Cell migration is dependent on different actin filament structures.

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Cell migration is dependent on different actin filament structures.

(A) In a cell, motility is initiated by an actin-dependent protrusion of the cell’s leading edge, which is composed of armlike structures called lamellipodia and filopodia. These protrusive structures contain actin filaments, with elongating barbed ends orientated toward the plasma membrane. (B) During cellular arm extension, the plasma membrane sticks to the surface at the leading edge. (C) Next, the nucleus and the cell body are pushed forward through intracellular contraction forces mediated by stress fibers. (D) Then, retraction fibers pull the rear of the cell forward.

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Microtubules and Filaments

Dynamic networks of protein filaments give shape to cells and power cell movement. Learn how microtubules, actin filaments, and intermediate filaments organize the cell.