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Volume 28 Issue 11, November 2021

Gearing up for GPCR activation

A new online GPCR structure analysis platform is presented and used to perform a comparative analysis of inactive/active state structures, resulting in detailed molecular mechanistic maps of activation of the major GPCR classes.

See Articles by Kooistra, Munk et al. and Hauser, Kooistra et al.

Image: Jonathan Knowles / Stone / Getty. Cover Design:Bethany Vukomanovic


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News & Views

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Brief Communications

  • An online and interactive G-protein coupled receptor (GPCR) structure analysis platform allows any researcher to analyze and visualize a plethora of structure–function relationships across the scales of atomic interactions to protein backbone rearrangements.

    • Albert J. Kooistra
    • Christian Munk
    • David E. Gloriam
    Brief Communication
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  • Here the authors computationally test the hypothesis that RNA organizes the three-dimensional genome via a triplex-forming mechanism, providing evidence that lncRNA-targeted triplex hotspots can contribute to large-scale chromosome compartmentalization.

    • Irene Farabella
    • Marco Di Stefano
    • Marc A. Marti-Renom
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Amendments & Corrections

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