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Research | 4 June 2020 | Open
Centrosome reduction in newly-generated tetraploid cancer cells obtained by separase depletion
- Claudia Galofré
- , Elena Asensio
- , Maria Ubach
- , Irianna M. Torres
- , Isabel Quintanilla
- , Antoni Castells
- & Jordi Camps
Scientific Reports 10 , 1–12

Rights & permissionsfor article Centrosome reduction in newly-generated tetraploid cancer cells obtained by separase depletion . Opens in a new window.
Research | 17 February 2020
A perinuclear microtubule-organizing centre controls nuclear positioning and basement membrane secretion
Nature Cell Biology 22 , 297–309

Rights & permissionsfor article A perinuclear microtubule-organizing centre controls nuclear positioning and basement membrane secretion . Opens in a new window.
Research | 29 November 2019 | Open
Innovative particle standards and long-lived imaging for 2D and 3D dSTORM
Scientific Reports 9 , 1–13

Rights & permissionsfor article Innovative particle standards and long-lived imaging for 2D and 3D dSTORM . Opens in a new window.
Research | 2 December 2019
Massive centriole production can occur in the absence of deuterosomes in multiciliated cells
- Olivier Mercey
- , Michelle S. Levine
- , Gina M. LoMastro
- , Philippe Rostaing
- , Eva Brotslaw
- , Valerie Gomez
- , Abhijay Kumar
- , Nathalie Spassky
- , Brian J. Mitchell
- , Alice Meunier
- & Andrew J. Holland
Nature Cell Biology 21 , 1544–1552

Rights & permissionsfor article Massive centriole production can occur in the absence of deuterosomes in multiciliated cells . Opens in a new window.
Research | 3 September 2019
The inner centromere is a biomolecular condensate scaffolded by the chromosomal passenger complex
Nature Cell Biology 21 , 1127–1137

Rights & permissionsfor article The inner centromere is a biomolecular condensate scaffolded by the chromosomal passenger complex . Opens in a new window.
Research | 25 October 2019 | Open
Fertilization and Cleavage Axes Differ In Primates Conceived By Conventional (IVF) Versus Intracytoplasmic Sperm Injection (ICSI)
- Calvin R. Simerly
- , Diana Takahashi
- , Ethan Jacoby
- , Carlos Castro
- , Carrie Hartnett
- , Laura Hewitson
- , Christopher Navara
- & Gerald Schatten
Scientific Reports 9 , 1–14

Rights & permissionsfor article Fertilization and Cleavage Axes Differ In Primates Conceived By Conventional (IVF) Versus Intracytoplasmic Sperm Injection (ICSI) . Opens in a new window.
Research | 3 October 2019 | Open
Centrosomal and ciliary targeting of CCDC66 requires cooperative action of centriolar satellites, microtubules and molecular motors
Scientific Reports 9 , 1–17

Rights & permissionsfor article Centrosomal and ciliary targeting of CCDC66 requires cooperative action of centriolar satellites, microtubules and molecular motors . Opens in a new window.
Research | 2 September 2019
Centrosome loss results in an unstable genome and malignant prostate tumors
Oncogene 39 , 399–413

Rights & permissionsfor article Centrosome loss results in an unstable genome and malignant prostate tumors . Opens in a new window.
Research | 2 September 2019
The balance between KIFC3 and EG5 tetrameric kinesins controls the onset of mitotic spindle assembly
- Shoji Hata
- , Ana Pastor Peidro
- , Marko Panic
- , Peng Liu
- , Enrico Atorino
- , Charlotta Funaya
- , Ursula Jäkle
- , Gislene Pereira
- & Elmar Schiebel
Nature Cell Biology 21 , 1138–1151

Rights & permissionsfor article The balance between KIFC3 and EG5 tetrameric kinesins controls the onset of mitotic spindle assembly . Opens in a new window.
Research | 8 August 2019 | Open
Mild replication stress causes chromosome mis-segregation via premature centriole disengagement
- Therese Wilhelm
- , Anna-Maria Olziersky
- , Daniela Harry
- , Filipe De Sousa
- , Helène Vassal
- , Anja Eskat
- & Patrick Meraldi
Nature Communications 10 , 1–14

