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Amendments and Corrections | 1 June 2017 | Open
Correction: Corrigendum: Small genomic insertions form enhancers that misregulate oncogenes
- Brian J. Abraham
- , Denes Hnisz
- , Abraham S. Weintraub
- , Nicholas Kwiatkowski
- , Charles H. Li
- , Zhaodong Li
- , Nina Weichert-Leahey
- , Sunniyat Rahman
- , Yu Liu
- , Julia Etchin
- , Benshang Li
- , Shuhong Shen
- , Tong Ihn Lee
- , Jinghui Zhang
- , A. Thomas Look
- , Marc R. Mansour
- & Richard A. Young
Nature Communications 8 , 1–1

Rights & permissionsfor article Correction: Corrigendum: Small genomic insertions form enhancers that misregulate oncogenes . Opens in a new window.
1 April 1996
CHROMOSOMAL REGIONS CONTAINING NEW CANDIDATE ONCOGENES AND TUMOR SUPPRESSORS IN WILMS TUMOR DETECTED BY COMPARATIVE GENOMIC HYBRIDIZATION. • 894
- Rachel A Altura
- , James DeCou
- , Marc Valentine
- , Patricia Shearer
- , A Thomas Look
- , James M Boyett
- & David N Shapiro
Pediatric Research 39 , 151–151

Rights & permissionsfor article CHROMOSOMAL REGIONS CONTAINING NEW CANDIDATE ONCOGENES AND TUMOR SUPPRESSORS IN WILMS TUMOR DETECTED BY COMPARATIVE GENOMIC HYBRIDIZATION. • 894 . Opens in a new window.
Amendments and Corrections | 14 July 2020 | Open
Correction: Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma
- Nicole Prutsch
- , Elisabeth Gurnhofer
- , Tobias Suske
- , Huan Chang Liang
- , Michaela Schlederer
- , Simone Roos
- , Lawren C. Wu
- , Ingrid Simonitsch-Klupp
- , Andrea Alvarez-Hernandez
- , Christoph Kornauth
- , Dario A. Leone
- , Jasmin Svinka
- , Robert Eferl
- , Tanja Limberger
- , Astrid Aufinger
- , Nitesh Shirsath
- , Peter Wolf
- , Thomas Hielscher
- , Christina Sternberg
- , Fritz Aberger
- , Johannes Schmoellerl
- , Dagmar Stoiber
- , Birgit Strobl
- , Ulrich Jäger
- , Philipp B. Staber
- , Florian Grebien
- , Richard Moriggl
- , Mathias Müller
- , Giorgio G. Inghirami
- , Takaomi Sanda
- , A. Thomas Look
- , Suzanne D. Turner
- , Lukas Kenner
- & Olaf Merkel
Leukemia 34 , 3105–3105

Rights & permissionsfor article Correction: Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma . Opens in a new window.
News and Views | 12 August 2002
A leukemogenic twist for GATA1
- A. Thomas Look
Nature Genetics 32 , 83–84

Rights & permissionsfor article A leukemogenic twist for GATA1 . Opens in a new window.
News and Views | 1 January 2006
Fishing for cancer models
- Clemens Grabher
- & A Thomas Look
Nature Biotechnology 24 , 45–46

Rights & permissionsfor article Fishing for cancer models . Opens in a new window.
News and Views | 1 December 2005
Small molecules thwart crash and burn
- Samuel Sidi
- & A Thomas Look
Nature Chemical Biology 1 , 351–353

Rights & permissionsfor article Small molecules thwart crash and burn . Opens in a new window.
Research | 6 July 2020
Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X
- Yu Liu
- , Chunliang Li
- , Shuhong Shen
- , Xiaolong Chen
- , Karol Szlachta
- , Michael N. Edmonson
- , Ying Shao
- , Xiaotu Ma
- , Judith Hyle
- , Shaela Wright
- , Bensheng Ju
- , Michael C. Rusch
- , Yanling Liu
- , Benshang Li
- , Michael Macias
- , Liqing Tian
- , John Easton
- , Maoxiang Qian
- , Jun J. Yang
- , Shaoyan Hu
- , A. Thomas Look
- & Jinghui Zhang
Nature Genetics 52 , 811–818

