(A) Removal of the RNA primer at the 3' end of the lagging strand leaves a region of DNA--the telomere--unreplicated. (B) The enzyme telomerase binds to the 3' end and extends the lagging strand of DNA. An RNA sequence embedded in telomerase provides a template so that, overall, the DNA does not get shorter. (C) Bright fluorescent staining marks the telomeric regions on these blue-stained human chromosomes.
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