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Volume 28 Issue 7, July 2021

TRP channels feel the heat

Cryo-EM structures of the sensory ion channels TRPV1 and TRPV3 at different temperatures reveal mechanistic principles of heat-dependent gating.

See Kwon et al. and Nadezhdin, Neuberger et al.

Image: Felipe Jansen / EyeEm / Getty. Cover Design: Bethany Vukomanovic.

Research Highlights

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News & Views

  • The autophagy protein Atg8 regulates autophagosome biogenesis and mediates cargo recruitment in different types of selective autophagy, but the molecular mechanisms mediating Atg8 functions during autophagosome biogenesis have been unclear. A study published in Nature Structural & Molecular Biology now shows that lipidated Atg8 possesses physicochemical activity that regulates membrane morphology, which underlies efficient autophagosome biogenesis.

    • Eeva-Liisa Eskelinen
    News & Views
  • A new cryo-EM study reveals how ATP hydrolysis in the p97 ATPase is coordinated to unfold the protein’s substrates and provides new foundations for the design of small molecule therapeutics targeting p97 in cancer, neurodegeneration and viral infection.

    • Edward C. Twomey
    News & Views
  • After years of only low-resolution and partial assemblies, the entire human preinitiation complex (PIC), including the large and flexible Mediator and TFIID complexes, has come into focus. Five recent papers from three different research groups have transformed our understanding of transcription initiation by RNA polymerase II.

    • Allison C. Schier
    • Dylan J. Taatjes
    News & Views
  • A spectrum of high-risk leukemias is caused by recurrent chromosomal translocations that result in the expression of fusion proteins. In a recent article in Nature, it has been demonstrated that the oncogenic properties of one such fusion, NUP98–HOXA9, are linked to its ability to self-associate and function through aberrantly phase-separated “onco-condensates.

    • Tanja Mittag
    • Aseem Z. Ansari
    News & Views
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Matters Arising

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