Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
This paper reviews the synthetic strategies for HBPs with controlled DB by specially designing monomer architectures. Several research groups including our group have been overcoming the statistical determination of DB in a random polymerization by tuning the rate constant of the first substitution reactions (k1) and that of the second reaction (k2) of an AB2 monomers. As a result, HBPs with 100% DB, linear polymers (0% DB) and HBPs with any percentage of DB have been successfully synthesized.
Protein adsorption on the poly(ethylene glycol) (PEG)-tethered-chain surface was almost completely suppressed by successive treatment of longer PEG chain followed by treatment of PEG (2 kDa; mixed-PEG tethered-chain surface) because of significant increase in PEG chain density. Using pentaethylenehexamine-ended PEG, which was newly designed by ourselves, antibody/PEG and oligoDNA/PEG co-immobilizations were carried out. The PEG tethered chain was found to work not only as a non-fouling character but also as an improvement in orientation of biomolecules. Thus, it is promising as a high-performance biointerface for versatile applications.
Slide-ring gel with freely movable crosslinks shows extremely small Young's modulus and recovers the deformed shape to the original one instantaneously and completely. The small modulus arises from new entropic elasticity because of the heterogenous distribution of free cyclic molecules on polyrotaxane. The sliding elasticity appears in the sliding state, where axis polymer chains and cyclic molecules are sliding actively. In addition, the slide-ring gel should show the sliding transition between the rubber and sliding states. These aspects indicate that the slide-ring gel has its unique dynamics in mechanical properties.
Poly[2]rotaxane and graft polyrotaxane were synthesized from a mixture of poly(crown ether) as a trunk polymer, boronic-acid-terminated secondary ammonium salt as an axle component and diol as an end-capping group by pseudorotaxane formation and subsequent catalyst-free dehydrative bondage between the boronic acid and the diol moieties. It turned out that the chemical stability of these supramolecular architectures primarily depends on the bulkiness of the diol group as the end-capping moiety and the inherence originating from the dynamic covalent bond of boronate.