Rights & permissionsfor article Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X . Opens in a new window.
Research | 22 June 2020
Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells (HSPCs) with TOP1-targeted drugs and PARP1 inhibitors
- Chang-Bin Jing
- , Cong Fu
- , Nicole Prutsch
- , Meng Wang
- , Shuning He
- & A. Thomas Look
Leukemia 34 , 2992–3006

Rights & permissionsfor article Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells (HSPCs) with TOP1-targeted drugs and PARP1 inhibitors . Opens in a new window.
Research | 15 July 2018 | Open
The MCL1-specific inhibitor S63845 acts synergistically with venetoclax/ABT-199 to induce apoptosis in T-cell acute lymphoblastic leukemia cells
Leukemia 33 , 262–266

Rights & permissionsfor article The MCL1-specific inhibitor S63845 acts synergistically with venetoclax/ABT-199 to induce apoptosis in T-cell acute lymphoblastic leukemia cells . Opens in a new window.
Research | 6 April 2020
Discovery of a selective inhibitor of doublecortin like kinase 1
- Fleur M. Ferguson
- , Behnam Nabet
- , Srivatsan Raghavan
- , Yan Liu
- , Alan L. Leggett
- , Miljan Kuljanin
- , Radha L. Kalekar
- , Annan Yang
- , Shuning He
- , Jinhua Wang
- , Raymond W. S. Ng
- , Rita Sulahian
- , Lianbo Li
- , Emily J. Poulin
- , Ling Huang
- , Jost Koren
- , Nora Dieguez-Martinez
- , Sergio Espinosa
- , Zhiyang Zeng
- , Cesear R. Corona
- , James D. Vasta
- , Ryoma Ohi
- , Taebo Sim
- , Nam Doo Kim
- , Wayne Harshbarger
- , Jose M. Lizcano
- , Matthew B. Robers
- , Senthil Muthaswamy
- , Charles Y. Lin
- , A. Thomas Look
- , Kevin M. Haigis
- , Joseph D. Mancias
- , Brian M. Wolpin
- , Andrew J. Aguirre
- , William C. Hahn
- , Kenneth D. Westover
- & Nathanael S. Gray
Nature Chemical Biology 16 , 635–643

Rights & permissionsfor article Discovery of a selective inhibitor of doublecortin like kinase 1 . Opens in a new window.
Research | 3 June 2009
A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish
Nature 459 , 996–999

Rights & permissionsfor article A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish . Opens in a new window.
Research | 4 June 1992
Human aminopeptidase N is a receptor for human coronavirus 229E
Nature 357 , 420–422

Rights & permissionsfor article Human aminopeptidase N is a receptor for human coronavirus 229E . Opens in a new window.
Research | 1 May 2000
Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN
- Tal Teitz
- , Tie Wei
- , Marcus B. Valentine
- , Elio F. Vanin
- , Jose Grenet
- , Virginia A. Valentine
- , Frederick G. Behm
- , A. Thomas Look
- , Jill M. Lahti
- & Vincent J. Kidd
Nature Medicine 6 , 529–535

Rights & permissionsfor article Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN . Opens in a new window.
Research | 8 August 1996
Reversal of apoptosis by the leukaemia-associated E2A–HLF chimaeric transcription factor
Nature 382 , 541–544

Rights & permissionsfor article Reversal of apoptosis by the leukaemia-associated E2A–HLF chimaeric transcription factor . Opens in a new window.
Research | 1 July 1994
Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma
- Jill M. Lahti
- , Marcus Valentine
- , Jialing Xiang
- , Bart Jones
- , Joseph Amann
- , Jose Grenet
- , Gail Richmond
- , A. Thomas Look
- & Vincent J. Kidd
Nature Genetics 7 , 370–375

Rights & permissionsfor article Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma . Opens in a new window.
Research | 10 December 2006
Chromosome 5q deletion and epigenetic suppression of the gene encoding α-catenin (CTNNA1) in myeloid cell transformation
- Ting Xi Liu
- , Michael W Becker
- , Jaroslav Jelinek
- , Wen-Shu Wu
- , Min Deng
- , Natallia Mikhalkevich
- , Karl Hsu
- , Clara D Bloomfield
- , Richard M Stone
- , Daniel J DeAngelo
- , Ilene A Galinsky
- , Jean-Pierre Issa
- , Michael F Clarke
- & A Thomas Look
Nature Medicine 13 , 78–83

