulates hexokinase 1 . Opens in a new window.
Reviews | 12 November 2018
A model for RAS mutation patterns in cancers: finding the sweet spot
Nature Reviews Cancer 18 , 767–777

Rights & permissionsfor article A model for RAS mutation patterns in cancers: finding the sweet spot . Opens in a new window.
Research | 25 May 2018
Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis
Nature Cell Biology 20 , 699–709

Rights & permissionsfor article Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis . Opens in a new window.
Research | 25 September 2017
Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma
- Phillips Y Huang
- , Eve Kandyba
- , Arnaud Jabouille
- , Jonas Sjolund
- , Atul Kumar
- , Kyle Halliwill
- , Melissa McCreery
- , Reyno DelRosario
- , Hio Chung Kang
- , Christine E Wong
- , Jost Seibler
- , Vincent Beuger
- , Maurizio Pellegrino
- , Adam Sciambi
- , Dennis J Eastburn
- & Allan Balmain
Nature Genetics 49 , 1624–1632

Rights & permissionsfor article <i>Lgr6</i> is a stem cell marker in mouse skin squamous cell carcinoma . Opens in a new window.
Research | 27 April 2015
Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole–imidazole polyamide conjugate
- Kiriko Hiraoka
- , Takahiro Inoue
- , Rhys Dylan Taylor
- , Takayoshi Watanabe
- , Nobuko Koshikawa
- , Hiroyuki Yoda
- , Ken-ichi Shinohara
- , Atsushi Takatori
- , Hirokazu Sugimoto
- , Yoshiaki Maru
- , Tadamichi Denda
- , Kyoko Fujiwara
- , Allan Balmain
- , Toshinori Ozaki
- , Toshikazu Bando
- , Hiroshi Sugiyama
- & Hiroki Nagase
Nature Communications 6 , 1–8

Rights & permissionsfor article Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole–imidazole polyamide conjugate . Opens in a new window.
Research | 2 November 2014
The mutational landscapes of genetic and chemical models of Kras-driven lung cancer
- Allan Balmain and colleagues use whole-exome...
- Peter M. K. Westcott
- , Kyle D. Halliwill
- , Minh D. To
- , Mamunur Rashid
- , Alistair G. Rust
- , Thomas M. Keane
- , Reyno Delrosario
- , Kuang-Yu Jen
- , Kay E. Gurley
- , Christopher J. Kemp
- , Erik Fredlund
- , David A. Quigley
- , David J. Adams
- & Allan Balmain
Nature 517 , 489–492

Rights & permissionsfor article The mutational landscapes of genetic and chemical models of <i>Kras</i>-driven lung cancer . Opens in a new window.
Research | 2 November 2015
Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers
- Melissa Q McCreery
- , Kyle D Halliwill
- , Douglas Chin
- , Reyno Delrosario
- , Gillian Hirst
- , Peter Vuong
- , Kuang-Yu Jen
- , James Hewinson
- , David J Adams
- & Allan Balmain
Nature Medicine 21 , 1514–1520

Rights & permissionsfor article Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers . Opens in a new window.
Research | 16 April 2013
Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas
- Il-Jin Kim
- , David Quigley
- , Minh D. To
- , Patrick Pham
- , Kevin Lin
- , Brian Jo
- , Kuang-Yu Jen
- , Dan Raz
- , Jae Kim
- , Jian-Hua Mao
- , David Jablons
- & Allan Balmain
Nature Communications 4 , 1–11

Rights & permissionsfor article Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas . Opens in a new window.
Reviews | 1 March 2003
The genetics and genomics of cancer
- Allan Balmain
- , Joe Gray
- & Bruce Ponder
Nature Genetics 33 , 238–244

Rights & permissionsfor article The genetics and genomics of cancer . Opens in a new window.
17 August 2000
High levels of phosphorylated c-Jun, Fra-1, Fra-2 and ATF-2 proteins correlate with malignant phenotypes in the multistage mouse skin carcinogenesis model
Oncogene 19 , 4011–4021

Rights & permissionsfor article High levels of phosphorylated c-Jun, Fra-1, Fra-2 and ATF-2 proteins correlate with malignant phenotypes in the multistage mouse skin carcinogenesis model . Opens in a new window.
Research | 27 July 2003
Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human
- Amanda Ewart-Toland
- , Paraskevi Briassouli
- , John P de Koning
- , Jian-Hua Mao
- , Jinwei Yuan
- , Florence Chan
- , Lucy MacCarthy-Morrogh
- , Bruce A J Ponder
- , Hiroki Nagase
- , John Burn
- , Sarah Ball
- , Maria Almeida
- , Spiros Linardopoulos
- & Allan Balmain
Nature Genetics 34 , 403–412

Rights & permissionsfor article Identification of <i>Stk6</i>/<i>STK15</i> as a candidate low-penetrance tumor-susceptibility gene in mouse and human . Opens in a new window.
Research | 1 August 1995
Distinct genetic loci control development of benign and malignant skin tumours in mice
- Hiroki Nagase
- , Sheila Bryson
- , Heather Cordell
- , Christopher J. Kemp
- , Frances Fee
- & Allan Balmain
Nature Genetics 10 , 424–429

Rights & permissionsfor article Distinct genetic loci control development of benign and malignant skin tumours in mice . Opens in a new window.
Reviews | 1 June 2003
Stem-cell hierarchy in skin cancer
- Jesus Perez-Losada
- & Allan Balmain
Nature Reviews Cancer 3 , 434–443

Rights & permissionsfor article Stem-cell hierarchy in skin cancer . Opens in a new window.
Reviews | 1 October 2001
TGF-β signaling in tumor suppression and cancer progression
Nature Genetics 29 , 117–129

Rights & permissionsfor article TGF-β signaling in tumor suppression and cancer progression . Opens in a new window.

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