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A chimeric mouse contains both normal cells and genetically manipulated


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A chimeric mouse contains both normal cells and genetically manipulated "knockout" cells. Coat color can reflect this with a spotted pattern.
A chimeric mouse is a patchwork of normal cells and genetically manipulated "knockout" cells.

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There are at least thousands of genes in the DNA of most organisms, and more than 20,000 in the DNA of each human being, for instance. How can we determine which genes lead to which observable traits? Scientists have developed techniques that delete individual gene sequences from an organism’s DNA. By observing the impact of this deletion on the entire biological system of an organism, scientists can connect previously unknown genes to their function.

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