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Research | 27 November 2020 | Open
Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H
- Yuki Shibayama
- , Kazuo Takahashi
- , Hisateru Yamaguchi
- , Jun Yasuda
- , Daisuke Yamazaki
- , Asadur Rahman
- , Takayuki Fujimori
- , Yoshihide Fujisawa
- , Shinji Takai
- , Toru Furukawa
- , Tsutomu Nakagawa
- , Hiroyuki Ohsaki
- , Hideki Kobara
- , Jing Hao Wong
- , Tsutomu Masaki
- , Yukio Yuzawa
- , Hideyasu Kiyomoto
- , Shinichi Yachida
- , Akihiro Fujimoto
- & Akira Nishiyama
Communications Biology 3 , 1–14

Rights & permissionsfor article Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H . Opens in a new window.
Reviews | 13 July 2020
Esaxerenone, a novel nonsteroidal mineralocorticoid receptor blocker (MRB) in hypertension and chronic kidney disease
Journal of Human Hypertension , 1–9

Rights & permissionsfor article Esaxerenone, a novel nonsteroidal mineralocorticoid receptor blocker (MRB) in hypertension and chronic kidney disease . Opens in a new window.
Reviews | 1 October 2020
Organ protection by SGLT2 inhibitors: role of metabolic energy and water conservation
- Adriana Marton
- , Tatsuroh Kaneko
- , Jean-Paul Kovalik
- , Atsutaka Yasui
- , Akira Nishiyama
- , Kento Kitada
- & Jens Titze
Nature Reviews Nephrology 17 , 65–77

Rights & permissionsfor article Organ protection by SGLT2 inhibitors: role of metabolic energy and water conservation . Opens in a new window.
Research | 14 February 2020
Effects of an SGLT2 inhibitor on the salt sensitivity of blood pressure and sympathetic nerve activity in a nondiabetic rat model of chronic kidney disease
- Ningning Wan
- , Yoshihide Fujisawa
- , Hideki Kobara
- , Tsutomu Masaki
- , Daisuke Nakano
- , Asadur Rahman
- & Akira Nishiyama
Hypertension Research 43 , 492–499

Rights & permissionsfor article Effects of an SGLT2 inhibitor on the salt sensitivity of blood pressure and sympathetic nerve activity in a nondiabetic rat model of chronic kidney disease . Opens in a new window.
Research | 14 January 2020
Renal sympathetic nerve activity regulates cardiovascular energy expenditure in rats fed high salt
- Norihiko Morisawa
- , Kento Kitada
- , Yoshihide Fujisawa
- , Daisuke Nakano
- , Daisuke Yamazaki
- , Shuhei Kobuchi
- , Lei Li
- , Yifan Zhang
- , Takashi Morikawa
- , Yoshio Konishi
- , Takashi Yokoo
- , Friedrich C. Luft
- , Jens Titze
- & Akira Nishiyama
Hypertension Research 43 , 482–491

Rights & permissionsfor article Renal sympathetic nerve activity regulates cardiovascular energy expenditure in rats fed high salt . Opens in a new window.
Reviews | 31 July 2020
Hypertension and related diseases in the era of COVID-19: a report from the Japanese Society of Hypertension Task Force on COVID-19
- Shigeru Shibata
- , Hisatomi Arima
- , Kei Asayama
- , Satoshi Hoshide
- , Atsuhiro Ichihara
- , Toshihiko Ishimitsu
- , Kazuomi Kario
- , Takuya Kishi
- , Masaki Mogi
- , Akira Nishiyama
- , Mitsuru Ohishi
- , Takayoshi Ohkubo
- , Kouichi Tamura
- , Masami Tanaka
- , Eiichiro Yamamoto
- , Koichi Yamamoto
- & Hiroshi Itoh
Hypertension Research 43 , 1028–1046

Rights & permissionsfor article Hypertension and related diseases in the era of COVID-19: a report from the Japanese Society of Hypertension Task Force on COVID-19 . Opens in a new window.
Research | 18 July 2019 | Open
A mouse model of renal fibrosis to overcome the technical variability in ischaemia/reperfusion injury among operators
- Yu Guan
- , Daisuke Nakano
- , Yifan Zhang
- , Lei Li
- , Ye Tian
- & Akira Nishiyama
Scientific Reports 9 , 1–9

