The strength of negative selection.
- Author: Laurence Loewe
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The strength of negative selection.
The fixation probability is given for heterozygous, harmful mutations. The vertical line indicates selection coefficients that satisfy Nes = 0.5 and roughly separates the domains where genetic drift (left) and selection (right) dominate the fate of new mutations. The effective population size Ne was estimated from DNA sequence diversity data in the fruitfly Drosophila miranda.
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How are humans contributing to negative selection? It's a part of evolution that can also drive some species to extinction; models of negative selection help us understand biodiversity.
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