Volume 6 Issue 5, May 1999

Volume 6 Issue 5

Four papers in this issue yield insight into DNA-protein interactions. The cover shows the DNA-binding domain of an orphan nuclear receptor, nerve growth factor-induced-B (NGFI-B), in complex with DNA. This represents the first structural analysis of a nuclear receptor DNA-binding domain bound as a monomer to DNA; see pages 471–477. Additional reports beginning on pages 427, 464 and 478 present studies of the arginine repressor, the heat shock transcription factor and the ADR1 zinc finger transcription factor, respectively.

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