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Volume 26 Issue 1, January 2019

Transcription shapes DNA replication

Two reports reveal that transcription start and stop sites shape DNA replication initiation and termination, and that transcription influences replication patterns to modulate genome stability.

See Chen et al. 26, 67–77 (2018) and Blin et al. 26, 58–66 (2018)

Image: Ganna Potapova/Alamy Stock Photo. Cover Design: Erin Dewalt.

News & Views

  • The intertwined structure of the Taf5–Taf6–Taf9 subcomplex is dependent on the chaperonin CCT for its assembly and subsequent integration into the general transcription factor TFIID.

    • Alan C. M. Cheung
    News & Views


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