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January 04, 2014 | By:  Dr. Bhavana Weidmann
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Healthcare Innovation: An Interview with Dr. Kiran Mazumdar-Shaw

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Responsible businesses make good businesses! Don't you agree? One such responsible business that has achieved great heights, was launched with a humble seed capital of 10,000 rupees in 1978 by a young and aspiring 25-year old entrepreneur in Bangalore, India. Despite all odds, it went onto become one of India's most respected and foremost biotech and pharmaceutical giants, Biocon, under the exemplary leadership of its founder and chairperson, Dr. Kiran Mazumdar-Shaw.

Over the years, Dr. Mazumdar-Shaw has strived hard to grow a company with a strong sense of corporate social responsibility. Today, Biocon prides itself in "delivering affordable innovation" in healthcare for millions across India and the world. Dr. Mazumdar-Shaw has also led an exceptional series of discussions on "India's Healthcare Challenge", which is a great learning resource for anyone looking to improve healthcare in the developing world.

She is widely recognised as one of the most influential and powerful women in the world of business (by Time, Forbes and Financial Times). Yet, at every stage of interaction with her, I was simply amazed by her exceptional humility and strong personal sense of responsiblity. Here is a glimpse into her remarkable journey as an entrepreneur and as a champion of healthcare improvement in India.*

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Photograph of Dr. Kiran Mazumdar-Shaw (Courtesy: Biocon Limited)

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The Interview:


Q. Dr. Mazumdar-Shaw, please share what inspired you to become an entrepreneur at quite an early stage in your scientific career.

A. I call myself an accidental entrepreneur. I was all set to take up a brewing job in Scotland when a chance encounter with an Irish entrepreneur led me to set up a biotech business in India instead.

I owe my drive and determination to my upbringing, which instilled in me a set of values that make me who I am. I was greatly inspired by my late father, who was a well-known name in the brewing industry. It was he who encouraged me to take the road less traversed and gave me the confidence to pursue my path of entrepreneurship. He prodded me to persevere and never give up in the face of adversity but rather learn from failure and seek new ways of doing things. In a sense, I learnt my lesson on differentiation from my father, which then became my business hall mark. My Irish collaborator, Les Auchincloss, also infused a tremendous sense of confidence in me, which enabled me to start Biocon in 1978 as a 25-year-old woman entrepreneur. It was he who gave me the break and the challenge that gave me a strong sense of purpose.

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Q. What were some of the initial challenges you faced as an entrepreneur and how did you overcome them?

A. When I started Biocon in 1978, the obstacles I needed to navigate were manifold – ranging from infrastructural hurdles to issues related to my credibility as a business woman. With no access to venture capital, money was scarce and high-cost, debt-based capital was all I had. Beyond the financial challenges was the business of biotechnology itself, which was unheard of in India. Enzyme technology, the biotechnology with which I started, was a new concept back then. There was skepticism about the commercial viability of eco-friendly but expensive enzymes to replace cheap chemical processes.

My challenge was to get the market to accept biotechnology and change old practices. Moreover, enzyme manufacturing for industrial application involved sophisticated fermentation procedures, which demanded uninterrupted power supply and precision process control. However, the unreliable power supply situation and the limited resources that I had at that time were a serious challenge.

Recruiting was another big challenge. My gender was a huge perceived handicap. I couldn't get anyone to join me not only because I was a woman but also because mine was a start-up company. I couldn't even get a secretary to work for me. However, I refused to let these challenges intimidate me. Eventually, a few brave folks did join me in my entrepreneurial journey.

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Q. What personal and professional qualities in your opinion have enabled you to ascend the heights of your profession?

A. I have been single-minded in my determination to see my venture succeed. I have never been the one to give up easily. So, when I faced the initial hiccups that any start-up in India faced during the pre-liberalization period, I simply became more determined to make it work.

What gave me the courage to pursue my ambition was my ability to attract scientific talent – people who were as excited as me, to create a new business model based on innovation and differentiation. Another key enabler was the fact that I had an Irish joint venture partner who was willing to support me through my starting phase.

I am also open to new ideas, experimentation and innovation. I knew then that we could make Biocon work if we followed a strategy of differentiation by leveraging our early-mover advantage. Instead of being hampered by what we did not have, we tried to use what we did have to our advantage and, through home-grown innovations, maximized results.

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Q. You are credited for pioneering biotechnology industry in India. What do you see as the key innovations of your company, Biocon?

A. My passion for innovation and my interest in the "business of science" has seen Biocon commercialize many innovative platforms and products. We started with a diverse portfolio of innovative enzymes and were credited with several proprietary platform technologies (e.g. a solid-state fermenter, the Plafractor, followed by a recombinant Pichia fermentation platform that has enabled us to commercialize the world's first Pichia-derived recombinant human insulin and insulin analogs). This has allowed us to be the lowest-cost producer of Insulins which are today competing in over 40 countries across the world.

