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Volume 28 Issue 5, May 2021

PDB 50th anniversary: celebrating the future of structural biology

In honour of the 50th anniversary of the Protein Data Bank, we and our colleagues at Nature Methodspresent a special online Collection that celebrates the past and future of structural biology.

See Editorial

Image: Cross-section through a B-cell showing release of antibodies. Illustration by David S. Goodsell, The Machinery of Life, published 2009 by Springer Nature. Cover Design: Bethany Vukomanovic.


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  • Structural biology plays a crucial role in the fight against COVID-19, permitting us to ‘see’ and understand SARS-CoV-2. However, the macromolecular structures of SARS-CoV-2 proteins that were solved with great speed and urgency can contain errors that may hinder drug design. The Coronavirus Structural Task Force has been working behind the scenes to evaluate and improve these structures, making the results freely available at

    • Tristan I. Croll
    • Kay Diederichs
    • Andrea Thorn
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News & Views

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Brief Communications

  • The cryo-EM structure of DNA-assembled histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus, a nucleocytoplasmic large DNA virus, reveals that these proteins form viral nucleosomes with highly conserved features when compared to canonical eukaryotic nucleosomes.

    • Marco Igor Valencia-Sánchez
    • Stephen Abini-Agbomson
    • Karim-Jean Armache
    Brief Communication
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Amendments & Corrections

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