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HER2/Neu: mechanisms of dimerization/oligomerization

Oncogene volume 19, pages 6093–6101 (2000)Cite this article

An Erratum to this article was published on 24 January 2002

Within a multi-celled organism, regulation and organization require that biological signals be transmitted from one cell to another, across cell membranes. Such is the case with growth factors, which originate from one site in an organism, yet need to be distributed throughout the organism to many cell types in order to exert their pleiotropic effects. Systems have evolved to allow a soluble signal, a growth factor for example, to be conveyed from the extracellular space to the cytoplasm and nucleus of a cell, thus directing protein synthesis, cellular growth, and cellular proliferation. To solve this problem of transmitting signals across membranes, growth factors appear to induce aggregation of their receptors, leading to activation of these receptors and signal propagation. Unregulated, however, these growth signals have the potential to promote inappropriate proliferation; receptor aggregation in the absence of signal represents a means of unregulated growth factor receptor activity which is postulated to occur in human neoplasia.

Though dimerization/oligomerization has been recognized as an integral component of signaling by erbB family receptors since shortly after the discovery of neu, the mechanism by which these receptors aggregate is still not fully understood. Extracellular, transmembrane, and intracellular domains of the protein have all been implicated in dimerization/oligomerization; the potential contribution of each of these domains to receptor aggregation will be discussed below.

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  1. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, PA, USA

    Patrick J Brennan, Toru Kumogai, Alan Berezov, Ramachandran Murali & Mark I Greene

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Brennan, P., Kumogai, T., Berezov, A. et al. HER2/Neu: mechanisms of dimerization/oligomerization. Oncogene 19, 6093–6101 (2000). https://doi.org/10.1038/sj.onc.1203967

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