Rights & permissionsfor article A mouse model of renal fibrosis to overcome the technical variability in ischaemia/reperfusion injury among operators . Opens in a new window.
Reviews | 8 April 2019
JSH Statement: Asahikawa declaration in promotion of diversity by the Japanese society of hypertension–the JSH Asahikawa declaration
- Satoko Nakamura
- , Naoyuki Hasebe
- , Midori Yatabe
- , Takuya Kishi
- , Mari Ishida
- , Atsuhiro Ichihara
- , Koichi Node
- , Toshihiko Ishimitsu
- , Hiroshi Itoh
- , Masaaki Ito
- , Mitsuru Ohishi
- , Takayoshi Ohkubo
- , Hisashi Kai
- , Naoki Kashihara
- , Kazuomi Kario
- , Shigeyuki Saitoh
- , Takuya Tsuchihashi
- , Akira Nishiyama
- , Jitsuo Higaki
- , Katsuyuki Miura
- , Hiromi Rakugi
- , Yuhei Kawano
- , Kouichi Tamura
- , Takashi Yatabe
- , Yusuke Ohya
- & Sadayoshi Ito
Hypertension Research 42 , 1483–1484

Rights & permissionsfor article JSH Statement: Asahikawa declaration in promotion of diversity by the Japanese society of hypertension–the JSH Asahikawa declaration . Opens in a new window.
Research | 21 January 2019
Effect of a novel nonsteroidal selective mineralocorticoid receptor antagonist, esaxerenone (CS-3150), on blood pressure and renal injury in high salt-treated type 2 diabetic mice
Hypertension Research 42 , 892–902

Rights & permissionsfor article Effect of a novel nonsteroidal selective mineralocorticoid receptor antagonist, esaxerenone (CS-3150), on blood pressure and renal injury in high salt-treated type 2 diabetic mice . Opens in a new window.
Reviews | 7 January 2019
JSH Statement: Kyoto declaration on hypertension research in Asia
- Masaaki Ito
- , Toshihiko Ishimitsu
- , Atsuhiro Ichihara
- , Hiroshi Itoh
- , Mitsuru Ohishi
- , Takayoshi Ohkubo
- , Hisashi Kai
- , Naoki Kashihara
- , Kazuomi Kario
- , Shigeyuki Saitoh
- , Takuya Tsuchihashi
- , Satoko Nakamura
- , Akira Nishiyama
- , Koichi Node
- , Naoyuki Hasebe
- , Jitsuo Higaki
- , Katsuyuki Miura
- , Hiromi Rakugi
- , Kouichi Tamura
- , Yuhei Kawano
- , Takashi Yatabe
- , Yusuke Ohya
- & Sadayoshi Ito
Hypertension Research 42 , 759–760

Rights & permissionsfor article JSH Statement: Kyoto declaration on hypertension research in Asia . Opens in a new window.
Reviews | 11 October 2018
The Japanese Society of Hypertension—Digest of plan for the future
- Koichi Node
- , Takuya Kishi
- , Atsushi Tanaka
- , Hiroshi Itoh
- , Hiromi Rakugi
- , Yusuke Ohya
- , Katsuyuki Miura
- , Tomonori Okamura
- , Toshihiko Ishimitsu
- , Atsuhiro Ichihara
- , Masaaki Ito
- , Mitsuru Ohishi
- , Takayoshi Ohkubo
- , Hisashi Kai
- , Naoki Kashihara
- , Kazuomi Kario
- , Shigeyuki Saitoh
- , Takuya Tsuchihashi
- , Satoko Nakamura
- , Akira Nishiyama
- , Naoyuki Hasebe
- , Jitsuo Higaki
- , Kouichi Tamura
- , Yuhei Kawano
- , Takashi Yatabe
- & Sadayoshi Ito
Hypertension Research 41 , 989–990

Rights & permissionsfor article The Japanese Society of Hypertension—Digest of plan for the future . Opens in a new window.
Reviews | 6 December 2018
Pathophysiological mechanisms of mineralocorticoid receptor-dependent cardiovascular and chronic kidney disease
- Akira Nishiyama
Hypertension Research 42 , 293–300

Rights & permissionsfor article Pathophysiological mechanisms of mineralocorticoid receptor-dependent cardiovascular and chronic kidney disease . Opens in a new window.
Research | 18 December 2018 | Open
Chronic intermittent hypoxia-mediated renal sympathetic nerve activation in hypertension and cardiovascular disease
- Keiko Takahashi
- , Seiji Ueda
- , Takashi Kobayashi
- , Akira Nishiyama
- , Yoshihide Fujisawa
- , Takeshi Sugaya
- , Satomi Shiota
- , Kazuhisa Takahashi
- , Tomohito Gohda
- , Satoshi Horikoshi
- & Yusuke Suzuki
Scientific Reports 8 , 1–7