On the original innovation front, we have commercialized the first novel biologic in India, an Anti-EGFR monoclonal antibody, Nimotuzamab, for head and neck cancer, which has benefited over 6000 patients since its launch in 2006. Most recently, we have commercialized our second novel biologic, Itolizumab, for Psoriasis. This drug has an enormous potential to address a number of unmet needs of multiple autoimmune diseases like Multiple Sclerosis, Sjogren's Disease, Lupus etc. We also have a very exciting oral insulin development program which can transform Insulin therapy for diabetic patients. It has also been my unfulfilled aspiration to deliver a global blockbuster from Biocon, with a "Made in India" label.

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Q. How would you describe the entrepreneurship climate in India? What needs to be done to make it more conducive to the birth and growth of new enterprises in India?

A. India is a fertile ground for entrepreneurs, given its large pool of world-class talent and resources. India's ability to generate wealth and create social good will come if we let entrepreneurs flourish by encouraging and enabling innovation. Innovation and biotechnology can transform our numerous challenges – healthcare, education, development, agriculture, environment, and energy among others – into opportunities by developing innovative products that can benefit millions and drive economic growth.

However, unlike in the West where capital markets are willing to invest in innovation for a long term, innovation in India is viewed as high-risk, low gain option and hence not investor-friendly. Investors in India are not prepared to invest in capital intensive long-term innovation based business models. India, therefore, needs a robust innovation "ecosystem." The government needs to establish strong industry-academia linkages to foster the spirit of enterprise and drive employment. However, a national innovation ecosystem is not enough, because if innovation is to flourish, ideas have to be funded to bring them to the market.

I believe the solution here is to set up a secondary stock exchange that allows technology-driven, revenue-less, innovative companies to access capital markets, emulating the role of NASDAQ in the US for technology companies and AIM in London for technology companies in the UK. If this were to happen, it will spur innovation and attract much-needed investment.

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Q. How can the gender gap be bridged in senior management positions, in the corporate world?

A. It's true that even today board rooms and senior management positions are still the preserve of men except for a handful of companies. However, it is also true that the situation is changing, albeit slowly. I have seen a positive shift in gender equality in Corporate India. I do believe that women are being provided greater opportunities to participate in strategic areas of management.

Indian business women like Indra Nooyi, Chanda Kochhar, Naina Lal Kidwai, Shikha Sharma, Swati Piramal, Anu Agha, Swati Piramal, Sulajja Firodia Motwani and Zia Mody have put India on the global firmament. These women have gained respect and made a big difference to the corporate world by managing the gender bias that exists in our world.

These enormously talented women in our country can be role models and drive corporates to realize that gender diversity is of key importance in all Boards. I believe gender diversity can introduce a balance of views and opinions that allow for more informed decisions.

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Q. How do you keep your team energized and motivated as their leader?

A. I believe in empowering, trusting, enabling and mentoring leaders at multiple levels in my team. By providing ample opportunities to others to develop their leadership potential, one can instill a sense of ownership among team members to take forward the leader's vision and mission. I also believe in leading from the front. At the same time, I am tremendously result-oriented and always open to new ideas.

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Q. What are some of your favorite lessons that you have learnt from your own mentors?

A. Right from my childhood days my parents instilled in me the values of integrity and humility. My teachers at Bishop Cottons taught me how to think for myself and to excel in everything I do. A few of my professors at college taught me to focus on doing things differently and creatively in order to make a difference. These exceptional professors encouraged me to develop my own perspective and personality.

"Science is about curiosity-driven learning" is what one of them said and it is etched in my mind even today. "Unless you are curious, you will never find science exciting" I was told. It is this approach that has allowed me to pursue a path of innovation. Innovation, as I understand it, is both about doing different things as well as doing things differently.

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Q. What policy, practice or mindset changes can help take India from being a collaborative manufacturer to a strong pioneer in innovation on the international stage?

A. As a traditionally risk-averse nation, India has rarely been at the forefront of innovation. Indian companies have mostly imitated others and became very good at it. Even in the biotech sector, most companies operate in the low-risk services and generic diagnostics, vaccines and therapeutics space.

It is time for biotechnology companies, especially in India and other developing countries, to re-orient their efforts to aggressively harness innovation through partnerships and collaborations to attain the dream of ensuring healthcare for all. As I have mentioned earlier, the government also needs to be an enabler by putting in place policies that will create a robust innovation "ecosystem" in India.

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Q. You champion the cause of healthcare improvement in India. What do you see as the major challenges & opportunities on this mission?

A. Today, the Indian government has abdicated its responsibility to provide basic healthcare to its people, but it's holding a gun at the pharma industry and asking it to shoulder the burden. The industry has worked very hard to create a cost-effective and competitive sector. It is actually producing the cheapest drugs in the world, but on top of that the government is dictating how much profit the pharma industry is allowed to make. A complete lack of political will and effective administration have kept accessible and affordable healthcare out of the reach of most Indians.

The lack of a universal healthcare system in our country compels patients to bear almost 80% of the healthcare costs directly from their pocket. The opportunity therefore lies in leveraging India's value advantage and scientific excellence to come up with innovative technology for offering world-class products at affordable prices, thus making a huge difference to millions of patients in India. This is exactly what Biocon has been doing.