Rights & permissionsfor article Mild replication stress causes chromosome mis-segregation via premature centriole disengagement . Opens in a new window.
Research | 29 May 2019 | Open
Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility
- Yi Luo
- , Miriam Barrios-Rodiles
- , Gagan D. Gupta
- , Ying Y. Zhang
- , Abiodun A. Ogunjimi
- , Mikhail Bashkurov
- , Johnny M. Tkach
- , Ainsley Q. Underhill
- , Liang Zhang
- , Mohamed Bourmoum
- , Jeffrey L. Wrana
- & Laurence Pelletier
Nature Communications 10 , 1–20

Rights & permissionsfor article Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility . Opens in a new window.
Research | 15 April 2019 | Open
CEP120 interacts with C2CD3 and Talpid3 and is required for centriole appendage assembly and ciliogenesis
- Jhih-Jie Tsai
- , Wen-Bin Hsu
- , Jia-Hua Liu
- , Ching-Wen Chang
- & Tang K. Tang
Scientific Reports 9 , 1–15

Rights & permissionsfor article CEP120 interacts with C2CD3 and Talpid3 and is required for centriole appendage assembly and ciliogenesis . Opens in a new window.
Research | 3 January 2019 | Open
Acto-myosin force organization modulates centriole separation and PLK4 recruitment to ensure centriole fidelity
- Elisa Vitiello
- , Philippe Moreau
- , Vanessa Nunes
- , Amel Mettouchi
- , Helder Maiato
- , Jorge G. Ferreira
- , Irène Wang
- & Martial Balland
Nature Communications 10 , 1–12

Rights & permissionsfor article Acto-myosin force organization modulates centriole separation and PLK4 recruitment to ensure centriole fidelity . Opens in a new window.
Research | 17 October 2018 | Open
Recruitment of the mitotic exit network to yeast centrosomes couples septin displacement to actomyosin constriction
Nature Communications 9 , 1–15

Rights & permissionsfor article Recruitment of the mitotic exit network to yeast centrosomes couples septin displacement to actomyosin constriction . Opens in a new window.
Research | 30 October 2018 | Open
M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole
- Ning Huang
- , Donghui Zhang
- , Fangyuan Li
- , Peiyuan Chai
- , Song Wang
- , Junlin Teng
- & Jianguo Chen
Nature Communications 9 , 1–15

Rights & permissionsfor article M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole . Opens in a new window.
Research | 7 June 2018 | Open
A novel atypical sperm centriole is functional during human fertilization
- Emily L. Fishman
- , Kyoung Jo
- , Quynh P. H. Nguyen
- , Dong Kong
- , Rachel Royfman
- , Anthony R. Cekic
- , Sushil Khanal
- , Ann L. Miller
- , Calvin Simerly
- , Gerald Schatten
- , Jadranka Loncarek
- , Vito Mennella
- & Tomer Avidor-Reiss
Nature Communications 9 , 1–12

Rights & permissionsfor article A novel atypical sperm centriole is functional during human fertilization . Opens in a new window.
Research | 11 June 2018 | Open
Ependymal cilia beating induces an actin network to protect centrioles against shear stress
Nature Communications 9 , 1–15

Rights & permissionsfor article Ependymal cilia beating induces an actin network to protect centrioles against shear stress . Opens in a new window.
Research | 22 May 2018 | Open
Super-resolution architecture of mammalian centriole distal appendages reveals distinct blade and matrix functional components
- T. Tony Yang
- , Weng Man Chong
- , Won-Jing Wang
- , Gregory Mazo
- , Barbara Tanos
- , Zhengmin Chen
- , Thi Minh Nguyet Tran
- , Yi-De Chen
- , Rueyhung Roc Weng
- , Chia-En Huang
- , Wann-Neng Jane
- , Meng-Fu Bryan Tsou
- & Jung-Chi Liao
Nature Communications 9 , 1–11