Rights & permissionsfor article Chronic intermittent hypoxia-mediated renal sympathetic nerve activation in hypertension and cardiovascular disease . Opens in a new window.
Research | 26 December 2018
Effects of the novel nonsteroidal mineralocorticoid receptor blocker, esaxerenone (CS-3150), on blood pressure and urinary angiotensinogen in low-renin Dahl salt-sensitive hypertensive rats
- Lei Li
- , Yu Guan
- , Hiroyuki Kobori
- , Asahiro Morishita
- , Hideki Kobara
- , Tsutomu Masaki
- , Daisuke Nakano
- & Akira Nishiyama
Hypertension Research 42 , 769–778

Rights & permissionsfor article Effects of the novel nonsteroidal mineralocorticoid receptor blocker, esaxerenone (CS-3150), on blood pressure and urinary angiotensinogen in low-renin Dahl salt-sensitive hypertensive rats . Opens in a new window.
Research | 25 August 2017 | Open
Responses of renal hemodynamics and tubular functions to acute sodium–glucose cotransporter 2 inhibitor administration in non-diabetic anesthetized rats
- Tuba M. Ansary
- , Yoshihide Fujisawa
- , Asadur Rahman
- , Daisuke Nakano
- , Hirofumi Hitomi
- , Hideki Kobara
- , Tsutomu Masaki
- , Jens M. Titze
- , Kento Kitada
- & Akira Nishiyama
Scientific Reports 7 , 1–9

Rights & permissionsfor article Responses of renal hemodynamics and tubular functions to acute sodium–glucose cotransporter 2 inhibitor administration in non-diabetic anesthetized rats . Opens in a new window.
Research | 6 May 2016 | Open
Generation and gene expression profiling of 48 transcription-factor-inducible mouse embryonic stem cell lines
- Kohei Yamamizu
- , Alexei A. Sharov
- , Yulan Piao
- , Misa Amano
- , Hong Yu
- , Akira Nishiyama
- , Dawood B. Dudekula
- , David Schlessinger
- & Minoru S. H. Ko
Scientific Reports 6 , 1–8

Rights & permissionsfor article Generation and gene expression profiling of 48 transcription-factor-inducible mouse embryonic stem cell lines . Opens in a new window.
19 January 2017
Cardioprotective effects of SGLT2 inhibitors are possibly associated with normalization of the circadian rhythm of blood pressure
Hypertension Research 40 , 535–540

Rights & permissionsfor article Cardioprotective effects of SGLT2 inhibitors are possibly associated with normalization of the circadian rhythm of blood pressure . Opens in a new window.
Research | 28 January 2016
A sodium-glucose co-transporter 2 inhibitor empagliflozin prevents abnormality of circadian rhythm of blood pressure in salt-treated obese rats
- Yui Takeshige
- , Yoshihide Fujisawa
- , Asadur Rahman
- , Wararat Kittikulsuth
- , Daisuke Nakano
- , Hirohito Mori
- , Tsutomu Masaki
- , Koji Ohmori
- , Masakazu Kohno
- , Hiroaki Ogata
- & Akira Nishiyama
Hypertension Research 39 , 415–422

Rights & permissionsfor article A sodium-glucose co-transporter 2 inhibitor empagliflozin prevents abnormality of circadian rhythm of blood pressure in salt-treated obese rats . Opens in a new window.
13 March 2014
Liver-specific angiotensinogen suppression: an old yet novel target for blood pressure control through RAS inhibition?
Hypertension Research 37 , 393–394

Rights & permissionsfor article Liver-specific angiotensinogen suppression: an old yet novel target for blood pressure control through RAS inhibition? . Opens in a new window.
Research | 15 January 2015
Effect of dipeptidyl peptidase-4 inhibition on circadian blood pressure during the development of salt-dependent hypertension in rats
- Abu Sufiun
- , Kazi Rafiq
- , Yoshihide Fujisawa
- , Asadur Rahman
- , Hirohito Mori
- , Daisuke Nakano
- , Hiroyuki Kobori
- , Koji Ohmori
- , Tsutomu Masaki
- , Masakazu Kohno
- & Akira Nishiyama
Hypertension Research 38 , 237–243