Rights & permissionsfor article Chromosome 5q deletion and epigenetic suppression of the gene encoding α-catenin (CTNNA1) in myeloid cell transformation . Opens in a new window.
Research | 16 October 2008
Activating mutations in ALK provide a therapeutic target in neuroblastoma
- Rani E. George
- , Takaomi Sanda
- , Megan Hanna
- , Stefan Fröhling
- , William Luther II
- , Jianming Zhang
- , Yebin Ahn
- , Wenjun Zhou
- , Wendy B. London
- , Patrick McGrady
- , Liquan Xue
- , Sergey Zozulya
- , Vlad E. Gregor
- , Thomas R. Webb
- , Nathanael S. Gray
- , D. Gary Gilliland
- , Lisa Diller
- , Heidi Greulich
- , Stephan W. Morris
- , Matthew Meyerson
- & A. Thomas Look
Nature 455 , 975–978

Rights & permissionsfor article Activating mutations in ALK provide a therapeutic target in neuroblastoma . Opens in a new window.
Research | 1 November 1986
The v-fms oncogene induces factor independence and tumorigenicity in CSF-1 dependent macrophage cell line
Nature 324 , 377–380

Rights & permissionsfor article The v-fms oncogene induces factor independence and tumorigenicity in CSF-1 dependent macrophage cell line . Opens in a new window.
13 March 1997
Identification and characterization of neogenin, a DCC-related gene
Oncogene 14 , 1129–1136

Rights & permissionsfor article Identification and characterization of neogenin, a DCC-related gene . Opens in a new window.
8 October 2001
E2A-HLF usurps control of evolutionarily conserved survival pathways
- Markus G Seidel
- & A Thomas Look
Oncogene 20 , 5718–5725

Rights & permissionsfor article E2A-HLF usurps control of evolutionarily conserved survival pathways . Opens in a new window.
Research | 9 December 2019 | Open
ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry
- Lu Wang
- , Tze King Tan
- , Adam D. Durbin
- , Mark W. Zimmerman
- , Brian J. Abraham
- , Shi Hao Tan
- , Phuong Cao Thi Ngoc
- , Nina Weichert-Leahey
- , Koshi Akahane
- , Lee N. Lawton
- , Jo Lynne Rokita
- , John M. Maris
- , Richard A. Young
- , A. Thomas Look
- & Takaomi Sanda
Nature Communications 10 , 1–15

Rights & permissionsfor article ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry . Opens in a new window.
Research | 23 August 2019 | Open
Mechanisms underlying synergy between DNA topoisomerase I-targeted drugs and mTOR kinase inhibitors in NF1-associated malignant peripheral nerve sheath tumors
- Dong Hyuk Ki
- , Felix Oppel
- , Adam D. Durbin
- & A. Thomas Look
Oncogene 38 , 6585–6598

Rights & permissionsfor article Mechanisms underlying synergy between DNA topoisomerase I-targeted drugs and mTOR kinase inhibitors in NF1-associated malignant peripheral nerve sheath tumors . Opens in a new window.
Research | 11 November 2015
Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism
- Derek A. Oldridge
- , Andrew C. Wood
- , Nina Weichert-Leahey
- , Ian Crimmins
- , Robyn Sussman
- , Cynthia Winter
- , Lee D. McDaniel
- , Maura Diamond
- , Lori S. Hart
- , Shizhen Zhu
- , Adam D. Durbin
- , Brian J. Abraham
- , Lars Anders
- , Lifeng Tian
- , Shile Zhang
- , Jun S. Wei
- , Javed Khan
- , Kelli Bramlett
- , Nazneen Rahman
- , Mario Capasso
- , Achille Iolascon
- , Daniela S. Gerhard
- , Jaime M. Guidry Auvil
- , Richard A. Young
- , Hakon Hakonarson
- , Sharon J. Diskin
- , A. Thomas Look
- & John M. Maris
Nature 528 , 418–421