Rights & permissionsfor article Super-resolution architecture of mammalian centriole distal appendages reveals distinct blade and matrix functional components . Opens in a new window.
Research | 30 April 2018 | Open
Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly
- Yi Liu
- , Gagan D. Gupta
- , Deepak D. Barnabas
- , Fikret G. Agircan
- , Shahid Mehmood
- , Di Wu
- , Etienne Coyaud
- , Christopher M. Johnson
- , Stephen H. McLaughlin
- , Antonina Andreeva
- , Stefan M. V. Freund
- , Carol V. Robinson
- , Sally W. T. Cheung
- , Brian Raught
- , Laurence Pelletier
- & Mark van Breugel
Nature Communications 9 , 1–15

Rights & permissionsfor article Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly . Opens in a new window.
Research | 28 March 2018 | Open
Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation
- Gaëlle Marteil
- , Adan Guerrero
- , André F. Vieira
- , Bernardo P. de Almeida
- , Pedro Machado
- , Susana Mendonça
- , Marta Mesquita
- , Beth Villarreal
- , Irina Fonseca
- , Maria E. Francia
- , Katharina Dores
- , Nuno P. Martins
- , Swadhin C. Jana
- , Erin M. Tranfield
- , Nuno L. Barbosa-Morais
- , Joana Paredes
- , David Pellman
- , Susana A. Godinho
- & Mónica Bettencourt-Dias
Nature Communications 9 , 1–17

Rights & permissionsfor article Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation . Opens in a new window.
Research | 20 February 2018 | Open
VPS4 is a dynamic component of the centrosome that regulates centrosome localization of γ-tubulin, centriolar satellite stability and ciliogenesis
- Carolyn Ott
- , Dikla Nachmias
- , Shai Adar
- , Michal Jarnik
- , Shachar Sherman
- , Ramon Y. Birnbaum
- , Jennifer Lippincott-Schwartz
- & Natalie Elia
Scientific Reports 8 , 1–19

Rights & permissionsfor article VPS4 is a dynamic component of the centrosome that regulates centrosome localization of γ-tubulin, centriolar satellite stability and ciliogenesis . Opens in a new window.
Research | 27 April 2017
Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative neuroepithelial cell division
Nature Cell Biology 19 , 493–503

Rights & permissionsfor article Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative neuroepithelial cell division . Opens in a new window.
Research | 5 May 2017 | Open
Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1
Nature Communications 8 , 1–15

Rights & permissionsfor article Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1 . Opens in a new window.
Research | 13 June 2017 | Open
Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay
Nature Communications 8 , 1–12

Rights & permissionsfor article Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay . Opens in a new window.
Research | 15 August 2017 | Open
Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles
- Hsin-Yi Chen
- , Chien-Ting Wu
- , Chieh-Ju C. Tang
- , Yi-Nan Lin
- , Won-Jing Wang
- & Tang K. Tang
Nature Communications 8 , 1–14

Rights & permissionsfor article Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles . Opens in a new window.
Research | 19 April 2017 | Open
Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68
- Ning Huang
- , Yuqing Xia
- , Donghui Zhang
- , Song Wang
- , Yitian Bao
- , Runsheng He
- , Junlin Teng
- & Jianguo Chen
Nature Communications 8 , 1–14

Rights & permissionsfor article Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68 . Opens in a new window.
Reviews | 24 January 2018
Once and only once: mechanisms of centriole duplication and their deregulation in disease
- Erich A. Nigg
- & Andrew J. Holland
Nature Reviews Molecular Cell Biology 19 , 297–312

Rights & permissionsfor article Once and only once: mechanisms of centriole duplication and their deregulation in disease . Opens in a new window.
Research | 17 July 2017
Budding yeast Wee1 distinguishes spindle pole bodies to guide their pattern of age-dependent segregation
- Jette Lengefeld
- , Manuel Hotz
- , Meaghen Rollins
- , Kristin Baetz
- & Yves Barral
Nature Cell Biology 19 , 941–951

Rights & permissionsfor article Budding yeast Wee1 distinguishes spindle pole bodies to guide their pattern of age-dependent segregation . Opens in a new window.
Research | 14 July 2017 | Open
CKAP2 phosphorylation by CDK1/cyclinB1 is crucial for maintaining centrosome integrity
- Bum Ho Yoo
- , Du-Seock Kang
- , Chi-Hu Park
- , Kyeongjin Kang
- & Chang-Dae Bae
Experimental & Molecular Medicine 49 , e354–e354

