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The lactose operon of Escherichia coli.

  • Author: Howard A. Shuman,Thomas J. Silhavy

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The lactose operon of Escherichia coli.
The genes lacZ, lacY and lacA are transcribed from a single promoter (P) that produces a single mRNA from which the three proteins are translated. The operon is regulated by Lac repressor, the product of the lacI gene, which is transcribed from its own promoter (PI). The repressor inhibits transcription by binding to the lac operator (O). Repressor binding to the operator is prevented by the inducer.

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