Cytogenetic localization of DNA sequences with fluorescence in situ hybridization (FISH)
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Cytogenetic localization of DNA sequences with fluorescence in situ hybridization (FISH)
(A) FISH produces a fluorescent signal (red) at the sites of a specific DNA sequence; in this case, a 150-kb segment of chromosome 1. (B) Several probes, each corresponding to a defined genomic segment, can be simultaneously analyzed and ordered with respect to each other using multicolor FISH.
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Some diseases involve regions of chromosomes that have been flipped or damaged. Find out what techniques scientists are using to dissect these chromosomes at the molecular level.
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