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Q. What initial steps would you recommend on the path towards providing high-quality, reliable healthcare to every Indian?

A. Tamil Nadu has taken an early lead in providing universal health coverage to its people by putting in place an effective drugs procurement and distribution mechanism as far back as 1994. Even more commendable is that Tamil Nadu created an IT-enabled supply chain management system that ensures delivery to real patients who need the medication - offering transparency to prevent misuse with stringent quality control, to weed out spurious drugs and their manufacturers. States like Kerala and Rajasthan have also made significant progress in healthcare by implementing this model.

Free medicines cannot fix an overburdened public healthcare system in which many hospitals lack up-to-date equipment and doctors. Thus, the free essential drugs scheme is just one of the many steps the government will need to take to ensure universal healthcare. I feel the adoption at the national level of an e-healthcare system like the one followed in Tamil Nadu can help to provide free medicines to those who need them in a transparent and efficient manner.

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Q. What would be your commandments for success for budding entrepreneurs and innovators?

A. 1. Evolve with the times: One of the significant lessons that I have learnt as an entrepreneur and innovator is that business visions evolve and change over time. As opportunities beckoned and better prospects for growth were found, I have changed my business model. I steered Biocon towards incremental innovation, thus morphing into improved versions of its older self over and over, while keeping our core values intact. I have also found it essential to always challenge myself through out-of-the-box solutions. At Biocon, we never forget that our sustainable success is rooted in the fact that we have made innovation the cornerstone of everything that we do.

2. Have a sense of purpose: Businesses must be driven by a sense of purpose and the spirit to take on challenges to ensure sustainable success. When we started Biocon, our resources were limited, the available infrastructure was primitive and we had to function in a fairly hostile business environment. But we succeeded against these odds because we believed in ourselves and our ability to succeed. Entrepreneurs must challenge themselves and the status quo and keep trying to differentiate - that will determine their success.

3. Work out the business model: One of the biggest challenges that any entrepreneur faces is working out an effective business model. I find most entrepreneurs don't know how to do that. So, even though they have a great product, they don't know how to market it. Business translation is something that entrepreneurs must address upfront.

4. Assess your capital needs: Another important thing that entrepreneurs need to do is to carefully work out their capital needs. They must work that out very carefully. Often people underestimate their resource and capital requirements.

5. Build an effective team: It is also important to get an effective team together. As an entrepreneur, you must lead the way and make sure that the team helps you in taking your vision forward.
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Q. Is there a favourite life wisdom that you would like to share with everybody?

A. In my entrepreneurial journey, my ability to face and learn from failure and move on has helped me a great deal in being successful. It is a trait that most entrepreneurs need to have in order to be successful. Failures provide the experience that no amount of success can. I am not suggesting one must seek failure, but when it comes, learn from it. I often say failure is temporary but giving up is permanent. We should never feel defeated in the face of failure, but should take it in our stride, learn from it and move on.

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Me: Thank you so much Dr. Mazumdar-Shaw for sharing such wonderful insights!
Dr. Kiran Mazumdar-Shaw: It's my pleasure! Thank you.
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June 25, 2013 | By:  Dr. Bhavana Weidmann
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Life Science Consulting: An Interview with Dr. Siegfried Bialojan

Imagine writing to someone at the height of their profession, seeking career insights, and then receiving a warm invitation to meet and learn from them! It's rare, but certainly not impossible as I discovered when I received a reply from Dr. Siegfried Bialojan, who is the executive director and head of European Life Science Center at Ernst & Young office in Mannheim, Germany.

After a post-doc at the German Cancer Research Center, Dr. Bialojan moved to the pharma industry and later went on to become a global leader in life science consulting. The transitions from academia to pharma and eventually to consulting were exciting and challenging. They were facilitated by his ability to seek out new possibilities and amalgamate his prior experience with new skills on the job.

With the signature humility and kindness of all great mentors, Dr. Bialojan generously shared with me his experienced take on the art of navigating career transitions and finding one's niche. I am delighted to bring you his valuable insights that can help students, young professionals and research institutions forge a strong partnership with the industry to sculpt the sciences for lasting commercial success.*



Dr. Siegfried Bialojan at the Ernst and Young Office, Mannheim (Photo by Dr. Bhavana Weidmann)


The Interview:


Q. Dr. Bialojan, please share what brought you from academia to the life science industry.

A. After my PhD and 2 years of post-doc at the German Cancer Research Center in Heidelberg, Germany, I made the decision to move into the commercial space of industry. I was more interested in contributing to the overall development of the final product that comes out of research. I had also partly completed my medical studies (however, I did not finish these). So, this was already directing me in a space for developing therapies. For me the pharma industry was just the next logical next step to take. It was also all about co-incidences. I joined BASF after some discussions and talks with the people I know. I didn't go through a very broad application process. I just had the opportunity to go and I chose to do it.



