Volume 7 Issue 7, July 2000


News & Views

  • News & Views |

    S100B, an EF-hand Ca2+-binding protein, grasps the C-terminus of the tumor suppressor p53 and inhibits protein kinase C-dependent phosphorylation and acetylation of p53 in a Ca2+-dependent manner. The mode of interaction between S100B and p53 is different from the interactions seen in S100A–annexin complex structures.

    • Mitsuhiko Ikura
    •  & Kyoko L. Yap
  • News & Views |

    The crystal structure of TolC, one of the most mysterious proteins in the outer membrane of Gram-negative bacteria, suggests a mechanism for its role in secretion of proteins and efflux of toxic chemicals.

    • Kathleen Postle
    •  & Hema Vakharia
  • News & Views |

    Some prokaryotic transcriptional activators act by binding to enhancers and directly changing the conformation of a specialized sigma factor in the RNA polymerase holoenzyme. This mechanism has interesting parallels in other transcription systems.

    • Jay D. Gralla
  • News & Views |

    The first high resolution structure of an ATP-dependent cation pump of the P-type family — the Ca2+-ATPase from the sarcoplasmic reticulum of rabbit muscle — has now been determined.

    • David B. McIntosh


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