Rights & permissionsfor article Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism . Opens in a new window.
Research | 30 May 2012
Oncogenic fusion E2A-HLF sensitizes t(17;19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors
- X Zhang
- , T Inukai
- , K Hirose
- , K Akahane
- , I Kuroda
- , H Honna-Oshiro
- , K Kagami
- , K Goi
- , K Nakamura
- , M Kobayashi
- , M Endo
- , H Yagita
- , H Kurosawa
- , A Thomas Look
- , H Honda
- , T Inaba
- , S Nakazawa
- & K Sugita
Leukemia 26 , 2483–2493

Rights & permissionsfor article Oncogenic fusion E2A-HLF sensitizes t(17;19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors . Opens in a new window.
Research | 20 August 2018
Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry
Nature Genetics 50 , 1240–1246

Rights & permissionsfor article Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry . Opens in a new window.
Research | 21 August 2018 | Open
Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma
- Nicole Prutsch
- , Elisabeth Gurnhofer
- , Tobias Suske
- , Huan Chang Liang
- , Michaela Schlederer
- , Simone Roos
- , Lawren C. Wu
- , Ingrid Simonitsch-Klupp
- , Andrea Alvarez-Hernandez
- , Christoph Kornauth
- , Dario A. Leone
- , Jasmin Svinka
- , Robert Eferl
- , Tanja Limberger
- , Astrid Aufinger
- , Nitesh Shirsath
- , Peter Wolf
- , Thomas Hielscher
- , Christina Sternberg
- , Fritz Aberger
- , Johannes Schmoellerl
- , Dagmar Stoiber
- , Birgit Strobl
- , Ulrich Jäger
- , Philipp B. Staber
- , Florian Grebien
- , Richard Moriggl
- , Mathias Müller
- , Giorgio G. Inghirami
- , Takaomi Sanda
- , A. Thomas Look
- , Suzanne D. Turner
- , Lukas Kenner
- & Olaf Merkel
Leukemia 33 , 696–709

Rights & permissionsfor article Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma . Opens in a new window.
Research | 9 February 2017 | Open
Small genomic insertions form enhancers that misregulate oncogenes
- Brian J. Abraham
- , Denes Hnisz
- , Abraham S. Weintraub
- , Nicholas Kwiatkowski
- , Charles H. Li
- , Zhaodong Li
- , Nina Weichert-Leahey
- , Sunniyat Rahman
- , Yu Liu
- , Julia Etchin
- , Benshang Li
- , Shuhong Shen
- , Tong Ihn Lee
- , Jinghui Zhang
- , A. Thomas Look
- , Marc R. Mansour
- & Richard A. Young
Nature Communications 8 , 1–13

Rights & permissionsfor article Small genomic insertions form enhancers that misregulate oncogenes . Opens in a new window.
Research | 21 January 2016 | Open
Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish
- Qin Tang
- , John C. Moore
- , Myron S. Ignatius
- , Inês M. Tenente
- , Madeline N. Hayes
- , Elaine G. Garcia
- , Nora Torres Yordán
- , Caitlin Bourque
- , Shuning He
- , Jessica S. Blackburn
- , A. Thomas Look
- , Yariv Houvras
- & David M. Langenau
Nature Communications 7 , 1–10

Rights & permissionsfor article Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish . Opens in a new window.
Research | 26 October 2014
Cyclin C is a haploinsufficient tumour suppressor
- Na Li
- , Anne Fassl
- , Joel Chick
- , Hiroyuki Inuzuka
- , Xiaoyu Li
- , Marc R. Mansour
- , Lijun Liu
- , Haizhen Wang
- , Bryan King
- , Shavali Shaik
- , Alejandro Gutierrez
- , Alban Ordureau
- , Tobias Otto
- , Taras Kreslavsky
- , Lukas Baitsch
- , Leah Bury
- , Clifford A. Meyer
- , Nan Ke
- , Kristin A. Mulry
- , Michael J. Kluk
- , Moni Roy
- , Sunkyu Kim
- , Xiaowu Zhang
- , Yan Geng
- , Agnieszka Zagozdzon
- , Sarah Jenkinson
- , Rosemary E. Gale
- , David C. Linch
- , Jean J. Zhao
- , Charles G. Mullighan
- , J. Wade Harper
- , Jon C. Aster
- , Iannis Aifantis
- , Harald von Boehmer
- , Steven P. Gygi
- , Wenyi Wei
- , A. Thomas Look
- & Piotr Sicinski
Nature Cell Biology 16 , 1080–1091