Q. What initial challenges did you come across during this shift from academia to industry?

A. The step from academia to industry was quite significant. It was not really appreciated from the academic side that I moved out, because at that time it was not really the normal thing to do. Scientists were in the science space and the industry people were considered to be a different breed. In Germany, going back and forth from the academia to industry is still not working that smoothly. There's still room for much improvement. In United States, it is much more customary for people to move out of academia, have some industry position for a while and then decide go back to the university. This is not really established in Germany or in Europe. Back then, it was even more complicated. Anyways I enjoyed that and moved on, having spent 8 or 9 years. Some would say may be even too long a time.

I think one advice would be to really ask yourself after roughly every 2 to 4 years – where am I now and is it still what I want to do or is it time to move on? Is there anything else you should probably add to your qualifications? When it's possible internally in a company that's fine, else one should also be confident enough to look externally. This is something I would do, if I had to chose again. I would probably be more flexible and more mobile.



Q. What were some of the highlights of your career in the pharmaceutical industry?

A. When I first joined BASF, a part of it was exclusively doing research in pharmaceuticals. This part had been acquired in 1970s and was called Knoll pharmaceuticals. There I started working with a team that did most of the drug development starting from pre-clinical studies and toxicology to pharmacology and finally clinical development. My tasks included looking after potential collaborations with academia and biotech firms and determining what is out there in terms of new ideas and technologies.

Also with the research we had done, Knoll started to develop, what is now the number one best-selling biological in the world – an antibody against tumor necrosis factor (TNF). In 2001, Knoll was sold to Abbott and it went onto manufacture this compound that we had started to develop, into the best-selling drug worldwide. It does give a sense of pride that one was involved in it at that time. Those were very interesting times at the company and I always enjoyed it. After the acquisition came about, Knoll became a subsidiary of Abbott. There were a lot of questions about whether even the site as such would stay, and so one starts looking for alternatives.



Q. How did the transition to life science consulting come about for you?

A. It was also a matter of coincidence. I never did a broad screen of where all the companies were. When Knoll had become a part of Abbott, I was getting in contact with my boss here at Ernst and Young, whom I had heard, was looking to build a team in the biotech arena. He was very visionary and thought that if one wants to work in the biotech field, one needs to have people who understand that field in greater detail. In this building only, where we speak, we had a meeting on a Saturday morning. It took about an hour and I was very convinced that this was what I needed to do. Namely, get out of the pharma industry and move into the consulting business and I was hired.

What I started to do here was to become more or less of an internal consultant. In the beginning it was really like me being the translator, because the scientists and researchers in the biotech companies would speak a different, more technical language to our audit experts. It meant understanding what the scientists were telling us and how it could translate into something we at Ernst & Young could do for them and communicate the suggestions of our experts back to the scientists in a manner that was relevant for them.



Q. What would be your advice to young professionals considering a career change?

It's important to make sure, especially if you go for a change, to bring in some of your previous training (background expertise) and professional experience into the new job. That's something I am very convinced about because if you have to start from scratch in a new position, its going to be very tough. I think it can be very difficult for beginners to find the first job because many companies want to hire people with some prior professional experience in the field. However, sometimes the bigger companies may like to get young people and train them through their own training programs. However, the more it goes into a very specific function, the more professional experience they will expect in that field. So look for opportunities where you add to what you know from your previous experience. At least it is not my strategy to do something totally from scratch. I mean, there may be people who do that, they just go for it, but it's not for me. I was always trying to link things.



Q. What kind of career options should a young biologist be open for?

A. As a young student, one doesn't always have the perspective to see the whole spectrum of possibilities. One must always keep the mind open to seeking out new possibilities. Being in a consulting firm, I now find scientists everywhere. Retrospectively, the spectrum was much broader than I had initially believed. If you look where biologists end up, it's a very a broad spectrum. You will find them in biotech and pharma industry, in investor companies and even banks. They have used their background in sciences and have just applied it in a totally different direction.



Q. In your opinion, how close is scientific research to its commercial application?

A. I think there are still a lot of opportunities and potential in science. There is a lot of federal and state money going into research funding and scientific collaborations and it is well-spent. However, there is still too much separation between academic research and industrial commercialization.

I think where we need more is in translation of scientific research into commercial development. There are examples where biotech firms founded here could not be financed because of the tough financing situation. These have been acquired by American companies which go on to benefit from the commercialization thereafter. What sense does it make if a country like Germany invests billions into research and then not much comes out on the commercial side? We have a lot of examples where the research and original patents have been developed here in Germany but the final commercial success happens in the US and elsewhere. For example, BASF sold their pharma business and now the major success from something that has been developed here, is happening in the US. Thus, the whole value creation done here is finally reaping dividends elsewhere.

It is a big responsibility for the whole research system that the link of research to commercial exploitation becomes more effective. It also comes with people. I think younger people may be much more open and flexible to stay in touch with both research and commercialization.



Q. With the media becoming more extensive, perhaps this awareness might also grow?

A. Of course, but then there is still another problem. There is quite a bit of bad reputation in the media for the pharmaceutical industry. Most of the time negative stories come out. Many of the positive ones are left behind. One predominantly hears only about the costs, not so much about benefits to patients.



