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Volume 28 Issue 6, June 2021

Retinoids induce 2CLC reprogramming

Retinoic acid signaling regulates the 2-cell-stage program and is essential for zygotic genome activation and developmental progression of mammalian embryos.

See Iturbide et al.

Image: Cover image inspired by Waddington’s epigenetic landscape. Credit:Arterra Picture Library / Alamy Stock Photo. Cover Design: Bethany Vukomanovic.

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  • Structural characterization of B6, a monoclonal antibody that cross-reacts with eight β-coronavirus spike proteins from three viral lineages, reveals a conserved cryptic epitope that could serve as a target for structure-guided design of a pan-β-coronavirus vaccine.

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    • Laiyin Nie
    • Tomas C. Pascoa
    • Elisabeth P. Carpenter
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