Rights & permissionsfor article Effect of dipeptidyl peptidase-4 inhibition on circadian blood pressure during the development of salt-dependent hypertension in rats . Opens in a new window.
Research | 12 September 2013
High sodium augments angiotensin II-induced vascular smooth muscle cell proliferation through the ERK 1/2-dependent pathway
- Gang Liu
- , Hirofumi Hitomi
- , Asadur Rahman
- , Daisuke Nakano
- , Hirohito Mori
- , Tsutomu Masaki
- , Hong Ma
- , Takahiro Iwamoto
- , Hiroyuki Kobori
- & Akira Nishiyama
Hypertension Research 37 , 13–18

Rights & permissionsfor article High sodium augments angiotensin II-induced vascular smooth muscle cell proliferation through the ERK 1/2-dependent pathway . Opens in a new window.
Research | 20 March 2014
Serum soluble (pro)renin receptor levels in patients with essential hypertension
Hypertension Research 37 , 642–648

Rights & permissionsfor article Serum soluble (pro)renin receptor levels in patients with essential hypertension . Opens in a new window.
Research | 27 November 2009
Systemic candesartan reduces brain angiotensin II via downregulation of brain renin–angiotensin system
- Nicolas Pelisch
- , Naohisa Hosomi
- , Masaki Ueno
- , Hisashi Masugata
- , Koji Murao
- , Hirofumi Hitomi
- , Daisuke Nakano
- , Hiroyuki Kobori
- , Akira Nishiyama
- & Masakazu Kohno
Hypertension Research 33 , 161–164

Rights & permissionsfor article Systemic candesartan reduces brain angiotensin II via downregulation of brain renin–angiotensin system . Opens in a new window.
Research | 7 April 2011
Mechanism underlying the efficacy of combination therapy with losartan and hydrochlorothiazide in rats with salt-sensitive hypertension
- Yuichiro Yamada
- , Koji Tsuboi
- , Takuya Hattori
- , Tamayo Murase
- , Masafumi Ohtake
- , Mayuko Furukawa
- , Jun Ueyama
- , Akira Nishiyama
- , Toyoaki Murohara
- & Kohzo Nagata
Hypertension Research 34 , 809–816

Rights & permissionsfor article Mechanism underlying the efficacy of combination therapy with losartan and hydrochlorothiazide in rats with salt-sensitive hypertension . Opens in a new window.
Research | 1 December 2005
Effects of a New Calcium Channel Blocker, Azelnidipine, on Systemic Hemodynamics and Renal Sympathetic Nerve Activity in Spontaneously Hypertensive Rats
- Takatomi Shokoji
- , Yoshihide Fujisawa
- , Hideyasu Kiyomoto
- , Matlubur Rahman
- , Guang-Ping Sun
- , Yu-Yan Fan
- , Shoji Kimura
- , Masakazu Kohno
- , Youichi Abe
- & Akira Nishiyama
Hypertension Research 28 , 1017–1023

Rights & permissionsfor article Effects of a New Calcium Channel Blocker, Azelnidipine, on Systemic Hemodynamics and Renal Sympathetic Nerve Activity in Spontaneously Hypertensive Rats . Opens in a new window.
Research | 25 November 2010
Involvement of activated prorenin in the pathogenesis of slowly progressive nephropathy in the non-clipped kidney of two kidney, one-clip hypertension
Hypertension Research 34 , 301–307

Rights & permissionsfor article Involvement of activated prorenin in the pathogenesis of slowly progressive nephropathy in the non-clipped kidney of two kidney, one-clip hypertension . Opens in a new window.
Research | 6 March 2013 | Open
Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells
- Akira Nishiyama
- , Alexei A. Sharov
- , Yulan Piao
- , Misa Amano
- , Tomokazu Amano
- , Hien G. Hoang
- , Bernard Y. Binder
- , Richard Tapnio
- , Uwem Bassey
- , Justin N. Malinou
- , Lina S. Correa-Cerro
- , Hong Yu
- , Li Xin
- , Emily Meyers
- , Michal Zalzman
- , Yuhki Nakatake
- , Carole Stagg
- , Lioudmila Sharova
- , Yong Qian
- , Dawood Dudekula
- , Sarah Sheer
- , Jean S. Cadet
- , Tetsuya Hirata
- , Hsih-Te Yang
- , Ilya Goldberg
- , Michele K. Evans
- , Dan L. Longo
- , David Schlessinger
- & Minoru S. H. Ko
Scientific Reports 3 , 1–6