Q. How is the financing situation in the life science industry and how it is influencing the job market?

A. If you look into the biotech space, most of the standard financing systems are not working that nicely and that's been going on for a while. This is not only in Germany, but it's all over Europe and may be it's a world-crisis in financing. So, the companies are very reluctant to build personnel and have to really become more focused on capital efficiency.

In contrast to what happened at the turn of the century, when there was a big boom in biotech sector resulting in the hiring of people and building of organizations, now there is more of a tendency to go virtual with less focus on building personnel and big infrastructures. This means jobs are not supported as much. Having the company as lean as possible in terms of their personnel and outsourcing to service providers is what we definitely see on the rise.

Today, I think job opportunities are more in the service sector than in the biotech field. The more virtual the original players become, the more there is a need of service provider companies to offer infrastructures and capacity. That could be clinical research organizations (CROs), companies doing contract research or toxicology companies for example. One could also instead become an entrepreneur and start a company of their own.



Q. How is the entrepreneurship climate in Germany for life sciences?

A. Maybe it is a German weakness that we have too few people that are really willing to take risks and become an entrepreneur. There are reasons for that. If you look at US, they are much more inclined to take risks. Even from an investor's perspective, they are preferred, even if they have had a failure as they have still gained some valuable experience. On the other hand, here people are definitely less willing to take risks, even myself – tending to be in the safe haven of a big company, rather than starting one's own company and taking all the risk.

If one fails in their entrepreneurial venture, which is quite a normal thing, often just a statistical chance, one is considered a loser here. Unfortunately it is extremely difficult to get that second chance here. This is where we do have mentality differences. It is difficult for young people to start their own business. Finding financing and taking risks is all very difficult and if one fails then one is a deemed a loser here. Who wants to do that? That has a lot to do with the whole sector, if you look at it.

The entrepreneurial sector needs people to take risks. It needs people to really go for it. It needs real entrepreneurs. We really need to seriously think about how we can train young people in advance to meet the challenge. Maybe it even goes back to schools and university programs as they offer only very specific subjects and not much training beyond that. This is where more thought about what is important to become an entrepreneur can really be initiated.



Q. Are additional qualifications helpful in making smooth career transitions?

A. I think today there are a lot of people with dual career tracks. Many complete their bachelors or master degrees and start studying MBA. If you are really looking to go into a more commercial setting, I think, it is quite appreciated to have some additional qualification that doesn't necessarily need to be a full-fledged MBA. We see this a lot, that people who do not want to stay in research try to do an additional course to gain some skills in management or economics.

One should not go to the other extreme either – gathering several degrees without any professional experience while growing older. The extra qualification is very theoretical and even with good publications one may be asked to show the professional experience for a job. The more you develop in your field, the more experience is asked for, rather than just a theoretical background. The balance between qualification and experience is crucial.

Rather than go from one internship to the next, the best thing is to talk to people, to find your path. If one has an idea and wants to move out of science, then one should go ahead and talk to the professionals and experts in their fields of interest. You can only learn. How else can you know about another field, just from doing science at the university? This can only come for interactions to get some information. As a student, I didn't know it back then myself. I knew someone at BASF, got talking with them and got a job there. One should apply and ask for a meeting with a company or institution they have in mind irrespective of whether they are offering a job. I have always gone directly to the people saying this is what I am doing and this is where I think I am good enough. It is so important to be proactive in approaching companies and building networks is key.



Q. What job opportunities may be available for young life science graduates at consulting firms such as Ernst and Young?

A. At Ernst and Young, our history comes from an audit perspective and later we moved into the life science consulting business. It's not that we hire a lot of scientists, unfortunately. What we do hire, are people who come from some very specialized sectors of the life science industry. For example, we are doing a lot of consulting work for performance improvement in supply chains of pharmaceutical industries. There we may hire people with professional experience in pharma supply chain. From that standpoint, me being in the company is more of an exception than the rule I must say. I think it might be different in other consultancies.

On the other hand, there are others for example McKinsey & Company, that are not so much into prior professional experience. They like to have open minds with creative thinking in running their projects. It is also a pretty tough job where as a young guy one may really experience burn-out. They have an up-or-out strategy, that means within two years you are so good that you are moving up or you are out. It's really tough. Some people say this is great – I have the chance to move up and even if I move out, the credentials are so good that I will find a job in another company afterwards.



Q. What would be your top suggestions for building a successful career in the life science industry?

A. Really explore and understand the networks in a company. Find out what are the rules, what are the dos and don'ts. It's really important to know the game. Nowadays most companies are more professional and organized. It starts with knowing the company, knowing the rules and then finding a mentor, one who is really close to you and interested in you. Because if you want to achieve something, you need support. Commitment is also very important. You have to be committed to company goals and also have personal goals for yourself in the company that show that you like to be in that company and that you want to bring this company forward. Commitment in the form of what I can do for the company is also recognized. One also needs to stay flexible for other opportunities – within or outside the company. It is always good to be receptive to what is happening outside or inside the company. In case there is a need to move, then one is at least more open to doing that.