Rights & permissionsfor article CKAP2 phosphorylation by CDK1/cyclinB1 is crucial for maintaining centrosome integrity . Opens in a new window.
Research | 21 March 2016
SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture
- Manuel Hilbert
- , Akira Noga
- , Daniel Frey
- , Virginie Hamel
- , Paul Guichard
- , Sebastian H. W. Kraatz
- , Moritz Pfreundschuh
- , Sarah Hosner
- , Isabelle Flückiger
- , Rolf Jaussi
- , Mara M. Wieser
- , Katherine M. Thieltges
- , Xavier Deupi
- , Daniel J. Müller
- , Richard A. Kammerer
- , Pierre Gönczy
- , Masafumi Hirono
- & Michel O. Steinmetz
Nature Cell Biology 18 , 393–403

Rights & permissionsfor article SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture . Opens in a new window.
Research | 23 March 2017 | Open
Cell-free reconstitution reveals centriole cartwheel assembly mechanisms
- P. Guichard
- , V. Hamel
- , M. Le Guennec
- , N. Banterle
- , I. Iacovache
- , V. Nemčíková
- , I. Flückiger
- , K. N. Goldie
- , H. Stahlberg
- , D. Lévy
- , B. Zuber
- & P. Gönczy
Nature Communications 8 , 1–9

Rights & permissionsfor article Cell-free reconstitution reveals centriole cartwheel assembly mechanisms . Opens in a new window.
Research | 18 March 2016 | Open
A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer
Nature Communications 7 , 1–16

Rights & permissionsfor article A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer . Opens in a new window.
Research | 6 March 2017
The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation
Nature Cell Biology 19 , 384–390

Rights & permissionsfor article The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation . Opens in a new window.
Research | 8 June 2016 | Open
Computational support for a scaffolding mechanism of centriole assembly
Scientific Reports 6 , 1–9

Rights & permissionsfor article Computational support for a scaffolding mechanism of centriole assembly . Opens in a new window.
Research | 11 April 2016
Opposing post-translational modifications regulate Cep76 function to suppress centriole amplification
- M Barbelanne
- , A Chiu
- , J Qian
- & W Y Tsang
Oncogene 35 , 5377–5387

Rights & permissionsfor article Opposing post-translational modifications regulate Cep76 function to suppress centriole amplification . Opens in a new window.
Research | 25 August 2016 | Open
A centrosome interactome provides insight into organelle assembly and reveals a non-duplication role for Plk4
Nature Communications 7 , 1–15

Rights & permissionsfor article A centrosome interactome provides insight into organelle assembly and reveals a non-duplication role for Plk4 . Opens in a new window.
Research | 19 February 2016 | Open
Cep70 overexpression stimulates pancreatic cancer by inducing centrosome abnormality and microtubule disorganization
- Songbo Xie
- , Juan Qin
- , Shiyu Liu
- , Yijun Zhang
- , Jun Wang
- , Xingjuan Shi
- , Dengwen Li
- , Jun Zhou
- & Min Liu
Scientific Reports 6 , 1–10

Rights & permissionsfor article Cep70 overexpression stimulates pancreatic cancer by inducing centrosome abnormality and microtubule disorganization . Opens in a new window.
Research | 18 January 2017 | Open
Expression of the novel maternal centrosome assembly factor Wdr8 is required for vertebrate embryonic mitoses
- Daigo Inoue
- , Manuel Stemmer
- , Thomas Thumberger
- , Thomas Ruppert
- , Felix Bärenz
- , Joachim Wittbrodt
- & Oliver J. Gruss
Nature Communications 8 , 1–12

Rights & permissionsfor article Expression of the novel maternal centrosome assembly factor Wdr8 is required for vertebrate embryonic mitoses . Opens in a new window.
Research | 21 November 2016 | Open
Autophagy controls centrosome number by degrading Cep63
- Yuichiro Watanabe
- , Shinya Honda
- , Akimitsu Konishi
- , Satoko Arakawa
- , Michiko Murohashi
- , Hirofumi Yamaguchi
- , Satoru Torii
- , Minoru Tanabe
- , Shinji Tanaka
- , Eiji Warabi
- & Shigeomi Shimizu
Nature Communications 7 , 1–12

