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Redox control of AP-1-like factors in yeast and beyond

Oncogene volume 20, pages 2336–2346 (2001)Cite this article

Abstract

Cells have evolved complex and efficient strategies for dealing with variable and often-harsh environments. A key aspect of these stress responses is the transcriptional activation of genes encoding defense and repair proteins. In yeast members of the AP-1 family of proteins are required for the transcriptional response to oxidative stress. This sub-family of AP-1 (called yAP-1) proteins are sensors of the redox-state of the cell and are activated directly by oxidative stress conditions. yAP-1 proteins are bZIP-containing factors that share homology to the mammalian AP-1 factor complex and bind to very similar DNA sequence sites. The generation of reactive oxygen species and the resulting potential for oxidative stress is common to all aerobically growing organisms. Furthermore, many of the features of this response appear to be evolutionarily conserved and consequently the study of model organisms, such as yeast, will have widespread utility. The important structural features of these factors, signaling pathways controlling their activity and the nature of the target genes they control will be discussed.

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References

  • Abate C, Patel L, Rauscher FJ, Curran T . 1990 Science 249: 1157–1161

  • Alvarez ME, Pennell RI, Meijer PJ, Ishikawa A, Dixon RA, Lamb C . 1998 Cell 20: 773–784

  • Bandyopadhyay S, Gronostajski RM . 1994 J. Biol. Chem. 269: 29949–29955

  • Bauer CE, Elsen S, Bird TH . 1999 Ann. Rev. Microbiol. 53: 495–523

  • Bobrowicz P, Wysocki R, Owsianik G, Goffeau A, Ulaszewski S . 1997 Yeast 13: 819–828

  • Buck V, Quinn J, Soto Pino T, Martin H, Saldanha J, Makino K, Morgan BA, Millar JBA . 2001 Mol. Biol. Cell 12: 407–419

  • Carmel-Harel O, Storz G . 2000 Ann. Rev. Microbiol. 54: 439–461

  • Coleman ST, Epping EA, Steggerda SM, Moye-Rowley WS . 1999 Mol. Cell. Biol. 19: 8302–8313

  • Cottarel G . 1997 Genetics 147: 1043–1051

  • Degols G, Shiozaki K, Russell P . 1996 Mol. Cell. Biol. 16: 2870–2877

  • Degols G, Russell P . 1997 Mol. Cell. Biol. 17: 3356–3363

  • Delaunay A, Isnard A-D, Toledano MB . 2000 EMBO J. 19: 5157–5166

  • DeRisi JL, Iyer VR, Brown PO . 1997 Science 278: 680–686

  • Ding H, Hidalgo E, Demple B . 1996 J. Biol. Chem. 271: 33171–33175

  • Fernandes L, Rodrigues-Pousada C, Struhl K . 1997 Mol. Cell. Biol. 17: 6982–6993

  • Finkel T, Holbrook NJ . 2000 Nature 408: 239–247

  • Freeman BA, Crapo JD . 1982 Lab. Invest. 47: 412–426

  • Gaits F, Degols G, Shiozaki K, Russell P . 1998 Genes Dev. 12: 1464–1473

  • Gaudu P, Weiss B . 1996 Proc. Natl. Acad. Sci. USA 93: 10094–10098

  • Gasch AP, Spellman PT, Kao CM, Carmel-Harel O, Eisen MB, Storz G, Botstein D, Brown PO . 2000 Mol. Biol. Cell. 11: 4241–4257

  • Godon C, Lagniel G, Lee J, Buhler JM, Kieffer S, Perrot M, Boucherie H, Toledano MB, Labarre J . 1998 J. Biol. Chem. 273: 22480–22489

  • Halliwell B, Gutteridge JM, Cross CE . 1992 J. Lab. Clin. Med. 119: 598–620

  • Hidalgo E, Ding H, Demple B . 1997 Cell 88: 121–129

  • Hinnebusch AG . 1988 Microbiol. Rev. 52: 248–273

  • Hirota K, Matsui M, Iwata S, Nishiyama A, Mori K, Yodoi J . 1997 Proc. Natl. Acad. Sci. USA 94: 3633–3638

  • Huang RP, Adamson ED . 1993 DNA Cell Biol. 12: 265–273

  • Inoue Y, Matsuda T, Sugiyama K, Izawa S, Kumura A . 1999 J. Biol. Chem. 274: 27002–27009

  • Izawa S, Maeda K, Sugiyama K, Mano J, Inoue Y, Kimura A . 1999 J. Biol. Chem. 274: 28459–28465

  • Kudo N, Taoka H, Toda T, Yoshida M, Horinouchi S . 1999 J. Biol. Chem. 274: 15151–15158

  • Kuge S, Jones N . 1994 EMBO J. 13: 655–664

  • Kuge S, Jones N, Nomoto A . 1997 EMBO J. 16: 1710–1720

  • Kuge S, Toda T, Iizuka N, Nomoto A . 1998 Genes Cells 3: 521–532

  • Lee J, Godon C, Lagniel G, Spector D, Garin J, Labarre J, Toledano MB . 1999 J. Biol. Chem. 274: 16040–16046

  • Levine A, Tenhaken R, Dixon R, Lamb C . 1994 Cell 79: 583–593

  • Liu H, Nishitoh H, Ichijo H, Kyriakis JM . 2000 Mol. Cell. Biol. 20: 2198–2208

  • Millar JB . 1999 Biochem. Soc. Symp. 64: 49–62

  • Millar JB, Buck V, Wilkinson MG . 1995 Genes Dev. 9: 2117–2130

  • Morgan BA, Banks GR, Toone WM, Raitt D, Kuge S, Johnston LH . 1997 EMBO J. 16: 1035–1044

