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Volume 30 Issue 6, June 2023

Protecting the sister chromatids at centromeres

A study by García-Nieto et al. shows that SGO1 bears the responsibility of protecting centromeric cohesin from WAPL-mediated unloading until the kinetochore and the microtubules have formed functional attachments.

See García-Nieto et al.

Image Credit: Chris Wallace / Alamy Stock Photo. Cover Design: Allen Beattie

News & Views

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Research Briefings

  • The correction of errors during mitochondrial DNA replication by the proofreading function of DNA polymerase-γ is crucial for maintaining the integrity of the mitochondrial genome and the production of cellular energy. Using cryo-electron microscopy, several steps of the DNA polymerase-γ proofreading pathway have been revealed at near-atomic resolution.

    Research Briefing
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Review Articles

  • Here, the authors describe the composition, architecture, functions and mechanisms of the SMC (structural maintenance of chromosomes) complex Smc5/6 in chromosomal replication and repair, as well as its involvement in disease.

    • Xiao P. Peng
    • Xiaolan Zhao
    Review Article
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Brief Communications

  • Gabapentinoid drugs are widely used for pain, epilepsy and mental disorders. Chen et al. report the structure of a gabapentin-bound brain and heart calcium channel, revealing the gabapentin binding site and isoform-selective binding determinants.

    • Zhou Chen
    • Abhisek Mondal
    • Daniel L. Minor Jr
    Brief Communication
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  • A systematic survey of the budding yeast proteome identifies hundreds of post-transcriptional regulators. Regulatory activity is enriched in RNA-binding proteins but lies outside the RNA-binding domains, often within intrinsically disordered regions.

    • Kendra Reynaud
    • Anna M. McGeachy
    • Nicholas T. Ingolia
    Article Open Access
  • Here, Zhouyan et al. present the structure of yeast SIN3–HDAC complex Rpd3L, revealing a distinctive organization mechanism compared with other class I HDAC complexes. The authors observe that two distinct arms hang on a T-shaped scaffold formed by two coiled-coil domains.

    • Zhouyan Guo
    • Chen Chu
    • Chengcheng Wang
  • Here, the authors reveal the architecture of the TRAP complex bound to the translating ribosome and Sec61 translocon, explaining its function in insertion and secretion of proteins, including the insulin hormone, at the endoplasmic reticulum membrane.

    • Mateusz Jaskolowski
    • Ahmad Jomaa
    • Nenad Ban
    Article Open Access
  • Here the authors use cryogenic electron microscopy to solve the Arabidopsis thaliana Argonaute10–guide RNA complex with and without a target RNA representing a slicing substrate, to provide insights into the slicing mechanism of a eukaryotic Argonaute.

    • Yao Xiao
    • Shintaro Maeda
    • Ian J. MacRae
  • Here the authors show that PIAS3/SENP1-mediated poly-SUMOylation of MAVS regulates its interaction with IRF3, whose SUMO-interacting motif (SIM) guides binding to SUMOylated MAVS. IRF3 phosphorylation, close to its SIM, dismantles SUMO-dependent aggregates and releases activated IRF3.

    • Tong Dai
    • Lei Zhang
    • Fangfang Zhou
  • Here, the authors determine the structural basis of how SGO1 protects centromeric cohesin from WAPL-mediated release until the kinetochores and the microtubules have formed functional attachments. In addition, they show that SGO1 and CTCF bind cohesin in a similar manner, suggesting a potential universal mechanism of cohesin control.

    • Alberto García-Nieto
    • Amrita Patel
    • Benjamin D. Rowland
    Article Open Access
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Amendments & Corrections

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