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Volume 28 Issue 1, January 2021

Volume 28 Issue 1

Architecture of the ciliary radial spoke

Structural work reveals the architecture of the radial spoke in unprecedented detail and provides insights into the mechanoregulation of motile cilia.

See Article by Grossman-Haham et al. and Article by Gui et al.

Image: Adam Beedle / Alamy Stock Photo. Cover Design: Bethany Vukomanovic.

Editorial

  • Editorial |

    Rapid progress is being made in our understanding of RNA–protein interactions, their role in disease and their influence on the action of oligonucleotide drugs.

Feature

  • Feature |

    How can structural biology help us understand and combat SARS-CoV-2? Researchers in the field share their experiences and opinions and point to the challenges that lie ahead.

    • Montserrat Bárcena
    • Christopher O. Barnes
    • Qiang Zhou

News & Views

  • News & Views |

    The multisubunit phospholipid transport system Mla has been under scrutiny to determine whether it functions as an exporter or an importer. Structural studies accompanied by the reconstitution of the entire Mla system into proteoliposomes now reveal that ATP binding and hydrolysis drive phospholipid import.

    • Russell E. Bishop
  • News & Views |

    The protein SARM1 is an executioner of axon degeneration through its NAD+ hydrolase activity. Three groups now report structures of human SARM1 in an inactive state and identify NAD+ as an allosteric inhibitor, illuminating an elegant mechanism of how SARM1 is activated at lower NAD+ levels and causes NAD+ collapse and axon degeneration.

    • Liang Tong

Articles

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