  • Myrset AH, Bostad A, Jamin N, Lirsac PN, Toma F, Gabrielsen OS . 1993 EMBO J. 12: 4625–4633

  • Nguyen AN, Lee A, Place W, Shiozaki K . 2000 Mol. Biol. Cell. 11: 1169–1181

  • Ohmiya R, Kato C, Yamada H, Aiba H, Mizuno T . 1999 J. Biochem. 125: 1061–1066

  • Pascual-Ahuir A, Serrano R, Proft M . 2001 Mol. Cell. Biol. 21: 16–25

  • Posas F, Wurgler-Murphy SM, Maeda T, Witten EA, Thai TC, Saito H . 1996 Cell 86: 865–875

  • Posas F, Saito H . 1998 EMBO J. 17: 1385–1394

  • Rainwater R, Parks D, Anderson ME, Tegtmeyer P, Mann K . 1995 Mol. Cell. Biol. 15: 3892–3903

  • Ross SJ, Findlay VJ, Malaksi P, Morgan BA . 2000 Mol. Biol. Cell 11: 2631–2642

  • Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada Y, Kawabata M, Miyazono K, Ichijo H . 1998 EMBO J. 17: 2596–2606

  • Samejima I, Mackie S, Fantes PA . 1997 EMBO J. 16: 6162–6170

  • Samejima I, Mackie S, Warbrick E, Weisman R, Fantes PA . 1998 Mol. Biol. Cell 9: 2325–2335

  • Schreck R, Albermann K, Baeuerle PA . 1992 Free Radic. Res. Commun. 17: 221–237

  • Segal AW, Shatwell KP . 1997 Ann. NY Acad. Sci. 832: 215–222

  • Shieh JC, Wilkinson MG, Buck V, Morgan BA, Makino K, Millar JB . 1997 Genes Dev. 11: 1008–1022

  • Shimanuki M, Saka Y, Yanagida M, Toda T . 1995 J. Cell. Sci. 108: 569–579

  • Shiozaki K, Russell P . 1995 Nature 378: 739–743

  • Shiozaki K, Russell P . 1996 Genes Dev. 10: 2276–2288

  • Shiozaki K, Shiozaki M, Russell P . 1997 Mol. Biol. Cell. 8: 409–419

  • Spataro V, Toda T, Craig R, Seeger M, Dubiel W, Harris AL, Norbury C . 1997 J. Biol. Chem. 272: 30470–30475

  • Stitzel ML, Durso R, Reese JC . 2001 Genes Dev. 15: 128–133

  • Stock JB, Ninfa AJ, Stock AM . 1989 Microbiol Rev. 53: 450–490

  • Storz G, Tartaglia LA, Ames BN . 1990 Science 248: 189–194

  • Takeda T, Toda T, Kominami K, Kohnosu A, Yanagida M, Jones N . 1995 EMBO J. 14: 6193–6208

  • Thannickal VJ, Fanburg BL . 2000 Am. J. Physiol. Lung Cell. Mol. Physiol. 279: L1005–L1028

  • Tibbles LA, Woodgett JR . 1999 Cell. Mol. Life Sci. 55: 1230–1254

  • Toda T, Shimanuki M, Saka Y, Yamano H, Adachi Y, Shirakawa M, Kyogoku Y, Yanagida M . 1992 Mol. Cell. Biol. 12: 5474–5484

  • Toone WM, Jones N . 1998 Genes Cells 3: 485–498

  • Toone WM, Kuge S, Samuels M, Morgan BA, Toda T, Jones N . 1998 Genes Dev. 12: 1453–1463

  • Toone WM, Jones N . 1999 Curr. Opin. Genet. Dev. 9: 55–61

  • Vido K, Spector D, Lagniel G, Lopex S, Toledano MB, Labarre J . 2001 J. Biol. Chem., in press

  • Weis K . 1998 Trends Biochem. Sci. 23: 185–189

  • Wemmie JA, Steggerda SM, Moye-Rowley WS . 1997 J. Biol. Chem. 272: 7908–7914

  • Wilkinson MG, Samuels M, Takeda T, Toone WM, Shieh JC, Toda T, Millar JB, Jones N . 1996 Genes Dev. 10: 2289–2301

  • Wu X, Bishopric NH, Discher DJ, Murphy BJ, Webster KA . 1996 Mol. Cell. Biol. 16: 1035–1046

  • Yan C, Lee LH, Davis LI . 1998 EMBO J. 17: 7416–7429

  • Zhang X, De Micheli M, Coleman ST, Sanglard D, Moye-Rowley WS . 2000 Mol. Microbiol. 36: 618–629

  • Zheng M, Aslund F, Storz G . 1998 Science 279: 1718–1721

  • Zheng M, Storz G . 2000 Biochem. Pharmacol. 59: 1–6

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Acknowledgements

We would like to thank Rachel J Morgan, Janet Quinn and Ann Marie Flenniken for help in making the figures and critically reading the manuscript.

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Authors and Affiliations

  1. CRC Cell Regulation Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, M20 4BX, Manchester, UK

    W Mark Toone & Nic Jones

  2. School of Biochemistry and Genetics, The Medical School, University of Newcastle, Newcastle-upon-Tyne, NE2 4HH, UK

    Brian A Morgan

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Toone, W., Morgan, B. & Jones, N. Redox control of AP-1-like factors in yeast and beyond. Oncogene 20, 2336–2346 (2001). https://doi.org/10.1038/sj.onc.1204384

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