Rights & permissionsfor article Cyclin C is a haploinsufficient tumour suppressor . Opens in a new window.
Reviews | 13 April 2006
Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia
Nature Reviews Cancer 6 , 347–359

Rights & permissionsfor article Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia . Opens in a new window.
Research | 10 June 2012
Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia
- Alex Kentsis
- , Casie Reed
- , Kim L Rice
- , Takaomi Sanda
- , Scott J Rodig
- , Eleni Tholouli
- , Amanda Christie
- , Peter J M Valk
- , Ruud Delwel
- , Vu Ngo
- , Jeffery L Kutok
- , Suzanne E Dahlberg
- , Lisa A Moreau
- , Richard J Byers
- , James G Christensen
- , George Vande Woude
- , Jonathan D Licht
- , Andrew L Kung
- , Louis M Staudt
- & A Thomas Look
Nature Medicine 18 , 1118–1122

Rights & permissionsfor article Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia . Opens in a new window.
Research | 21 May 2007
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
- Richard S. Maser
- , Bhudipa Choudhury
- , Peter J. Campbell
- , Bin Feng
- , Kwok-Kin Wong
- , Alexei Protopopov
- , Jennifer O’Neil
- , Alejandro Gutierrez
- , Elena Ivanova
- , Ilana Perna
- , Eric Lin
- , Vidya Mani
- , Shan Jiang
- , Kate McNamara
- , Sara Zaghlul
- , Sarah Edkins
- , Claire Stevens
- , Cameron Brennan
- , Eric S. Martin
- , Ruprecht Wiedemeyer
- , Omar Kabbarah
- , Cristina Nogueira
- , Gavin Histen
- , Jon Aster
- , Marc Mansour
- , Veronique Duke
- , Letizia Foroni
- , Adele K. Fielding
- , Anthony H. Goldstone
- , Jacob M. Rowe
- , Yaoqi A. Wang
- , A. Thomas Look
- , Michael R. Stratton
- , Lynda Chin
- , P. Andrew Futreal
- & Ronald A. DePinho
Nature 447 , 966–971

Rights & permissionsfor article Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers . Opens in a new window.

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Correction: Corrigendum: Small genomic insertions form enhancers that misregulate oncogenes

CHROMOSOMAL REGIONS CONTAINING NEW CANDIDATE ONCOGENES AND TUMOR SUPPRESSORS IN WILMS TUMOR DETECTED BY COMPARATIVE GENOMIC HYBRIDIZATION. • 894

Correction: Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma

A leukemogenic twist for GATA1

Fishing for cancer models

Small molecules thwart crash and burn

Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X

Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells (HSPCs) with TOP1-targeted drugs and PARP1 inhibitors

The MCL1-specific inhibitor S63845 acts synergistically with venetoclax/ABT-199 to induce apoptosis in T-cell acute lymphoblastic leukemia cells

Discovery of a selective inhibitor of doublecortin like kinase 1

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

Human aminopeptidase N is a receptor for human coronavirus 229E

Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN

Reversal of apoptosis by the leukaemia-associated E2A–HLF chimaeric transcription factor

Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma

Chromosome 5q deletion and epigenetic suppression of the gene encoding α-catenin (CTNNA1) in myeloid cell transformation

Activating mutations in ALK provide a therapeutic target in neuroblastoma

The v-fms oncogene induces factor independence and tumorigenicity in CSF-1 dependent macrophage cell line

Identification and characterization of neogenin, a DCC-related gene

E2A-HLF usurps control of evolutionarily conserved survival pathways

ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry

Mechanisms underlying synergy between DNA topoisomerase I-targeted drugs and mTOR kinase inhibitors in NF1-associated malignant peripheral nerve sheath tumors

Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism

Oncogenic fusion E2A-HLF sensitizes t(17;19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma

Small genomic insertions form enhancers that misregulate oncogenes

Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish

Cyclin C is a haploinsufficient tumour suppressor

Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia

Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

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