Q. Could you elaborate some more about the need for a mentor in professional life?

It is really important to have somebody who actively supports you in the company. In most of the cases, if you do not have a mentor or a supportive network, then it is not going to work. Finding a mentor cannot really be done strategically. This person will have to find you. On your part you can actively try to be identified as someone who adds value to the company. It could well be that you may not find someone, then be flexible and reconsider your position.

It might also be counter productive if one is too much in the admiring mode. Being admired doesn't only always motivate one to mentor someone – it must come from the content one presents to foster a bi-directional input. It's far more impactful if one tries to get to an eye-level discussion where one adds quality content that is creating respect for one's background knowledge. One has to be self confident and really diplomatic rather than only decent and quiet, to move up in their career. It may be helpful to even have a controversial discussion sometimes, without insisting, where you can politely defend your argument with good knowledge of the content. That gives a totally different and far better impression rather than just quietly admiring.



Q. Finally, any additional recommendations for making successful career transitions?

A. Have a clear idea of what you can achieve in the new job - sometimes it may be difficult because you may not know about the job much, but at least the employers would see that you are targeted and focused. Also, some people tend to be very calm and quiet. However, it gives more of a feeling of self confidence if you can actually step-up and tell people that you are looking for more, for example a particular job title, or about the money you get, the support and the team you want. Ask about what are the criteria you are measured with. Every company has an evaluation system. In companies you are evaluated on certain preset criteria that decide your promotion. So do find out what you can do to fit in best in the system.

In case you are not really satisfied with the job offered, it may be difficult sometimes but you should also ponder on whether you should really accept it. Look for what you can work with and there will always be room to improve. If you are a team player make them know that you would like to work in teams and ask how you would be integrated into the team. You need to have an open minded attitude and communicate effectively. Being really authentic and confident is key. Ultimatley, it boils down to just being serious about whatever you set out to do.



Me: Thank you Dr. Bialojan. That's such great advice!

Dr. Bialojan: My pleasure! Thank you.



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May 22, 2013 | By:  Dr. Bhavana Weidmann
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Biotech Entrepreneurship: An Interview with Dr. Christian Tidona


Have you ever observed a true mentor at work? One who isn't hesitant to thrust his people forward, crack their shells of shyness, sharing useful career advice enthusiastically without holding back. I got to witness one such mentor, Dr. Christian Tidona, as he trained young life science graduates during a recent biotech entrepreneurship training program in Heidelberg, Germany.

Dr. Tidona is a serial biotech entrepreneur and the managing director of the blooming biotech cluster, BioRN, in southwest Germany. His business acumen is backed by a stellar academic record. Back in 1999, he finished his doctorate in molecular biology and virology from the University of Heidelberg, in three years straight, graduating summa cum laude. Immediately after, he moved from academia into the high seas of biotech entrepreneurship. This was a new journey, one on which there was a great deal to be learnt. Much of this knowledge, he acquired through his own experiences and with the aid of his mentors. Today, despite his pressing schedule, he makes time to train young scientists for entrepreneurship, something that academia often does not actively prepare one for.

I am happy to present you this candid interview with him, where he generously shares industry insights on what it takes to succeed as an entrepreneur in the biotech and pharma industry. Read on to get a closer glimpse of his journey and to gather some must-know tips for becoming a dream leader!*


Photograph of Dr. Christian Tidona (Courtesy: BioRN Cluster Management, GmbH)


The Interview:


Q. Dr. Tidona, please share how did you decide to move out of the academia into the life science industry.

A. I had studied molecular biology and virology in the lab at Heidelberg and I just wanted to see the application of the basic research in the patient. Basically, I was just desirous to be a part of the transfer of this scientific knowledge that could be used to help patients. That led to the foundation of the first startup in 1999, a little diagnostic company in Regensburg, Germany.



Q. Was this company founded based on your research work?

A. It was in connection with the research work. It was actually the technology of a pretty newly founded company in Austin, Texas. I had heard of this technology, which allowed hundred different diagnostic tests, from one drop of blood and I was excited about it. My scientific mentor at that time, was involved in this startup and they were looking for a managing director. I helped to write the business plan and they liked the business plan so much that they thought, that I might be a good CEO of this company. That was how it all started.



Q. Certainly when you shifted from academia to a completely new field, that of industry, there must have been some initial challenges. What were those?

A. Oh yes, basically everything - starting with negotiating the licensing agreement with the American company to attracting the venture capital and convincing the venture capitalists. At that time, I had 2.4 million Deutsche Mark to start with (around 1.2 million Euros). I had been the lab head at the laboratory in Heidelberg, but it is different when you hire people that work in the lab on scientific things and when you try to put a team together that is trying to build products and trying to do marketing, sales, financial reporting and things like that. So, it was basically learning by doing.



Q. What were some of the first things that you had to learn by yourself upon arriving into the industry?

A. Oh, they were quite a many. I think, the things I knew the least about were the finance and the accounting that comes with it. Especially in this case, I also had public funds and research grants involved. There is a huge difference between public funds, where you have to basically spend the money doing research. On the other hand, financial planning for venture capital, is a quite different because you have other milestones - you have to think about things like depreciation, tax issue and such things, which I never had to think about as a scientist in the lab before. I found quite good people I could learn from, like a good accountant who taught me a lot, and mentors who helped me to understand what a P&L (profit and loss) statement looks like, how to read a balance sheet, what's important and what's not.