Rights & permissionsfor article Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells . Opens in a new window.
Research | 27 January 2011
Angiotensin II induces human astrocyte senescence through reactive oxygen species production
- Gang Liu
- , Naohisa Hosomi
- , Hirofumi Hitomi
- , Nicolas Pelisch
- , Hua Fu
- , Hisashi Masugata
- , Koji Murao
- , Masaki Ueno
- , Masayasu Matsumoto
- & Akira Nishiyama
Hypertension Research 34 , 479–483

Rights & permissionsfor article Angiotensin II induces human astrocyte senescence through reactive oxygen species production . Opens in a new window.
Research | 1 March 2012
The optimal timing of antihypertensive medication administration for morning hypertension in patients with cerebral infarction
- Naohisa Hosomi
- , Yoshimasa Sueda
- , Hisashi Masugata
- , Hiroaki Dobashi
- , Koji Murao
- , Masaki Ueno
- , Takanori Miki
- , Masakazu Kohno
- , Akira Nishiyama
- & Masayasu Matsumoto
Hypertension Research 35 , 720–724

Rights & permissionsfor article The optimal timing of antihypertensive medication administration for morning hypertension in patients with cerebral infarction . Opens in a new window.
Research | 1 July 2005
Ischemic preconditioning protects post-ischemic renal function in anesthetized dogs: role of adenosine and adenine nucleotides
- Fan-zhu Li
- , Shoji Kimura
- , Akira Nishiyama
- , Matlubur Rahman
- , Guo-xing Zhang
- & Youichi Abe
Acta Pharmacologica Sinica 26 , 851–859

Rights & permissionsfor article Ischemic preconditioning protects post-ischemic renal function in anesthetized dogs: role of adenosine and adenine nucleotides . Opens in a new window.
Research | 25 September 2009
Comparison of central blood pressure and cardio-ankle vascular index for association with cardiac function in treated hypertensive patients
- Hisashi Masugata
- , Shoichi Senda
- , Hiroyuki Okuyama
- , Koji Murao
- , Michio Inukai
- , Naohisa Hosomi
- , Kazushi Yukiiri
- , Akira Nishiyama
- , Masakazu Kohno
- & Fuminori Goda
Hypertension Research 32 , 1136–1142

Rights & permissionsfor article Comparison of central blood pressure and cardio-ankle vascular index for association with cardiac function in treated hypertensive patients . Opens in a new window.
Research | 23 November 2011 | Open
Generation of mouse ES cell lines engineered for the forced induction of transcription factors
- Lina S. Correa-Cerro
- , Yulan Piao
- , Alexei A. Sharov
- , Akira Nishiyama
- , Jean S. Cadet
- , Hong Yu
- , Lioudmila V. Sharova
- , Li Xin
- , Hien G. Hoang
- , Marshall Thomas
- , Yong Qian
- , Dawood B. Dudekula
- , Emily Meyers
- , Bernard Y. Binder
- , Gregory Mowrer
- , Uwem Bassey
- , Dan L. Longo
- , David Schlessinger
- & Minoru S. H. Ko
Scientific Reports 1 , 1–6

Rights & permissionsfor article Generation of mouse ES cell lines engineered for the forced induction of transcription factors . Opens in a new window.
Research | 1 July 2008
Possible Involvement of Rho-Kinase in Aldosterone-Induced Vascular Smooth Muscle Cell Remodeling
- Kayoko Miyata
- , Hirofumi Hitomi
- , Peng Guo
- , Guo-Xing Zhang
- , Shoji Kimura
- , Hideyasu Kiyomoto
- , Naohisa Hosomi
- , Shoji Kagami
- , Masakazu Kohno
- & Akira Nishiyama
Hypertension Research 31 , 1407–1413

Rights & permissionsfor article Possible Involvement of Rho-Kinase in Aldosterone-Induced Vascular Smooth Muscle Cell Remodeling . Opens in a new window.
Research | 7 October 2010
Mechanical stretch potentiates angiotensin II-induced proliferation in spontaneously hypertensive rat vascular smooth muscle cells
- Gang Liu
- , Hirofumi Hitomi
- , Naohisa Hosomi
- , Bai Lei
- , Nicolas Pelisch
- , Daisuke Nakano
- , Hideyasu Kiyomoto
- , Hong Ma
- & Akira Nishiyama
Hypertension Research 33 , 1250–1257

