The key steps leading to glucose-stimulated insulin secretion
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The key steps leading to glucose-stimulated insulin secretion
Increased levels of glucose in the circulation lead to increased glucose uptake into pancreatic beta cells through GLUT2, a glucose transporter. Increased intracellular glucose then leads to increased production of ATP, and an increase in the ATP/ADP ratio (1); the increased ATP/ADP ratio leads to closing of the potassium channel and depolarization of the cell (2); and cell depolarization opens a calcium channel (3) which leads to insulin secretion (4).
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G-protein coupled receptors regulate hormone secretions in the pancreas. Learn how the complex signaling features of these receptors are illuminating diabetes research.
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