Q. Is this one of the reasons that you take so much initiative to train and mentor young students, because of the challenges you faced yourself?

A. Yes, it's part of it. The way I learnt it was very expensive, from a socioeconomic point of view and also for myself. This is because the first startup did not go well. After two years, my share holders who were professors, wanted to pursue research while I was somebody that wanted to do products and profits. This didn't match. So, we split up. I left the company, lost a lot of money - money of my family and friends. The company afterwards, did not do well, either. From a socioeconomic and personal point of view, this was a very expensive learning experience. But I am convinced that failure is part of the process. It might have been more efficient if I had already had some entrepreneurship training at the university before. If I had known some things before, that I know today, I wouldn't have made that many mistakes. You always make mistakes, but not that many.



Q. After learning from you, that one can meet failures along the way to a good position in the industry, it seems quite encouraging for younger talent to feel that perhaps it's alright, even if there are a few failures along the way.

A. Well, unfortunately in Europe it's not alright. Because in Europe if you fail, you are stigmatized. I mean people usually do that once and then they won't get back. But I was pretty lucky.



Q. So, it is a rare phenomenon in Europe to recover from a business failure?

A. Yeah. The spirit in the United States is different from the spirit here in Europe, specifically in Germany. Whenever, I do the Biotechnology Entrepreneurship Training seminar, I ask the students what was their perspective, when they began studying molecular biology. About 80% answer by saying "Well, I was interested in an academic lab career doing research" and up to 20% say "Well, I was thinking about a career in a big company," but basically 0% think about starting their own company! The reason for this is that in Europe and Germany we do not have this training level, like many incubators and accelerators with good mentors. In addition to that, as I said, you are stigmatized when you fail. In the United States, if this failure doesn't go back to very severe mistake you made and was a part of the learning process, your CV actually gains from the failures you survived. In Europe, it's different. If one has a failure in the CV, then one is basically done with this type of career. This is the attitude, which we have to change.



Q. What personal and professional qualities have enabled you to reach the position you are at in the industry today?

A. It's an incredible belief in the fact, that if you only try hard enough and don't give up, you will make it sometime. That's the most important lesson, I have learnt as a startup entrepreneur, especially in the biotech field, where it takes a lot of money to begin and you loose a lot of money if you fail. It's an experience where you change from euphoria to terror, from day-to-day. If you don't believe that much in yourself, that if you only work hard enough and follow your passion, you will make it sometime, you will give up sometime along the way. That's the distinguishing factor. If I look back at some colleagues, that started their first companies together with me in the 90s, most of them had given up after a while, although they had good potential. They have become consultants and so on. So, it is important to believe in what you are doing and in yourself. Believe that you can do it and stand up, whenever you fall stand up - just get back up.



Q. What are the job prospects for freshly graduated doctoral students in the biotech industry in the region?

A. In the biotech and the pharma industry, especially when it comes to bigger companies, it's bad timing, essentially at the moment. Most of those companies are cutting down their workforce, especially in Europe, though not so much in Asia. Most of them are building up in Asia and also in United States, but in Europe they are basically cutting down their workforce. So, this is a phenomenon, that is just due to bad timing and not due to general principle. Today I am not sure, if I had to decide once again whether to do a PhD or start a company earlier, then if I knew what I know now, I would probably have started earlier. But it was not clear for me that I was going to end up an entrepreneur. In the 90s, I had very straight forward paths of academic science in front of me. I was teaching at the University, I had students and quite a lot of good publications. So, it was some sort of an accident that I ended up as an entrepreneur and then found out that this is my way. If there had been some entrepreneurship training during my diploma studies, I would have probably started much earlier.



Q. What should young scientists who aspire to become entrepreneurs, keep in mind?

A. Maybe a little bit of advice for younger people. It is not easy in biotech to start a company. You will need a lot of money and big risks. The venture capital situation in Europe is not very good and neither is the situation with incubators and accelerators. Having served in juries and as a coach for quite a few business plan competitions, I would strongly recommend to people who have technology or product ideas for startups, the first thing they should try to do is to get involved with one of those business plan competitions because they give you access to coaches, mentors, lots of jury members who give you feedback regarding your idea, your business plan and the way you present it. Then, may be as a second step, once you have those connections, you should use social media. I am a firm believer in personal networks and social media. Take part in one of those incubator or accelerator programs, where in a period of 3, 6 or sometimes 12 months, you are in a protected incubator environment with lots of good mentors, that help you work out the real idea and make it ready for presentation to venture capitalists. So, the advice would be to not go too early for venture capital, because these guys are used to well thought through ideas and well trained teams. If you don't have these types of skills from the start it can be very disappointing because you don't get a second chance at those. If you have wasted that chance once, you won't get a second appointment, if you get an appointment at all.