Rights & permissionsfor article Mechanical stretch potentiates angiotensin II-induced proliferation in spontaneously hypertensive rat vascular smooth muscle cells . Opens in a new window.
Research | 1 August 2008
Evidence for Abundant Presence of Chymase-Positive Mast Cells in the Kidneys of Patients with Immunoglobulin A Nephropathy: Effect of Combination Therapy with Prednisolone and Angiotensin II Receptor Blocker Valsartan
- Yoshio Konishi
- , Takashi Morikawa
- , Noriyuki Okada
- , Isseki Maeda
- , Chizuko Kitabayashi
- , Katsunobu Yoshioka
- , Michiaki Okumura
- , Akira Nishiyama
- , Makiko Ueda
- , Shinji Takai
- , Mizuo Miyazaki
- & Masahito Imanishi
Hypertension Research 31 , 1517–1524

Rights & permissionsfor article Evidence for Abundant Presence of Chymase-Positive Mast Cells in the Kidneys of Patients with Immunoglobulin A Nephropathy: Effect of Combination Therapy with Prednisolone and Angiotensin II Receptor Blocker Valsartan . Opens in a new window.
Research | 28 July 2011
Roles of central renin-angiotensin system and afferent renal nerve in the control of systemic hemodynamics in rats
- Yoshihide Fujisawa
- , Yukiko Nagai
- , Bai Lei
- , Daisuke Nakano
- , Toshiki Fukui
- , Hirofumi Hitomi
- , Hirohito Mori
- , Tsutomu Masaki
- & Akira Nishiyama
Hypertension Research 34 , 1228–1232

Rights & permissionsfor article Roles of central renin-angiotensin system and afferent renal nerve in the control of systemic hemodynamics in rats . Opens in a new window.
Research | 20 March 2009
The expression of matrix metalloproteinase-13 is increased in vessels with blood–brain barrier impairment in a stroke-prone hypertensive model
- Masaki Ueno
- , Bin Wu
- , Akira Nishiyama
- , Cheng-long Huang
- , Naohisa Hosomi
- , Takashi Kusaka
- , Toshitaka Nakagawa
- , Masayuki Onodera
- , Mizue Kido
- & Haruhiko Sakamoto
Hypertension Research 32 , 332–338

Rights & permissionsfor article The expression of matrix metalloproteinase-13 is increased in vessels with blood–brain barrier impairment in a stroke-prone hypertensive model . Opens in a new window.
Research | 19 August 2019 | Open
The p21 dependent G2 arrest of the cell cycle in epithelial tubular cells links to the early stage of renal fibrosis
- Takayuki Koyano
- , Masumi Namba
- , Tomoe Kobayashi
- , Kyomi Nakakuni
- , Daisuke Nakano
- , Masaki Fukushima
- , Akira Nishiyama
- & Makoto Matsuyama
Scientific Reports 9 , 1–11

Rights & permissionsfor article The p21 dependent G2 arrest of the cell cycle in epithelial tubular cells links to the early stage of renal fibrosis . Opens in a new window.
Research | 17 December 2018 | Open
(Pro)renin receptor promotes colorectal cancer through the Wnt/beta-catenin signalling pathway despite constitutive pathway component mutations
- Juan Wang
- , Yuki Shibayama
- , Anqi Zhang
- , Hiroyuki Ohsaki
- , Eisuke Asano
- , Yasuyuki Suzuki
- , Yoshio Kushida
- , Hideki Kobara
- , Tsutomu Masaki
- , Zhiyu Wang
- & Akira Nishiyama
British Journal of Cancer 120 , 229–237

Rights & permissionsfor article (Pro)renin receptor promotes colorectal cancer through the Wnt/beta-catenin signalling pathway despite constitutive pathway component mutations . Opens in a new window.
Research | 9 July 2018
Simultaneous GLP-1 receptor activation and angiotensin receptor blockade increase natriuresis independent of altered arterial pressure in obese OLETF rats
- Ruben Rodriguez
- , Meagan Moreno
- , Andrew Y. Lee
- , Jose A. Godoy-Lugo
- , Daisuke Nakano
- , Akira Nishiyama
- , David Parkes
- , Mouhamed S. Awayda
- & Rudy M. Ortiz
Hypertension Research 41 , 798–808