Rights & permissionsfor article Autophagy controls centrosome number by degrading Cep63 . Opens in a new window.
Research | 31 May 2016 | Open
Aurora-A recruitment and centrosomal maturation are regulated by a Golgi-activated pool of Src during G2
Nature Communications 7 , 1–13

Rights & permissionsfor article Aurora-A recruitment and centrosomal maturation are regulated by a Golgi-activated pool of Src during G2 . Opens in a new window.
Research | 18 March 2016 | Open
Actin nucleation at the centrosome controls lymphocyte polarity
- Dorian Obino
- , Francesca Farina
- , Odile Malbec
- , Pablo J. Sáez
- , Mathieu Maurin
- , Jérémie Gaillard
- , Florent Dingli
- , Damarys Loew
- , Alexis Gautreau
- , Maria-Isabel Yuseff
- , Laurent Blanchoin
- , Manuel Théry
- & Ana-Maria Lennon-Duménil
Nature Communications 7 , 1–14

Rights & permissionsfor article Actin nucleation at the centrosome controls lymphocyte polarity . Opens in a new window.
Research | 14 December 2015
The centrosome is an actin-organizing centre
Nature Cell Biology 18 , 65–75

Rights & permissionsfor article The centrosome is an actin-organizing centre . Opens in a new window.
Reviews | 2 May 2014
Mitotic spindle multipolarity without centrosome amplification
- Helder Maiato
- & Elsa Logarinho
Nature Cell Biology 16 , 386–394

Rights & permissionsfor article Mitotic spindle multipolarity without centrosome amplification . Opens in a new window.
Research | 23 November 2015
Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis
Nature Cell Biology 18 , 100–110

Rights & permissionsfor article Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis . Opens in a new window.
Research | 27 May 2013
Role of Nek2 on centrosome duplication and aneuploidy in breast cancer cells
- P Cappello
- , H Blaser
- , C Gorrini
- , D C C Lin
- , A J Elia
- , A Wakeham
- , S Haider
- , P C Boutros
- , J M Mason
- , N A Miller
- , B Youngson
- , S J Done
- & T W Mak
Oncogene 33 , 2375–2384

Rights & permissionsfor article Role of Nek2 on centrosome duplication and aneuploidy in breast cancer cells . Opens in a new window.
Research | 23 November 2015
Conserved molecular interactions in centriole-to-centrosome conversion
Nature Cell Biology 18 , 87–99

Rights & permissionsfor article Conserved molecular interactions in centriole-to-centrosome conversion . Opens in a new window.
Research | 20 July 2015
PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2
Nature Cell Biology 17 , 1024–1035

Rights & permissionsfor article PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2 . Opens in a new window.
Reviews | 23 October 2015
Centrosomes and cancer: revisiting a long-standing relationship
- Pierre Gönczy
Nature Reviews Cancer 15 , 639–652

Rights & permissionsfor article Centrosomes and cancer: revisiting a long-standing relationship . Opens in a new window.
Research | 1 May 2014 | Open
Quantitative multi-parametric evaluation of centrosome declustering drugs: centrosome amplification, mitotic phenotype, cell cycle and death
- A Ogden
- , A Cheng
- , P C G Rida
- , V Pannu
- , R Osan
- , R Clewley
- & R Aneja
Cell Death & Disease 5 , e1204–e1204

Rights & permissionsfor article Quantitative multi-parametric evaluation of centrosome declustering drugs: centrosome amplification, mitotic phenotype, cell cycle and death . Opens in a new window.
Research | 18 April 2013 | Open
Mitotic catastrophe and cell death induced by depletion of centrosomal proteins
- M Kimura
- , T Yoshioka
- , M Saio
- , Y Banno
- , H Nagaoka
- & Y Okano
Cell Death & Disease 4 , e603–e603

Rights & permissionsfor article Mitotic catastrophe and cell death induced by depletion of centrosomal proteins . Opens in a new window.

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