Watson et al. obtained magnetic resonance images of the brains of 10- to 19-year-olds who had undergone the Fontan procedure for single-ventricle defects and compared them with those of healthy controls. They found significant and widespread reduction in regional gray matter. Several surgery-related issues were associated with reduction in volume, suggesting potentially modifiable risk factors. See the article on page 881.

Dubruc et al. studied the amount of C5b9 immunostaining in liver tissue from patients with neonatal hemochromatosis caused by gestational alloimmune liver disease, and compared the results with those for tissue from livers with and without iron overload. See the article on p. 712.

Ellery et al. studied the effect of maternal creatinine supplementation on chronic kidney disease using a mouse model of birth asphyxia. Only males exhibited significant renal changes, which were ameliorated in those whose mothers were fed a diet supplemented with creatinine. See the article on p. 646.

Jeanne et al. investigated the impact of thrombospondin-targeting TAX2 peptide effects on tumor growth in a mouse model of neuroblastoma. See the article on p. 480.

Filippi et al. evaluated the safety and efficacy of propranolol eye micro-drops in preterm newborns with ROP. See p. 307

Cover art by Erin Dewalt. See “Introduction: Standing on Each Other’s Shoulders” on p. 137.