Rights & permissionsfor article Simultaneous GLP-1 receptor activation and angiotensin receptor blockade increase natriuresis independent of altered arterial pressure in obese OLETF rats . Opens in a new window.
Research | 25 July 2017 | Open
Apoptosis inhibitor of macrophage ameliorates fungus-induced peritoneal injury model in mice
- Takako Tomita
- , Satoko Arai
- , Kento Kitada
- , Masashi Mizuno
- , Yasuhiro Suzuki
- , Fumiko Sakata
- , Daisuke Nakano
- , Emiri Hiramoto
- , Yoshifumi Takei
- , Shoichi Maruyama
- , Akira Nishiyama
- , Seiichi Matsuo
- , Toru Miyazaki
- & Yasuhiko Ito
Scientific Reports 7 , 1–14

Rights & permissionsfor article Apoptosis inhibitor of macrophage ameliorates fungus-induced peritoneal injury model in mice . Opens in a new window.
Reviews | 22 January 2018
Hypertension with diabetes mellitus complications
Hypertension Research 41 , 147–156

Rights & permissionsfor article Hypertension with diabetes mellitus complications . Opens in a new window.
Research | 20 September 2017 | Open
BRD4 regulates adiponectin gene induction by recruiting the P-TEFb complex to the transcribed region of the gene
- Naoko Sakurai
- , Yuko Inamochi
- , Takuya Inoue
- , Natsuyo Hariya
- , Musashi Kawamura
- , Masami Yamada
- , Anup Dey
- , Akira Nishiyama
- , Takeo Kubota
- , Keiko Ozato
- , Toshinao Goda
- & Kazuki Mochizuki
Scientific Reports 7 , 1–12

Rights & permissionsfor article BRD4 regulates adiponectin gene induction by recruiting the P-TEFb complex to the transcribed region of the gene . Opens in a new window.
Research | 7 January 2016
Augmented circadian rhythm of the intrarenal renin–angiotensin systems in anti-thymocyte serum nephritis rats
- Shinsuke Isobe
- , Naro Ohashi
- , Sayaka Ishigaki
- , Takayuki Tsuji
- , Yukitoshi Sakao
- , Akihiko Kato
- , Hiroaki Miyajima
- , Yoshihide Fujigaki
- , Akira Nishiyama
- & Hideo Yasuda
Hypertension Research 39 , 312–320

Rights & permissionsfor article Augmented circadian rhythm of the intrarenal renin–angiotensin systems in anti-thymocyte serum nephritis rats . Opens in a new window.
Research | 4 January 2016
Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice
- Satoko Arai
- , Kento Kitada
- , Tomoko Yamazaki
- , Ryosuke Takai
- , Xizhong Zhang
- , Yoji Tsugawa
- , Ryoichi Sugisawa
- , Ayaka Matsumoto
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Rights & permissionsfor article Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice . Opens in a new window.
Research | 19 September 2014
IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils
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Nature Communications 5 , 1–15

Rights & permissionsfor article IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils . Opens in a new window.
Research | 13 May 2014 | Open
Transcription factor IRF5 drives P2X4R⁺-reactive microglia gating neuropathic pain
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Nature Communications 5 , 1–11

Rights & permissionsfor article Transcription factor IRF5 drives P2X4R<sup>+</sup>-reactive microglia gating neuropathic pain . Opens in a new window.
Research | 9 March 2015 | Open
(Pro)renin receptor is crucial for Wnt/β-catenin-dependent genesis of pancreatic ductal adenocarcinoma
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Scientific Reports 5 , 1–9

Rights & permissionsfor article (Pro)renin receptor is crucial for Wnt/β-catenin-dependent genesis of pancreatic ductal adenocarcinoma . Opens in a new window.
Research | 1 March 2006
Augmentation of Intrarenal Angiotensin II Levels in Uninephrectomized Aldosterone/Salt-Treated Hypertensive Rats; Renoprotective Effects of an Ultrahigh Dose of Olmesartan
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Rights & permissionsfor article Augmentation of Intrarenal Angiotensin II Levels in Uninephrectomized Aldosterone/Salt-Treated Hypertensive Rats; Renoprotective Effects of an Ultrahigh Dose of Olmesartan . Opens in a new window.
27 August 2012
Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to pSmad3
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Laboratory Investigation 92 , 1686–1697

Rights & permissionsfor article Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to pSmad3 . Opens in a new window.

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