Q. Could you share some of lessons that you have learnt from your own mentors?

A. Certainly. One of the greatest mentor I was able to spend time with in the past, is actually Mr. Ashok Rao. He is the first person of Indian origin to bring his startup to the NASDQ, in the United States. He is also the chairman of our global entrepreneurship organization, The Indus Entrepreneurs (TiE) and he is really a brilliant mentor.

In every speech he gives, he presents, his ten so-called "Ashokisms." I am trying to follow some of them myself. Particularly, two of them are quite important. The first one, he mentions is that "You should not shave superman every morning." As a young entrepreneur when you get control over a lot of money, perhaps many millions, people start looking up at you, although you do not have much experience yet. It can be very easy to come to a position where you loose context. You think you are basically superman and start behaving like superman. However, it is very important to stay humble because there are ten thousands of people out there that are much, much more clever, have much more money, have much more access and much more ideas. So, it is very important to stay humble and "do not shave superman when you look in the mirror every morning."

Another thing is that, as an entrepreneur and as a creative person, most people have short attention spans and think that things are not moving fast enough all the time. While it's important to have this attitude to speed up things when they are too slow, sometimes young people tend to overdo it a little. What Ashok always says is, "Don't push the river. Let the river flow." When you want something, you should keep it in focus but do not try to force it immediately because then you can ruin it. Somethings need time and effort and don't come that fast. So you shouldn't "push the river, rather let the river flow."



Q. What are the key ideas that an emerging manager should keep in mind that help the entire organization, the team and the individuals?

A. It takes a while until people understand it in their career. Their role as leaders is not doing everything by themselves and also not to delegate everything. Rather their role is to create an environment, that makes the great people they hire, happy and productive. That is the most important thing. That's what I am doing here. I am creating an environment for my employees to be as productive and as happy as possible, because my productivity is the productivity of my team.

So, it's important to enable and energize the team, so they can perform in an optimal way. This is the performance of the leader in the end. Basically, if your are a good leader, it seems like you are not necessary anymore, because you are not really doing the work - you are just helping the work environment. On the other hand, it may be quite dangerous, when some people tend hold on to their jobs very tightly in leadership positions. They tend to do everything by themselves to be irreplaceable. I think the best thing a leader can do is becoming replaceable, and then move onto the next position.



Q. What are the key ways in which you enable your team to stay energized and actually produce their best?

A. Before you can do that, you have to understand that this begins with hiring the team. It's important to understand what are the specific capabilities of the team members and what are the requirements they need met, in order to be really productive. Especially what's important, is to make sure that they have access to what they need, so they don't have to procure it by themselves - it needs to be provided.

To give you an example, the first instrument bought at my first company in 1999, was a fully automated cappuccino machine. From an economic point of view, the depreciation of this object is gone after three years and if people are happy drinking coffee and being social, this experience stays over the entire lifetime of the company. Salary increase might have a similar effect, but I don't think that it stays with you forever. So, from an economic point of view as a leader, it's better to invest in the work environment, the infrastructure and everything people need to be productive, instead of attracting people just through high salaries.

People spend more of their lives with their boss and at their company, than with their families. Therefore, it should be an environment where they can be productive and happy. Also, to give another example, in my companies (which have been quite a few up to now, which I have either led or restructured) I was always very happy about women that had their first children. They were a little less flexible than everybody else, but on the other hand, they wanted to succeed and do their work. After the children, they wanted to come back to the job. Once you give them the flexibility they need, to bring the children to kindergarten (nursery) and take them back, they work much more productively and with much more energy than most men that have a simple life. This is also a lesson that I learnt during the first startups, that it's also about personal motivation, capabilities and possibilities.



Q. How do you guide your team for more success in their careers?

A. When I hire people, I tell them right from the start that I don't expect you to be here forever. I expect you to do in the next couple of years, something that is very, very useful and has a high impact on your CV, which will then be a high impact for my company. Then, I will do whatever necessary to bring you to the next level, even if this would mean to hand you over to another career, where you can do the next steps if you can't do them here.

Also, I expect people to improve their skills constantly. I don't want people that just do the assigned work. I want people that have the ambition to learn new things. Every employee in my company has to do a course or special educational program which they can choose by themselves, that costs the company money, but which brings them another bullet in their CV. This makes them happy and makes me proud that they are developing. This again, makes them more productive. That is something, I think leaders need to understand now a days - that employees are not a given, especially the motivation of employees is not a given. Basically, leaders are there to enable the employees to be as productive as possible by themselves.



Q. Finally, before we close, what is that one life wisdom that you would like to share with everybody?

A. I guess, what I have learnt and what is very important for everyone that wants to change something in the world for the positive, is that you must focus on quality and performance, nothing else. What I see in many companies and institutions, are some people that are always looking and comparing themselves to others, trying to be better than others or trying with political steps to inhibit others and suppress them in order to look bigger and things like that. In the end, I am a firm believer that if you focus just on your own performance and the quality of things you are doing, success will come by itself. So, once again, "you shouldn't push the river" and success will come by itself if you focus on the right things, which is just quality, nothing else.



Me: Thank you Dr. Tidona. That was really insightful!

Dr. Tidona: My pleasure! Thank you.



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