Using Alu sequences to detect oncogenes.
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Using Alu sequences to detect oncogenes.
Scientists in Robert Weinberg's laboratory in the late 1970s and early 1980s used DNA from tumor cell lines to transform mouse fibroblasts (NIH-3T3 cells). They then isolated the transforming gene (a mutant oncogene) using the Alu sequences that went along for the ride.
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Alu elements have long been considered "junk" DNA--or, even worse, "selfish" DNA. Turns out, these prolific transposons are much more useful than originally thought.
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