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Idealized representation of the hierarchical shotgun sequencing strategy

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Idealized representation of the hierarchical shotgun sequencing strategy
The hierarchical shotgun sequencing strategy involves several steps. First, a library is created by fragmenting the target genome and cloning it into vectors. Next, the genomic DNA fragments are organized and mapped to individual human chromosomes. The clones are then individually sequenced using a random shotgun approach. Lastly, the shotgun sequences are assembled.

This image is linked to the following Scitable pages:

DNA Sequencing Technologies Key to the Human Genome Project

Thanks to the Human Genome Project, researchers have sequenced all 3.2 billion base pairs in the human genome. How did researchers complete this chromosome map years ahead of schedule?

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